Mon.Aug 12, 2024

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Dementia Risk Dropped With Anti-Inflammatory Diet for Certain Patients

Med Page Today

(MedPage Today) -- An anti-inflammatory diet was tied to a lower risk for dementia in people ages 60 and older with cardiometabolic diseases, U.K. Biobank data showed. Among people with cardiometabolic diseases including type 2 diabetes, heart.

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Back-to-School Asthma and Lung Health with Juanita Mora, MD and S. Christy Sadreameli, MD

HCPLive

Mora and Sadreameli join Lungcast to provide a back-to-school health blueprint, including topics like rescue inhalers, vaccination, vaping and air quality.

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Gene-related metabolic dysfunction may be driving heart arrhythmia

Science Daily - Heart Disease

Patients with a common heart arrhythmia called Atrial Fibrillation could benefit from future treatments that target inefficiencies in heart cell metabolism, according to a new article.

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Burden of Atopic Dermatitis and its Impact on Patient’s Quality of Life

HCPLive

Experts on atopic dermatitis describe the burden of the disease and provide clinical insights on counseling patients who are experiencing sleep disturbances.

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GLP-1 Agonists for Diabetes Tied to Lower Hyperkalemia Rates

Med Page Today

(MedPage Today) -- Hyperkalemia in type 2 diabetes occurred less often with GLP-1 receptor agonists in routine care than dipeptidyl peptidase-4 (DPP-4) inhibitors, a large observational study in Sweden showed. Over a median 3.9-month treatment.

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Cardiovascular Management of Aortopathy in Children: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Aortopathy encompasses a spectrum of conditions predisposing to dilation, aneurysm, dissection, or rupture of the aorta and other blood vessels. Aortopathy is diagnosed commonly in children, from infancy through adolescence, primarily affecting the thoracic aorta, with variable involvement of the peripheral vasculature. Pathogeneses include connective tissue disorders, smooth muscle contraction disorders, and congenital heart disease, including bicuspid aortic valve,

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What's the Best Way to Help Specialists Succeed? Beef Up Primary Care

Med Page Today

(MedPage Today) -- In today's modern world, where does primary care fit in? Especially at large academic medical centers like ours, the focus across the institution tends to be on secondary, tertiary, and quaternary care. This is the stuff that.

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Impact of Nasal Epinephrine Spray for Patients with Severe Allergies, with Edwin H. Kim, MD

HCPLive

In this interview, Kim speaks about the significance of the FDA approval of neffy for patients who face the threat of anaphylaxis and other severe allergic reactions.

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ACC CardiaCast: Hope on the Horizon: Emerging Therapies for Elevated Lp(a)

American College of Cardiology

In this episode, Drs. Erin Michos and Steven Nissen discuss newly emerging therapies for elevated Lp(a) management and forthcoming developments in research. Drs. Michos and Nissen highlight the key differences between therapies in late trial stages and discuss upcoming cardiovascular outcome trials.

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MDMA-Assisted Therapy Trial Participant Reacts to FDA’s Decision on Lykos’ NDA

HCPLive

Cristina Pearse, an MDMA-assisted therapy trial participant, expresses disappointment in the FDA’s decision not to approve MDMA-assisted therapy.

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Clinical characteristics and biomarkers feature analysis using a proteomics platform in young patients with acute coronary syndrome

Frontiers in Cardiovascular Medicine

BackgroundAcute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide. In recent years, ACS has been reported to be associated with age, and the incidence has become more common in younger patients. Previous studies have identified various risk factors that contribute to the stratification of ACS patients. However, it remains unclear whether these risk factors, along with proteomic and clinical characteristics, are applicable to young ACS patients, as they are for middl

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Introducing Medical Ethics Unpacked, with Dominic Sisti, PhD, and Steve Levine, MD

HCPLive

An introductory episode for Medical Ethics Unpacked, a monthly multimedia series hosted by medical ethicist Dominic Sisti, PhD, and psychiatrist Steven Levine, MD, exploring ethical issues in contemporary healthcare.

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Cardiac ultrasound simulation for autonomous ultrasound navigation

Frontiers in Cardiovascular Medicine

IntroductionUltrasound is well-established as an imaging modality for diagnostic and interventional purposes. However, the image quality varies with operator skills as acquiring and interpreting ultrasound images requires extensive training due to the imaging artefacts, the range of acquisition parameters and the variability of patient anatomies. Automating the image acquisition task could improve acquisition reproducibility and quality but training such an algorithm requires large amounts of na

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Real-World Analysis Finds Tirzepatide Offers Greater Benefit than GLP-1 RAs for Heart, Kidney in T2D

HCPLive

A new real-world study suggests tirzepatide provides greater reductions in mortality, cardiovascular risk, and kidney events than GLP-1 receptor agonists in type 2 diabetes.

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EVT on Large Core Strokes: Sobering Results for the Oldest Old

Med Page Today

(MedPage Today) -- The older the patient, the worse the functional outcome tended to be after endovascular thrombectomy (EVT) for an acute ischemic stroke with a large infarct, observational data suggested. Based on a German multicenter registry.

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Naim Alkhouri, MD: Using AGILE Scoring to Estimate MASLD Fibrosis, Cirrhosis

HCPLive

Alkhouri explains the value of AGILE 3+ and AGILE 4, reviewing key findings from a recent study applying the scores to NHANES data to estimate MASLD fibrosis and cirrhosis.

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Risk Stratification in Cardiac Sarcoidosis With PET

American College of Cardiology

What is the prognostic value of positron emission tomography (PET) in patients with cardiac sarcoidosis?

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Abrocitinib Drug Survival Significantly Higher Than Dupilumab for Atopic Dermatitis

HCPLive

This analysis compared drug survival rates of abrocitinib and dupilumab in the treatment of adults with eczema, with different benefits highlighted for both therapies.

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Pulsed Field Epicardial Ablation for VT Storm: A Case Report of Bail-Out Therapy

HeartRhythm

Achieving transmural and durable lesions during radiofrequency-based endocardial Ventricular Tachycardia (VT) ablation remains challenging when substrate is located within the septum, the mid-myocardium or the epicardium. In such situations, epicardial ablation, bipolar ablation, half-normal saline infusion, or bailout therapies such as ethanol injection with double-balloon technique1 have been proposed.

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Stable HbA1c Levels Linked to Lower Alzheimer Risk in Older Adults with Diabetes

HCPLive

Maintaining stable HbA1c levels in target ranges reduces Alzheimer Disease risk in older adults with diabetes, emphasizing the importance of personalized glycemic control.

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Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular EventsĂ¢â‚¬â€œIII

American College of Cardiology

The goal of the TRACE-III trial was to demonstrate the efficacy and safety of tenecteplase administered 4.5Ă¢â‚¬â€œ24 hours after stroke onset in patients who had had ischemic stroke resulting from large-vessel occlusion, had salvageable tissue, and did not have access to endovascular thrombectomy.

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Study Reveals Higher Economic, Quality of Life Burden With Rheumatoid Arthritis

HCPLive

Adjusted analyses reveal a statistically significantly higher prescription medication cost in patients with RA compared to those without.

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Clinical Considerations For Cardiovascular Health in Transgender Adults Receiving Gender-Affirming Hormone Therapy

American College of Cardiology

Current cardiovascular (CV) guidelines do not incorporate gender identity and hormone status into risk stratification and clinical decision-making. Clinical understanding of gender-affirming hormone therapy (GAHT) on CV health has been limited by a lack of high-quality research.

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FDA Approves Palopegteriparatide for Hypoparathyroidism

HCPLive

Palopegteriparatide’s approval was based on positive data from the global Phase 2 PaTH Forward and Phase 3 PaTHway trials.

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Canagliflozin mediates mitophagy through the AMPK/PINK1/PARKIN pathway to alleviate isoprenaline-induced cardiac remodelling

Journal of Cardiovascular Pharmacology

Heart failure has always been a prevalent, disabling, and potentially life-threatening disease. For the treatment of heart failure, controlling cardiac remodeling is very important. In recent years, clinical trials have shown that SGLT-2 inhibitors not only excel in lowering glucose levels but also demonstrate favorable cardiovascular protective effects.

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Ravulizumab Boosts Activity Levels, Quality of Life in Patients with PNH

HCPLive

Ravulizumab therapy may enable patients with PNH to achieve activity and patient-reported outcomes comparable to the US general population.

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Significant hemolysis is present during irreversible electroporation of cardiomyocytes in vitro

HeartRhythm

Pulsed-field ablation (PFA) of atrial fibrillation (AF) is a new method in clinical practice. Despite a favorable safety profile of PFA in AF ablation, rare cases of renal failure, probably due to hemolysis, have been recently reported.

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Heterogenous Presentation of Atopic Dermatitis

HCPLive

A panel of dermatologists discuss the heterogeneity of clinical presentations of atopic dermatitis and offer ways to reduce misdiagnosis.

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Trends in Ambulatory Follow-Up After CV Hospitalizations

American College of Cardiology

What are the trends in follow-up after acute myocardial infarction (AMI) and heart failure (HF) hospitalization?

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Bimekizumab Shows Consistent Efficacy With Or Without Concomitant Methotrexate in PsA

HCPLive

Similar trends were seen in study participants that transitioned from receiving placebo to bimekizumab after study week 16.

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Sex-specific association of cardiovascular drug doses with adverse outcomes in atrial fibrillation

Open Heart

Objectives Sex differences occur in atrial fibrillation (AF), including age at first manifestation, pathophysiology, treatment allocation, complication rates and quality of life. However, optimal doses of cardiovascular pharmacotherapy used in women with AF with or without heart failure (HF) are unclear. We investigated sex-specific associations of beta-blocker and renin–angiotensin system (RAS) inhibitor doses with cardiovascular outcomes in patients with AF or AF with concomitant HF.

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New Prediction Tool Projects Pediatric IgA Nephropathy Progression Post-Biopsy

HCPLive

The updated pediatric IgAN prediction tool allows clinicians to assess risk of disease progression 1-2 years post-biopsy.

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Refilling of PDS and Overall Safety Profile

HCPLive

Dr Marcus highlights procedure and safety overview for the port delivery system (PDS).

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