Wed.Aug 14, 2024

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One in Four Brain Injury Patients Who Appear Unresponsive Respond Covertly

Med Page Today

(MedPage Today) -- Cognitive-motor dissociation -- a phenomenon that occurs when patients who appear unresponsive perform cognitive tasks that can be detected on functional MRI (fMRI) or electroencephalography (EEG) -- occurred in one in four.

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Ranibizumab Biosimilar Reduces Treatment Cost Across nAMD Subtypes

HCPLive

A ranibizumab biosimilar lowers costs compared with aflibercept across all nAMD subtypes from both the patient and societal perspectives.

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10 hospitals with highest, lowest readmissions for heart failure patients

Becker's Hospital Review - Cardiology

Boise, Idaho-based St. Luke's Regional Medical Center has the lowest readmission rate for heart failure patients, CMS found.

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Where did the P waves go?

Dr. Smith's ECG Blog

Written by Willy Frick I was reading through ECGs in the queue when I saw the following. What do you think of the rhythm? At first glance there seems to be a lot of variation happening, but by focusing on one part of the ECG at a time we can make sense of it. Ignore the first QRS complex and look at beats 2 through 5. I have labeled them below for ease of reference: We see P waves which are upright in leads I, II, and aVF, and upside down in aVR.

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Work-related stress may increase the risk of an irregular heart rhythm

Science Daily - Heart Disease

Job strain and effort-reward imbalance at work were associated with a greater chance of developing an abnormal heart rhythm condition, finds a new study.

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Itch Improvement Impacts Dermatology Life Quality Index Scores for Eczema, Psoriasis

HCPLive

This analysis was conducted to evaluate the effect of pruritus on quality of life ratings among individuals with atopic dermatitis and psoriasis.

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Bleeding Better Controlled When Protamine Is Part of TAVR Wrap-Up Routine

Med Page Today

(MedPage Today) -- With protamine routinely given at the end of transcatheter aortic valve replacement or implantation (TAVR or TAVI), patients achieved hemostasis quicker and with greater success, according to the ACE-PROTAVI trial. Successful.

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More Trending

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19th Annual Cardiometabolic Health Congress: Honoring the Life and Legacy of CMHC Co-Chair Dr. George L. Bakris

Cardiometabolic Health Congress

This October, top medical minds will converge to tackle the alarming surge in cardiometabolic conditions, drawing inspiration from Dr. George L. Bakris’ distinguished career as a leading educator and mentor. Boca Raton, FL, Aug. 14, 2024 (GLOBE NEWSWIRE) — For nearly two decades, Dr. George L. Bakris was a pillar of the Cardiometabolic Health Congress (CMHC) , generously sharing his expertise, passion, and unwavering dedication to advancing cardiometabolic health.

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True Prevalence of Hypercortisolism

HCPLive

The panel of medical experts discuss the prevalence of hypercortisolism based on the CATALYST trial.

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Work-related stress may increase the risk of an irregular heart rhythm

Medical Xpress - Cardiology

Work-related stress caused by job strain and an imbalance between efforts applied vs. rewards received may increase the risk of developing atrial fibrillation, according to new research published in the Journal of the American Heart Association.

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Safety and Behavior of Implantable Electronic Devices During Cremation

HeartRhythm

The current standard of practice for cremating patients with cardiac implantable electronic devices (CIEDs) is surgical explantation prior to cremation to mitigate the risk of device explosion. This surgery may conflict with patient or family beliefs, whereas cremation of CIEDs may create occupational hazards.

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Apolipoprotein B test may be more accurate measure of heart disease risk

Medical Xpress - Cardiology

The traditional lipid panel may not give the full picture of cholesterol-related heart disease risk for many Americans, according to a study led by UT Southwestern Medical Center researchers and published in JAMA Cardiology.

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FDA Grants Accelerated Approval to Seladelpar (Livdelzi) for Primary Biliary Cholangitis

HCPLive

The accelerated approval is based on phase 3 data demonstrating seladelpar’s impact on ALP reduction and is contingent upon verification and description of clinical benefit in confirmatory trial(s).

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People with untreated high blood pressure may have higher risk of Alzheimer's disease

Medical Xpress - Cardiology

People 60 and older with untreated high blood pressure may have an increased risk of Alzheimer's disease compared to both people who have been or are being treated for high blood pressure as well as people without the chronic condition.

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Management of secondary mitral regurgitation: from drugs to devices

Heart BMJ

Severe secondary mitral regurgitation carries a poor prognosis with one in five patients dying within 12 months of diagnosis. Fortunately, there are now a number of safe and effective therapies available to improve outcomes. Here, we summarise the most up-to-date treatments. Optimal guideline-directed medical therapy is the mainstay therapy and has been shown to reduce the severity of mitral regurgitation in 40–45% of patients.

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Sleep Pills May Not Enhance Quality of Life in Hepatocellular Carcinoma Patients

HCPLive

Investigators highlight the need for tailored interventions to improve sleep disturbances and overall health in patients with hepatocellular carcinoma.

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Study: Chronic High Caffeine Consumption May Heighten Cardiovascular Disease Risk

DAIC

tim.hodson Wed, 08/14/2024 - 10:29 Aug. 15, 2024 — According to a new study being presented at ACC Asia 2024 in Delhi, India, drinking over 400 mg of caffeine per day on most days of the week could increase the susceptibility of healthy individuals to cardiovascular disease. “Regular caffeine consumption could disturb the parasympathetic system, leading to elevated blood pressure and heart rates,” said lead author Nency Kagathara, MBBS, Department of Internal Medicine, Zydus Medical College and

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Mazen Noureddin, MD, MHSc: MASLD-Related Fibrosis Risk Stratification with FIB-4, VCTE

HCPLive

Noureddin explains the discordance between FIB-4 and transient elastography for stratifying fibrosis risk and emphasizes the importance of repetition and attentiveness with FIB-4.

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Rivus HU6 Shows Obesity-HFpEF Potential

CardiacWire

Rivus Pharmaceuticals’ HU6 is showing promise as a future obesity-related HFpEF treatment, after topline results from its Phase 2a HuMAIN trial revealed valuable weight, symptom, and cardiometabolic improvements – without the risk of muscle loss. HU6 is an oral Controlled Metabolic Accelerator that promotes weight loss by making energy production less efficient, forcing the body to rev up metabolism to maintain homeostasis, while avoiding muscle loss.

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Teriparatide Biosimilar Demonstrates Therapeutic Equivalence in Postmenopausal Women With Osteoporosis

HCPLive

Both treatment arms experienced significant improvements in measured parameters from baseline, although these were not all statistically significant.

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Certain metabolites linked to heart failure risk: Study

Becker's Hospital Review - Cardiology

Certain gut metabolites are linked to an increased risk of heart failure, according to a study published Aug. 9 in Circulation: Heart Failure , an American Heart Association journal.

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Increased Physical Activity Results in Skin Clearance Among Individuals with Psoriasis

HCPLive

These data suggest that physical activity interventions can lead to visible improvements in PASI scores after 20 weeks of implementation, as well as cardiometabolic improvements.

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Creative Alliances in Cardiorenal Metabolic Management: A Game Changer (Part 2) 

Cardiometabolic Health Congress

Harnessing Collaborative Innovation to Combat Cardiometabolic Risk Building on the foundation in Part 1 , explore real-world examples of how creative partnerships transform cardiorenal metabolic risk management. Dynamic collaborations unite patients, healthcare providers, and multidisciplinary experts, putting into practice the principles of shared decision-making, open communication, patient education, and motivational interviewing discussed.

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Empowering Patients: Defining Moderate Plaque Psoriasis and the Promise of Novel Oral Systemic Treatment

HCPLive

Plaque psoriasis experts explore recent advancements in treatment options, patient experiences, and the potential of novel oral systemic therapies to reduce the burden of this prevalent chronic condition.

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Why Spicy Foods Appeal; Congressman Has Mild Stroke; Indian Doctors on Strike

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Do you dig really spicy foods? It might be because of the adrenaline rush. (NBC News) Former House majority leader Steny Hoyer (D-Md.) experienced a mild ischemic.

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Abnormal echocardiographic finding mimicking paracardiac cystic lesion

Heart BMJ

Clinical introduction The patient was a man in his 40s with a medical history of hypertension, Behcet’s disease (BD) and chronic renal dysfunction. Previous medical interventions included a spectrum of procedures, including catheter-directed thrombectomy for popliteal artery aneurysms with thrombosis, vascular bypass grafting for cerebral-anterior communicating artery aneurysms and arch replacement and stent implantation for aortic dissecting aneurysms.

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Lifestyle Changes and Non-Pharmacological Options for Fibromyalgia

HCPLive

A key opinion leaders explore effective non-pharmacological therapies and lifestyle modifications that have shown significant promise in managing fibromyalgia symptoms, complementing traditional medication-based approaches.

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Automatic detection of cardiac conditions from photos of electrocardiogram captured by smartphones

Heart BMJ

Background Researchers have developed machine learning-based ECG diagnostic algorithms that match or even surpass cardiologist level of performance. However, most of them cannot be used in real-world, as older generation ECG machines do not permit installation of new algorithms. Objective To develop a smartphone application that automatically extract ECG waveforms from photos and to convert them to voltage-time series for downstream analysis by a variety of diagnostic algorithms built by researc

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Responses More Likely With Bimekizumab Over Ustekinumab, Risankizumab in Treating PsA

HCPLive

A retrospective analysis compared data from the BE OPTIMAL and BE COMPLETE trials with data from pivotal trials of the IL-23–targeting therapies.

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Aspirin: latest evidence and developments

Heart BMJ

Aspirin is a foundation drug of the pharmaceutical industry originally derived as an analgesic/anti-inflammatory agent but serendipitously discovered to have use as a prophylactic drug for major adverse cardiovascular events (MACE). Its modern-day utility in this latter role relies on its efficacy/safety balance in a contemporary population where, at least in high-income countries, age-standardised incident rates for MACE are falling, and where there are now competing therapeutic agents.

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Antihypertensive Medication Use in First 2 Years Postpartum

American College of Cardiology

What is the incidence of initiation of antihypertensive medication use in the first 2 years after delivery among women with hypertensive disorders of pregnancy (HDP)?

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Improving how we determine who should take blood pressure and lipid-lowering medications

Heart BMJ

Cardiovascular disease (CVD) risk equations are useful to guide treatment decisions for blood pressure and lipid-lowering medications because they identify patients who are at high risk of CVD but do not have either blood pressure or cholesterol measurements above the levels when considering treatment as individual risk factors. National guideline groups can then set thresholds that prioritise the use of these medications to those at high risk of CVD based on this global, or absolute, risk asses

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Is Home Treatment Safe for Patients with Acute Pulmonary Embolism?

NEJM Journal Watch - Cardiology

A meta-analysis of individual participant–level data provides reassurance that early home discharge is safe in carefully selected patients.

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AI-enabled diagnosis from an electrocardiogram image: the next frontier of innovation in a century-old technology

Heart BMJ

A hundred years ago, in 1924, Willem Einthoven won the Nobel Prize for Physiology and Medicine for his invention of electrocardiography. Over a century, we have continued to perfect the science behind ECGs, making them easier to acquire, improving their quality, and defining pathognomonic features of conditions spanning a wide range of rhythm and conduction disorders.

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Baricitnib Withdrawal Leads to Loss of Benefit in Up to 80% with Alopecia Areata

HCPLive

Withdrawal of baricitinib in severe alopecia areata led to hair loss in 80% of patients, highlighting the need for ongoing therapy to maintain regrowth.

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Plot thickens: the progression of left ventricular 'hypertrophy in Fabry disease

Heart BMJ

Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder from a mutation in the alpha-galactosidase A (GLA) gene, with absolute or partial GLA deficiency causing accumulation of glycosphingolipids in various organs. The causative pathogenic mutation (classical vs late onset) plays a significant role in the resultant phenotype. Due to the X-linked inheritance, males have more severe and earlier disease manifestations (~10 years earlier than in females).

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Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR

American College of Cardiology

What is the relationship between diffusion-weighted magnetic resonance imaging (DW-MRI) total lesion number (TLN), individual lesion volume (ILV), and total lesion volume (TLV) with clinical stroke outcomes after transcatheter aortic valve replacement (TAVR)?

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