Sun.Dec 10, 2023

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Very high LDL no impact on plaque progression

Dr. Malcolm Kendrick

10th December 2023 A very important study – please watch Very high low density lipoprotein levels with no impact on plaque progression I interrupt my series on what is wrong with the health service to bring you breaking news. I was sent the e-mail below, directing me to a short YouTube presentation by Dr Shawn Baker. It highlights a study which provides very strong evidence that a very high LDL (as seen in some people who go on a keto diet), has no impact on coronary artery plaque progression.

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Race, Ethnicity Do Not Impact Immune Tolerance Induction Success, Study Finds

HCPLive

Study results presented at the 2023 American Society of Hematology Annual Meeting and Exposition found equal immune tolerance induction success rates regardless of race/ethnicity.

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Mechanical thrombectomy safe, effective for high-risk pulmonary embolism

Medical Xpress - Cardiology

Mechanical thrombectomy (MT) is safe and effective in real-world, high-risk patients with pulmonary embolism (PE), according to a study published online Oct. 31 in the Journal of the Society for Cardiovascular Angiography & Interventions.

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Algorithm Accurately Identifies Pregnant Women with Inherited Bleeding Disorders

HCPLive

The revised algorithm demonstrates 97% sensitivity in identifying pregnant patients with inherited bleeding disorders.

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High-grade AV Block

ECG Guru

Why is this a high-grade AV block? If at least 3 P-waves are not conduced and there is nominal AV conduction before and after, this can be considered a high-grade AV block. In this Holter strip, P1, P2 and all P-waves from P6 onwards are conducted, albeit with a prolonged PR interval (first-degree AV block). P3, P4, P5 are not conducted. A junctional escape beat is seen before P5.

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Study Addresses Menstrual Pain in Sickle Cell Disease, Role of Reproductive Health Specialists

HCPLive

Although more than half of female patients with sickle cell disease reported sickle cell pain associated with their menstrual cycles, only 12.5% had used ≥1 hormonal therapies within the past 3 months.

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The Grinch’s Guide to Women’s Heart Attacks (with apologies to Dr. Seuss)

Heart Sisters

With apologies to Dr. Seuss, I offer my own poetic interpretation of what getting misdiagnosed in mid-heart attack can feel like for far too many women.

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Sickle Cell Trait Linked to Increased Leukemia Risk

HCPLive

New case-control data from ASH 2023 show a particularly increased link between sickle cell trait and monocytic and myeloid leukemia progression.

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HIGH GRADE AVB

ECG Guru

Why is this a high-grade AV block? If at least 3 P-waves are not conduced and there is nominal AV conduction before and after, this can be considered a higher-grade AV block. in this Holter strip, P1, P2 and all P-waves from P6 onwards are conduced, albeit with a prolonged PR interval (first-grade AV block). P3, P4, P5 are not conducted. A junctional escape beat is seen before P5.

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Mitapivat Maintains Safety, Tolerability Over 2 Years in Sickle Cell Disease

HCPLive

Extension analysis from a phase 1 trial show the investigative oral mitapivat was not associated with any discontinuations nor deaths over 2 years.

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Amal Mattu’s ECG Case of the Week – December 11, 2023

ECG Weekly Workout

This content is for members only

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Positive Phase 2/3 Results Suggest Potential for GBT021601 As Future Treatment for Sickle Cell

HCPLive

These findings presented at ASH show promise for future studies on GBT02601 as a potential alternative to voxelotor for sickle cell disease.

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Role of activation signatures in re?entrant ventricular tachycardia circuits

Journal of Cardiovascular Electrophysiology

The activation signal, or signature, defined as the cumulative number of recording sites that have activated per millisecond, was utilized to segment each re-entrant ventricular tachycardia (VT) circuit into inner and outer circuit pathways, and as an estimate of best ablation lesion location to prevent VT. Abstract Introduction Development of a rapid means to verify the ventricular tachycardia (VT) isthmus location from heart surface electrogram recordings would be a helpful tool for the electr

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Correction to: 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Circulation

Circulation, Volume 148, Issue 24 , Page e281-e281, December 12, 2023.

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Safety and feasibility of same?day discharge following uncomplicated transvenous lead extraction

Journal of Cardiovascular Electrophysiology

Abstract Introduction Transvenous lead extraction (TLE), while mostly a safe procedure, has risk of serious periprocedural complications. As such, overnight hospitalization remains a routine practice. In our center, we routinely discharge patients on the same day following an uncomplicated TLE. Methods This is a retrospective study of 265 consecutive patients who underwent uncomplicated TLE in our center between 2019 and 2021.

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Response by Tang et al to Letter Regarding Article, “Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy”

Circulation

Circulation, Volume 148, Issue 24 , Page 1980-1981, December 12, 2023.

Article 49
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Serial fractional flow reserve, coronary flow reserve and index of microcirculatory resistance after percutaneous coronary intervention in patients treated for stable angina pectoris assessed with PET

Coronary Artery Disease Journal

Background Cardiac 15O-water PET is a noninvasive method to evaluate epicardial and microvascular dysfunction and further quantitate absolute myocardial blood flow (MBF). Aim: The aim of this study was to assess the impact of revascularization on MBF and myocardial flow reserve (MFR) assessed with 15O-water PET and invasive flow and pressure measurements.

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Letter by Li et al Regarding Article, “Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy”

Circulation

Circulation, Volume 148, Issue 24 , Page 1979-1979, December 12, 2023.

Article 49
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Us2.ai’s Echo Strain Validation

CardiacWire

A new study in European Heart Journal – Digital Health showed that Us2.ai’s AI echo algorithm can interpret echocardiographic strain images with similar accuracy as conventional measurements, highlighting how AI can democratize cardiac strain exams and improve heart failure assessments. Echo strain imaging reflects myocardial deformation, and supports early heart failure diagnosis.

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Overcoming Challenges to Implementing New Evidence for Low-Dose Anticoagulant Use in Peripheral Artery Disease

Circulation

Circulation, Volume 148, Issue 24 , Page 1929-1931, December 12, 2023.

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From the Literature

Circulation

Circulation, Volume 148, Issue 24 , Page 1974-1975, December 12, 2023.

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Both Sides of the Stethoscope

Circulation

Circulation, Volume 148, Issue 24 , Page 1917-1918, December 12, 2023.

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Energetic Basis of Recovered Ejection Fraction in Human Heart Failure

Circulation

Circulation, Volume 148, Issue 24 , Page 1976-1978, December 12, 2023.