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Nature Reviews Cardiology, Published online: 12 February 2025; doi:10.1038/s41569-025-01137-y Differing definitions and questionable prognostic significance have caused confusion and controversy around the applicability of the current definitions of periprocedural and perioperative myocardial infarction in clinical practice. In this Clinical Outlook, we review the definitions and the clinical and prognostic relevance of the various entities and provide implications for clinical practice.
Newborns with heart complications can rely on their newly developed immune systems to regenerate cardiac tissues, but adults aren't so lucky. After a heart attack, most adults struggle to regenerate healthy heart tissue, leading to scar-tissue buildup and, often, heart failure. A new study in experimental animals reveals a critical difference in how macrophages -- a part of the immune system -- help repair the heart in newborns versus adults after a heart attack.
BackgroundIndividuals diagnosed with type 2 diabetes mellitus (T2DM) commonly exhibit elevated lipid levels and an increased body mass index (BMI). The impact of BMI on the efficacy of statins in reducing lipid levels among diabetic patients remains uncertain. We aim to evaluate whether BMI will affect the lipid-lowing effects of statins in patients with T2DM.MethodsIn this retrospective analysis, we screened T2DM patients who were prescribed statins and underwent a 1-year outpatient follow-up r
Background Left ventricular (LV) mass is closely associated with atherosclerotic heart disease, but the mechanisms are not well defined. This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascular disease. Methods The SingHEART study is a population-based cohort in which individuals underwent ambulatory blood pressure (BP) monitoring, cardiac MRI to measure indexed LV mass index (LVMI) and
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This Viewpoint advocates for prompt aortic valve replacement (rather than clinical surveillance) as the default strategy for patients with asymptomatic severe aortic stenosis.
Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of cardiovascular diseases. However, clopidogrel responsiveness shows variability based on CYP2C19 polymorphism. Therefore, we planned a study with an objective of evaluating safety, tolerability, pharmacodynamics and pharmacokinetics of a novel thienopyridine antiplatelet agent AT-10 in healthy Indian subjects compared with standard dosage regimen of clopidogrel based on their
ABSTRACT Background The use of cardiac implantable electronic devices (CIEDs) continues to grow. Despite the presence of implanted hardware, patient compliance with in-clinic visits and remote transmissions is poor. We performed a quality improvement (QI) initiative to assess and optimize CIED follow-up in the New England area. Methods A regional network of eight pediatric institutions was created.
ABSTRACT Background The use of cardiac implantable electronic devices (CIEDs) continues to grow. Despite the presence of implanted hardware, patient compliance with in-clinic visits and remote transmissions is poor. We performed a quality improvement (QI) initiative to assess and optimize CIED follow-up in the New England area. Methods A regional network of eight pediatric institutions was created.
Every year, more than 5 million people in the U.S. are diagnosed with heart valve disease, but this condition has no effective long-term treatment. When a person's heart valve is severely damaged by a birth defect, lifestyle, or aging, blood flow is disrupted. If left untreated, there can be fatal complications.
CTVS patient, William Penny, shared his aortic dissection story with Nicole Villalpando from the Austin American Statesman to help raise awareness about heart health during American Heart Month. You can read his story below or find it on the Austin American Statesman website here. Will Penny and his wife were going for a run on Oct. 30 in their Northwest Austin neighborhood.
Newborns with heart complications can rely on their newly developed immune systems to regenerate cardiac tissues, but adults aren't so lucky. After a heart attack, most adults struggle to regenerate healthy heart tissue, leading to scar-tissue buildup and, often, heart failure.
Patients aged between 50 to 70 years with a mechanical heart valve replacement had better long-term survival compared to those with a biological valve, new research has found.
In 2024, Boston-based Tufts Medical Center performed 70 adult heart transplants, breaking its 2023 record by nine and setting the New England region record for the second year in a row.
(MedPage Today) -- Some cardiologists and other doctors are becoming unrecognizable after losing weight on GLP-1 drugs like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). (New York Times) Film director David Lynch's cause.
Patients with a prothrombotic clinical course often associated with thrombocytopenia may have a monoclonal paraprotein, even at low levels, that activates platelets by binding to platelet factor 4.
Rates of major bleeding and intracranial hemorrhage are similar for apixaban and dabigatran versus aspirin, while rates are higher for rivaroxaban, according to a review published online Feb. 11 in the Annals of Internal Medicine.
What is the safety and utility of invasive implanted hemodynamic monitoring (IHM) using the CardioMEMS™ HF System in pediatric patients with heart failure (HF) and pulmonary hypertension (PH)?
Children with urticaria or angioedema face greater risks of adverse events after COVID-19 vaccination, but most tolerate subsequent doses with proper management.
Calcified coronary lesions are associated with lower procedural success and higher complications with percutaneous coronary intervention. Previous study data have shown improved procedural success with routine use of atherectomy in these patients without meaningful differences in clinical outcomes.
BackgroundIt is well known that abnormal dietary behavior increases the risk for cardiovascular disease especially if the person is depressed and/or anxious. The purpose of this study was to construct a moderated mediation model to explore the roles of abnormal dietary behavior and family health in the mechanism through which depression/anxiety influences Quality of life (QoL) in patients with cardiovascular disease.MethodsA field survey was conducted in China and ultimately included 730 patient
BackgroundThe acute myocardial infarction (AMI) is a prevalent and severe cardiovascular disease, characterized by its sudden onset, high mortality rate, and unfavorable prognosis. The presence of type 2 diabetes not only signifies a chronic metabolic disorder, but also serves as a catalyst for various cardiovascular and cerebrovascular ailments such as coronary heart disease and stroke.
These data point to inaccessibility, distance from providers, and insurance-related barriers as obstacles to mental health improvement among children with atopic dermatitis.
BackgroundSpontaneous coronary artery dissection (SCAD) significantly contributes to myocardial infarction among young individuals. Despite the elusive nature of its etiology, empirical evidence indicates a substantial correlation between sociopsychological factors and the disorder. This investigation endeavored to discern a genetic basis for personality traits influencing SCAD susceptibility.MethodsBidirectional univariate and multivariate Mendelian randomization (MR) analyses were hereby condu
PurposeTo explore the expanding role of artificial intelligence (AI) in managing aortic valve stenosis (AVS) by bibliometric analysis to identify research trends, key contributors, and the impact of AI on enhancing diagnostic and therapeutic strategies for AVS.MethodsA comprehensive literature review was conducted using the Web of Science database, covering publications from January 1990 to March 2024.
Cleveland-based University Hospitals' Harrington Heart & Vascular Institute will establish a new limb preservation center with a $5 million gift from Lorraine and Bill Dodero.
In this retrospective analysis, investigators in Japan highlighted the prevalence and incidence of comorbidities in those with atopic dermatitis, psoriasis, alopecia areata, and vitiligo.
This cohort study investigates the arrhythmic risk profile of carriers of filamin C truncating variants (FLNCtv) and the risk factors associated with the risk of life-threatening ventricular arrhythmias.
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