Sun.Aug 04, 2024

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Intermittent Fasting May Improve Memory, Executive Function, Early Trial Suggests

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Intermittent calorie restriction improved executive function and memory measures in cognitively intact older adults, an exploratory pilot study suggested. The 8-week randomized clinical trial of 40 overweight.

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Digital Consults to Enhance Heart Failure Treatment: The ADMINISTER Trial

Cardiology Update

Despite proven benefits in reducing morbidity and mortality, many heart failure (HF) patients do not receive optimal guideline-directed medical therapy (GDMT). The 2021 European Society of Cardiology guidelines recommend guideline-directed medical therapy (GDMT) for patients with HF with reduced ejection fraction (HFrEF). This includes beta-blockers, ACE inhibitors, ARBs, ARNIs, MRAs, and SGLT2 inhibitors.

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Zuranolone Offers New Hope for Treating Postpartum Depression in New Mothers

HCPLive

A year after zuranolone’s FDA approval for postpartum depression on August 3, 2023, prescribers and a patient weigh in about the medication’s success in alleviating symptoms.

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What does this ECG show?

Dr. Smith's ECG Blog

Written by Pendell Meyers Try first to interpret the ECG without any clinical context: What do you think? Sinus rhythm with abnormal STE in V2-V6, and I, II, aVF. Reciprocal STD in aVR and V1. Most leads with STE have remarkably non-hyperacute, flat T waves. Most would say that there is Spodick's sign. The PR depression in II (and its reciprocal PR elevation in aVR) is probably beyond normal baseline values.

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When you have a ‘silent’ heart attack

Heart Sisters

"People often believe that their 'silent' heart attack is something else - like the flu or a pulled muscle. Much later, when they end up getting diagnosed with a heart attack that they didn't know they were having, they might recall an episode of feeling vaguely unwell." - Dr.

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Clinical Disease Control in PsA Improves Quality of Life

HCPLive

Responders at week 104 demonstrated more significant changes from baseline and achieved normative values in PROs compared with non-responders.

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Omega-3 Fatty Acids and Arrhythmias

Circulation

Circulation, Volume 150, Issue 6 , Page 488-503, August 6, 2024. The pro- and antiarrhythmic effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been extensively studied in preclinical and human trials. Despite early evidence of an antiarrhythmic role of n-3 PUFA in the prevention of sudden cardiac death and postoperative and persistent atrial fibrillation (AF), subsequent well-designed randomized trials have largely not shown an antiarrhythmic benefit.

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Development of idealized human aortic models for in vitro and in silico hemodynamic studies

Frontiers in Cardiovascular Medicine

BackgroundThe aorta, a central component of the cardiovascular system, plays a pivotal role in ensuring blood circulation. Despite its importance, there is a notable lack of idealized models for experimental and computational studies.ObjectiveThis study aims to develop computer-aided design (CAD) models for the idealized human aorta, intended for studying hemodynamics or solid mechanics in both in vitro and in silico settings.MethodsVarious parameters were extracted from comprehensive literature

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Endocrinology Month in Review: July 2024

HCPLive

The July 2024 endocrinology month in review recaps a pair of regulatory updates, multiple studies on incretin therapies, and the most recent episodes of our flagship diabetes podcast, Diabetes Dialogue.

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Ruxolitinib as a CaMKII Inhibitor for the Treatment of Cardiac Arrhythmias: Applications and Prospects

HeartRhythm

Recent studies have highlighted the critical role of calcium/calmodulin-dependent protein kinase II (CaMKII) overactivation in the pathogenesis of various cardiac arrhythmias. Ruxolitinib, a Janus kinase (JAK) inhibitor widely used for the treatment of myelofibrosis and acute graft-versus-host disease, has expanded its research horizons to include its potential as a CaMKII inhibitor in the treatment of cardiac arrhythmias.

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Retraction of: Abstract 18128: How Long Should We Tilt?: Challenging the 10-Minute Cutoff in the Diagnosis of Postural Tachycardia Syndrome (POTS)

Circulation

Circulation, Volume 150, Issue 6 , Page e152-e152, August 6, 2024.

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Fetal T-wave and Isovolumetric Relaxation Time Alternans Can be Identified by Fetal Echocardiography

HeartRhythm

Although fetal cardiac arrhythmia and repolarization abnormalities can be associated with sudden death before and after delivery, cardiac electrical activity is not easily assessed in the fetus due to the limitations of the fetal electrocardiogram (ECG). Fetal magnetocardiography (fMCG) has shown high efficacy for the diagnosis of fetal arrhythmia,1 including the detection of abnormalities such as QTc prolongation and T-wave alternans (TWA) in fetuses with long QT syndrome (LQTS).

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Correction to: ChaMP-CMD: A Phenotype-Blinded, Randomized Controlled, Cross-Over Trial

Circulation

Circulation, Volume 150, Issue 6 , Page e151-e151, August 6, 2024.

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Response by Chatur et al to Letter Regarding Article, “Outpatient Worsening Among Patients With Mildly Reduced and Preserved Ejection Fraction Heart Failure in the DELIVER Trial”

Circulation

Circulation, Volume 150, Issue 6 , Page e107-e108, August 6, 2024.

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Letter by Wang Regarding Article, “Outpatient Worsening Among Patients With Mildly Reduced and Preserved Ejection Fraction Heart Failure in the DELIVER Trial”

Circulation

Circulation, Volume 150, Issue 6 , Page e106-e106, August 6, 2024.

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Eicosapentanoic Acid Supplementation for Atherosclerotic Cardiovascular Disease Prevention

Circulation

Circulation, Volume 150, Issue 6 , Page 435-438, August 6, 2024.

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From the Literature

Circulation

Circulation, Volume 150, Issue 6 , Page 504-505, August 6, 2024.

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Recognition of an Unusual Pattern in a Case of Narrow Complex Tachycardia

Circulation

Circulation, Volume 150, Issue 6 , Page 506-508, August 6, 2024.