Tue.Dec 12, 2023

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New AI-powered algorithm could better assess people's risk of common heart condition

Medical Xpress - Cardiology

A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure. The model picks up on tiny variations in a person's normal heartbeat that signify AFib risk, which standard screening tests cannot detect.

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USPSTF Draft Calls for Lifestyle Shift -- Not Meds -- for Kids With Obesity

Med Page Today

(MedPage Today) -- The U.S. Preventive Services Task Force (USPSTF) plans to recommend intensive behavioral interventions -- but not pharmacologic therapies -- for kids with a high body mass index (BMI). In its draft recommendation statement.

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Contraindications for Use of JAK Inhibitors in AD

HCPLive

Peter Lio, MD, reviews the contraindications of JAK inhibitors in AD and approaches for monitoring patients who are prescribed a JAK inhibitor.

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Use of Anticoagulant Drug after Aortic Valve Replacement Lowers Mortality Risk, Mayo Clinic Study Finds

DAIC

milla1cf Tue, 12/12/2023 - 07:00 December 12, 2023 — Patients who received the anticoagulant drug warfarin after bioprosthetic aortic valve replacement had lower incidence of mortality and a decreased risk of blood clots, according to a retrospective study published in Mayo Clinic Proceedings. The use of bioprosthetic aortic valve replacement has increased significantly during the past decade.

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Anti-Inflammatory Diet May Prevent, Improve Gout

HCPLive

Patients with the highest Dietary Inflammatory Index have an increased risk of gout.

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New AI-powered algorithm could better assess people's risk of common heart condition

Science Daily - Heart Disease

Early detection of atrial fibrillation can reduce the risk of stroke and heart failure, but screening people for the condition has been historically challenging.

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Etranacogene Dezaparvovec Significantly Improves Hemophilia B Past 2 Years

HCPLive

Phase 3 data presented at ASH 2023 show the gene therapy significantly reduced annualized bleeding rates and the number of total bleeds.

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Gout Is Not Significantly Associated with Increased Risk of Colorectal Cancer

HCPLive

In a new study, a subgroup analysis demonstrated a reduced risk of colorectal cancer among patients <65 years old with gout.

Cancer 105
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Metformin for Diabetes in Pregnancy: Maybe Not, Trial Says

Med Page Today

(MedPage Today) -- Adding metformin to insulin treatment for pregnant women with preexisting type 2 or gestational diabetes did not reduce composite neonatal adverse outcomes, according to the randomized MOMPOD trial. The composite outcome -.

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ASE and its Foundation Award Three $25,000 Grants to Early Career Investigators in Cardiovascular Imaging

DAIC

Getty Images milla1cf Tue, 12/12/2023 - 09:04 December 12, 2023 — The American Society of Echocardiography (ASE) and the ASE Foundation have awarded grant funding totaling $75,000 for three innovative cardiovascular ultrasound research projects led by early career investigators. The Society’s EDGES ( Early-Career Development Grant for Echo Scientists ) research program is intended to fund projects that address a clinical gap in cardiovascular ultrasound imaging through research directed by a

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High-Altitude Mountain Trips Can Be Tolerated Despite Pulmonary Hypertension

Med Page Today

(MedPage Today) -- Stable patients with pulmonary vascular disease (PVD) tolerated travel to high altitudes fairly well with frequent monitoring and supplemental oxygen therapy provided as necessary, a field study found. Despite the perceived.

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A vascular procedure some physicians may be abusing

Becker's Hospital Review - Cardiology

Some physicians may be overusing an invasive vascular procedure for patients with mild disease — making millions in the process, a ProPublica investigation into CMS data found.

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Antirheumatic Drugs May Impact Risk of NAFLD in Patients with Rheumatoid Arthritis, Study Finds

HCPLive

Nonsteroidal anti-inflammatory drug use and prednisolone equivalent dose >5 mg per day were associated with an increased risk of NAFLD, whereas hydroxychloroquine use and prednisolone equivalent dose ≤5 mg per day were associated with a decreased risk of NAFLD.

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New 'atherosclerosis atlas' sheds light on heart attacks, strokes

Medical Xpress - Cardiology

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes, and coronary artery disease.

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Olive oil consumption, plasma metabolites, and risk of type 2 diabetes and cardiovascular disease

Cardiovascular Diabetology

Olive oil consumption has been inversely associated with the risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). However, the impact of olive oil consumption on plasma metabolites remains poorly un.

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Pain Scores, Opioid Receipt Predict Hospitalization in Children with Sickle Cell Disease

HCPLive

Final emergency department pain scores, opioid doses in the emergency department, and receipt of an opioid prescription at discharge predicted hospitalization and return visits.

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Revolutionary Results: How Modern Weight Loss Medications are Changing the Game

Dr. Paddy Barrett

I don’t usually quote Vladimir Lenin, but he may have had a point when it comes to weight loss medications. "There are decades where nothing happens; and there are weeks where decades happen" Vladimir Ilyich Lenin. That’s what the field of obesity therapeutics feels like right now. Historically, weight loss medications have been a graveyard of failures.

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Clinical trial finds cell therapy improves quality of life in advanced heart failure

Medical Xpress - Cardiology

Stem cell-based therapy improved quality of life for patients with advanced heart failure, Mayo Clinic researchers and international collaborators discovered in a late-stage multinational clinical trial. In one of the largest studies of cell intervention after a heart attack, patients reported their daily hardship lessened when stem cells optimized for heart repair supplemented the standard of care.

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Spontaneous Coronary Artery Dissection Across the Health Care Pathway: A National, Multicenter, Patient?Informed Investigation

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundClinical practice guidelines for the management and convalescence of patients with spontaneous coronary artery dissection (SCAD) have yet to be developed. The targeted content, delivery, and outcomes of interventions that benefit this population remain unclear. Patient‐informed data are required to substantiate observational research and provide evidence to inform and standardize clinical activities.Methods and ResultsPatients

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The silent killer gets louder as high blood pressure risks trend upward

Science Daily - Heart Disease

Researchers have found an increased need for urgent dialysis and a rising mortality rate in people hospitalized for dangerously high blood pressure. Younger people needed more dialysis and leaner patients had a higher risk of dying in the hospital. The trends show that acute hypertension remains a serious condition. People affected need appropriate treatment to control their blood pressure and avoid hospital admission.

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Japanese researchers warn that rates of urgent dialysis and death are on the rise

Medical Xpress - Cardiology

High blood pressure is called the silent killer because symptoms can remain hidden until a medical crisis strikes. You might think hypertension is no longer serious because blood pressure medication is widely available, but newly reported trends in people with dangerously high blood pressure might change your mind.

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Long-Term Follow-Up of Patients With Elevated Aldosterone-to-Renin Ratio but Negative Confirmatory Test: The Progression of Primary Aldosteronism Phenotypes

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:About 10% of patients with arterial hypertension have a positive screening test for primary aldosteronism (PA) and 50% to 70% of them have a negative confirmatory test: the appropriate follow-up of these patients is currently unknown. We investigate the incidence of PA in patients with previous negative confirmatory testing, after at least a 2-year follow-up.METHODS:One hundred eighty-four patients with a previously elevated aldosterone-to-renin ratio fol

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Heart attacks spike during holidays: Tips to protect yourself

Medical Xpress - Cardiology

Late December is typically a time when holiday stress and winter weather can collide, creating a perfect recipe for a rise in heart attacks and stroke.

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Urate Lowering Treatment: Lipid Profile Changes in Patients with Gout, Hyperuricemia

HCPLive

This new data expanded upon research into gout’s molecular pathogenesis and into ULT for managing non-gout diseases such as hyperuricemia.

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Long-Term Safety of Inclisiran for Treatment of Hypercholesterolemia

American College of Cardiology

What is the evidence on the long-term safety profile of inclisiran for treatment of hypercholesterolemia?

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STS-PAC Webinar with Rep. Miller-Meeks, MD (R-IA)

Society of Thoracic Surgeons - Surgeon

Webinar STS-PAC Webinar with Rep. Miller-Meeks, MD (R-IA) gtrainyte Tue, 12/12/2023 - 13:40 December 20, 2023 Image Representative Mariannette Miller-Meeks Join Representative Mariannette Miller-Meeks and members of the STS Council on Health Policy and Relationships for this 1-hour long exclusive webinar specially dedicated for STS-PAC contributors.

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Tricuspid Regurgitation Progression and Clinical Implications

American College of Cardiology

What are the predictors of tricuspid regurgitation (TR) progression and the prognostic impact of TR progression?

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FDA, EMA Accept Regulatory Submission for Marstacimab Treatment of Hemophilia A, B

HCPLive

The submissions to both agencies were based upon positive results from the BASIS trial that had been presented at the American Society of Hematology Annual Meeting.

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AHA 2023 Scientific Sessions: Sports Cardiology Session Summary

American College of Cardiology

This year's American Heart Association Scientific Sessions (AHA 2023) in Philadelphia featured several sessions dedicated to exercise and sports cardiology, including an expert-led session on sudden cardiac arrest (SCA) on the athletic field and two major sports cardiology studies.

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Statins and CKD; Farxiga's Limited Symptom Improvement; Stop Wasted TNKase

Med Page Today

(MedPage Today) -- The prevalence of lower extremity artery disease was an estimated 9.7% around the world, reaching a high of 14.5% in South-Central Asia. (European Journal of Preventive Cardiology) Removal of race stratification did not improve.

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ACC CardiaCast: Courtside with the Chair - Pitfalls and Solutions to Consider When Screening Athletes, Part 2

American College of Cardiology

“Courtside with the Chair” is a new series within CardiaCast presented by the Sports and Exercise Cardiology Member Section covering topics within the field of sports and exercise cardiology. In Part 2 of this episode, Dr. Jonathan Kim is joined by Drs. Sawalla Guseh, Rachel Lampert, and Dermot Phelan who continue the discussion of pitfalls in various cardiac screening strategies employed for athletes.

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Tregs, Blood Monocyte Subtypes Shown to be Targets for Treating Patients with Gout

HCPLive

This analysis resulted in several valuable insights related to the landscape of gout patients’ changes in their blood immune cells between flares and periods of remission.

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Improved Outcomes With OCT-Guided PCI Versus Angiography-Guided PCI

American College of Cardiology

Percutaneous coronary intervention (PCI) of complex bifurcation lesions is challenging and associated with greater procedural risk and worse clinical outcomes compared with PCI of nonbifurcation lesions.

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High Waist Circumference, Lipid Levels Predict Poor Gout Outcomes

HCPLive

Waist circumference and high lipid levels were associated with poor disease outcomes in gout, including flares and failure to achieve treatment target.

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Bicaval TricValve Implantation in Patients With Severe Symptomatic TR

American College of Cardiology

What is the impact of caval implantation of the TricValve system on quality of life (QOL) outcomes at 1 year among patients with severe symptomatic tricuspid regurgitation (TR)?

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Study Explores Role of Traditional Chinese Medicine in Gouty Arthritis Treatment

HCPLive

A virtual screening combined with experimental verification identified the potential mechanism of fuzitang decoction in the treatment of Gouty Arthritis.

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Incident cardiac arrhythmias associated with metabolic dysfunction-associated steatotic liver disease: a nationwide histology cohort study

Cardiovascular Diabetology

Prior studies suggest a link between metabolic dysfunction-associated steatotic liver disease (MASLD) and incident arrhythmias, including atrial fibrillation (AF). However, robust data are lacking from cohorts.