Thu.Nov 30, 2023

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Lost brain function restored in mice after stroke

Science Daily - Stroke

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

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Rude Awakening on Trying to Keep Donor Hearts Usable With Common Hormone Infusions

Med Page Today

(MedPage Today) -- Giving unstable brain-dead heart donors intravenous levothyroxine did not lead to more hearts being transplanted, a randomized trial showed. In hemodynamically unstable potential donors, administering the thyroid hormone supplement.

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Early Rhythm Control, Lifestyle Modification and More Tailored Stroke Risk Assessment Are Top Goals in Managing Atrial Fibrillation

American Heart News - Heart News

DALLAS and WASHINGTON (Nov. 30, 2023) — The American Heart Association (AHA) and the American College of Cardiology (ACC), along with several other leading medical associations, have issued a new guideline for preventing and optimally managing atrial.

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Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction

JAMA Cardiology

This secondary analysis of a randomized clinical trial assesses whether myocardial viability testing identifies patients with ischemic left ventricular dysfunction who benefit from percutaneous coronary intervention.

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Intermittent Theta-Burst Stimulation for Stroke: Primary Motor Cortex Versus Cerebellar Stimulation: A Randomized Sham-Controlled Trial

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:Stroke survivors with impaired balance and motor function tend to have relatively poor functional outcomes. The cerebellum and primary motor cortex (M1) have been suggested as targets for neuromodulation of balance and motor recovery after stroke. This study aimed to compare the efficacy and safety of intermittent theta-burst stimulation (iTBS) to the cerebellum or M1 on balance and motor recovery in patients with stroke.METHODS:In this randomized, double-blind

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Concordance of a High Lipoprotein(a) Concentration Among Relatives

JAMA Cardiology

This cross-sectional study measures the association of lipoprotein(a) concentrations in pairs of first- and second-degree relatives of participants in the UK Biobank with high lipoprotein(a) levels.

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Headset identifies 78% of strokes prior to hospital arrival: Study

Becker's Hospital Review - Cardiology

Sacramento, Calif.-based Sutter Health has taken part in testing and researching a headset designed to help emergency technicians better identify large vessel occlusion ischemic strokes prior to patients arriving at the hospital.

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Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease Due to Coronary Embolism Clarified by Cardiac Computed Tomography

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Ahead of Print.

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An Elderly Woman With Ventricular Tachycardia

JAMA Cardiology

A woman in her 90s presented to the emergency department with fever, hemoptysis, and syncopal episodes. An electrocardiogram showed monomorphic ventricular tachycardia with a morphology suggesting right ventricular (RV) origin. What would you do next?

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Outside the Laboratory Assessment of Upper Limb Laterality in Patients With Stroke: A Cross-Sectional Study

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:The rehabilitation of upper limb sensorimotor performance after stroke requires the assessment of daily use, the identification of key levels of impairment, and monitoring the course of recovery. It needs to be answered, how laboratory-based assessments and everyday behavior are connected, which dimension of metrics, that is, volume, intensity, or quality, is most sensitive to reduced function, and what sensor, that is, gyroscope or accelerometer, is best suite

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Deep Learning in ECGs in Sinus Rhythm to Predict AF

JAMA Cardiology

This prognostic study investigates whether deep learning models applied to electrocardiograms (ECGs) of sinus rhythm in a population of US Veterans Affairs (VA) patients can predict the presence of concurrent atrial fibrillation (AF).

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Histone Modifications and Their Contributions to Hypertension

Hypertension Journal

Hypertension, Ahead of Print. Essential hypertension, a multifaceted disorder, is a worldwide health problem. A complex network of genetic, epigenetic, physiological, and environmental components regulates blood pressure (BP), and any dysregulation of this network may result in hypertension. Growing evidence suggests a role for epigenetic factors in BP regulation.

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Epicardial arrhythmogenic substrate in long QT syndrome

HeartRhythm

The advent of transseptal puncture has enabled the study of atrial fibrillation mechanisms, while epicardial access has enabled exploration of the epicardium in ventricular arrhythmias (ventricular tachycardia/ventricular fibrillation [VF]).1,2 This has uncovered the electrophysiological signature of various cardiogenetic disorders within the epicardium.

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Optimizing Educational Environments in Stroke and Neurovascular Fields

Stroke Journal

Stroke, Ahead of Print.

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A swinging rhythm

HeartRhythm

A previously healthy 45-year-old man was referred to the emergency department post–cardiopulmonary resuscitation after documented ventricular fibrillation (VF). His blood pressure was 80/40 mm Hg. There was no family history of sudden death. His family noted that he drank Chinese steamed herbal medication several hours before admission. He complained of nausea, vomiting, and numbness of the face and limbs, followed by a sudden collapse due to VF.

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Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study

Circulation

Circulation, Ahead of Print. BACKGROUND:Primary aldosteronism, characterized by overt renin-independent aldosterone production, is a common but underrecognized form of hypertension and cardiovascular disease. Growing evidence suggests that milder and subclinical forms of primary aldosteronism are highly prevalent, yet their contribution to cardiovascular disease is not well characterized.METHODS:This prospective study included 1284 participants between the ages of 40 and 69 years from the random

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Cardiac arrest and a bifid T wave

HeartRhythm

A 35-year-old woman without a history of cardiac disease was seen in the emergency department after an abrupt syncopal episode. She denied the use of any medications, and her family history was unremarkable. Her cardiac echocardiogram and serum electrolytes were normal. What are the important features of the electrocardiographic (ECG) tracings (Figure 1), and what is the most likely diagnosis?

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Connection and communication

HeartRhythm

I am starting this sitting here in my hotel room at APHRS in Hong Kong so impressed with the global world of electrophysiology (EP) and the common language we all speak. Of course, I am looking out the window at howling seas, rain, and Typhoon Saola—which, if we all get home without issue, will afford bragging rights of what we have been through (we did…).

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Detecting deceased patients on cardiac device remote monitoring: a case series and management guide for cardiac device services.

HeartRhythm

Remote monitoring (RM) of implantable cardiac devices provides substantial and complex information, presenting new challenges such as detection of a patient's death.

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