Fri.Feb 23, 2024

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ECG Blog #418 — A Single Lead Tells the Tale.

Ken Grauer, MD

The ECG in Figure-1 was obtained from a previously healthy man in his 40s — who presented to the ED ( E mergency D epartment ) with new-onset CP ( C hest P ain ) that awakened him from sleep. ECG #1 was recorded ~90 minutes after the patient was awakened from sleep. He was still having CP. QUESTIONS: In view of this history — How would YOU interpret the ECG in Figure-1 ?

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Researchers explore whether gut microbes cause some COVID-19 patients to have higher blood clot risk

Medical Xpress - Cardiology

A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis—the formation of blood clots—researchers report February 23 in the journal Cell Metabolism. The results also revealed that 2MBC is accumulated in individuals with COVID-19, potentially explaining why these patients are at increased risk of thrombosis.

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Alzheimer's Supplements Fail Compared With Generic Drugs

Med Page Today

(MedPage Today) -- Galantamine sold as prescription generic drugs was labeled accurately and free of contamination, but galantamine sold as dietary supplements was not, an analysis showed. Across 10 brands of dietary supplements, the actual quantity.

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Greater Daytime Light Exposure Linked to Better Sleep for Parkinson’s Disease

HCPLive

A new study found patients with Parkinson’s disease have a lower daytime light exposure with a mean light intensity of 201.1 lux than controls with a light intensity of 337.7 lux.

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Genes affect your blood pressure from early childhood, data show

Medical Xpress - Cardiology

Certain genes associated with hypertension affect blood pressure from early in life, and they increase the risk of cardiovascular disease as you get older. But you can do something about it.

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Physiology Friday #206: Is Too Much Protein Damaging to Your Arteries?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including Zeit Calendar , Examine.com , and my eBook “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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3 Powerful Strategies: Combatting Cardiometabolic Risk Factors for Black Americans 

Cardiometabolic Health Congress

This February the intersection of American Heart Health Month and Black History Month underscores the deeply profound and layered legacy of health inequality in America—which, sadly, persists to this day. Black History Month is a poignant backdrop to the alarming rise in obesity and type 2 diabetes, particularly among those of marginalized populations.

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Women Working in Healthcare Have Significantly More Burnouts Than Men Colleagues

HCPLive

A new study found gender inequality, poor work-life balance, a lack of workplace autonomy, and caregiving responsibilities contribute to women in healthcare professions having more stress than their male colleagues.

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Cleerly ISCHEMIA Software Device Billable With AMA Category I CPT Code for Noninvasive Estimates of Fractional Flow Reserve

DAIC

milla1cf Fri, 02/23/2024 - 11:54 February 23, 2024 — Cleerly , the company creating a new standard of care to aid in the diagnosis of heart disease, announced that its recently U.S. Food and Drug Administration ( FDA )-cleared Cleerly ISCHEMIA software device applied to a non-invasive coronary CT angiogram ( CCTA ) can be billed using the new Category I CPT code 75580.

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New study shows glycan sugar coating of IgG immunoglobulin can predict cardiovascular health

Medical Xpress - Cardiology

When people hear about predicting heart disease, most will think of cholesterol levels. While cholesterol is a major contributor to heart disease, a recent study from Brigham and Women's Hospital, a founding member of Mass General Brigham, found that a glycan biomarker of IgG is also an important predictor for cardiovascular diseases (CVD).

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Distribution and prognostic value of high-sensitivity cardiac troponin T and I across glycemic status: a population-based study

Cardiovascular Diabetology

Whether distributions and prognostic values of high-sensitivity cardiac troponin (hs-cTn) T and I are different across normoglycemic, prediabetic, and diabetic populations is unknown.

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Vision Impairment Associated with Symptoms of Depression, Anxiety

HCPLive

Worse examination-based and self-reported vision impairment was associated with depressive and anxiety symptoms among adults aged ≥65 years.

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Insulin resistance and coronary inflammation in patients with coronary artery disease: a cross-sectional study

Cardiovascular Diabetology

Insulin resistance (IR) is associated with coronary artery disease (CAD) severity. However, its underlying mechanisms are not fully understood. Therefore, our study aimed to explore the relationship between IR.

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NBA Champion, 'Survivor' Contestant Receives Heart Transplant

Med Page Today

(MedPage Today) -- NBA champion and "Survivor" contestant Scot Pollard is "awake and feeling great" a day after a heart transplant, his wife said Saturday on social media. "Scot has a new heart!" Dawn Pollard posted Friday night on X, formerly.

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syngo Virtual Cockpit Remote Scanning Technology Cleared by FDA

Cassling

First and only FDA-cleared, multi-vendor remote scanning software Enables remote scanning and support for up to three scanners simultaneously Addresses technologist shortage and standardizes care across sites Siemens Healthineers has announced the Food and Drug Administration (FDA) clearance of syngo Virtual Cockpit , a private, secure communication platform for real-time image visualization, acquisition, and collaboration between healthcare professionals across multiple sites.

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DMARD Therapy Improves Work Capacity in Patients with PsA

HCPLive

b/tsDMARD treatment led to a mean relative improvement of 41% for total work productivity in patients with psoriatic arthritis.

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Dos and don'ts developed for direct oral anticoagulants

Medical Xpress - Cardiology

Direct oral anticoagulants (DOACs) are a common treatment for patients with a wide variety of cardiovascular conditions. DOACs are the preferred treatment over vitamin K antagonists (VKAs) for many patients with atrial fibrillation or venous thromboembolism since the latter would have a higher risk of intracranial bleeding and a more complex dosing routine.

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Augmenting reality in echocardiography

Heart BMJ

Echocardiography is a vital first-line imaging tool for the diagnosis and management of many cardiovascular diseases. Its availability and low cost have encouraged widespread use by clinicians for the diagnosis and management of patients with heart failure. 1 Visual estimation is widely used to assess ejection fraction (EF), the percentage of blood the left ventricle pumps out during a contraction.

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Preventive Interventions to Reduce the Burden of Rheumatic Heart Disease in Populations at Risk: A Systematic Review

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundRheumatic heart disease (RHD) is a devastating yet preventable condition that disproportionately affects low‐middle–income countries and indigenous populations in some high‐income countries. Various preventive interventions have been implemented across the globe, but evidence for the effectiveness of these measures in reducing the incidence or prevalence of acute rheumatic fever and RHD is scattered.

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Medically Tailored Meals to Address the Health Consequences of Food Insecurity

The New England Journal of Medicine

Collaborators from Massachusetts General Hospital, Community Servings, and the University of North Carolina provide medically tailored meals for people with chronic illness and food insecurity.

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Medical therapy of cardiogenic shock: Contemporary use of inotropes and vasopressors

European Journal of Heart Failure

Cardiogenic shock is a primary cardiac disorder that results in both clinical and biochemical evidence of tissue hypoperfusion and can lead to multi-organ failure and death depending on its severity. Inadequate cardiac contractility or cardiac power secondary to acute myocardial infarction remains the most frequent cause of cardiogenic shock, although its contribution has declined over the past two decades, compared with other causes.

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A wolf in sheep's clothing—aortic stenosis and cardiac amyloidosis: “RAISE”ing awareness in clinical practice

Frontiers in Cardiovascular Medicine

Aesop's fable of the wolf in sheep's clothing encourages us to look beneath the exterior appearance of a situation and evaluate the truth that lies beneath. This concept should be applied when managing older patients with severe aortic stenosis. This population of patients is increasingly being identified as having concomitant cardiac amyloidosis, which is an underrecognized cause of common cardiac conditions.

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Right atrial function, a mostly ignored but very valuable parameter in patients with secondary tricuspid regurgitation

Heart BMJ

Significant secondary tricuspid regurgitation (STR) has increasing prevalence with age, it is associated with impaired quality of life, and it is an independent predictor of patients’ morbidity and mortality. Although the association of right ventricular (RV) function with outcome has been reported in patients with STR, 1 2 the role of the right atrial (RA) geometry and function remains to be elucidated.

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Food for a happy heart

Medical Xpress - Cardiology

It's only about the size of your fist. Yet it pumps about 2,000 gallons of blood throughout your body every day. If you could stretch out the complex network of blood vessels in your body through which your heart pumps oxygen and nutrients, it would extend over 60,000 miles.

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Effect of SGLT-2 inhibitors on arrhythmia events: insight from an updated secondary analysis of?>?80,000 patients (the SGLT2i—Arrhythmias and Sudden Cardiac Death)

Cardiovascular Diabetology

Objective We aimed to assess the effect of SGLT2i on arrhythmias by conducting a meta-analysis using data from randomized controlled trials(RCTs). Background Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have shown cardioprotective effects via multiple mechanisms that may also contribute to decrease arrhythmias risk. Methods We searched in databases (PubMed, Embase, Cochrane Library, and clinicaltrials.gov) up to April 2023.

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Your heart changes in size and shape with exercise—this can lead to heart problems for some athletes and gym rats

Medical Xpress - Cardiology

Exercise has long been recognized by clinicians, scientists and public health officials as an important way to maintain health throughout a person's lifespan. It improves overall fitness, helps build strong muscles and bones, reduces the risk of chronic disease, improves mood and slows physical decline.

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MANDARA: Benralizumab Proves Noninferiority to Mepolizumab for EGPA

HCPLive

The MANDARA trial results, published in NEJM, show benralizumab's noninferiority to mepolizumab in eosinophilic granulomatosis with polyangiitis, with potential for oral glucocorticoid discontinuation.

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The impact of concomitant chronic total occlusion on clinical outcomes in patients undergoing transcatheter aortic valve replacement: a large single-center analysis

Frontiers in Cardiovascular Medicine

Background Coronary artery disease (CAD) is a common finding in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). However, the impact on prognosis of chronic total occlusions (CTOs), a drastic expression of CAD, remains unclear. Methods and results We retrospectively reviewed 1,487 consecutive TAVR cases performed at a single tertiary care medical center.

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Ozone, Air Pollutant Exposure Linked to Nasal Key Driver Gene Expression for Patients with Asthma

HCPLive

These findings, to be presented at AAAAI, may help to expand upon clinicians’ awareness of the mechanics of air pollution’s effect on asthma.

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Non-coronary atherosclerosis: a marker of poor prognosis in patients undergoing coronary artery bypass surgery

Frontiers in Cardiovascular Medicine

Introduction The presence of non-coronary atherosclerosis (NCA) in patients with coronary artery disease is associated with a poor prognosis. We have studied whether NCA is also a predictor of poorer outcomes in patients undergoing coronary artery bypass grafting (CABG). Materials and methods This is an observational study involving 567 consecutive patients who underwent CABG.

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Coming Soon! The Heart Health Formula.

Dr. Paddy Barrett

Last year, I asked whether you would be interested in a course that would help you prevent heart disease. The overwhelming response was yes. It has taken a LONG time, but it is almost here. The course is a product of over a decade's worth of research on the best approaches to preventing heart disease, with the biggest emphasis being on lifestyle measures.

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Lung Transplant With HCV-Viremic Organ Does Not Increase Rejection, Allograft Dysfunction

HCPLive

All patients who received an HCV+ organ achieved SVR12 and had lower rates of rejection and chronic lung allograft dysfunction compared to uninfected donor organ recipients.

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Stroke and Bleeding Risks of Endocardial Ablation for Ventricular Arrhythmias

American College of Cardiology

What is the incidence of the embolic and bleeding complications in relation to pre- and post- periprocedure antithrombotic regimens in patients undergoing ventricular arrhythmia radiofrequency ablation (RFA)?

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The inflammatory spectrum of cardiomyopathies

Frontiers in Cardiovascular Medicine

Infiltration of the myocardium with various cell types, cytokines and chemokines plays a crucial role in the pathogenesis of cardiomyopathies including inflammatory cardiomyopathies and myocarditis. A more comprehensive understanding of the precise immune mechanisms involved in acute and chronic myocarditis is essential to develop novel therapeutic approaches.

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Prevalence of Subclinical Atrial Fibrillation in HFpEF

American College of Cardiology

What is the prevalence of subclinical atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF), and how does it impact outcomes?

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Partnering to Enhance Clinical Trial Retention of Black Men

The New England Journal of Medicine

Working with the community, Ohio State University clinician–scientists curated trusting relationships that facilitated recruitment and retention of Black Americans in a clinical trial.

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Coronary Lithotripsy in Calcified Coronary Arteries

American College of Cardiology

What is the performance of coronary intravascular lithotripsy (IVL) in calcified coronary lesions in a real-life, all-comers, setting?

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