Wed.Mar 19, 2025

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Rethinking how we study the impact of heat on heart health

Science Daily - Heart Disease

A new study reveals that encapsulated heating methods, an often-used heat simulation method, significantly increase heart rates and cardiac strain compared to natural heat exposure like those experienced during hot weathers. Understanding how extreme heat impacts heart function is crucial for developing effective strategies to protect vulnerable groups, especially as global temperatures continue to rise.

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Mitochondrial quality control in cardiomyocytes: safeguarding the heart against disease and ageing

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 20 March 2025; doi:10.1038/s41569-025-01142-1 In this Review, Ravindran and Gustafsson describe the mechanisms involved in regulating mitochondrial quality control in cardiomyocytes, discuss how these pathways are altered in cardiovascular disease and ageing, and highlight the therapeutic potential of targeting mitochondrial quality control pathways in cardiovascular disease.

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Amulet’s Slight Edge over Watchman for LAAO

CardiacWire

Although theres still ongoing debate on who should receive LAAO devices, new five year results from the Amulet IDE trial confirm that both Abbotts Amulet occluder and Boston Scientifics Watchman 2.5 are safe and effective in the long run. LAAO (left atrial appendage occlusion) devices help prevent stroke in patients with AFib by sealing off the left atrial appendage where blood clots can form.

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Cardiovascular Toxicity in Patients Treated for Childhood Cancer: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. The field of cardio-oncology has expanded over the past 2 decades to address the ever-increasing issues related to cardiovascular disease in patients with cancer and survivors. There is increasing recognition that nearly all cancer treatments pose some short- or long-term risk for development of cardiovascular disease and that pediatric patients with cancer may be especially vulnerable to cardiovascular disease because of young age at treatment and expected long life

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A Transformative Two Days: Recap of the Management of Calcified Coronary Lesions Training

ADN Center of Excellence

Over the past two days, interventional cardiologists from around the worldgathered at Freeman Hospital, Newcastle, for an intensive and enriching experience focused on tackling one of the most complex challenges in percutaneous coronary intervention (PCI): calcified coronary lesions.

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Oxypurinol Formulation May Be Adapted for Gout Treatment

HCPLive

XORTX is meeting with the FDA in a Type B meeting regarding a potential NDA for XORLO.

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Dementia Risk Rises for Older Women With Changing Sleep Patterns

Med Page Today

(MedPage Today) -- Changes in sleep patterns among cognitively unimpaired women in their 80s were associated with an increased risk of dementia, a longitudinal study showed. Compared with women who had stable sleep patterns, those who had increasing.

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Type 2 Diabetes Patients Also Reap Benefits of Automated Insulin Delivery

Med Page Today

(MedPage Today) -- An automated insulin delivery (AID) system boosted glycemic control in insulin-treated adults with type 2 diabetes using continuous glucose monitoring (CGM), a randomized trial showed. Over 13 weeks, drops in HbA1c averaged.

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Rethinking how we study the impact of heat on heart health

Medical Xpress - Cardiology

Scientists have been testing how heat affects our hearts for years. But here's the thing: the most commonly used method might not provide much insight into what happens to the heart during heat waves.

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Skin of Color Savvy: News Update—Debunking Myths and Highlighting the SOCS Symposium

HCPLive

This March 2025 SOCS News Update highlights misconceptions related to skin health, the value of diversity in clinical research, and SOCS Symposium highlights.

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Development of an EMR-Based Registry to Define Cardiovascular Risk in South Asian Adults

American College of Cardiology

The risk of cardiovascular disease (CVD) among individuals of South Asian (SA) ancestry is nearly twofold higher than in individuals of European ancestry.

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Diabetes Dialogue: Bionic Pancreas Brings AID to Primary Care & Telehealth

HCPLive

In this episode, hosts discuss a study assessing the benefit and feasibility of AID for type 1 diabetes with the iLet Bionic Pancreas in different settings.

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E-cigarettes linked to lower cardiac risks compared to tobacco cigarettes in people with HIV

Medical Xpress - Cardiology

Electronic cigarette use may pose lower cardiovascular risks in people living with HIV compared to tobacco cigarette use, new UCLA-led research shows.

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Low-Dose Doxycycline Effective for Managing Lymphocytic Scarring Alopecia Symptoms

HCPLive

These recent data demonstrate small doses of doxycycline, an anti-inflammatory medication, may help manage lymphocytic scarring alopecia.

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Scientists test accessible, affordable diagnostic tool for heart disease risk via molecular blood screening

Medical Xpress - Cardiology

A groundbreaking study has successfully translated high-field nuclear magnetic resonance (NMR) spectroscopy-based lipoprotein analysis into "low-cost" and easy-to-use benchtop NMR systems, enabling more accessible, high-throughput cardiovascular disease (CVD) risk assessment in clinics and laboratories worldwide.

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High Cooccurrence of Chronic Pain With Depression, Anxiety, Warrant Better Screening and Treatment

HCPLive

Women, younger patients, and those with fibromyalgia were at particular risk of anxiety and depression, a new analysis shows.

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Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis

Cardiovascular Diabetology

This study aims to identify early metabolomic biomarkers of gestational diabetes mellitus (GDM) and evaluate their association with hepatic steatosis.

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Eneboparatide Hits Primary Phase 3 Endpoint for Hypoparathyroidism

HCPLive

AstraZeneca announced eneboparatide normalized serum calcium with statistical significance at 24 weeks compared with placebo.

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Evaluation of glycemic status and subclinical atherosclerosis in familial hypercholesterolemia subjects with or without LDL receptor mutation

Cardiovascular Diabetology

Familial hypercholesterolemia (FH) is a genetic condition characterized by elevated LDL-C and increased cardiovascular risk. Beyond LDL-C levels, the impact of genotype on glucose homeostasis has not been well.

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Advancements in diagnosis and treatment of lung adenocarcinoma patients under ECMO support: a case series and comprehensive literature review

Journal of Cardiothoracic Surgery

This case series explores the use of veno-venous extracorporeal membrane oxygenation (VV ECMO) as a bridge to diagnosis and treatment in patients with suspected lung adenocarcinoma and severe respiratory failu.

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Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway

Cardiovascular Diabetology

Increasing evidence highlights the critical role of Piezo1 in cardiovascular diseases, with its expression upregulated in diabetic heart. However, the involvement of Piezo1 in the pathogenesis of diabetic card.

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Global trends and research hotspots in acupuncture treatment for cardiovascular diseases over the past decade: a bibliometric study

Journal of Cardiothoracic Surgery

This study aims to examine the status and emerging trends of acupuncture treatment for cardiovascular disease (CVD) over the past decade. By conducting a visual analysis of existing literature, it seeks to off.

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Dysglycaemia is associated with the pattern of valvular calcification in micro-computed tomography analysis: an observational study in patients with severe aortic stenosis

Cardiovascular Diabetology

Diabetes mellitus (DM) has been shown to increase the rate of aortic stenosis (AS) progression. However, the impact of impaired plasma glucose on valvular calcification remains poorly understood. Using ex vivo.

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Effects of different doses of ulinastatin on organ protection of deep hypothermic circulatory arrest in rats

Journal of Cardiothoracic Surgery

Deep hypothermic circulatory arrest (DHCA) can cause systemic inflammatory response (SIR) and ischemia-reperfusion (I/R) injury, potentially exacerbating organ failure. Ulinastatin (UTI) is a frequently employ.

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Study shows seniors benefit from tight blood pressure control

Medical Xpress - Cardiology

Systolic blood pressure kept under 130 reduces the risk of heart-related death by about 26% among people 80 or older, researchers report in the Journal of the American College of Cardiology.

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Research progress and hotspot analysis of type B aortic dissection: a bibliometric analysis from 2004 to 2023

Journal of Cardiothoracic Surgery

This study aimed to analyze and visualize the research on type B aortic dissection (TBAD) over the past 20 years through bibliometric research. To reveal the development process of TBAD research and the transi.

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STS/ACC TVT Registry: Trends in Mortality After Mitral TEER, TAVR

American College of Cardiology

Two studies analyzing data from the STS/ACC TVT Registry exploring out-of-hospital 30-day mortality after mitral transcatheter edge-to-edge repair (TEER) and one-year cause-specific mortality after TAVR were published in JACC: Cardiovascular Interventions on March 19.

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Adults with congenital heart disease can boost exercise capacity by reducing sedentary time, study suggests

Medical Xpress - Cardiology

Adult patients with congenital heart disease (CHD) have poor exercise capacity, which is associated with adverse outcomes. In a study published in the International Journal of Cardiology Congenital Heart Disease, researchers found that reducing sedentary time and spending more time on moderate-to-vigorous physical activity may be associated with exercise capacity enhancement in adult patients with CHD.

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Food Insecurity Increases Risk of Incident CVD

American College of Cardiology

Food insecurity is associated with a 41% increased risk of incident cardiovascular disease, even after accounting for demographic and socioeconomic factors, according to a study published March 12 in JAMA Cardiology.

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Pregnancy complications may indicate genetic risk for heart disease

Medical Xpress - Cardiology

Coronary artery disease, a collective term for angina and heart attacks, is among the most common causes of death among women. A study published in Circulation, conducted by Tormod Rogne from Yale University/University of Oslo and Dipender Gill from Imperial College London, finds a genetic link between adverse birth outcomes and the risk of heart disease.

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Does Industry Marketing Lead to Increased Rates of Prescribed GDMT For Patients With HFrEF?

American College of Cardiology

Guideline-directed medical therapy (GDMT), including angiotensin receptor-neprilysin inhibitors (ARNIs) and SGLT2 inhibitors, for treating heart failure with reduced ejection fraction (HFrEF) is underused.

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The adverse effect of metabolic syndrome on left ventricular global strains and myocardial energetic efficiency in non-ischemic dilated cardiomyopathy patients: a cardiac magnetic resonance study

Cardiovascular Diabetology

Metabolic syndrome (MetS) is a known risk factor for cardiovascular dysfunction; however, its impact on left ventricular (LV) global strains and myocardial energetic efficiency in non-ischemic dilated cardiomy.

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Federal Funding Bill Extends Telehealth Flexibilities Through September

American College of Cardiology

Congress has passed a continuing resolution (CR) to fund the government until Sept. 30, which includes an extension of telehealth flexibilities under Medicare.

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Endo-epicardial mapping of human sinus node in-vivo: novel electrophysiological findings and anatomical correlations

HeartRhythm

The human sinoatrial node (SAN) pacemaker is a complex structure located at the right atrium- superior vena cava (SVC) junction.

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Cardioprotective effects of semaglutide on isolated human ventricular myocardium

European Journal of Heart Failure

Semaglutide reduces late sodium current (I Na ) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end-stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients. Improved Ca storage may underly the enhanced contractility of human cardiomyocytes upon semaglutide. Pathologic remodelling of cardiomyocytes in HFrEF may lead to decreased glucagon-like peptide-1 (GLP-1) receptor expression, thereby reducing the efficacy o

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Piezo2 expressed in GP: Potential therapeutic target of atrial fibrillation

HeartRhythm

Atrial fibrillation (AF) is closely linked to autonomic nervous system activity, with activation of the cardiac ganglionated plexus (GP) often presents in AF. Piezo, a mechanosensitive ion channel, plays a pivotal role in neuronal modulation. However, its involvement in the GP and AF remains poorly understood.

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Ventricular arrhythmias in acute heart failure. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), the European Heart Rhythm Association (EHRA) and the Heart Failure Association (HFA) of the ESC

European Journal of Heart Failure

Abstract Patients presenting with or alerting emergency networks due to acute heart failure (AHF) form a diverse group with a plethora of symptoms, risks, comorbidities, and aetiologies. During AHF, there is an increased risk of destabilizing the functional substrate and modulatory adding to the risk of ventricular arrhythmias (VAs) already created by the structural substrate.