Physiologically Speaking

DECEMBER 17, 2024

Coronary artery calcium (CAC) is a measure of atherosclerosis and a strong predictor of cardiovascular disease. While CAC is typically associated with traditional risk factors such as age, hypertension, and smoking, paradoxically elevated CAC scores have been observed in male endurance athletes despite their otherwise healthy profiles. This has raised concerns that long-term, high-volume exercise might be detrimental to heart health.

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Risk Factors Genetic predisposition Plaque Exercise 98

Med Page Today

DECEMBER 17, 2024

(MedPage Today) -- A 53-year-old woman is free from dialysis after receiving a gene-edited pig kidney transplant at NYU Langone Health, doctors announced on Tuesday. The 7-hour surgery was performed on November 25, marking the third time that.

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Transplant 98

HCPLive

DECEMBER 17, 2024

These findings highlight the safety and effectiveness of ESO-101 among adult patients with active eosinophilic esophagitis (EoE).

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Cardiometabolic Health Congress

DECEMBER 17, 2024

Cardiovascular and renal health are undeniably linkedwhen one system is compromised, the other is often at risk. For healthcare providers, adopting an integrated, patient-centered approach is important for better outcomes. Here are our five top tips to help you stay aligned with the latest guidelines and improve cardiorenal care. 1. Embrace a Multidisciplinary Perspective Cardiorenal health isnt just a focus area for cardiologists and nephrologistsit affects a wide range of specialties, includi

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Kidney Disease CME Research Education 52

HCPLive

DECEMBER 17, 2024

Clark reviews open-label extension data from the phase 2b SEQUOIA study of fazirsiran for AATD liver disease.

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Journal of Clinical Investigation - Cardiology

DECEMBER 17, 2024

Acute respiratory distress syndrome (ARDS) is associated with significant morbidity and mortality, and neutrophils are critical to its pathogenesis. Neutrophil activation is closely regulated by inhibitory tyrosine phosphatases including Src homology region 2 domaincontaining phosphatase-1 (Shp1). Here, we report that loss of neutrophil Shp1 in mice produced hyperinflammation and lethal pulmonary hemorrhage in sterile inflammation and pathogen-induced models of acute lung injury (ALI) through a

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Hemorrhage Pulmonary Pharmacology 52

HCPLive

DECEMBER 17, 2024

The FDA has accepted the NDA for TNX-102 SL, a non-opioid, centrally acting analgesic, for the bedtime treatment of fibromyalgia; the PDUFA date still needs to be assigned.

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HCPLive

DECEMBER 17, 2024

This interview featured a discussion with Browning regarding his teams findings prior to the FDA approval of tapinarof cream 1% for atopic dermatitis.

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Med Page Today

DECEMBER 17, 2024

(MedPage Today) -- The FDA is alerting clinicians to a recall of Boston Scientific's Accolade pacemakers, which have an increased risk of permanently entering "safety mode," possibly requiring early device replacement. The agency also cleared.

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Pacemaker 52

HCPLive

DECEMBER 17, 2024

A hematologist discusses the role of internal and family medicine practitioners in improving the diagnosis and management of iron deficiency.

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Becker's Hospital Review - Cardiology

DECEMBER 17, 2024

"Study reveals 15 million U.S. adults at risk for heart failure, using American Heart Association's PREVENT risk equation.

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Heart Failure 52

HCPLive

DECEMBER 17, 2024

In this video, Steven Fein, MD, discusses updates and topics of note from the American Society of Hematology annual meeting.

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American College of Cardiology

DECEMBER 17, 2024

The following are key points to remember from a state-of-the-art review on atrioventricular node ablation (AVNA) for atrial fibrillation (AF) in the era of conduction system pacing.

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Ablation Atrial Fibrillation Article 45

HCPLive

DECEMBER 17, 2024

In part 2 of our 5-part series, Steven Fein, MD, discusses updates in iron deficiency management from 2024.

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HeartRhythm

DECEMBER 17, 2024

We appreciate the immense effort undertaken by the writing committee to produce the outstanding 2024 Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation (AF)(1). A notable omission exists in section 7.4: Anticoagulation during Atrial Fibrillation Ablation, which states that a large meta-analysis supports an activated clotting time (ACT) >300 seconds during AF ablation, and that the members of the writing committee employ a target of either >300 s or >350 s.

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Atrial Fibrillation Ablation 40

HCPLive

DECEMBER 17, 2024

In this video, a hematologist discusses trials and areas of advancement he is excited about in the current landscape.

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HeartRhythm

DECEMBER 17, 2024

Understanding the conduction axis location aids in avoiding iatrogenic damage and guiding targeted heart rhythm therapy.

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Heart Rhythm 40

HCPLive

DECEMBER 17, 2024

Steven Fein, MD, discusses news and updates in sickle cell disease following ASH 2024.

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Sickle Cell Disease 52

Journal of Cardiovascular Electrophysiology

DECEMBER 17, 2024

The cover image is based on the article Five Criteria Predict Induction and Ablation of Supraventricular Tachycardia by Thomas J. McGarry et al.

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Article Tachycardia Ablation 40

HCPLive

DECEMBER 17, 2024

Nathan D. Wong, MD, PhD discusses the evolution of Lp(a) in risk assessment, given its role as a genetic risk factor for cardiovascular complications.

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Risk Factors 52

Journal of Cardiovascular Electrophysiology

DECEMBER 17, 2024

Rhythm-related and clinical differences between symptomatic and asymptomatic Atrial Fibrillation. Abstract Introduction Not all patients experience debilitating symptoms during Atrial Fibrillation (AF), some are asymptomatic. The reasons for this inter- and intrasubject variability is unknown. Purpose The study objective was NOAH characterize episode-level and clinical characteristics associated with symptomatic versus asymptomatic episodes of AF in patients with an implantable cardiac monitor (

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Atrial Fibrillation Article 40

HCPLive

DECEMBER 17, 2024

A study shows young adults with negative emotionality, particularly alienation, who experienced childhood adversities often experience more stressful life events in adulthood.

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Journal of Cardiovascular Electrophysiology

DECEMBER 17, 2024

Abstract Background Postoperative atrial fibrillation (POAF) is the most frequent cardiac arrhythmia following cardiac operations. It has been associated with an increased risk of postoperative cerebrovascular complications, morbidity and mortality. The aim of this study is to evaluate if the type of venous cannulation to institute the cardiopulmonary bypass (CPB) during major cardiac surgery procedures can influence the rate of POAF and late FA onset.

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Atrial Fibrillation Risk Factors Arrhythmia Article 40

HCPLive

DECEMBER 17, 2024

The Boxed Warning is based on the FDAs review of a postmarketing case of serious liver injury with fezolinetant reported to the FAERS database.

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Journal of Cardiovascular Electrophysiology

DECEMBER 17, 2024

ABSTRACT Background The need for transvenous lead extractions (TLEs) in the setting of cardiac implantable electronic device-(CIED) related infections continues to rise. Delays in referral for TLE in this setting are common and are associated with increased mortality. Objective To describe the outcomes of a comprehensive approach, including an electronic medical record (EMR)-based notification algorithm designed to identify patients with active CIED-related infections to facilitate timely TLE.

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Inpatient Electrophysiology Education Outcomes 40

HCPLive

DECEMBER 17, 2024

Panelists discuss how bempedoic acid offers a promising alternative for patients who are statin-intolerant, demonstrating efficacy in reducing major cardiovascular events and low-density lipoprotein cholesterol, while addressing its role in managing residual cardiovascular risk, particularly in high-risk populations.

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Cholesterol 52

Journal of Cardiovascular Electrophysiology

DECEMBER 17, 2024

ABSTRACT Introduction Catheter ablation (CA) is the first-line treatment with a high success rate for patients with symptomatic WolffParkinsonWhite syndrome, while three-dimensional (3D) mapping systems enable the identification of accessory pathways (APs). We aimed to develop a novel mapping method using wave-speed mapping (WSM) to determine AP locations and CA outcomes.

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Ablation Tachycardia Outcomes Article 40

HCPLive

DECEMBER 17, 2024

Positive phase 2b data show duvakitug met primary endpoints for clinical remission in ulcerative colitis and endoscopic response in Crohn disease.

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Stroke Journal

DECEMBER 17, 2024

Stroke, Ahead of Print. Several trials of endovascular treatment for patients with large-core acute ischemic stroke have been completed. Whereas future stroke clinical guidelines will provide specific recommendations, this advisory aims to summarize the results of these trials, analyze the commonalities and differences among the studies, and discuss the clinical implications of these new results.

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Stroke Strokes 40

HCPLive

DECEMBER 17, 2024

Laurence Sperling, MD described the evolving role of cardiologists in obesity care, particularly with the increasing adoption of therapies such as GLP-1 agonists.

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Obesity 52

American College of Cardiology

DECEMBER 17, 2024

The ACC has issued new guidance on practical approaches for arrhythmia monitoring after stroke, offering clinicians tailored strategies to improve post-stroke care by identifying and managing atrial fibrillation (AFib) and other arrhythmias linked to recurrent stroke risk.

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Arrhythmia Stroke Strokes Atrial Fibrillation 40

The American Journal of Cardiology

DECEMBER 17, 2024

Publication date: Available online 16 December 2024 Source: The American Journal of Cardiology Author(s): Filippo Luca Gurgoglione, Dario Gattuso, Antonio Greco, Giorgio Benatti, Giampaolo Niccoli, Bernardo Cortese

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Stents Stent 40

American College of Cardiology

DECEMBER 17, 2024

In this interview, Andrew M. Kates, MD, FACC, and Alison L. Bailey, MD FACC, discuss the Top General CardiologyTakeaways from 2024. Dr. Kates discusses the 2024 Perioperative Guidelines, cardiac rehab, ACCs proposal for a new Board of Cardiovascular Medicine, and more.

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General Cardiology Article 40

The American Journal of Cardiology

DECEMBER 17, 2024

Publication date: Available online 16 December 2024 Source: The American Journal of Cardiology Author(s): Omar Abdel-Razek, Nhi Vo, Jeffrey Weinstein, Cyrus A.

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Pulmonary 40

American College of Cardiology

DECEMBER 17, 2024

Coronary artery disease (CAD) affected >315 million people worldwide in 2022. Individuals with CAD have a 20% increased 5-year risk of adverse cardiac events.

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Coronary Artery Disease Heart Disease Article 40

Med Page Today

DECEMBER 17, 2024

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American College of Cardiology

DECEMBER 17, 2024

The goal of the GMRx2_PCT trial was to evaluate a single-pill low-dose combination antihypertensive agent compared with placebo among patients with hypertension.

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Hypertension Article 40