Wed.Jul 17, 2024

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D.C. Hospital Gets a Wake-Up Call to Chagas Disease

Med Page Today

(MedPage Today) -- Researchers from one Washington, D.C., center confirmed that there was a high prevalence of Chagas disease in a sample of Latin American immigrants hospitalized with cardiac conditions. Of 97 adults who underwent a transthoracic.

Hospital 124
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BioCardia Announces United States Patent Issuance on Morph DNA Multi-Directional Steerable Catheter Transseptal Application

DAIC

mtaschetta-millane Wed, 07/17/2024 - 11:06 July 17, 2024 — BioCardia, Inc. , a company focused on cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases announced that the Unites States Patent Office has granted Patent No: 12,036,371 titled “Method of Accessing the Left Atrium with a Multi-Directional Steerable Catheter,” with a patent term that will expire in 2035.

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U.S. News Hospital Rankings Are One Piece of the CHD Care Puzzle

Conquering CHD

Where to receive care is one of the most important decisions a family can make. Conquering CHD has a strong commitment to transparency and ensuring patients and families have essential information at their fingertips when they need it to assist them in making the best choice for their family. With the publishing of this year’s U.S. News & World Hospital Report rankings , we remind you this is only one of many tools you can use to have a conversation with your care team and should not be used

Hospital 105
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Association of diabetes with cardiovascular calcification and all-cause mortality in end-stage renal disease in the early stages of hemodialysis: a retrospective cohort study

Cardiovascular Diabetology

The main goal of this study was to examine how diabetes, cardiovascular calcification characteristics and other risk factors affect mortality in end-stage renal disease (ESRD) patients in the early stages of h.

Diabetes 105
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An Update on Lp(a) and Aspirin in Primary Prevention

American College of Cardiology

The 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (CVD) has softened prior recommendations regarding aspirin use for primary prevention, as the net cardiovascular (CV) benefit is small compared to the bleeding risk.

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Exploring the common mechanisms and biomarker ST8SIA4 of atherosclerosis and ankylosing spondylitis through bioinformatics analysis and machine learning

Frontiers in Cardiovascular Medicine

BackgroundAtherosclerosis (AS) is a major contributor to cerebrovascular and cardiovascular events. There is growing evidence that ankylosing spondylitis is closely linked to AS, often co-occurring with it; however, the shared pathogenic mechanisms between the two conditions are not well understood. This study employs bioinformatics approaches to identify common biomarkers and pathways between AS and ankylosing spondylitis.MethodsGene expression datasets for AS (GSE100927, GSE28829, GSE155512) a

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Discussing Post-Hoc Data on Ruxolitinib for Nonsegmental Vitiligo, with David Rosmarin, MD

HCPLive

In this interview, Rosmarin discussed the results of a new post-hoc analysis of the TRuE-V1 and TRuE-V2 studies on treating younger vitiligo patients with ruxolitinib cream.

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67% of cardiology fellows receive industry payments: Study

Becker's Hospital Review - Cardiology

More than two-thirds of cardiology fellows receive industry payments, according to a study published as a research letter July 15 in JAMA Internal Medicine.

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2024’s Mid-Year Review: FDA-Approved Cardiorenal Metabolic Drugs and Devices 

Cardiometabolic Health Congress

The first half of 2024 has ushered in a wave of transformative FDA approvals in cardiorenal metabolic health. Staying informed about these cutting-edge developments is critical for providing exceptional patient care. Join us as we examine the landmark approvals that are revolutionizing patient outcomes. January 2024 FDA Approvals: Advancing Emergency Cardiac Care TZ Medical Adult and Pediatric Multi-Function Defibrillation Electrodes and Adaptors (Approved: 01/09/2024) This defibrillator tech

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Effects of ICD Leads on Tricuspid Valve and Right Ventricle

American College of Cardiology

What is the effect of a transvenous implantable cardioverter-defibrillator (TV-ICD) on tricuspid regurgitation (TR) severity, and secondarily, on right ventricular (RV) size and function?

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Fenofibrate’s impact on cardiovascular risk in patients with diabetes: a nationwide propensity-score matched cohort study

Cardiovascular Diabetology

The beneficial effects of fenofibrate on atherosclerotic cardiovascular disease (ASCVD) outcomes in patients with diabetes and statin treatment are unclear. We investigated the effects of fenofibrate on all-ca.

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Unraveling the gut microbiota's role in salt-sensitive hypertension: current evidences and future directions

Frontiers in Cardiovascular Medicine

The gut microbiota plays a pivotal role in both maintaining human health and in the pathogenesis of diseases. Recent studies have brought to light the significant correlation between gut microbiota and hypertension, particularly focusing on its role in the development and advancement of SSH, a subtype characterized by elevated blood pressure in response to high salt consumption.

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Lexeo LX2006 Shows Promise for Friedreich’s Ataxia Cardiomyopathy

CardiacWire

Lexeo Therapeutics gave the 5,000 Americans with Friedreich’s ataxia cardiomyopathy reason for optimism, publishing early results that suggest its LX2006 gene therapy could be able to treat FA cardiomyopathy. Friedreich’s ataxia (FA) is a neurodegenerative disorder caused by loss of function mutations in the frataxin gene, although FA patients generally die from FA cardiomyopathy.

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Expression of pro- and anti-inflammatory cytokines during anti-proprotein convertase subtilisin/kexin type 9 therapy in patients with statin-resistant familial hypercholesterolemia

Frontiers in Cardiovascular Medicine

BackgroundSome clinical dyslipidemia cases do not respond to statins, known as statin-resistant familial hypercholesterolemia (SR-FH), in which patients are under a high cardiovascular risk despite statin therapy. Therefore, novel therapeutic alternatives are required. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) reduce cholesterol levels and cardiovascular disease risk, particularly in patients with SR-FH, where PCSK9i may differentially affect pro- and anti-inflammatory me

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Psoriasis Improvement with Certolizumab Pegol Persisted a Year Later

HCPLive

A study with real-world data showed certolizumab pegol was effective in treating psoriasis a year later, with a probability of 1-year persistence at approximately 85%.

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Case Report: two cases of anti-neutrophil cytoplasmic antibody-associated vasculitis involving large vessels

Frontiers in Cardiovascular Medicine

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of systemic diseases caused by a combination of many factors, including genetics, environment, and immunity. AAV is characterized by predominantly small-vessel involvement and has a variety of clinical manifestations. Small-vessel lesions of the kidneys and lungs are common, and lesions of medium-sized arteries may also present, but the involvement of large arteries and their primary branches is very rare.

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Lifestyle factors and their relative contributions to longitudinal progression of cardio-renal-metabolic multimorbidity: a prospective cohort study

Cardiovascular Diabetology

The role of lifestyle factors and their relative contributions to the development and mortality of cardio-renal-metabolic multimorbidity (CRMM) remains unclear.

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Weekly Cendakimab 720 mg Linked to Reduced EASI Scores in Atopic Dermatitis

HCPLive

A phase 2 trial showed cendakimab, an IL-13 inhibitor, reduced Eczema Area and Severity Index scores in moderate to severe atopic dermatitis patients.

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The predictive value of cumulative atherogenic index of plasma (AIP) for cardiovascular outcomes: a prospective community-based cohort study

Cardiovascular Diabetology

Atherogenic index of plasma (AIP) has been reported as a critical predictor on the risks and clinical outcomes of cardiovascular diseases (CVDs), and we aimed to explore the potential predictive value of cumul.

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Safety of one 8.5-Fr pigtail catheter for postoperative continuous open gravity drainage after uniportal video-assisted thoracoscopic surgery pneumonectomy

Journal of Cardiothoracic Surgery

Uniportal video-assisted thoracoscopic surgery pneumonectomy (U-VATS-P) is feasible and safe from a perioperative standpoint. How to choose the proper chest tube and drainage method is important in enhanced re.

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A high-volume study on the impact of diabetes mellitus on clinical outcomes after surgical and percutaneous cardiac interventions

Cardiovascular Diabetology

Type I and type II diabetes mellitus (DM) patients have a higher prevalence of cardiovascular diseases, as well as a higher mortality risk of cardiovascular diseases and interventions. This study provides an u.

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A case of posterior mediastinal myelolipoma and a literature review of its imaging manifestations

Journal of Cardiothoracic Surgery

Mediastinal myelolipoma is a rare condition and has no obvious symptoms. In the past 20 years, some clinical cases have been documented. However, the literature has not systematically summarized its imaging fe.

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Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction

Cardiovascular Diabetology

Mitochondria play a central role in cellular energy metabolism, and their dysfunction is increasingly recognized as a critical factor in the pathogenesis of diabetes-related cardiac pathophysiology, including vu.

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Aprotinin in high-risk isolated coronary artery bypass graft patients: a 3-year propensity matched study

Journal of Cardiothoracic Surgery

Aprotinin, a serine protease inhibitor, has been used variably in cardiac surgery amidst ongoing debates about its safety following several previous studies. This study assesses the outcomes of aprotinin in hi.

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The Business of Heart Health: Best Practices for Managing a Small Cardiology Clinic Efficiently and Profitably

GEMMS

Running a small cardiology clinic comes with its own set of challenges and opportunities. While providing high-quality patient care is the primary focus, managing the business aspects efficiently is equally important. Small cardiology clinics often need help with profitability, especially when they are not part of more extensive hospital networks. Independent cardiologists face the dual challenge of delivering excellent patient care while ensuring the clinic remains financially viable.

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Hyperandrogenism Linked to Increased Risk of MASLD in PCOS

HCPLive

Findings highlight an increased risk of diabetes, MASLD, and cardiovascular disease in patients with PCOS, with risk varying by PCOS phenotype.

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Women more likely than men to leave interventional cardiology: Study

Becker's Hospital Review - Cardiology

Women are more likely to leave the cardiology field compared to their male peers, according to a research letter published July 10 in JAMA Cardiology.

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5 Clinical Trials to Watch at ASRS 2024

HCPLive

We break down 5 top trials to keep an eye on at ASRS 2024, taking place in Stockholm, Sweden from May 17 to 20, 2024.

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ACC Grassroots Drives Momentum For Federal Prior Auth Reform

American College of Cardiology

The Improving Seniors’ Timely Access to Care Act of 2024 (H.R. 8702/S. 4532) has achieved significant bipartisan support in recent weeks, reaching 166 cosponsors in the U.S. House of Representatives and 47 cosponsors in the U.S. Senate. The legislation builds on regulatory action taken by the Centers for Medicare and Medicaid Services earlier this year, requiring the use of electronic prior authorization, tightening response timelines and updating transparency requirements.

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Medicaid Direct-Acting Antiviral Restrictions Linked to Reduced HCV Treatment Rates

HCPLive

The cross-sectional analysis found Medicaid nonexpansion status, fibrosis, and sobriety restrictions negatively impacted annual rates of DAA prescription fills.

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Physical Activity and Progression of Coronary Artery Calcification

American College of Cardiology

What is the relationship between physical activity (PA) at baseline and during follow-up and progression of coronary artery calcium (CAC) over time?

Article 55
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SGLT2 Inhibitors Outclass GLP-1s, DPP4is in Lowering Retinopathy Risk

HCPLive

SGLT2 inhibitors may provide a favorable impact on the risk of sight-threatening diabetic retinal complications compared with other glucose-lowering therapies.

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Correlation between simplified treadmill score, significantly stenosed blood vessels and SYNTAX score in CAD

The British Journal of Cardiology

The purpose of this study was to determine the correlation between the simplified treadmill score (STS) and both the number of blood vessels with significant stenosis and the severity of the SYNTAX score in patients with coronary artery disease (CAD). This was an observational, cross-sectional study conducted at Dr. Soetomo General Hospital and Premier Surabaya Hospital in Indonesia from January 2011 to February 2012.

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PRISM Interim Analysis Finds 4D-150 Reduces Burden, Treatment interval with Anti-VEGF Therapy

HCPLive

The PRISM trial's 24-week data show 4D-150 reduced anti-VEGF injection rates by 89% in wet AMD, with 77% of patients injection-free at 24 weeks.

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Periprocedural Cardiac Implantable Device Care: Key Points

American College of Cardiology

The following are key points to remember from a scientific statement on periprocedural management and multidisciplinary care pathways for patients with cardiac implantable electronic devices (CIED).

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CU06 Shows Potential as Oral Therapy for Diabetic Macular Edema

HCPLive

Phase 2a results demonstrated the efficacy and safety of orally administered CU06-1004 and may warrant further clinical studies in DME.

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Pacing on the tail of paced QRS: What is the mechanism?

HeartRhythm

An electrocardiogram on the day following the implantation of a dual-chamber pacemaker revealed two closely coupled pacing spikes at 100ms intervals with the latter being on the trailing edge of the paced QRS complex. Differential diagnoses of such closely coupled pacing pulses include atrial lead displacement, lead reversal on the pulse generator, a ventricular premature complex in the post-atrial ventricular blanking period, and backup pacing pulse following a loss of capture.