Dupilumab Reduces Itch in Chronic Spontaneous Urticaria in Phase 3 Data
HCPLive
NOVEMBER 4, 2024
According to Phase 3 LIBERTY-CUPID trial results, dupilumab significantly reduces itch and hive activity from baseline in chronic spontaneous urticaria.
Mon.Nov 04, 2024
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Efficacy and diabetes risk of moderate-intensity statin plus ezetimibe versus high-intensity statin after percutaneous coronary intervention
Cardiovascular Diabetology
NOVEMBER 4, 2024
High-intensity statin is recommended for patients undergoing percutaneous coronary intervention (PCI), and ezetimibe is recommended to be added in patients not achieving low-density lipoprotein cholesterol (LD.
Risankizumab Effectively Clears Psoriasis in Indirect Comparison to Deucravacitinib
HCPLive
NOVEMBER 4, 2024
Risankizumab achieves significantly higher rates of skin clearance and improved quality of life versus deucravacitinib in matching-adjusted indirect comparison analysis.
Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction
Cardiovascular Diabetology
NOVEMBER 4, 2024
Aging is influenced by genetic determinants and comorbidities, among which diabetes increases the risk for heart failure with preserved ejection fraction. There is no therapy to prevent heart dysfunction in ag.
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Apremilast Improves Outcomes in Scalp Psoriasis
HCPLive
NOVEMBER 4, 2024
The oral therapy may address limitations including difficulty in application and adverse events with topical therapies.
Heart transplant patients need more support in managing severe symptoms, researcher says
Medical Xpress - Cardiology
NOVEMBER 4, 2024
When a patient with heart failure has received a new heart and survives—the transplantation is deemed a success. However, health care overlooks heart recipients who suffer from long-term and often severe symptoms, such as pain and fatigue. New research at Lund University in Sweden shows that simple support in symptom management can make a considerable difference to the patients' well-being.
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Egas Moniz: A Centennial Tribute to Innovation
Stroke: Vascular and Interventional Neurology
NOVEMBER 4, 2024
Stroke: Vascular and Interventional Neurology, Volume 4, Issue 6 , November 1, 2024.
Phase 3 Data Shows Long-Term Efficacy, Safety of Stapokibart for Atopic Dermatitis
HCPLive
NOVEMBER 4, 2024
More patients with atopic dermatitis on stapokibart than on placebo achieved ≥ 75% improvement in Eczema Area and Severity Index over 52 weeks.
Dose-dependent association seen for smoking, CVD risk
Medical Xpress - Cardiology
NOVEMBER 4, 2024
There is a dose-dependent association for smoking and cardiovascular disease (CVD) risk, according to a study published online Nov. 1 in JAMA Network Open.
The Psychosocial Impact of CSU
HCPLive
NOVEMBER 4, 2024
Panelists discuss how patients with chronic spontaneous urticaria (CSU) experience increased rates of depression, sleep disturbances, and absenteeism, significantly impacting their professional life and overall quality of life.
Transcatheter valve replacement best for severe tricuspid regurgitation
Medical Xpress - Cardiology
NOVEMBER 4, 2024
Transcatheter tricuspid-valve replacement is superior to medical therapy alone for patients with severe tricuspid regurgitation, according to a study published online Oct. 30 in the New England Journal of Medicine to coincide with the annual Transcatheter Cardiovascular Therapeutics conference, held from Oct. 27 to 30 in Washington, D.C.
Roflumilast Reduces Disease Impact of Atopic Dermatitis
HCPLive
NOVEMBER 4, 2024
New PRO data from the INTEGUMENT-1 and –2 studies were presented at the ACAAI 2024 Meeting.
Orbital atherectomy no better than balloon angioplasty
Medical Xpress - Cardiology
NOVEMBER 4, 2024
For patients with severely calcified coronary lesions, routine treatment with orbital atherectomy prior to drug-eluting stent implantation does not yield greater minimal stent area or reduce the rate of target vessel failure compared with conventional balloon angioplasty, according to a study presented at the annual Transcatheter Cardiovascular Therapeutics conference, held from Oct. 27 to 30 in Washington, D.C.
Dermatology Month in Review | October 2024
HCPLive
NOVEMBER 4, 2024
In this Month in Review summary, some of the most notable advancements and developments in the field of dermatology were highlighted.
The Ubiquitin Ligase HERC2 promotes Ang II-induced cardiac hypertrophy via destabilization of MeCP2 to enhance Lin28a expression
Journal of Cardiovascular Pharmacology
NOVEMBER 4, 2024
HECT-type E3 ubiquitin ligases (HECT E3s) participate in the progression of cardiovascular diseases. HERC2 has been reported to play critical roles in many pathological processes, but its role in cardiac hypertrophy remains unclear. In this study, we observed that the expression and activity of HERC2 was significantly upregulated in hypertrophic hearts and angiotensin II (Ang II)-stimulated primary cardiomyocytes.
Study Identifies Simple Markers for Inflammatory Burden Among Patients with Psoriasis
HCPLive
NOVEMBER 4, 2024
In this analysis, investigators identified several markers such as monocyte-high-density lipoprotein cholesterol ratio and C-reactive protein values.
Complications associated with pulsed field ablation versus radiofrequency catheter ablation of atrial fibrillation
HeartRhythm
NOVEMBER 4, 2024
The first commercial systems for pulsed field ablation(PFA) were recently approved by the Food and Drug Administration(FDA), but their safety profile in nationwide practice remains underexplored.
The Pathogenesis of CSU
HCPLive
NOVEMBER 4, 2024
Panelists discuss how recent insights into chronic spontaneous urticaria (CSU) pathogenesis reveal potential autoimmune responses and highlight the role of Bruton tyrosine kinase (BTK) as a key mediator in mast cell degranulation and histamine release.
Behavior of Leadless atrioventricular synchronous pacing during exercise.
HeartRhythm
NOVEMBER 4, 2024
The leadless Micra AV pacemaker is designed to provide atrio-ventricular (AV) synchronous tracking by detecting the atrial contraction. Detection of the mechanical atrial signals can become challenging at fast sinus rate.
FDA Approves Minocycline Hydrochloride Extended Release Capsules for Individuals with Rosacea
HCPLive
NOVEMBER 4, 2024
The approval by the FDA of minocycline hydrochloride modified release capsules, also known as DFD-29, will allow for treatment of inflammatory lesions and erythema among adults.
Twin Atrioventricular Nodes and Accessory Pathways in Congenital Heart Diseases with Abnormal Atrioventricular Connections: Association with the Developmental Hierarchy of Cardiac Morphology
HeartRhythm
NOVEMBER 4, 2024
Twin atrioventricular nodes (TWAVNs) are common in heterotaxy syndrome.
Housing Insecurity and Cardiovascular Care: A Call to Action for Veteran Health
Circulation: Cardiovascular Quality & Outcomes
NOVEMBER 4, 2024
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print.
The Electrical Substrate of the Right Ventricle in Valvar Pulmonary Stenosis: Early Observations from Electrophysiology Studies Prior to Pulmonary Valve Replacement
HeartRhythm
NOVEMBER 4, 2024
Infants with severe valvar pulmonary stenosis (PS) are palliated by transcatheter balloon pulmonary valvuloplasty or surgical pulmonary valvotomy. Either strategy effectively relieves the obstruction, but one long-term sequela is pulmonary regurgitation (PR) necessitating pulmonary valve replacement. The recent introduction of transcatheter self-expanding platforms, such as the Harmony Transcatheter Pulmonary Valve (Medtronic Inc.) and the Alterra Adaptive Prestent (Edwards Lifesciences), has si
Clinical Images Enhance Pathologists' Accuracy in Diagnosing Skin Lesions
HCPLive
NOVEMBER 4, 2024
Clinical images help pathologists improve diagnostic confidence and agreement, leading to more accurate diagnoses of melanocytic skin lesions.
Pain management following cardiac implantable electronic device procedures in a single center out of the U.S.: Emphasis on opioid prescription.
HeartRhythm
NOVEMBER 4, 2024
In the era of globalization, medical practices remain influenced by local norms, affecting cultural, financial, and medical dimensions. Pain management is vital in post-procedural care, with techniques employed potentially having lasting consequences, as highlighted by the ongoing opioid crisis in the United States.
Nanomedicine-based strategies for the treatment of vein graft disease
Nature Reviews - Cardiology
NOVEMBER 4, 2024
Nature Reviews Cardiology, Published online: 05 November 2024; doi:10.1038/s41569-024-01094-y In this Review, Tao and colleagues discuss the design and applications of nanoparticles and nanofabricated biomaterials, such as hydrogels, external graft support devices and cell-based therapies, for the treatment of vein graft disease and highlight the potential of using these nanofabricated biomaterials alongside bypass surgery to improve local delivery efficiency and therapeutic efficacy.
Intramyocardial fibrofatty deposits in ischemic sudden cardiac death
HeartRhythm
NOVEMBER 4, 2024
Recent studies suggest that intramyocardial adipose tissue facilitates ventricular tachycardia (VT) in subjects with coronary artery disease (CAD) and prior myocardial infarction (MI) scar.1-2 We aimed to determine the prevalence of intramyocardial adipose deposits in sudden cardiac death (SCD) victims with CAD, and to analyze any associated characteristics.
Ablation of Premature Ventricular Complexes originating from Papillary Muscle using Pulsed Field Energy: The First in USA Experience
HeartRhythm
NOVEMBER 4, 2024
Pulsed field ablation (PFA) is a novel technique that is increasingly utilized in the management of atrial fibrillation (AF). This method employs high-energy, non-thermal electrical pulses to induce irreversible electroporation, selectively disrupting myocardial cells while sparing non-myocardial tissues such as the pulmonary veins, esophagus, and nerves.1 PFA’s precision and safety profile has made it a promising alternative to traditional thermal ablation techniques.
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