Ken Grauer, MD

MARCH 15, 2024

What if you were asked to interpret the ECG in Figure-1 ? How would YOU interpret the rhythm? Even without the benefit of any history — Has there been a recent MI? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). MY Approach to Today’s Tracing: As always — I favor beginning assessment with a quick look at the long lead rhythm strips at the bottom of the tracing.

Blog 161

Blog Arrhythmia STEMI Ischemia 161

HCPLive

MARCH 15, 2024

On March 15, 2024, the FDA approval of fluticasone propionate nasal spray marks the first approval in agency history for treatment of chronic rhinosinusitis without nasal polyps.

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Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Aneuploidy, a deviation from the normal chromosome copy number, is common in human embryos and is considered a primary cause of implantation failure and early pregnancy loss. Meiotic errors lead to uniformly abnormal karyotypes, while mitotic errors lead to chromosomal mosaicism: the presence of cells with at least 2 different karyotypes within an embryo.

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Med Page Today

MARCH 15, 2024

(MedPage Today) -- A computerized clinical decision support (CDS) tool for primary care helped lower blood pressure (BP) in patients with chronic kidney disease (CKD) and uncontrolled hypertension, a cluster-randomized trial found. When primary.

Hypertension 116

Hypertension Kidney Disease Blood Pressure 116

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

As the leading cause of disability worldwide, low back pain (LBP) is recognized as a pivotal socioeconomic challenge to the aging population and is largely attributed to intervertebral disc degeneration (IVDD). Elastic nucleus pulposus (NP) tissue is essential for the maintenance of IVD structural and functional integrity. The accumulation of senescent NP cells with an inflammatory hypersecretory phenotype due to aging and other damaging factors is a distinctive hallmark of IVDD initiation and p

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HCPLive

MARCH 15, 2024

A post-hoc analysis of the Ocular Hypertension Treatment Study shows the inclusion of a PRS improved the prediction of POAG onset in patients with ocular hypertension.

Hypertension 111

Hypertension 111

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Radiotherapy (RT) is considered immunogenic, but clinical data demonstrating RT-induced T cell priming are scarce. Here, we show in a mouse tumor model representative of human lymphocyte–depleted cancer that RT enhanced spontaneous priming of thymus-derived (FOXP3+Helios+) Tregs by the tumor. These Tregs acquired an effector phenotype, populated the tumor, and impeded tumor control by a simultaneous, RT-induced CD8+ cytotoxic T cell (CTL) response.

Cancer 115

Cancer 115

HCPLive

MARCH 15, 2024

New data suggest children with atopic dermatitis and comorbid ADHD are nearly 3 times more likely to struggle with memory compared to those with just ADHD.

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Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrogenase–high (ALDHhi) BCSCs, leading to BCSC expansion and tumor initiation in mice.

Cancer 105

Cancer 105

HCPLive

MARCH 15, 2024

From 1990 to 2019, the prevalence, incidence, and disability-adjusted life years of gout worldwide increased by 22.4%, 18%, and 22.2%, respectively.

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Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Virus-induced memory T cells often express functional cross-reactivity, or heterologous immunity, to other viruses and to allogeneic MHC molecules that is an important component of pathogenic responses to allogeneic transplants. During immune responses, antigen-reactive naive and central memory T cells proliferate in secondary lymphoid organs to achieve sufficient cell numbers to effectively respond, whereas effector memory T cell proliferation occurs directly within the peripheral inflammatory

Transplant 98

Transplant 98

Cardiomatics

MARCH 15, 2024

The quality of the ECG signal is an important factor affecting the accuracy of analysis and proper interpretation, particularly for long-term ECG monitoring such as with Holter monitors or ECG patch devices. Misinterpretation can lead to a wrong diagnosis and consequently the selection of inappropriate treatment. The purpose of this article is to discuss possible ways of improving the quality of ECG signals in order to obtain more reliable results.

Technology 98

Technology Best Practices Electrocardiogram Heart Rhythm 98

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus, where it initiates collagen gene transcription. However, it is still not known whether FUS is profibrotic in vivo and whether preventing its nuclear translocation might inhibit development of fibrosis following injury.

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HCPLive

MARCH 15, 2024

In this post-AAD 2024 interview, Stein Gold commented on her team’s two recent sub-analyses of the phase 4 IMMpulse studies on risankizumab for psoriasis.

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Open Heart

MARCH 15, 2024

Aim Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional benefit to prevent further recurrences.

Pericarditis 96

Pericarditis 96

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Epigenetics is a biological process that modifies and regulates gene expression, affects neuronal function, and contributes to pain. However, the mechanism by which epigenetics facilitates and maintains chronic pain is poorly understood. We aimed to determine whether N6-methyladenosine (m6A) specifically modified by methyltransferase-like 14 (METTL14) alters neuronal activity and governs pain by sensitizing the GluN2A subunit of the N-methyl-d-aspartate receptor (NMDAR) in the dorsal root gangli

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Society of Thoracic Surgeons - Early Career

MARCH 15, 2024

Blog The Cost of Changing Jobs KCummings Fri, 03/15/2024 - 14:08 Resident / Fellow Surgeon At some point in their career, nearly every cardiothoracic surgeon will grapple with the decision of whether to remain in their current position or seek opportunities elsewhere. This decision can stem from unexpected offers, personal and professional aspirations, or dissatisfaction with one’s situation.

Cardiothoracic 69

Cardiothoracic Blog Quality of Life Education 69

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underlying cues may provide novel strategies for managing metastatic disease. Using breast cancer experimental models and transcriptomic analyses, we show that stem cell antigen-1 positive (SCA1+) murine breast cancer cells enriched during tumor prog

Cancer 94

Cancer Education 94

Medical Xpress - Cardiology

MARCH 15, 2024

If at 58, I were to agree to a boxing match with a person half my age, much alarm would be caused. My daughters would burst into tears, my partner would have strong words, and my students would have final confirmation that I had lost the plot. I, however, am not "Iron Mike" Tyson.

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Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

In the relentless battle against the COVID-19 pandemic, the deployment of mRNA vaccines has stood out as a beacon of hope. The successes of Pfizer-BioNTech NT162b2 and Moderna mRNA-1273 vaccines have been remarkable, marking a revolutionary advancement in the field of vaccinology. Despite their rapid development and impressive efficacy, challenges have emerged, particularly concerning the waning immune response over time and the evolving landscape of SARS-CoV-2 variants.

COVID-19 102

COVID-19 Outcomes 102

American College of Cardiology

MARCH 15, 2024

A high social vulnerability index (SVI) score was associated with worse cardiovascular disease outcomes, including premature cardiovascular death, according to results from a scoping review published March 6 in JACC: Advances.

Outcomes 67

Outcomes Cardiovascular Disease Article 67

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Mammalian preimplantation embryos often contain chromosomal defects that arose in the first divisions after fertilization and affect a subpopulation of cells — an event known as mosaic aneuploidy. In this issue of the JCI, Chavli et al. report single-cell genomic sequencing data for rigorous evaluation of the incidence and degree of mosaic aneuploidy in healthy human in vitro fertilization (IVF) embryos.

Technology 96

Technology 96

American College of Cardiology

MARCH 15, 2024

In these panel discussions, host Andrea Price MS, AACC brings together Bailey Estes MSN, AGNP-C, Nicole Dellise, NP, and Kristen deAlmeida, PharmD to explore best practices related to structural heart disease. In this episode, the focus is on mitral valve disease.

Bicuspid/Mitral 67

Bicuspid/Mitral Best Practices Heart Disease Article 67

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Diffuse intrinsic pontine glioma (DIPG) is a devastating brain tumor with a need for novel therapies. So far, monotherapies have failed to prolong survival for these patients, and combinatorial strategies have often shown severe, dose-limiting toxicities. In this issue of the JCI, Duchatel, Jackson, and colleagues address this challenge by introducing a drug combination that mitigates side effects and overcomes resistance.

Outcomes 86

Outcomes 86

CardiacWire

MARCH 15, 2024

Silence Therapeutics’ zerlasiran continued to demonstrate its lipoprotein(a) impact, as topline Phase 2 data showed that the injectable siRNA slashed LP(a) levels by over 90% through 36 weeks. Zerlasiran is a siRNA (short interfering RNA), designed to reduce LP(a) levels by “silencing” the LPA gene that tells the body to make the apolipoprotein(a) protein.

Risk Factors 59

Risk Factors Cardiovascular Disease 59

HCPLive

MARCH 15, 2024

Curtis discusses findings from her recent health economic study about the cost-effectiveness of treating perinatal HCV earlier, a growing concern amid rising rates of HCV in reproductive-aged adults.

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Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

The lymphatic vascular system is gaining recognition for its multifaceted role and broad pathological significance. Once perceived as a mere conduit for interstitial fluid and immune cell transport, recent research has unveiled its active involvement in critical physiological processes and common diseases, including inflammation, autoimmune diseases, and atherosclerosis.

Atherosclerosis 85

Atherosclerosis Physiology Research 85

HCPLive

MARCH 15, 2024

The results of this analysis highlight the link between patients’ experiences with pruritus intensity and the mental health difficulties such struggles place on patients.

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American College of Cardiology

MARCH 15, 2024

What are the outcomes in patients with left main disease with and without diabetes undergoing percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG)?

Coronary Artery Bypass Graft 61

Coronary Artery Bypass Graft Diabetes Outcomes Article 61

HCPLive

MARCH 15, 2024

James Palmer, MD, provides perspective on the FDA's decision to approve fluticasone propionate nasal spray for adults with chronic rhinosinusitis without nasal polyps.

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DAIC

MARCH 15, 2024

milla1cf Fri, 03/15/2024 - 18:29 March 15, 2024 — BioCardia, Inc. , a biotechnology company focused on advancing late-stage cell therapy interventions for cardiovascular disorders, and StemCardia, Inc. , a biotechnology company focused on cell and gene therapy to re-muscularize the failing heart, today announced a long-term partnership to advance StemCardia ’s investigational pluripotent stem cell product candidate for the treatment of heart failure.

Heart Failure 52

Heart Failure 52

Cassling

MARCH 15, 2024

Last August, Field Service Engineer Duane Losh celebrated 35 years of dedicated service. As one of Cassling’s longest-tenured employees, Duane is a true pioneer of “The Cassling Way” and an embodiment of the organization’s culture. These qualities made Duane an ideal recipient of the 2024 Bob Cassling Service Excellence Award. The award, created in 2015, recognizes employees who go above and beyond in exemplifying the organization’s culture and commitment to providing world-class service.

Blog 52

Blog 52

MIBHS

MARCH 15, 2024

Bloodless heart surgery is performed to prevent blood loss and eliminate the need for blood transfusions and has been shown to provide an easier recovery process. It uses cutting-edge medical techniques that preserve the patient’s own blood. Also known as transfusion-free surgery, it can be a viable alternative for those who need traditional heart surgery but prefer a bloodless approach for personal or religious reasons.

Blood Clot 52

Blood Clot Chest Pain Hospital 52

HCPLive

MARCH 15, 2024

Patients whose primary care practitioners were randomized to a clinical decision support system intervention achieved a statistically significant reduction in SBP versus usual care but had similar rates of BP control.

Hypertension 52

Hypertension Outcomes 52

Physiologically Speaking

MARCH 15, 2024

Greetings! Welcome to the Physiology Friday newsletter. ICYMI On Monday, I released a video interview/podcast with Dr. Tamara Hew-Butler on hydration facts and myths. On Wednesday, I published a post about whether VO2 max is a good indicator of fitness and performance. Check out my podcast interview with the guys at Your Jeevn : we chat about all things human performance ( also on Spotify ).

Exercise 52

Exercise Physiology Blood Pressure Outcomes 52

American College of Cardiology

MARCH 15, 2024

The fifth-generation SAPIEN 3 Ultra Resilia valve (S3UR) transcatheter heart valve (THV), used in TAVR procedures, is associated with lower mean gradients and lower rates of paravalvular leak (PVL) when compared to outcomes from the SAPIEN 3 (S3) and SAPIEN 3 Ultra (S3U) valves, according to a study presented at CRT 2024 and simultaneously published in JACC: Cardiovascular Interventions.

Outcomes 54

Outcomes TAVR Heart Valves Cardiovascular Interventions 54

HCPLive

MARCH 15, 2024

A new study found the achievement of remission or low disease activity for PsA patients on apremilast was 53.8% by month 12.

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