Wed.Jan 10, 2024

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Why Nighttime Light Exposure is So Harmful for Cardiovascular Health

Physiologically Speaking

Our body’s physiological processes oscillate on a 24-hour cycle known as the circadian rhythm. Circadian rhythms in blood pressure and heart rate, among other functions, are crucial for cardiovascular health and preventing cardiovascular disease. Recent evidence indicates that nighttime light exposure impacts melatonin release, the autonomic nervous system, and cortisol — with potentially harmful effects on cardiovascular health.

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U.S. heart disease deaths linked with substance use rose 4% per year between 1999-2019

American Heart News - Heart News

Research Highlights: Despite drops in overall cardiovascular disease deaths from 1999-2019, cardiovascular disease deaths in which substance use was cited as a contributing factor increased an average of 4% per year, with the death rate accelerating.

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Hepatitis B Markers, Reactivation Do Not Impact Effectiveness of DAA Therapy for HCV

HCPLive

Response to direct-acting antiviral therapy was similar between patients with and without HBV coinfection, with most patients completing the planned course of treatment and achieving SVR, even in the case of HBV reactivation.

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A beating biorobotic heart aims to better simulate valves

Science Daily - Heart Disease

Combining a biological heart and a silicone robotic pump, researchers created a biorobotic heart that beats like a real one, with a focus on a valve on the left side of the heart. The heart valve simulator can mimic the structure, function, and motion of a healthy or diseased heart, allowing surgeons and researchers to demonstrate various interventions while collecting real-time data.

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Risk Factors for IgA Nephropathy Recurrence After Kidney Transplant

HCPLive

Younger age at the time of kidney transplantation, faster progression to end-stage renal disease, a history of kidney transplantation, and no induction therapy were associated with IgAN recurrence, which was linked to poorer graft survival.

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A beating biorobotic heart aims to better simulate valves

Medical Xpress - Cardiology

Combining a biological heart and a silicone robotic pump, researchers created a biorobotic heart that beats like a real one, focusing on a valve on the left side of the heart. The heart valve simulator, presented on January 10 in the journal Device, can mimic the structure, function, and motion of a healthy or diseased heart, allowing surgeons and researchers to demonstrate various interventions while collecting real-time data.

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Patients with HS Shown to be at Higher Risk of Developing Osteoarthritis

HCPLive

In this analysis, the investigators note that the clinical association may be helpful to be taken into account as clinicians treat patients with HS.

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Only 1 Out of 10 of Clinicians Adhere to ACR Criteria for Fibromyalgia

HCPLive

Only 10% of providers surveyed follow the American College of Rheumatology criteria for fibromyalgia.

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Preeclampsia and preterm birth risk may be reduced by calcium dose lower than current WHO standard

Medical Xpress - Cardiology

To help prevent preeclampsia and preterm birth—common complications in pregnancy that can be fatal to women and newborns—low-dose calcium supplementation (equivalent to one 500-milligram pill per day) may be as effective as the World Health Organization (WHO) recommended high-dose calcium supplementation (equivalent to three 500-milligram pills taken throughout each day), according to a new study led by Harvard T.H.

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Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy

The New England Journal of Medicine

In patients with transthyretin amyloid cardiomyopathy, the TTR stabilizer acoramidis resulted in a better primary hierarchical outcome (including mortality, morbidity, and function) than placebo.

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Preexisting conditions seen in all patients with tachycardia after COVID-19 vaccine

Medical Xpress - Cardiology

Patients with post-COVID-19 vaccination postural orthostatic tachycardia syndrome (POTS) all have preexisting conditions, according to a study published in the January issue of Heart Rhythm.

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Prevention and Assessment of SCD in Young Athletes Focus of State-of-the-Art-Review

American College of Cardiology

Sudden cardiac death (SCD) in young athletes is uncommon yet highly tragic, and the precise epidemiological burden is not yet established. Prevention can be achieved through preparticipation screenings and implementation of policies aimed at prompt CPR, according to a state-of-the-art-review published Jan. 8 in JACC.

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Genetics may influence the body's response to low oxygen, study finds

Medical Xpress - Cardiology

University of Pittsburgh Schools of Medicine researchers uncovered a fundamental mechanism that controls the body's response to limited oxygen and regulates blood vessel disease of the lung.

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Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy

The New England Journal of Medicine

In randomized trials conducted in India and Tanzania comparing two daily doses of calcium supplementation, 500 mg was noninferior to 1500 mg for preeclampsia risk in both trials but was noninferior for preterm birth only in India.

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Diet in childhood linked to blood vessel damage in teenage years

Medical Xpress - Cardiology

Diets high in calories, fat and sugar in childhood can cause damage to blood vessel function, known to heighten the risk of early heart attacks and strokes, as early as adolescence according to new research from the University of Bristol.

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Rheumatoid Arthritis Quiz: Gastrointestinal Symptoms and RA

HCPLive

As gastrointestinal (GI) symptoms are common in the US, how does rheumatoid arthritis (RA) affect the frequency of GI events? Test your knowledge with this quiz.

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Inflammation of the heart muscle following viral infection can impede long-term cardiac function

Medical Xpress - Cardiology

Inflammation of the heart muscle, also known as myocarditis, is a serious consequence of a viral infection. This can impede the heart's ability to pump blood in the long term. In a recent study, researchers of the Faculty of Medicine of the University of Freiburg have discovered a new approach for treating myocarditis.

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Long-Term Efficacy of Risankizumab Observed for Psoriasis Regardless of Disease Characteristics

HCPLive

These data indicate a significant ability of this treatment to address patients’ psoriatic symptoms in a comprehensive manner, despite varying characteristics and demographics.

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Escitalopram-induced sinus bradycardia in coronary heart disease combined with depression: a case report and review of literature

Frontiers in Cardiovascular Medicine

For patients with cardiovascular disease, using the antidepressant escitalopram may lead to unexpected adverse events. Here, a rare repeated sinus bradycardia event due to escitalopram is first reported. In an 82-year-old female patient with cardiac dysfunction using digoxin, tachycardia (average heart rate of 93 beats/min) was demonstrated by electrocardiogram (ECG).

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Carvedilol No Help in Preventing Heart Failure in Childhood Cancer Survivors

Med Page Today

(MedPage Today) -- The use of low-dose carvedilol did not significantly improve certain cardiac measures of heart failure risk in long-term survivors of childhood cancer exposed to anthracycline compared with placebo, the randomized phase IIb PREVENT.

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Peripartum Cardiomyopathy

The New England Journal of Medicine

The author discusses the epidemiology and clinical presentation of peripartum cardiomyopathy, as well as the mechanistic basis for potential therapeutics.

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Intensive Statin and Antiplatelet Therapy for Acute High-Risk Intracranial or Extracranial Atherosclerosis

American College of Cardiology

The goal of the INSPIRES trial was to determine whether DAPT with clopidogrel and aspirin initiated within 72 hours of mild ischemic stroke or high-risk TIA was associated with decreased incidence of recurrent stroke compared with aspirin monotherapy.

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Genetics may influence the body's response to low oxygen

Science Daily - Heart Disease

Researchers uncovered a fundamental mechanism that controls the body's response to limited oxygen and regulates blood vessel disease of the lung.

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Arrhythmias in children undergoing orthotopic heart transplantation

Frontiers in Cardiovascular Medicine

Introduction Heart transplantation (HT) is the only treatment option in children with heart failure secondary to cardiomyopathies and non-reparable congenital heart diseases. Methods We performed a retrospective clinical data review of all consecutive pediatric patients (aged 2–18 years) who underwent orthotopic HT for advanced heart failure at our institution between January 2007 and January 2023.

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Exposure to high humidity and temperature in pregnancy could influence blood pressure changes in childhood

Science Daily - Heart Disease

Outdoor humidity and temperature levels during pregnancy could affect the future blood pressure of the unborn child, according to new research.

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SGLT2 inhibitor improves the prognosis of patients with coronary heart disease and prevents in-stent restenosis

Frontiers in Cardiovascular Medicine

Coronary heart disease is a narrowing or obstruction of the vascular cavity caused by atherosclerosis of the coronary arteries, which leads to myocardial ischemia and hypoxia. At present, percutaneous coronary intervention (PCI) is an effective treatment for coronary atherosclerotic heart disease. Restenosis is the main limiting factor of the long-term success of PCI, and it is also a difficult problem in the field of intervention.

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Bariatric Surgery is Linked to Lowering Anxiety, Depression Symptoms

HCPLive

A new study found, after bariatric surgery, participants had a 9.5% reduction in anxiety and a 22.3% reduction in depression.

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Congenital heart disease research landscape in the Arab world: a 25-year bibliometric review

Frontiers in Cardiovascular Medicine

Background While research on congenital heart disease has been extensively conducted worldwide, comprehensive studies from developing countries and the Arab world remain scarce. Aim This study aims to perform a bibliometric review of research on congenital heart disease in the Arab world from 1997 to 2022. Methods We analyzed data from the Web of Science, encompassing various aspects such as topics, countries, research output, citations, authors, collaborations, and affiliations.

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Michael B. Gorin, MD, PhD: Interim TEASE-3 Trial Data in Stargardt Disease

HCPLive

Positive interim data from the TEASE-3 clinical trial show gildeuretinol slows the progression of Stargardt Disease for up to six years.

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Infection remediation after septic device extractions: analysis of three treatment strategies including a 1-year follow-up

Frontiers in Cardiovascular Medicine

Introduction In CIED infections, all device material needs to be removed. But, especially in pacemaker-dependent patients it is often not possible to realize a device-free interval for infection remediation. In those patients, different treatment options are available, however the ideal solution needs still to be defined. Methods This retrospective analysis includes 190 patients undergoing CIED extractions due to infection.

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Eagle’s Eye View: Artificial Intelligence in Cardiology, Arterial Thromboembolism, and the Advanced Cardiovascular Life Support (ACLS) Guidelines

American College of Cardiology

In this week’s View, Dr. Eagle explores using AI Large Language Models for cardiology. He then discusses arterial thromboembolism in patients with atrial fibrillation and a CHA2DS2-VASc score of 1.

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Case Report: Left bundle branch pacing in an amyloid light-chain cardiac amyloidosis patient with atrioventricular block

Frontiers in Cardiovascular Medicine

Introduction Amyloid light-chain cardiac amyloidosis is a progressive infiltrative disease characterized by the deposition of amyloid fibrils in the cardiac tissue, which can cause serious atrioventricular block requiring pacemaker implantation. Left bundle branch pacing has emerged as an alternative method for delivering physiological pacing to achieve electrical synchrony of the left ventricle.

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Exposure to high humidity and temperature in pregnancy could influence blood pressure changes in childhood

Medical Xpress - Cardiology

Outdoor humidity and temperature levels during pregnancy could affect the future blood pressure of the unborn child, according to new research by the University of Bristol, published in JACC: Advances.

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Predictive value of soluble suppression of tumorigenicity 2 in atrial fibrillation: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Purpose Atrial fibrosis is the main pathological basis for the pathogenesis and progression of atrial fibrillation (AF). Soluble suppression of tumorigenicity 2 (sST2) is involved in fibrosis. Recent studies have explored its predictive value in AF outcomes. We performed this study to assess whether sST2 is an independent biomarker of AF outcomes and explore the potential mechanism.

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Diabetes Dialogue: Diabetes Technology Updates in January 2024

HCPLive

In this episode, hosts discuss recent news and updates in diabetes technology from Abbott, Dexcom, and Medtronic in the first half of January 2024.

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Case report: Widely split P' waves in a patient with focal atrial tachycardia

Frontiers in Cardiovascular Medicine

Background Widely split P waves in sinus rhythm have been reported previously. However, widely split P' waves in focal atrial tachycardia (AT) on a surface electrocardiogram (ECG) have rarely been reported. The electrophysiological mechanism is relatively difficult to clarify, requiring a electrophysiological study. Case summary A 67-year-old patient, who had undergone two radiofrequency ablations for atrial fibrillation, presented with recurrent palpitation.

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Growth differentiation factor-15 in patients with or at risk of heart failure but before first hospitalisation

Heart BMJ

Objective Identification of patients at risk of adverse outcome from heart failure (HF) at an early stage is a priority. Growth differentiation factor (GDF)-15 has emerged as a potentially useful biomarker. This study sought to identify determinants of circulating GDF-15 and evaluate its prognostic value, in patients at risk of HF or with HF but before first hospitalisation.