Sun.Apr 07, 2024

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Incentives Prompt Increased Daily Walking in Patients at Risk for Heart Disease

DAIC

milla1cf Sun, 04/07/2024 - 18:45 April 7, 2024 — Strategies such as earning points or small amounts of money encouraged people at high risk for heart disease or stroke to increase their daily walking by about 10% and sustain the increase for a year, according to research being presented at the American College of Cardiolog y’s Annual Scientific Session.

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Proof of Benefit in Acute MI Again Evades an SGLT2 Inhibitor

Med Page Today

(MedPage Today) -- ATLANTA -- The SGLT2 inhibitor empagliflozin (Jardiance) did not exactly prevent deaths and heart failure (HF) events when initiated atop other standard therapies for acute myocardial infarction (MI), the EMPACT-HF trial found.

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Novel PCSK9 Inhibitor Cut LDL Cholesterol Levels by More Than Half

DAIC

milla1cf Sun, 04/07/2024 - 18:09 April 7, 2024 — Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or “bad” cholesterol, levels by more than half on average, compared with a placebo. In addition, 90% of patients treated with lerodalcibep, versus 16% of those on placebo, attained the newer, more stringent guideline-recommended LDL targets set by the Amer

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Understanding Total Costs Associated with Hospitalization for Heart Failure, with Veraprapas Kittipibul, MD

HCPLive

Veraprapas Kittipibul, MD, discusses a study examining costs associated with heart failure hospitalization among patients with HFrEF or HFpEF from within the GWTG-HF registry.

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One Injection of Novel Drug Cuts Systolic Blood Pressure by Up to 12 mmHg

DAIC

mtaschetta-millane Sun, 04/07/2024 - 18:43 April 7. 2024 — A single subcutaneous injection of the investigational drug zilebesiran , when added to existing treatment with a standard antihypertensive medication, reduced systolic blood pressure by between 4 to 12 mmHg on average at three months in patients whose blood pressure had remained uncontrolled despite compliance with their medication regimen, according to a study presented at the American College of Cardiology ’s Annual Scientific Session

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Interatrial Shunt's Prospects in Heart Failure Shrink After RELIEVE-HF

Med Page Today

(MedPage Today) -- ATLANTA -- An interatrial shunt failed to provide a clinical benefit to people with heart failure (HF) overall in the RELIEVE-HF trial, though actual harm or benefit seemed to hinge on the patient's left ventricular ejection.

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Plozasiran Reduces Triglyceride Levels by 74% at 24 Weeks

DAIC

milla1cf Sun, 04/07/2024 - 17:57 April 7, 2024 — In patients with severely elevated triglyceride levels at risk for developing acute pancreatitis, the investigational drug plozasiran reduced triglyceride levels by an average of 74% after 24 weeks of use without causing any significant safety concerns, according to research presented at the American College of Cardiology ’s Annual Scientific Session.

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ULTIMATE-DAPT: Most Patients With ACS Can Safely Stop Aspirin One Month Post PCI

American College of Cardiology

Ticagrelor monotherapy following one month of dual antiplatelet therapy (DAPT) outperforms 12-month DAPT (aspirin and ticagrelor) post PCI for reducing clinically meaningful bleeding with no increased thrombotic risk, according to the results of the ULTIMATE-DAPT study, presented during a Late Breaking Clinical Trial session at ACC.24 and published simultaneously in The Lancet.

Article 75
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Another Early Win for TAVI in Low-Risk Patients

The New England Journal of Medicine

Transcatheter aortic-valve implantation (TAVI) has become the dominant, if not default, therapy for patients with severe, symptomatic aortic stenosis who are at intermediate, high, or prohibitive risk for surgical aortic-valve replacement (SAVR). Several randomized trials have shown that TAVI in patients at low surgical risk is either noninferior or.

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Cardiogenic Shock

American College of Cardiology

The goal of the DanGer Shock trial was to compare the safety and efficacy of Impella CP on top of standard care compared with standard care alone among patients with ST-segment elevation myocardial infarction (STEMI) and cardiogenic shock.

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Semaglutide Improves Outcomes in Patients with Obesity, HFpEF, and Type 2 Diabetes

NEJM Journal Watch - Cardiology

In a randomized, controlled trial, semaglutide resulted in greater weight loss, improved symptoms, and fewer serious adverse events compared with placebo.

Obesity 74
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One-month Ticagrelor Monotherapy After PCI in Acute Coronary Syndromes

American College of Cardiology

The goal of the ULTIMATE-DAPT trial was to compare the safety and efficacy of ticagrelor monotherapy compared with dual antiplatelet therapy (DAPT) with aspirin and ticagrelor for 12 months following completion of 1-month DAPT for patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).

Article 69
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Plozasiran Reduces Triglycerides, ApoC3 in Phase 2b SHASTA-2 Trial

HCPLive

Plozasiran demonstrates a 74% reduction in triglyceride levels at 24 weeks in patients with severe hypertriglyceridemia in the phase 2b SHASTA-2 trial.

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Randomized Evaluation of Decreased Usage of Beta-Blockers After Acute Myocardial Infarction

American College of Cardiology

The goal of the REDUCE-AMI trial was to evaluate the potential benefit of beta-blockade following acute myocardial infarction (AMI) in patients with preserved left ventricular ejection fraction (LVEF) in the modern era of coronary revascularization and medical therapy.

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Alberto Foà, MD, PhD: Understanding Hypotension, Benefit, and LVEF in PARAGON-HF

HCPLive

Alberto Foà, MD, PhD, discusses a PARAGON-HF analysis from ACC.24 examining treatment-related hypotension in people with HFmrEF/HFpEF.

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FEEL Study: Focus on Spirituality, Gratitude Can Lead to Decrease in BP, Increase in FMD

American College of Cardiology

Twelve weeks of daily smartphone messages, designed to cultivate spirituality and promote reflection, was associated with a reduction in systolic blood pressure (BP) and improvement in flow-mediated dilation (FMD).

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Aspiration of thrombus for intermediate-risk subacute pulmonary embolism

Journal of Cardiothoracic Surgery

Pulmonary embolism is the most common cardiovascular disease after myocardial infarction and stroke. Konstantinides (Eur Heart J 41(4):543–603, 2020) Current guidelines categorize patients with PE as being at.

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REDUCE-AMI: Long-Term Beta-Blockers May Not Lower Risk of Death, MI in Patients With MI, Preserved LVEF

American College of Cardiology

Long-term treatment with beta-blockers may not lower the risk of death or myocardial infarction (MI) in patients with MI, a preserved left ventricular ejection fraction (LVEF) of ≥50% and coronary artery disease, according to the results of the REDUCE-AMI study, presented during a Late-Breaking Clinical Trial session at ACC.24 and published simultaneously in the New England Journal of Medicine.

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Experience with aortic arch inclusion technique using artificial blood vessel for type A aortic dissection: an application study

Journal of Cardiothoracic Surgery

This study aimed to elucidate the methodology and assess the efficacy of the aortic arch inclusion technique using an artificial blood vessel in managing acute type A aortic dissection (ATAAD).

Aortic 52
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HUDDLE: Prevalence of CVD Risk Factors High, Awareness Low Among Former NFL Players

American College of Cardiology

A substantial gap was found between the self-reports of cardiovascular disease (CVD) by former players in the National Football League (NFL) and a "surprisingly high" prevalence of hypertension, with a "significant discrepancy between participants' awareness and observed disease prevalence," according to the findings.

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Optimal patient selection for maze procedure in patients undergoing mitral valve disease

Journal of Cardiothoracic Surgery

Although risk factors for unsuccessful Maze procedure have been demonstrated, an appropriate patient selection is still controversial. In our institute, Maze procedure is indicated for those whom normal sinus.

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DanGer Shock: Impella CP Improves Survival After STEMI With Cardiogenic Shock

American College of Cardiology

Implantation of the Impella CP micro-axial flow pump may increase survival at six months among patients with STEMI complicated by cardiogenic shock (CS), according to the results of the DanGer Shock study.

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Antler Sign in Pulmonary Venous Hypertension

All About Cardiovascular System and Disorders

Transcript of the video: Now we will discuss a chest X-ray showing antler sign in pulmonary venous hypertension. For a change, first we will see the picture of a stag, with antlers. You can see the antlers here. So, the shape of the upper lobe vessels in venous hypertension, pulmonary venous hypertension, will be resembling the antlers of the stag. That is why, the name antler sign has been given.

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Bishop Keynote to Expand on Hot Topics in the Business of Cardiology

American College of Cardiology

The increasing need for cardiovascular clinicians to be equipped with the business know-how to navigate the rapidly evolving practice landscape is the focus of the Business of Cardiology Intensive Sessions at ACC.24.

Article 60
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CHD-CXR: a de-identified publicly available dataset of chest x-ray for congenital heart disease

Frontiers in Cardiovascular Medicine

Congenital heart disease is a prevalent birth defect, accounting for approximately one-third of major birth defects. The challenge lies in early detection, especially in underdeveloped medical regions where a shortage of specialized physicians often leads to oversight. While standardized chest x-rays can assist in diagnosis and treatment, their effectiveness is limited by subtle cardiac manifestations.

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Video: Day 2 — ACCess Points Daily Wrap Up | ACC.24

American College of Cardiology

Drs. Kim Eagle, Dharam Kumbhani, Payal Kohli, and Ajay Kirtane debate and discuss the outcomes of the trials presented on day 2 at ACC.24 including REDUCE-AMI (0:35), DanGer-Shock (3:28), ULTIMATE-DAPT (6:17), and TACT2 (10:04).

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Predictors, clinical impact, and management strategies for conduction abnormalities after transcatheter aortic valve replacement: an updated review

Frontiers in Cardiovascular Medicine

Transcatheter aortic valve replacement (TAVR) has increasingly become a safe, feasible, and widely accepted alternative surgical treatment for patients with severe symptomatic aortic stenosis. However, the incidence of conduction abnormalities associated with TAVR, including left bundle branch block (LBBB) and high-degree atrioventricular block (HAVB), remains high and is often correlated with risk factors such as the severity of valvular calcification, preexisting conditions in patients, and pr

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Ashman Phenomenon in A F and Fish Criteria

All About Cardiovascular System and Disorders

Transcript of the video: Now I am going to describe Ashman Phenomenon in atrial fibrillation, which is responsible for a long and short sequence followed by a wide QRS, in atrial fibrillation noted on ECG, which may resemble a ventricular ectopic beat. This is the diagrammatic representation of Ashman phenomenon. You have sequences of AF beats, and a long cycle occurs, followed by a short cycle.

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Cardiology's Bid to Defect From ABIM Plows Ahead

Med Page Today

(MedPage Today) -- ATLANTA -- Cardiology's bid to escape what many see as burdensome requirements for board certification maintenance under the American Board of Internal Medicine (ABIM) is well underway, a panel reported at the American College.

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TACT2: Chelation Therapy Does Not Improve Post-MI Outcomes in Patients With DM

American College of Cardiology

Edetate disodium-based chelation does not lead to improved outcomes in patients with diabetes who had previously suffered a myocardial infarction (MI), according to the results of the TACT2 study, presented during a Late-Breaking Clinical Trial session.

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SGLT2 Inhibition Across a Range of Left Ventricular Hypertrophy, with Muthiah Vaduganathan, MD, MPH

HCPLive

Muthiah Vaduganathan, MD, MPH, discusses a presentation from ACC.24 assessing the effects of dapagliflozin across a range of left ventricular hypertrophy from DELIVER.

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Philanthropic Giving Helping to Accelerate ACC’s Mission

American College of Cardiology

Generous contributions from ACC members around the world are helping to develop solutions for some of the biggest challenges of today, including inspiring and encouraging the next generation of leaders, educators, clinicians and scientists and tangibly addressing the global burden of cardiovascular disease.

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REDUCE-AMI: No Benefit to Beta Blockers Post-Myocardial Infarction If LVEF is Normal

HCPLive

REDUCE-AMI concluded beta-blockers show no significant benefit following myocardial infarction among patients with normal left ventricular ejection fraction

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Trial to Assess Chelation Therapy 2

American College of Cardiology

The goal of the TACT2 trial was to determine the potential clinical benefit of the chelating agent edetate disodium (EDTA) in older adults with a history of myocardial infarction (MI) and diabetes mellitus (DM).

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The Rising Trend in the Use of Patient-Reported Outcomes in Atrial Fibrillation Clinical Trials

HeartRhythm

Atrial fibrillation (AF), already the most prevalent clinical arrhythmia, is increasing in prevalence1. It is associated with adverse outcomes that significantly impact the quality of life (QoL) experienced by patients. Thus, the accurate evaluation of QoL is an emerging part of the assessment of AF patients2. Several tools have arisen to evaluate clinically relevant endpoints.

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Small Annuli Randomized to Evolut or SAPIEN Trial

American College of Cardiology

The goal of the SMART trial was to evaluate a self-expanding valve compared with a balloon-expandable valve among patients with aortic stenosis and a small aortic annulus undergoing treatment with transcatheter aortic valve replacement (TAVR).

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Role of Physiology in the Management of Nonculprit Lesions in Acute Coronary Syndrome

The New England Journal of Medicine

Current international clinical practice guidelines recommend complete revascularization for patients with ST-segment elevation myocardial infarction (STEMI) with multivessel coronary artery disease1 on the basis of evidence from randomized, controlled trials.2 The COMPLETE trial (Complete versus Culprit-Only Revascularization Strategies to Treat Multivessel Disease after Early PCI for.