Tue.Jul 02, 2024

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Study discovers connection between between heart and brain in KBG syndrome

Medical Xpress - Cardiology

A new study sheds light on a medical question scientists have long wondered: why do 40% of children with the rare neurodevelopmental disorder KBG syndrome have heart defects? The research now points to a critical link between the heart and the brain. The research is published in the journal Nature Communications.

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Two researchers to receive first-ever Ralph L. Sacco Scholarships for Brain Health

American Heart News - Stroke News

DALLAS and MINNEAPOLIS, July 2, 2024 — The American Academy of Neurology and the American Heart Association have awarded the first-ever Ralph L. Sacco Scholarships for Brain Health to two researchers, Patrick Devlin, Ph.D., of Houston, Texas, and Cyprien.

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Mediterranean diet linked to lower risk of mortality, especially from cardiovascular disease, in cancer survivors

Medical Xpress - Cardiology

The Mediterranean diet is a powerful ally for health even after a cancer diagnosis. This is the key result of an Italian study carried out as part of the UMBERTO Project, conducted by the Joint Research Platform Umberto Veronesi Foundation—Department of Epidemiology and Prevention of the I.R.C.C.S. Neuromed of Pozzilli, in collaboration with the LUM "Giuseppe Degennaro" University of Casamassima (BA).

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Potassium Chloride Recall; Exercise vs Valve Disease; Cuffless Continuous BP Monitor

Med Page Today

(MedPage Today) -- Over 100 batches of potassium chloride are being recalled because they are not dissolving correctly, which may lead to hyperkalemia that can ultimately cause cardiac arrhythmias and death in some cases, per an FDA alert. And.

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Biotronik Introduces Expanded Maximum Diameter Dimensions for Orsiro Mission DES

DAIC

mtaschetta-millane Tue, 07/02/2024 - 09:45 July 2, 2024 — Biotronik announced the availability of an expanded Maximum Allowed Diameters (MAD) range for the Orsiro Mission Drug Eluting Stent (DES). Diameters 2.25 mm to 3.00 mm of the Orsiro Mission DES can now be extended up to 4.0mm, while diameters 3.5 mm and 4.0 mm can reach up to 5.0 mm. This new MAD expansion follows the approvals from CE, FDA, and Health Canada obtained in the past months.

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Detachable cardiac pacing lead may improve safety for cardiac patients

Medical Xpress - Cardiology

In 2012, Neil Armstrong, the first man to walk on the moon, died of post-surgery complications at the age of 82 following what should have been a routine heart surgery. Armstrong had undergone bypass surgery, the most common open-heart operation in the United States, and a surgery where the overall chance of death has dropped to almost zero.

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DAIC's Top 10 for June

DAIC

From FDA approvals to new clinical trials, here is a look at DAIC's top-read content during the month of June: 1. Medtronic Launches the Avalus Ultra Valve Engineered for Ease of Use at Implant and Lifetime Patient Management 2. Landmark Clinical Study in The Lancet Finds New AI Technology Can Predict Cardiac Events Due to Coronary Inflammation at Least 10 Years in Advance 3.

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Sorting therapeutic stem cells by function improves healing after heart attack, lab study shows

Medical Xpress - Cardiology

Selecting specific cells to be used in an investigational therapy has led to improved recovery of heart function in a new study employing a lab model for myocardial infarction, the medical term for heart attacks.

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The Role of Hyperbaric Oxygen Therapy for Treating Fibromyalgia, with Shai Efrati, MD

HCPLive

Treatment involved repairing the brain tissue using HBOT, which led to significant symptom improvement.

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Guide to Hemodynamic Assessment in HF: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on practical guidance for hemodynamic assessment by right heart catheterization (RHC) in the management of heart failure (HF):

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Mitchell Shiffman, MD: Phase 2b AHFIRM Data for Larsucosterol in Alcohol-Associated Hepatitis

HCPLive

Shiffman reviews some of the key findings from AHFIRM, explaining important considerations for interpreting the results and potential reasons for regional differences in the data.

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TR in Patients With HFpEF the Focus of JACC State-of-the-Art Review

American College of Cardiology

Many patients with severe, symptomatic tricuspid regurgitation (TR) may also present with advanced heart failure with preserved ejection fraction (HFpEF), and treatments for each condition may impact the other condition. A JACC State-of-the-Art Review on the topic, published on July 1, explores the relationship between these two conditions and proposes management strategies.

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Clinical Quiz: Psoriasis Guidelines in Pediatric Patients

HCPLive

In this clinical quiz, you will test your knowledge of psoriasis guidelines, with special focus on important clinical questions related to management of psoriasis and recent evidence-based recommendations.

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Lerodalcibep in Patients With or at High Risk of Cardiovascular Disease

JAMA Cardiology

This randomized clinical trial evaluates the safety and efficacy of lerodalcibep vs placebo in reduction of low-density lipoprotein cholesterol in patients with or at risk of cardiovascular disease.

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Cardiology Month in Review: June 2024

HCPLive

Our Cardiology Month in Review for June 2024 spotlights the pharmacotherapies making waves within the pipeline, the latest news in dyslipidemia, and updates in heart failure.

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Comparative CV Benefits of Bempedoic Acid and Statin Drugs

American College of Cardiology

Does the relationship between low-density lipoprotein cholesterol (LDL-C) lowering and cardiovascular (CV) benefit achieved with bempedoic acid resemble that observed with statins when standardized per unit change in LDL-C?

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New Insight: A Look at Gildeuretinol (ALK-001) for Stargardt Disease w/ Seemi Khan, MD

HCPLive

In this episode, Veeral Sheth, MD speaks with Alkeus Pharmaceutical's CMO on the company's lead candidate for Stargardt disease and the TEASE clinical trial program.

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Surgical treatment of atrial fibrillation in elderly patients undergoing high risk cardiac surgery

Journal of Cardiothoracic Surgery

Background Evaluating outcomes of concurrent Cox-Maze procedures in elderly patients undergoing high-risk cardiac surgery. Mehods We retrospectively identified patients aged over 70 years with Atrial Fibrillation (AF) from 2011 to 2017 who had two or more other cardiac procedures. They were subdivided into two groups: 1. Cox-Maze IV AF ablation. 2. No-Surgical AF treatment.

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Extended-Release Subcutaneous Buprenorphine Injection May Reduce Fentanyl Use

HCPLive

HCPLive spoke with Joshua M. Cohen, MD, MPH, to discuss a post-hoc analysis of a phase 3 study that showed buprenorphine may be effective at reducing fentanyl use.

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Successful open surgical treatment for persistent type II endoleak following thoracic endovascular aortic repair: a case report

Journal of Cardiothoracic Surgery

The occurrence of type II endoleaks after endovascular repair of aortic aneurysm has gradually gained increasing attention. We present a case of a patient with an expanding aneurysm after thoracic endovascular.

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Metabolic Syndrome Linked to Renal, Cardiovascular Outcomes in IgA Nephropathy

HCPLive

Findings highlight the prognostic value of metabolic syndrome components in predicting both renal and cardiovascular outcomes in patients with IgA nephropathy.

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Impact of minimal invasive extracorporeal circulation on systemic inflammatory response – a randomized trial

Journal of Cardiothoracic Surgery

Extracorporeal circulation causes a systemic inflammatory response, that may cause postoperative haemodynamic instability and end-organ dysfunction. This study aimed to investigate the impact of minimal invasi.

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Trusting EBM too much… could be an early sign of Impaired clinical wisdom

Dr. S. Venkatesan MD

I don’t want to do this …but EBM compels me to do it The word “Evidence” is the most powerful in the world of science and enjoys disproportionate bias towards positivity (of course in any walk of life). But, the fact of the matter is, it can result in either monumental breakthroughs or mindless havoc to mankind in equal quantities.

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Long-term outcomes following mitral valve replacement in children at heart center Leipzig: a 20-year analysis

Journal of Cardiothoracic Surgery

Although mitral valve repair is the preferred surgical strategy in children with mitral valve disease, there are cases of irreparable severe dysplastic valves that require mitral valve replacement. The aim of.

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Investigators identify novel plasma proteins linked to future risk of hypertension

Medical Xpress - Cardiology

Exercise testing can serve as a powerful physiologic probe to unmask subclinical cardiovascular abnormalities well before disease onset. For example, blood pressure changes during exercise (EBP) can reveal a latent tendency toward future development of hypertension. At present, there is no reliable circulating biomarker—a protein or other molecule present in the blood stream—indicative of hypertension risk.

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A novel degradable PEG superparamagnetic iron oxide capsule coupled with a polyphenolic nano-enzymatic conjugate (PSPM-NE), to treat ROS-driven cardiovascular-diseases, tested in atherosclerosis as a model disease, and hypothesizing autoimmunity as an atheroma's trigger

Frontiers in Cardiovascular Medicine

Cardiovascular diseases account for a significant portion of the worldwide mortality rate. This aroused interest among the specialised scientific community, seeking for solutions based on non-clinical and clinical investigations, to shed light onto the physio-pathology of cardiovascular impairment. It is proven challenging managing chronic cardiovascular illnesses like atherosclerosis, arrhythmias, and diverse cardiomyopathies.

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Gastroesophageal reflux disease increases risk for atrial fibrillation: Study

Medical Xpress - Cardiology

Gastroesophageal reflux disease (GERD) is associated with an increased incidence of atrial fibrillation, according to a study published online June 2 in Frontiers in Cardiovascular Medicine.

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Outcomes of pulmonary endarterectomy for patients with pulmonary artery sarcoma

Frontiers in Cardiovascular Medicine

ObjectivePulmonary artery sarcoma (PAS) is an exceedingly rare and insufficiently investigated disease, leading to uncertain in its optimal management. This study aims to present our institutional experience and the outcomes of pulmonary endarterectomy for PAS.MethodsWe gathered clinical characteristics, intraoperative data, postoperative outcomes, and prognosis information from PAS patients who underwent surgical treatment at our institution between December 2016 and September 2023.ResultsA tot

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Restarting Therapy in Patients with HIV

HCPLive

Addressing patients with HIV who have fallen out of care, Shauna Applin, ARNP, provides clinical insights on treatment options and best practices for restarting therapy.

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Case Report: Endoluminal removal of a conical retrievable superior vena cava filter with a retraction hook attached to the wall

Frontiers in Cardiovascular Medicine

We report the case of a 22-year-old male who underwent endoluminal surgery and was implanted an Option Elite filter in the superior vena cava (SVC) while the filter retraction hook was attached to the vessel wall. The patient requested to remove the filter after 155 days. Preoperative ultrasonography and CT examination revealed that the filter retraction hook was very likely to penetrate the SVC wall and its tip was very close to the right pulmonary artery.

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Early Rhythm Control, Low-Dose Aspirin and Prevention, Autoimmune Diseases and Atherosclerosis

American College of Cardiology

In this week’s View, Dr. Eagle looks at the clinical impact of early rhythm control and healthy lifestyles in patients with atrial fibrillation, then explores the use of low-dose aspirin in the prevention of atherosclerotic cardiovascular disease.

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Researchers show cholesterol type can affect your heart attack risk

Medical Xpress - Cardiology

Vascular plaque. It starts with inflammation. Perhaps your blood pressure has been a little too high for a little too long, putting strain on your blood vessels.

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Randomized Controlled Trial of Myval Transcatheter Heart Valve

American College of Cardiology

The goal of the LANDMARK trial was to evaluate transcatheter aortic valve replacement (TAVR) with the Myval prosthesis compared with a contemporary prosthesis among patients with symptomatic severe aortic stenosis.

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Large-Scale Proteomics and Hypertensive Disorders of Pregnancy

JAMA Cardiology

This case-control study investigates the ability of a large-scale proteomics panel from first-trimester blood samples to predict the development of hypertensive disorders of pregnancy.

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Aldose Reductase Inhibitor Treatment in Diabetic Cardiomyopathy

American College of Cardiology

What is the effect of AT-001, an aldose reductase inhibitor, on exercise capacity among individuals with diabetic cardiomyopathy (DbCM) with reduced exercise capacity and at high risk for progression to overt heart failure (HF)?

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Hematology Month in Review: June 2024

HCPLive

Our May 2024 month-in-review for hematology focuses on the latest updates to the hematologic pipeline.

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Combination Chemotherapy/Immunotherapy Regimens in Patients With Breast Cancer

American College of Cardiology

One pivotal study, the phase 3 trial known as KEYNOTE-522, focused on previously untreated stage II or stage III triple-negative breast cancer patients.

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