Wed.Aug 07, 2024

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3D-printed blood vessels bring artificial organs closer to reality

Science Daily - Heart Disease

Lab-grown organs are a long-time 'holy grail' of organ engineering that has yet to be achieved, but new research has brought that goal a big step closer to reality using a new 3D-printing method called co-SWIFT. co-SWIFT prints branching networks of double-layered vessels that are infused with smooth muscle cells and endothelial cells into living human cardiac tissue, and can even replicate patient-specific vascular structures,indicating that it could one day be used for personalized medicine.

Research 132
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Study Highlights Gender Disparities in Treatment Outcomes for Skin Diseases

HCPLive

These data point to differences between genders such as time to initiation of treatment, treatment choice, response to medication, adverse events, and adherence.

Outcomes 111
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Adding a 9th psychological health metric to life's essential 8 enhances the cardiovascular health construct for predicting mortality risk

Science Daily - Heart Disease

A cardiovascular health construct based on the American Heart Association's Life's Essential 8 but enhanced with a ninth psychological health metric strongly predicts all-cause and cardiovascular mortality.

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FDA Issues Warning for Certain Smelling Salts and Other Inhalants Marketed for Energy, Alertness

HCPLive

On August 6, 2024, the FDA warned against using unapproved inhalant products marketed for alertness and energy, citing reports of adverse events including seizures and fainting.

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Alternative access in transcatheter aortic valve replacement—an updated focused review

Frontiers in Cardiovascular Medicine

Aortic Stenosis (AS) is a common condition with an estimated pooled prevalence of all AS in the elderly population at around 12.4%, with that of severe AS estimated to be around 3.4%. In the past, surgical aortic valve replacement was the primary treatment option for severe AS for decades. However, with the compelling evidence on the safety and efficacy of transcatheter aortic valve replacement (TAVR), it has become the gold standard treatment option for many patients with symptomatic severe AS.

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Kidney Function in IgA Nephropathy Not Impacted by Mild, Moderate COVID-19 Infection

HCPLive

Study findings suggest the need for individualized management of patients with IgAN following COVID-19 infection based on baseline renal function status.

COVID-19 105
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Myeloma Therapy for Monoclonal Gammopathy of Thrombotic Significance

The New England Journal of Medicine

A patient with serious thrombotic episodes was found to have a monoclonal gammopathy of an anti–PF4 antibody. Myeloma therapy reduced the paraprotein level and prevented further thrombotic events.

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Mentorship, strategy, vision: Leadership insights from 4 top cardiologists

Becker's Hospital Review - Cardiology

Leaders from four cardiology hospitals that ranked among the best in U.S. News & World Report shared with Becker's the best leadership advice they have ever received.

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Obesity Linked to Elevated Gout Risk

HCPLive

Obesity was more prevalent among patients with gout and obesity indicators were significantly higher in this group.

Obesity 119
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Multimodality Imaging for Pericardial Disease: Key Points

American College of Cardiology

The following are key points to remember from an international position statement on multimodality imaging for pericardial disease.

Article 75
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AI Model Detects Pediatric Eye Diseases Using Smartphone Images

HCPLive

A deep-learning model displayed a strong performance in accurately identifying myopia, strabismus, and ptosis using smartphone images.

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Pulmonary Hypertension and HF, Obesity in Adolescents, Noncardiac Surgery After TAVR

American College of Cardiology

In this week’s View, Dr. Eagle looks at post-capillary pulmonary hypertension in heart failure and the revised European guideline definition. He then explores obesity in adolescents and its impact on our societal health.

Obesity 61
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Iptacopan Receives Accelerated Approval for Reducing Proteinuria in IgA Nephropathy

HCPLive

On August 07, 2024, Novartis announced the FDA's accelerated approval of iptacopan for reducing proteinuria in primary IgAN based on interim data from APPLAUSE-IgAN.

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Ultrasound enhancing agents in cardiovascular imaging: expanding horizons beyond coronary arteries

Cardiovascular Ultrasound

From its inception as a two-dimensional snapshot of the beating heart, echocardiography has become an indelible part of cardiovascular diagnostics. The integration of ultrasound enhancing agents (UEAs) marks a.

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Clinical Uncertainty More Likely in Black Patients Seeing Dermatologists for Psoriasis

HCPLive

New study highlights racial disparities in psoriasis management, revealing non-Hispanic Black patients are twice as likely to receive a skin biopsy compared to White counterparts.

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The impact of diabetes mellitus on cardiac function assessed by magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Cardiovascular Diabetology

The adverse prognostic impact of diabetes on hypertrophic cardiomyopathy (HCM) is poorly understood. We sought to explore the underlying mechanisms in terms of structural and functional remodelling in HCM pati.

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Defining Difficult to Control Diabetes

HCPLive

Key opinion leaders navigate challenges associated with diabetes management.

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S100a8/A9 proteins: critical regulators of inflammation in cardiovascular diseases

Frontiers in Cardiovascular Medicine

Neutrophil hyperexpression is recognized as a key prognostic factor for inflammation and is closely related to the emergence of a wide range of cardiovascular disorders. In recent years, S100 calcium binding protein A8/A9 (S100A8/A9) derived from neutrophils has attracted increasing attention as an important warning protein for cardiovascular disease.

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Patients with PsA, PsO Prefer Guselkumab Treatment via One-Press Autoinjector Pen

HCPLive

Subjects reported pain at the injection site was significantly reduced with the One-Press autoinjector pen and 98% chose the pen as their preferred medication delivery system.

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Case Report: Epi-endocardial bridges in refractory cavotricuspid isthmus-dependent atrial flutter: technical analysis of epi-endocardial breakthrough

Frontiers in Cardiovascular Medicine

BackgroundTypical isthmus-dependent atrial flutter (AFL) is traditionally treated through radiofrequency (RF) ablation to create a bidirectional conduction block across the cavo-tricuspid isthmus (CTI) in the right atrium. While this approach is successful in many cases, certain anatomical variations can present challenges, making CTI ablation difficult.MethodsWe enrolled four patients with typical counter-clockwise AFL who displayed an epicardial bridge at the CTI.

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Leading Experts Discuss FDA's Pending Decision on MDMA-Assisted Therapy for PTSD

HCPLive

PTSD experts explore unmet PTSD needs, the potential of psychedelic therapies, and key unanswered questions about MDMA-assisted therapy for PTSD.

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Case Report: A case suffered acute cerebral infarction after removal of temporary cardiac pacing lead which led to the perforation of interventricular septum

Frontiers in Cardiovascular Medicine

We report an elderly male patient with frequent episodes of dizziness due to a complete atrioventricular block who underwent temporary pacemaker insertion in a local hospital. After the implantation of a permanent pacemaker and removal of the temporary pacemaker lead, the patient developed sudden neurological symptoms, upon which an acute cerebellar infarction was diagnosed via head CT.

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Reducing Treatment Burden in IBD with At-Home Therapy Options

HCPLive

Jean-Frederic Colombel, MD, offers insights into subcutaneous infliximab-dyyb injection, detailing its administration and approved indications for ulcerative colitis and Crohn's disease.

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GDMT Initiative Increases ARNI and MRA Use Among Patients With HFrEF

American College of Cardiology

A novel quality improvement (QI) initiative for guideline-directed medical therapy (GDMT) utilization increased angiotensin receptor-neprilysin inhibitor (ARNI) and mineralocorticoid receptor antagonist (MRA) prescriptions in outpatients with heart failure with reduced ejection fraction (HFrEF,) according to an implementation perspective paper published in JACC: Heart Failure.

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Efficacy and Safety of Subcutaneous Infliximab

HCPLive

A key opinion leader analyzes the clinical remission and endoscopic response data from the LIBERTY CD and LIBERTY UC trials for subcutaneous infliximab-dyyb injection, contrasts it with intravenous infliximab, and evaluates the drug's safety and efficacy profile.

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Leadless Ultrasound-Based CRT System in HF

American College of Cardiology

In patients with heart failure (HF) unable to receive conventional cardiac resynchronization therapy (CRT), is a leadless left ventricular (LV) endocardial pacing system (WiSE CRT System) for CRT safe and effective?

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Patient Selection and Switching Patients to Subcutaneous Infliximab

HCPLive

Jean-Frederic Colombel, MD, examines considerations for transitioning patients from intravenous to subcutaneous infliximab and evaluates the role of subcutaneous infliximab within the evolving landscape of inflammatory bowel disease treatments.

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CMS Releases the FY 2025 IPPS Final Rule, Finalizes TEAM Program

American College of Cardiology

The Centers for Medicare and Medicaid Services (CMS) released the Fiscal Year (FY) 2025 Inpatient Prospective Payment System (IPPS) Final Rule on Aug. 1, including a 2.9% increase in operating payment rates for general acute care hospitals, representing a 3.4% increase in the hospital market basket with a 0.5% percentage point reduction for the productivity adjustment.

CMS 49
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Targeted Memory Reactivation Enhances PTSD Treatment Effectiveness

HCPLive

A study suggests TMR can boost PTSD treatment by enhancing memory consolidation during sleep, showing significant symptom reduction without affecting sleep quality.

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The right ventricular dysfunction and ventricular interdependence in patients with T2DM and aortic regurgitation: an assessment using CMR feature tracking

Cardiovascular Diabetology

Patients with concomitant type 2 diabetes mellitus (T2DM) and aortic regurgitation (AR) can present with right ventricular (RV) dysfunction. The current study aimed to evaluate the impact of AR on RV impairmen.

Aortic 45
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Topical Betamethasone Versus Tacrolimus Ointment: Atopic Dermatitis Severity Reduction

HCPLive

These findings were the result of an active-comparator study, highlighting the benefits of betamethasone versus tacrolimus among patients with eczema.

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Outcomes of Pediatric In-Hospital Cardiac Arrests

American College of Cardiology

Does hospital median cardiopulmonary resuscitation (CPR) duration in patients without return of circulation (ROC) predict survival among hospitalized children?

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Illicit Fentanyl Use Linked to Greater HCV Risk Among People Who Inject Drugs

HCPLive

Use of illicitly manufactured fentanyl was linked to a 64% increased risk of acquiring hepatitis C infection among people who inject drugs.

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Role of subpulmonary right ventricle in sudden cardiac death in adults with congenital heart disease

HeartRhythm

Despite improved childhood survival in congenital heart disease (CHD) due to advances in management, late-onset sudden cardiac death (SCD) from malignant ventricular arrhythmias remains a leading cause of mortality in adults with CHD (ACHD). Preventing SCD in these patients requires an understanding of underlying pathophysiological mechanisms. Many CHD patients experience significant hemodynamic stress on the subpulmonary right ventricle (RV), leading to pathological remodeling.

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Ferritin Cutoff Choice Linked to Rates of Iron Deficiency Diagnosis

HCPLive

Ferritin cutoffs of 30 and 45 ng/mL notably increase the rate of iron deficiency diagnoses.

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Rethinking the role of comorbidities in transthyretin cardiac amyloidosis: Cinderella or princess? The case of anemia and iron deficiency

The American Journal of Cardiology

Publication date: Available online 6 August 2024 Source: The American Journal of Cardiology Author(s): Giuseppe D.

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Patient Communication and Fibromyalgia Diagnosis

HCPLive

Key elements for discussion with patients around their fibromyalgia diagnosis are highlighted by a medical expert.

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