Medical Xpress - Cardiology

DECEMBER 24, 2024

Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since the heart has minimal ability to regenerate itself. But what if we could reprogram the body's own cells to restore damaged tissue?

Cardiovascular Disease 109

Cardiovascular Disease 109

Med Page Today

DECEMBER 24, 2024

(MedPage Today) -- Trials evaluating anticoagulation in patients hospitalized for COVID-19 did not consistently favor stepping up dosing for short-term survival, according to a systematic review and prospective meta-analysis. Among 22 studies.

COVID-19 102

COVID-19 Hospital 102

HCPLive

DECEMBER 24, 2024

Panelists discuss how the clinical heterogeneity of Atopic Dermatitis (AD) presents diagnostic challenges, with varying criteria for pediatric and adult-onset AD, highlighting the need for age-specific approaches to accurately diagnose and treat the condition.

Pediatrics 94

Pediatrics 94

Med Page Today

DECEMBER 24, 2024

(MedPage Today) -- Note that some links may require registration or subscription. Former President Bill Clinton was admitted to MedStar Georgetown University Hospital in Washington, D.C. on Monday with a fever, according to his spokesperson.

Hospital 98

Hospital 98

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

Medical Xpress - Cardiology

DECEMBER 24, 2024

Cardiovascular diseases remain a global health crisis, spurring an urgent demand for innovative diagnostic tools that enable early detection and effective treatment. Wearable heart sound devices represent a significant shift in cardiac care, offering continuous, non-invasive monitoring with the potential to revolutionize the prevention, diagnosis, and treatment of cardiovascular conditions.

Cardiovascular Disease 88

Cardiovascular Disease Innovation Patient Care Outcomes 88

Med Page Today

DECEMBER 24, 2024

(MedPage Today) -- Use of assisted reproductive technology (ART) was not significantly associated with an increased long-term risk of cardiovascular diseases in women, according to a meta-analysis. (European Heart Journal) A randomized trial in.

TAVR 97

TAVR Technology Cardiovascular Disease 97

HCPLive

DECEMBER 24, 2024

Atogepant 60 mg, an oral CGRP receptor antagonist, demonstrated rapid and effective migraine prevention, reducing frequency and improving function in 4 weeks.

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Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundThis study compared the risks of atherothrombotic major adverse cardiovascular events in patients with type 2 diabetes taking SGLT2 (sodiumglucose cotransporter 2) inhibitors to those taking DPP4 (dipeptidyl peptidase4) inhibitors.Methods and ResultsAll adult patients (18 years of age) with type 2 diabetes and newly prescribed with SGLT2 inhibitors or DPP4 inhibitors across all public hospitals in Hong Kong between January 2015

Diabetes 75

Diabetes Myocardial Infarction Outcomes Stroke 75

HCPLive

DECEMBER 24, 2024

After 16 weeks of treatment, a significantly greater proportion of deucravacitinib-treated patients achieved ACR20 response.

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59

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. Up to 50% of patients with pulmonary embolism (PE) experience hemodynamic instability and approximately 70% of patients who die of PE experience an accelerated cascade of symptoms within the first hours of onset of symptoms, thus necessitating rapid evaluation and intervention. Venoarterial extracorporeal membrane oxygenation and other ventricular assist devices, depending on the hemodynamic derangements present, may be used to stabilize

Embolism 75

Embolism Pulmonary Ischemia Circulation 75

HCPLive

DECEMBER 24, 2024

Post-hoc analysis findings suggest tenapanor improves both abdominal and bowel symptoms in adult patients with IBS-C.

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Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. Arterial and venous thromboembolism are leading causes of morbidity and death worldwide. Despite significant advances in the diagnosis, prognostication, and treatment of thrombotic diseases over the past 3 decades, the adoption of findings stemming from translational biomarker research in clinical practice remains limited.

Biomarkers 45

Biomarkers Thrombosis Research Innovation 45

Circulation: Heart Failure

DECEMBER 24, 2024

Circulation: Heart Failure, Ahead of Print.

Heart Failure 40

Heart Failure Circulation 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. Structural, functional, and molecularlevel changes in the aging heart are influenced by a dynamic interplay between immune signaling and cellular metabolism that is referred to as immunometabolism. This review explores the crosstalk between cellular metabolic pathways including glycolysis, oxidative phosphorylation, fatty acid metabolism, and the immune processes that govern cardiac aging.

Quality of Life 45

Quality of Life Cancer Cardiac Function Research 45

The American Journal of Cardiology

DECEMBER 24, 2024

Publication date: Available online 24 December 2024 Source: The American Journal of Cardiology Author(s): He Jiao, Xiankun Liu, Yiming Bai, Lin Cong, Yunpeng Bai, Zhigang Guo

Aortic 40

Aortic 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundThis realworld evidence study compared risks of cardiovascular events in hospital settings among patients with chronic kidney disease (CKD) with and without hyperkalemia.Methods and ResultsAdults with CKD stages 3b/4 with and without hyperkalemia were identified from Optum's deidentified Market Clarity Data (January 2016August 2022).

Kidney Disease 45

Kidney Disease Arrhythmia Myocardial Infarction Atrial Fibrillation 45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundChronic arterial hypertension restructures the vascular architecture of the brain, leading to a series of pathological responses that culminate in cerebral smallvessel disease. Pericytes respond dynamically to vascular challenges; however, how they manifest under the continuous strain of hypertension has not been elucidated.Methods and ResultsIn this study, we characterized pericyte behavior alongside hypertensive states in the

Hypertension 45

Hypertension Biomarkers Circulation 45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundTranscatheter edgetoedge repair of the mitral valve (mTEER) reduced a hierarchical end point that included death and heart failure hospitalization in COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation Trial).

Bicuspid/Mitral 45

Bicuspid/Mitral Heart Failure Medicare Inpatient 45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundPrevious studies suggest the relationship between activation time (AT) and action potential duration (APD) in the heart is dependent on electrotonic coupling, but this has not been directly tested. This study assessed whether acute changes in electrical coupling, or other determinants of conduction or repolarization, modulate APD heterogeneity.Methods and ResultsLangendorffperfused guinea pig hearts were epicardially paced and

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45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundRisk stratification of patients with symptomatic nonobstructive coronary artery disease remains uncertain. Our study assessed the clinical value of singlevessel, multivessel, and 3vessel computational angiographyderived fractional flow reserve (caFFR) measurement in patients with nonobstructive coronary artery disease.Methods and ResultsWe enrolled patients with 50% stenosis with a caFFR value 0.8 in all 3 coronary arteries on

Coronary Artery Disease 45

Coronary Artery Disease Myocardial Infarction Stenosis 45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundOral treatment with the exogenous ketone body 3hydroxybutyrate improves cardiac function in patients with heart failure with reduced ejection fraction, but ketosis is limited to 3 to 4 hours. Treatment with (R)1,3butanediol (BD) provides prolonged ketosis in healthy controls, but the hemodynamic and metabolic profile is unexplored in patients with heart failure with reduced ejection fraction.Methods and ResultsThis was a random

Heart Failure 45

Heart Failure Circulation Cardiac Function Stroke 45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print.

Thrombolysis 45

Thrombolysis Hospital Stroke Strokes 45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundTPM3 (tropomyosin 3) is an actinbinding protein in vascular smooth muscle cells, where posttranslational modifications critically regulate its actin affinity, influencing cardiovascular function. Emerging evidence suggests that Khib (2hydroxyisobutyrylation) plays a significant role in the cardiovascular system.

Hypertension 40

Hypertension Aortic 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundThe optimal definition and risk stratification approach to identify highrisk patients with prediabetes and stable coronary heart disease has not been well studied to date. The objective of the current study is to compare the prognostic value of different definitions of prediabetes, and to explore the role of veryhighrisk (VHR) criteria according to the 2018 American Heart Association/American College of Cardiology cholesterol g

Heart Disease 40

Heart Disease Myocardial Infarction Cholesterol 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundDoxorubicininduced cardiotoxicity is still an important medical problem associated with a high mortality rate in cancer survivors. p53 plays a key role in doxorubicininduced cardiotoxicity. Diacylglycerol kinase (Dgk), a 130kDa enzyme abundant in cardiomyocytes, regulates the p53 protein expression level in neurons.

Cardiac Function 40

Cardiac Function Cancer 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundPeople with kidney failure have a high risk of cardiovascular morbidity/death, including thromboembolic events. Factor XIa inhibitors are a new class of anticoagulants in development that may offer antithrombotic benefits with a lower risk of incremental bleeding events than traditional therapies.

Cerebrovascular Disease 40

Cerebrovascular Disease Cardiovascular Disease Outcomes Hospital 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundImmune checkpoint inhibitors have improved the clinical outcomes of several cancers but have also been associated with a greater risk of immunerelated adverse effects, especially when combined. The objective of this study was to investigate the incidence of myocarditis in relation to the use of dual concurrent versus single immune checkpoint inhibitors therapies.Methods and ResultsA cohort study was conducted using medical and

Cancer 40

Cancer Heart Failure Outcomes 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundPoststroke fatigue affects 50% of patients with stroke, causing significant personal, societal, and economic burden. In the FASTER (Fatigue After Stroke Educational Recovery) study, we assessed a groupbased educational intervention for poststroke fatigue.Methods and ResultsTwo hundred patients with clinically significant fatigue were included and randomized to either a general stroke education control or fatigue management grou

Education 40

Education Stroke Strokes Quality of Life 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundHypertrophic cardiomyopathy (HCM) is a common heritable heart disease where the most frequently associated mutations occur in the myosinbinding protein C (MYBPC3) sarcomereassociated gene. HCM is also a common veterinary clinical problem in certain cat breeds such as Maine Coons and Ragdolls, also most associated with mutations inMYBPC3.

Cardiomyopathy 40

Cardiomyopathy Heart Disease 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundCurrent guidelines lack recommendations regarding the use of proton pump inhibitors (PPIs) for preventing upper gastrointestinal bleeding (UGIB) among patients at low risk for UGIB treated with dual antiplatelet therapy for ischemic stroke (IS). Our objective was to assess the effectiveness of PPIs in lowering the risk of significant UGIB in this patient group.Methods and ResultsA retrospective cohort study was conducted involv

Stroke 40

Stroke Strokes 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundIn obstructive hypertrophic cardiomyopathy, myectomy improves symptoms, quality of life, and left ventricular (LV) outflow tract gradients. We prospectively evaluated the temporal changes in various echo parameters after myectomy.Methods and ResultsIn 173 adults with obstructive hypertrophic cardiomyopathy (5310 years, 63% men) who underwent myectomy between March 2017 and June 2020, clinical and blinded echo assessment (before

Cardiomyopathy 40

Cardiomyopathy Quality of Life 40

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundCardiovascular health (CVH) assessment may have important benefits for adults with chronic diseases to prevent incident cardiovascular disease and additional chronic conditions. Few studies have compared CVH in adults with chronic diseases and healthy adults without chronic disease using the American Heart Association's (AHA's) Life's Essential 8 (LE8) metrics.Methods and ResultsWe used National Health and Nutrition Examination

Chronic Disease 45

Chronic Disease Cardiovascular Disease Kidney Disease Cancer 45

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundAortic valve stenosis (AVS) is a progressive disease characterized by fibrosis, inflammation, calcification, and stiffening of the aortic valve leaflets, leading to disrupted blood flow. If untreated, AVS can progress to heart failure and death within 2 to 5 years. Uncovering the molecular mechanisms behind AVS is key for developing effective noninvasive therapies.

Stenosis 45

Stenosis Aortic Aortic valve Heart Failure 45