Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial platforms, patient site–directed biopsies, and multiomics analyses to define metabolic drivers of invasive glioblastoma cells.

Pharmacology 138

Pharmacology 138

HCPLive

FEBRUARY 1, 2024

In the wake of Vera Therapeutics announcing positive 72-week data from the phase 2b ORIGIN trial, we sat down with lead investigator Richard Lafayette, MD, to learn more about how he interprets the latest data from the atacicept program in IgA nephropathy.

119

119

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer’s disease (AD) and related tauopathies. Here, we found that reduced levels of the memory-associated protein KIdney/BRAin (KIBRA) in the brain and increased KIBRA protein levels in cerebrospinal fluid are associated with cognitive impairment and pathological tau levels in disease.

Biomarkers 133

Biomarkers 133

American Heart News - Heart News

FEBRUARY 1, 2024

Research Highlights: The risk of a heart attack among adults after a clot-caused stroke or a stroke plus a tear in the wall of a neck artery (carotid or vertebral artery dissection) was almost double within the first year compared to the heart attack.

Heart attacks 111

Heart attacks Heart Attack Stroke Strokes 111

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

This study investigates a mechanistic link of bacterial biofilm–mediated host-pathogen interaction leading to immunological complications associated with breast implant illness (BII). Over 10 million women worldwide have breast implants. In recent years, women have described a constellation of immunological symptoms believed to be related to their breast implants.

130

130

Cardiometabolic Health Congress

FEBRUARY 1, 2024

The profound link between the heart and mind has been the subject of much research for some time, with newer studies reinforcing the existing evidence as well as offering deeper insights. A large number of studies have shown that individuals coping with conditions like depression, anxiety, or stress face an elevated risk of cardiovascular problems. Past studies have often attributed this association to behavioral aspects, such as a person coping with emotional distress through smoking or drinkin

Cardiovascular Disease 106

Cardiovascular Disease Coronary Artery Bypass Graft Heart Disease Risk Factors 106

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well as modern therapeutics, such as targeted therapy and immunotherapy, including anti–programmed cell death protein (anti-PD) therapy. We demonstrate that programmed death-1 homolog (PD-1H), an immune coinhibitory molecule, is highly expressed in blasts from the bone marrow of AML patients, while normal myeloid cell subsets and T cells express PD-1H.

Ablation 128

Ablation 128

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Nonalcoholic fatty liver disease (NAFLD) is prevalent in the majority of individuals with obesity, but in a subset of these individuals, it progresses to nonalcoholic steatohepatitis (0NASH) and fibrosis. The mechanisms that prevent NASH and fibrosis in the majority of patients with NAFLD remain unclear. Here, we report that NAD(P)H oxidase 4 (NOX4) and nuclear factor erythroid 2–related factor 2 (NFE2L2) were elevated in hepatocytes early in disease progression to prevent NASH and fibrosis.

Obesity 111

Obesity Diet 111

Medical Xpress - Cardiology

FEBRUARY 1, 2024

In a new study published in iScience, Mayo Clinic researchers found that a novel 4D echo imaging method that measures cardiac strain may detect subtle changes in the heart's dysfunction during acute myocarditis, a deadly heart disease.

Heart Disease 99

Heart Disease Heart Dysfunction Research 99

American Heart News - Stroke News

FEBRUARY 1, 2024

Research Highlights: In a study conducted in China, adults treated with 14 days of intravenous injections of ginkgo diterpene lactone meglumine (GDLM) — a combination of biologically active components of ginkgo biloba — after an ischemic (clot-caused).

Stroke 104

Stroke Strokes Research 104

DAIC

FEBRUARY 1, 2024

February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. Each year, the American Heart Association (AHA) gathers a Statistical Update, described as a major source for monitoring cardiovascular health, risk factors and disease in the United States and globa

Cardiovascular Disease 104

Cardiovascular Disease Stroke Strokes Atherosclerosis 104

American Heart News - Stroke News

FEBRUARY 1, 2024

Research Highlights: Stimulating a nerve that runs between various organs and the brain with intense physical rehabilitation improved arm and hand function in people with stroke. The improved motor function remained at the end of the one-year.

Stroke 103

Stroke Strokes Research 103

Science Daily - Heart Disease

FEBRUARY 1, 2024

Scientists have developed a new approach to machine learning -- a form of artificial intelligence -- to identify drugs that help minimize harmful scarring after a heart attack or other injuries.

Heart attacks 106

Heart attacks Heart Attack 106

American Heart News - Stroke News

FEBRUARY 1, 2024

Research Highlights: Compared with the standard medication alteplase, the newer clot-busting medication tenecteplase may offer a safe, effective and simpler way to treat clot-caused stroke in special ambulances called mobile stroke units. Tenecteplase.

Stroke 102

Stroke Strokes Research 102

Science Daily - Heart Disease

FEBRUARY 1, 2024

Adults treated with 14 days of intravenous injections of ginkgo diterpene lactone meglumine (GDLM) -- a combination of biologically active components of ginkgo biloba -- after an ischemic (clot-caused) stroke had better cognitive recovery at 14 days and 90 days.

Stroke 103

Stroke Strokes 103

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Pancreatic β cells are specialized for coupling glucose metabolism to insulin peptide production and secretion. Acute glucose exposure robustly and coordinately increases translation of proinsulin and proteins required for secretion of mature insulin peptide. By contrast, chronically elevated glucose levels that occur during diabetes impair β cell insulin secretion and have been shown experimentally to suppress insulin translation.

Diabetes 102

Diabetes 102

HCPLive

FEBRUARY 1, 2024

In a survey, 1 in 6 cisgender men and women reported unmet mental health needs at their latest visit with a healthcare professional. Mental health needs for other gender identities ranged from 1 in 5 and 1 in 4.

99

99

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Microscopic hemorrhage is a common aspect of cancers, yet its potential role as an independent factor influencing both cancer progression and therapeutic response is largely ignored. Recognizing the essential function of macrophages in red blood cell disposal, we explored a pathway that connects intratumoral hemorrhage with the formation of cancer-promoting tumor-associated macrophages (TAMs).

Cancer 98

Cancer Hemorrhage 98

Conquering CHD

FEBRUARY 1, 2024

Today, U.S. Representatives Gus Bilirakis (R-FL) and Adam Schiff (D-CA), along with original cosponsors Representatives Tony Cardenas (D-CA), Buddy Carter (R-GA), María Elvira Salazar (R-FL), and Darren Soto (D-FL), introduced the Congenital Heart Futures Reauthorization Act of 2024 – a bipartisan bill that will authorize continued funding for congenital heart disease research and surveillance programs at the Centers for Disease Control and Prevention (CDC).

Congenital 98

Congenital Congenital Heart Disease Public Health Pediatrics 98

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the enzyme that synthesizes it, aconitate decarboxylase 1 (Acod1, also known as immune-responsive gene 1 [IRG1]), are upregulated during atherogenesis in mice. Deletion of Acod1 in myeloid cells exacerbated inflammation and atherosclerosis in vivo and resulted in an elevated frequency of a specific subset of M1-polarized pr

Atherosclerosis 98

Atherosclerosis Cholesterol 98

Medical Xpress - Cardiology

FEBRUARY 1, 2024

A team of obstetricians, gynecologists and data analysts from West Virginia University School of Medicine and the West Virginia University School of Public Health, working with colleagues from WHOOP Inc., has found evidence that wrist-based heart rate monitors could predict a premature birth.

Public Health 87

Public Health 87

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in the development and progression of PAH, yet the underlying mechanisms are incompletely understood. The endosome-lysosome system is important to maintain cellular health, and the small GTPase RAB7 regulates many functions of this system.

Pulmonary 98

Pulmonary Hypertension 98

American Heart News - Stroke News

FEBRUARY 1, 2024

Research Highlights: One month after hospital evaluation for stroke-like symptoms, people whose symptoms were attributed to another condition were 3 times more likely to have increased risk of post-traumatic stress disorder (PTSD) than people.

Stroke 84

Stroke Strokes Hospital Research 84

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Oxygen and nutrient deprivation are common features of solid tumors. Although abnormal alternative splicing (AS) has been found to be an important driving force in tumor pathogenesis and progression, the regulatory mechanisms of AS that underly the adaptation of cancer cells to harsh microenvironments remain unclear. Here, we found that hypoxia- and nutrient deprivation–induced asparagine endopeptidase (AEP) specifically cleaved DDX3X in a HIF1A-dependent manner.

Cancer 98

Cancer 98

American Heart News - Stroke News

FEBRUARY 1, 2024

Research Highlights: Black women who develop high blood pressure before age 35 may have triple the odds of having a stroke, and those who develop high blood pressure before age 45 may have twice the risk of suffering a subsequent stroke.

Blood Pressure 80

Blood Pressure Strokes Stroke Research 80

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

AIOLOS, also known as IKZF3, is a transcription factor that is highly expressed in the lymphoid lineage and is critical for lymphocyte differentiation and development. Here, we report on 9 individuals from 3 unrelated families carrying AIOLOS variants Q402* or E82K, which led to AIOLOS haploinsufficiency through different mechanisms of action. Nonsense mutant Q402* displayed abnormal DNA binding, pericentromeric targeting, posttranscriptional modification, and transcriptome regulation.

93

93

Medical Xpress - Cardiology

FEBRUARY 1, 2024

People with so-called stroke mimics may be even more likely to develop post-traumatic stress disorder (PTSD) than those with a confirmed stroke, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2024. The meeting will be held in Phoenix, Feb. 7-9.

Stroke 83

Stroke Strokes Research 83

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate single-cell RNA sequencing, spatial transcriptomics, and immunostaining to provide an unprecedented view of the pathogenesis of chronic HS, characterizing the main cellular players and defining their interactions.

92

92

Medical Xpress - Cardiology

FEBRUARY 1, 2024

Black women who develop high blood pressure before age 35 and are on medication for hypertension may have triple the odds of having a stroke, and those who develop high blood pressure before age 45 may have twice the risk of suffering a stroke, according to a preliminary study to be presented at the American Stroke Association's International Stroke Conference 2024.

Blood Pressure 80

Blood Pressure Strokes Stroke Hypertension 80

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Challenging skeletal repairs are frequently seen in patients experiencing systemic inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we performed single-cell RNA sequencing and revealed that progenitor cells were one of the major lineages responsive to elevated inflammation and this response adversely affected progenitor differentiation by upregulation of Rbpjk in fracture nonunion.

Ablation 81

Ablation 81

Medical Xpress - Cardiology

FEBRUARY 1, 2024

Dr. Tracy Madsen has been studying the topic of women and stroke since beginning her residency in emergency medicine at Brown's Warren Alpert Medical School in 2008. She originally focused on the disparities in the treatment of women in the emergency department.

Stroke 67

Stroke Strokes 67

American Heart News - Stroke News

FEBRUARY 1, 2024

Research Highlights: Living in neighborhoods with more recreational and fitness centers may influence people’s engagement in physical activity during the first year after a stroke. A small study found that people in New York City who survived a mild.

Stroke 76

Stroke Strokes Research 76

Stroke Journal

FEBRUARY 1, 2024

Stroke, Ahead of Print. Cervical artery dissection is an important cause of stroke, particularly in young adults. Data conflict on the diagnostic evaluation and treatment of patients with suspected cervical artery dissection, leading to variability in practice. We aim to provide an overview of cervical artery dissection in the setting of minor or no reported mechanical trigger with a focus on summarizing the available evidence and providing suggestions on the diagnostic evaluation, treatment app

Genetic predisposition 75

Genetic predisposition Outcomes Thrombolysis Congenital 75

American Heart News - Stroke News

FEBRUARY 1, 2024

Research Highlights: Among most ischemic (clot-caused) stroke survivors including those taking anticoagulant medications, use of antidepressants in the SSRI or SNRI class did not increase the risk of hemorrhagic (bleeds) stroke or other serious.

Stroke 75

Stroke Strokes Hemorrhage Research 75

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP83-ATP83, February 1, 2024. Background:The success of post-stroke rehabilitation depends on the cooperation of many components such as: severity of the stroke, speed with which treatment begins, skills of the rehabilitation team, cooperation of the survivor with family and friends. Telerehabilitation (TLR) involves home rehabilitation with a nurse or physician, who evaluates and supports survivors remotely and in remote locations through the use of tele

Strokes 75

Strokes Stroke Quality of Life Nursing 75

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide, and comprises a spectrum of several different disorders, including simple steatosis, steatohepatitis, cirrhosis, and superimposed hepatocellular carcinoma. Although tremendous progress has been made in the field of ALD over the last 20 years, the pathogenesis of ALD remains obscure, and there are currently no FDA-approved drugs for the treatment of ALD.

Cancer 75

Cancer Research 75

Medical Xpress - Cardiology

FEBRUARY 1, 2024

Unexplained rapid weight loss in older people could be a sign of underlying disease and can be linked with increased risk of falls and fractures, as well as a poorer long-term prognosis.

71

71