HCPLive
JANUARY 18, 2024
Both the FDA and EU regulators indicated visual acuity may serve as primary endpoint to evaluate MCO-010 in the treatment of low-vision retinitis pigmentosa patients.
Med Page Today
JANUARY 18, 2024
(MedPage Today) -- The new nomenclature for classifying steatotic liver disease (SLD) can help clinicians determine distinct prognoses, with the integration of alcohol intake as an aid in risk stratification, according to an analysis of a prospective.
Becker's Hospital Review - Cardiology
JANUARY 18, 2024
New York City-based NewYork-Presbyterian Morgan Stanley Children's Hospital performed the first "domino" heart transplant on babies, according to an American Hospital Association report.
DAIC
JANUARY 18, 2024
The American Heart Association has issued a new Policy Statement focused on the need to address structural racism as a central component to reducing cardiovascular disparities across the United States. Image courtesy: AHA christine.book Thu, 01/18/2024 - 13:33 January 18, 2024 — A new American Heart Association (AHA) policy statement examines the history of structural racism, and offers public policy considerations for several key social drivers of health disparities, including health care, heal
Med Page Today
JANUARY 18, 2024
(MedPage Today) -- Operators reported the initial success of a novel transcatheter technique for treating complex paravalvular leaks (PVLs) after transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve replacement (TMVR) in.
DAIC
JANUARY 18, 2024
Dr. Rundback (second from left) and team from AIVS in West Orange, NJ. (Photo: Business Wire milla1cf Thu, 01/18/2024 - 14:05 January 18, 2024 — Summa Therapeutics, LLC announced that the first-in-man injectable angioplasty procedures for patients with below-knee peripheral arterial disease (PAD) were performed successfully using its Finesse Injectable balloon catheter platform.
HCPLive
JANUARY 18, 2024
In a new study, nearly a third of participants with OSA reported using > 3 coping strategies, but participants without OSA reported never using > 3 coping strategies.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
HCPLive
JANUARY 18, 2024
Renal failure risk group classification based on pathological findings from patients’ kidney biopsy, eGFR, and proteinuria was significantly associated with a composite 50% increase in serum creatinine.
Open Heart
JANUARY 18, 2024
Background Heart failure (HF) remains a major public health problem with a high mortality and morbidity worldwide. Currently, there is no optimal revascularisation strategy for patients with ischaemic cardiomyopathy despite suggestions that coronary artery bypass graft (CABG) may be superior to medical therapy in improving survival. However, CABG may be associated with substantial risk in HF subjects.
HCPLive
JANUARY 18, 2024
In the CLEAR Outcomes trial, bempedoic acid was associated with a 20% reduction in relative risk for total cardiovascular events, with further analysis shining light on the effects of specific types of events.
Open Heart
JANUARY 18, 2024
Objective Residual sequelae after surgical repair of tetralogy of Fallot (rTOF) affect clinical outcome. We investigated the prognostic impact of right ventricular (RV) dyssynchrony in adults with rTOF years after the surgical repair. Methods Patients from the Swiss Adult Congenital HEart disease Registry were included. NT-proBNP levels, echocardiography, exercise testing and MRI data were collected.
Medical Xpress - Cardiology
JANUARY 18, 2024
Cardiovascular disease (CVD) is the leading cause of death in the United States. Black women have a disproportionally higher burden of coronary heart disease (CHD) and CHD-related mortality and earlier onset than women of other racial and ethnic groups.
Stroke Journal
JANUARY 18, 2024
Stroke, Ahead of Print. Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias. Sleep disorders such as sleep-disordered breathing (eg, obstructive sleep apnea), and other sleep disturbances, as well, some of which are also considered sleep disorders (eg, insomnia, sleep fragment
HCPLive
JANUARY 18, 2024
Investigators observed no change in Insomnia Severity Index scores from baseline to weeks 7 and 25 with CBT-1, trazodone, or placebo, suggesting these insomnia treatment options are not effective for patients undergoing hemodialysis.
Open Heart
JANUARY 18, 2024
Introduction Three recent randomised controlled trials have demonstrated that pulmonary vein isolation as an initial rhythm control strategy with cryoablation reduces atrial arrhythmia recurrence in patients with symptomatic paroxysmal atrial fibrillation (PAF) compared with antiarrhythmic drug (AAD) therapy. The aim of this study was to evaluate the cost-effectiveness of first-line cryoablation compared with first-line AADs for treating symptomatic PAF in an English National Health Service (NHS
Frontiers in Cardiovascular Medicine
JANUARY 18, 2024
Adipose-derived mesenchymal stem cells (ASCs) represent an innovative candidate to treat ischemic heart disease (IHD) due to their abundance, renewable sources, minor invasiveness to obtain, and no ethical limitations. Compared with other mesenchymal stem cells, ASCs have demonstrated great advantages, especially in the commercialization of stem cell-based therapy.
Medical Xpress - Cardiology
JANUARY 18, 2024
Exposure to air pollutants, even at very low concentrations, was associated with adverse changes in cardiometabolic risk factors in a recent Finnish study. The main pollutant affecting these risk factors was particulate matter, which can be emitted from traffic and wood burning, among other sources. Interestingly, diet quality appeared to modify several associations of pollutants with cardiometabolic health.
Frontiers in Cardiovascular Medicine
JANUARY 18, 2024
Background Sacubitril/valsartan (SacVal) has been shown to improve the prognosis of heart failure; however, whether SacVal reduces the occurrence of atrial fibrillation (AF) in heart failure has not yet been elucidated. In this study, we aimed to determine whether SacVal is effective in reducing the occurrence of AF in heart failure and identify the underlying mechanism of its electrophysiological effect in mice.
Dr. S. Venkatesan MD
JANUARY 18, 2024
Question A cath lab is an “ optional accessory ” in the management of Acute coronary syndrome (ACS). True or False ? Answer “ Without a CCU…you can never , treat any Acute coronary syndrome … while we can treat most ACSs successfully without a cath lab “ (If you still got the answer wrong …sorry, no comments) Best comment Accessory is ok , but it is “20% foolish ” to state cath-lab is optional, it should be mandatory.
Frontiers in Cardiovascular Medicine
JANUARY 18, 2024
Background With the rapid development of artificial intelligence, prediction of warfarin dose via machine learning has received more and more attention. Since the dose prediction involve both linear and nonlinear problems, traditional machine learning algorithms are ineffective to solve such problems at one time. Objective Based on the characteristics of clinical data of Chinese warfarin patients, an improved stacking ensemble learning can achieve higher prediction accuracy.
HCPLive
JANUARY 18, 2024
A new study reports previously unknown inherited genetic variants that contribute to glaucoma risk among more than 11,000 people of African ancestry.
Medical Xpress - Cardiology
JANUARY 18, 2024
Receipt of a cardiac-resynchronization therapy-defibrillator (CRT-D) offers long term benefit for patients with heart failure, reduced ejection fraction, and a widened QRS complex, according to a study published in the Jan. 18 issue of the New England Journal of Medicine.
HCPLive
JANUARY 18, 2024
Consuming a 5mg piperine capsule once daily for 12 weeks was linked to several pharmacological improvements in patients with NAFLD.
Journal of Cardiothoracic Surgery
JANUARY 18, 2024
The celiacomesenteric trunk (CMT) is a common duct of the celiac artery (CA) and the superior mesenteric artery originating from the aorta, which is an uncommon anatomical variant of visceral artery circulatio.
Open Heart
JANUARY 18, 2024
Background The Heart Failure Association Pretest assessment, echocardiography and natriuretic peptide, functional testing and final aetiology (HFA-PEFF) score has been developed for diagnosing heart failure with preserved ejection fraction (HFpEF), which is frequently associated with atrial fibrillation (AF). We aimed to investigate whether preprocedural HFA-PEFF score could be used to predict clinical outcomes in patients with AF who underwent catheter ablation (CA).
HCPLive
JANUARY 18, 2024
Test your knowledge of treatment persistence, adherence, and switching patterns of adalimumab biosimilar ABP 501 between adalimumab-naïve patients and adalimumab-experienced patients.
American College of Cardiology
JANUARY 18, 2024
What is the prevalence and penetrance of sarcomeric genes in clinical studies with patients and families with hypertrophic cardiomyopathy (HCM) as compared with population-based studies of asymptomatic individuals?
HCPLive
JANUARY 18, 2024
An analysis of the RAFT trial showed patients with heart failure treated with CRT-D experienced continued survival benefits during a median of nearly 14 years of follow-up.
Circulation
JANUARY 18, 2024
Circulation, Ahead of Print. BACKGROUND:Racism is highly prevalent in the United States. Few data exist about whether perceived interpersonal racism is associated with risk of coronary heart disease (CHD).METHODS:We followed 48 305 participants in the Black Women’s Health Study through biennial mailed and Internet-based health questionnaires from 1997, when they provided information on perceived interpersonal racism and were free of cardiovascular disease and cancer, until the end of 2019.
HCPLive
JANUARY 18, 2024
In this segment of Porter’s interview, she delves further into the phase 2 findings on lutikizumab and discusses any adverse events and future research.
Circulation
JANUARY 18, 2024
Circulation, Ahead of Print. BACKGROUND:TTNtruncation variants (TTNtvs) are the most common genetic lesion identified in individuals with dilated cardiomyopathy, a disease with high morbidity and mortality rates. TTNtvs reduce normal TTN (titin) protein levels, produce truncated proteins, and impair sarcomere content and function. Therapeutics targeting TTNtvs have been elusive because of the immense size of TTN, the rarity of specific TTNtvs, and incomplete knowledge of TTNtv pathogenicity.METH
HCPLive
JANUARY 18, 2024
Improvements in insulin resistance were reported in patients with RA and type 2 diabetes treated with tofacitinib.
American College of Cardiology
JANUARY 18, 2024
Phosphodiesterase type 5 inhibitors (PDE5i) are a common medical treatment for erectile dysfunction (ED) in men with cardiovascular disease. However, a study published Jan. 15 in JACC suggests that patients are at higher risk for morbidity and mortality over time when PDE5is and nitrate medication are both prescribed.
HCPLive
JANUARY 18, 2024
Bhatia discussed some of the major takeaways from his Winter Clinical presentation titled ‘What's New and Hot in AK Management.
Circulation
JANUARY 18, 2024
Circulation, Ahead of Print. BACKGROUND:Heart failure is associated with a high rate of mortality and morbidity, and ventricular remodeling invariably precedes heart failure. Ventricular remodeling is fundamentally driven by mechanotransduction that is regulated by both the nervous system and the immune system. However, it remains unknown which key molecular factors govern the neuro/immune/cardio axis that underlies mechanotransduction during ventricular remodeling.
BMH Medical Journal
JANUARY 18, 2024
Acute promyelocytic leukemia is a unique subset of acute myeloid leukemias characterised by the proliferation of neoplastic promyelocytes bearing chromosomal translocation t (15;17). Although APML accounts for nearly 13% of acute myeloblastic leukemia cases, it usually affects young adults and hence increasing the possibility of its occurrence during pregnancy.
Circulation
JANUARY 18, 2024
Circulation, Ahead of Print. BACKGROUND:Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an enzyme that is required for cardiolipin maturation. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) use to provide hemodynamic support for acute myocardial infarction has grown exponentially, is associated with poor outcomes, and is under active clin
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