Fri.Feb 07, 2025

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How To Reduce Your Risk Of Heart Disease By Over 90%.

Dr. Paddy Barrett

It is possible to reduce your risk of heart disease by over 90% 1. Let me show you how. But first, let’s get some facts straight. Over a long enough time frame, pretty much everyone will get heart disease. By the time you get to age 80, you will almost certainly have evidence of plaque in your coronary arteries - you will have heart disease. But remember: Heart disease doesn’t kill people.

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Pregnancy complications linked to cardiovascular disease in the family

Science Daily - Heart Disease

Women who have experienced pregnancy complications have an increased risk of cardiovascular disease. Now, a new study shows that sisters of women with complicated pregnancies are also at higher risk, even if they had uncomplicated pregnancies. The findings suggest that genes and shared environmental factors may influence the association between pregnancy complications and cardiovascular disease risk.

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The Weekend Effect Touches TAVR Too

CardiacWire

It seems even interventional cardiologists arent immune to the Weekend Effect as a recent study suggests patients admitted on weekends for TAVR procedures face significantly higher risks. The “weekend effect” is a well-documented phenomenon in hospital care, often linked to reduced staffing levels, leading to potential delays in diagnosis and intervention.

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Hemophilia B Gene Therapy Achieves Sustained Benefit Over 4 Years

HCPLive

More than 90% of patients with hemophilia B eliminated factor IX prophylaxis 4 years after treatment with etranacogene dezaparvovec (HEMGENIX) gene therapy.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Clot-busting meds may be effective up to 24 hours after initial stroke symptoms

American Heart News - Stroke News

Research Highlights: In a randomized clinical trial in China, giving the clot-busting medication alteplase up to 24 hours after stroke symptoms first appeared increased the odds of better recovery by 50% compared to those who received standard.

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New Tool Helps Parents Manage Dietary Needs of Children with Food Allergies

HCPLive

Investigators in Korea developed and validated PSED-FA, a reliable tool to assess parental confidence in managing children's food allergies and nutrition.

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Dupilumab Reduced COPD Exacerbations Compared to Placebo

HCPLive

Approved under the name dupixent in September 2024, the biologic is the first of its kind approved for COPD.

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Clot-busting meds may be effective up to 24 hours after initial stroke symptoms

Science Daily - Heart Disease

In a randomized clinical trial, giving the clot-busting medication alteplase up to 24 hours after stroke symptoms first appeared increased the odds of better recovery by 50% compared to those who received standard antiplatelet treatment.

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GLP-1 RAs Reduce Alcohol-Related Liver Disease Risk in Patients with AUD

HCPLive

GLP-1 RA use was linked to a reduced risk of alcohol-associated liver disease, lower rates of hepatic decompensation, and improved survival.

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Electric Stimulation Comes Up Short for Motor Recovery After Stroke

Med Page Today

(MedPage Today) -- LOS ANGELES -- A course of transcranial direct current stimulation (tDCS) did not help with post-stroke motor recovery when tested in a larger multicenter randomized trial. Among stroke survivors 1-6 months out from their.

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ADP101 Immunotherapy Increases Food Allergy Threshold but Misses Primary Endpoint

HCPLive

ADP101 raised food allergy thresholds in children but missed its primary endpoint. Findings support further research into multi-food oral immunotherapy.

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YTHDF2 mediates the protective effects of MG53 on myocardial infarction injury via recognizing the m6A modification of MG53

Journal of Cardiothoracic Surgery

High levels of MG53 may attenuate the damage from myocardial infarction (MI). Furthermore, N6-methyl-adenosine (m6A) methylation is a mode of RNA modification that influences mRNA functions. Whether m6A modifi.

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FDA Approves Emblaveo Combination Antibiotic Therapy for Complicated Intra-Abdominal Infections

HCPLive

Emblaveo combines aztreonam, a monobactam antibiotic, and avibactam, a -lactamase inhibitor.

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Intra-Arterial Lytics Find Redemption as Adjuncts to Endovascular Stroke Therapy

Med Page Today

(MedPage Today) -- LOS ANGELES -- For patients with large vessel occlusion (LVO) strokes, researchers found ways to make adjunctive intra-arterial (IA) thrombolytics work to improve outcomes after successful endovascular therapy (EVT), according.

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REGENCY: Obinutuzumab Proves Efficacy in Lupus Nephritis

HCPLive

Use of obinutuzumab was associated with significant improvements in complete renal response rate and markers of disease activity in active lupus nephritis.

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Chest X-ray Features of Pulmonary Hypertension

All About Cardiovascular System and Disorders

Couple of chest X-rays showing serial changes in pulmonary hypertension over the years and another with features of severe pulmonary hypertension. The post Chest X-ray Features of Pulmonary Hypertension appeared first on All About Cardiovascular System and Disorders.

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GOLD 2025 Report: Ensifentrine, a New Treatment in COPD

HCPLive

Panelists discuss how ensifentrine is a nebulized inhaled therapy, a small molecule inhibitor of PDE3 and PDE4, and is compelling because there are very few adverse effects. There are also compelling results from studies that show bronchial dilatation and exacerbation reduction.

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Patients Residing in Rural Areas Transferred for Mechanical Thrombectomy Undergo Decreased Catheter‐Based Treatment

Stroke: Vascular and Interventional Neurology

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDNearly one fifth of the US population resides in rural areas. Although endovascular therapy can substantially improve clinical outcomes in patients treated with large vessel occlusion acute ischemic stroke, the penetration and outcomes of this therapy in rural US populations remain incompletely characterized.METHODSFrom the nationwide Get With The Guidelines Stroke registry, incorporating select social determinants of healt

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Acceptance, Commitment Therapy Program Effective in Children with Atopic Dermatitis

HCPLive

These data suggest that the Family Acceptance and Commitment Therapy-based Eczema Management Program, or FACT-EMP, may be helpful to children with atopic dermatitis.

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Clinical Impact of P2Y12 Pretreatment in ST-segment Elevation Myocardial Infarction: Insights From the SEMPRE (St-Elevation Mestre Pretreatment REgistry) Study

The American Journal of Cardiology

Publication date: Available online 6 February 2025 Source: The American Journal of Cardiology Author(s): Francesco Gallo, Ada Cutolo, Antonio Antonucci, Gabriele Cordoni, Elisabetta Demurtas, Andrea Panza, Sakis Themistoclakis

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VIVID-2: Mirikizumab (Omvoh) Shows Long-Term Efficacy for Crohn’s Disease

HCPLive

Findings from the VIVID-2 open-label extension study in patients with CD highlight long-term clinical and endoscopic outcomes with mirikizumab.

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Exploring Current Diagnosis and Management of Amiodarone-Induced Thyrotoxicosis

The American Journal of Cardiology

Publication date: Available online 7 February 2025 Source: The American Journal of Cardiology Author(s): Yudi Her Oktaviano, Ali Mustofa, Pandit Bagus Tri Saputra, Wynne Widiarti, Novia Nurul Faizah, Firas Farisi Alkaff

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Mim8 Prophylaxis Tolerable for Children with Hemophilia A in Phase 3 Analysis

HCPLive

Interim analysis of the Phase 3 FRONTIER3 trial found Mim8 well-tolerated in children with hemophilia A with and without inhibitors.

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ECG Blog #468 — Aberrant or VT?

Ken Grauer, MD

I was sent the ECG in Figure-1 without the benefit of any clinical information. QUESTIONS: What is the rhythm? How certain are you of your answer? Figure-1: The ECG I was sent. ( To improve visualization I've digitized the original ECG using PMcardio ). MY Thoughts on Making the Diagnosis: Rather than a "Yes-No" answer ( ie, Rather than saying the rhythm is VT vs SVT ) it is preferable to simply describe what you see.

Blog 101
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Second Xenotransplant with Gene-Edited Pig Kidney Performed at Mass General

HCPLive

The genetically edited pig kidney was provided by eGenesis and successfully transplanted into a 66-year-old male patient with end-stage kidney disease.

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Physiology Friday #256: Caffeine Boosts Performance & Fat Burning during Carb-Restricted Training

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Something to share: This week, I appeared as a guest on the FoundMyFitness podcast with Dr. Rhonda Patrick. We discuss how to train for aerobic fitness, muscle mass and strength, heart health, and more! You can find the full episode on YouTube or links to the podcast on other platforms here. Enjoy!

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Dupilumab Survival Compared to Upadacitinib, Tralokinumab in Atopic Dermatitis

HCPLive

These data suggest that dupilumabs drug survival rate at 12 and 24 months is greater than that of upadacitinib and tralokinumab among patients with atopic dermatitis.

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Clot-buster Meds, Mechanical Retrieval Equally Reduce Disability from Some Strokes

DAIC

tim.hodson Fri, 02/07/2025 - 10:41 Feb. 5, 2025 Removing a clot blocking a medium- or small-sized artery in the brain mechanically is a safe treatment for a common type of stroke; however, it did not lessen disability more than best medical treatment (including clot-busting medication if indicated) alone, according to preliminary late-breaking science presented at theAmerican Stroke Associations International Stroke Conference 2025 in Los Angeles.

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GOLD 2025 Report: Dupilumab, a New Treatment in COPD

HCPLive

Panelists discuss how the BOREAS and NOTUS phase 3 trials demonstrated that dupilumab significantly reduced exacerbations, improved lung function, and enhanced quality of life in patients with uncontrolled chronic obstructive pulmonary disease (COPD), particularly those with elevated eosinophil counts, highlighting its potential in targeted therapy.

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Theranostics at Nebraska Cancer Specialists: A Patient's Journey

Cassling

When Glenda was diagnosed with neuroendocrine tumors, her treatment options seemed limited. Learn how theranostics turned her life-threatening illness into a manageable, chronic condition, offering her a new path forward. For more than 15 years, 61-year-old Glenda suffered from severe, recurring abdominal pain. After repeated visits at doctors' offices and emergency rooms, a CT scan finally revealed the diagnosis: Glenda had neuroendocrine tumors.

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Study Finds Disparities in Post-Stroke Care for Women

DAIC

Getty Images tim.hodson Fri, 02/07/2025 - 11:01 Feb. 6, 2025 New findings from the DiVERT Stroke clinical study showed women spent less time in the hospital, saw fewer referrals to cardiology, and were prescribed less frequent post-stroke cardiac monitoring than men when admitted to comprehensive stroke centers following stroke. The data were presented at the International Stroke Conference (ISC) in Los Angeles.

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