Mon.Nov 04, 2024

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Maternal Hidradenitis Suppurativa Linked to Pregnancy Complications, Morbidity

HCPLive

Findings suggest HS is associated with pregnancy complications and adverse outcomes for both mothers and offspring.

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Efficacy and diabetes risk of moderate-intensity statin plus ezetimibe versus high-intensity statin after percutaneous coronary intervention

Cardiovascular Diabetology

High-intensity statin is recommended for patients undergoing percutaneous coronary intervention (PCI), and ezetimibe is recommended to be added in patients not achieving low-density lipoprotein cholesterol (LD.

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Phase 3 Data Shows Long-Term Efficacy, Safety of Stapokibart for Atopic Dermatitis

HCPLive

More patients with atopic dermatitis on stapokibart than on placebo achieved ≥ 75% improvement in Eczema Area and Severity Index over 52 weeks.

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Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction

Cardiovascular Diabetology

Aging is influenced by genetic determinants and comorbidities, among which diabetes increases the risk for heart failure with preserved ejection fraction. There is no therapy to prevent heart dysfunction in ag.

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Risankizumab Effectively Clears Psoriasis in Indirect Comparison to Deucravacitinib

HCPLive

Risankizumab achieves significantly higher rates of skin clearance and improved quality of life versus deucravacitinib in matching-adjusted indirect comparison analysis.

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Nanomedicine-based strategies for the treatment of vein graft disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 05 November 2024; doi:10.1038/s41569-024-01094-y In this Review, Tao and colleagues discuss the design and applications of nanoparticles and nanofabricated biomaterials, such as hydrogels, external graft support devices and cell-based therapies, for the treatment of vein graft disease and highlight the potential of using these nanofabricated biomaterials alongside bypass surgery to improve local delivery efficiency and therapeutic efficacy.

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The Psychosocial Impact of CSU

HCPLive

Panelists discuss how patients with chronic spontaneous urticaria (CSU) experience increased rates of depression, sleep disturbances, and absenteeism, significantly impacting their professional life and overall quality of life.

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Dupilumab Reduces Itch in Chronic Spontaneous Urticaria in Phase 3 Data

HCPLive

According to Phase 3 LIBERTY-CUPID trial results, dupilumab significantly reduces itch and hive activity from baseline in chronic spontaneous urticaria.

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Ablation of Premature Ventricular Complexes originating from Papillary Muscle using Pulsed Field Energy: The First in USA Experience

HeartRhythm

Pulsed field ablation (PFA) is a novel technique that is increasingly utilized in the management of atrial fibrillation (AF). This method employs high-energy, non-thermal electrical pulses to induce irreversible electroporation, selectively disrupting myocardial cells while sparing non-myocardial tissues such as the pulmonary veins, esophagus, and nerves.1 PFA’s precision and safety profile has made it a promising alternative to traditional thermal ablation techniques.

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Study Identifies Simple Markers for Inflammatory Burden Among Patients with Psoriasis

HCPLive

In this analysis, investigators identified several markers such as monocyte-high-density lipoprotein cholesterol ratio and C-reactive protein values.

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Complications associated with pulsed field ablation versus radiofrequency catheter ablation of atrial fibrillation

HeartRhythm

The first commercial systems for pulsed field ablation(PFA) were recently approved by the Food and Drug Administration(FDA), but their safety profile in nationwide practice remains underexplored.

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FDA Approves Minocycline Hydrochloride Extended Release Capsules for Individuals with Rosacea

HCPLive

The approval by the FDA of minocycline hydrochloride modified release capsules, also known as DFD-29, will allow for treatment of inflammatory lesions and erythema among adults.

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Behavior of Leadless atrioventricular synchronous pacing during exercise.

HeartRhythm

The leadless Micra AV pacemaker is designed to provide atrio-ventricular (AV) synchronous tracking by detecting the atrial contraction. Detection of the mechanical atrial signals can become challenging at fast sinus rate.

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The Pathogenesis of CSU

HCPLive

Panelists discuss how recent insights into chronic spontaneous urticaria (CSU) pathogenesis reveal potential autoimmune responses and highlight the role of Bruton tyrosine kinase (BTK) as a key mediator in mast cell degranulation and histamine release.

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The Electrical Substrate of the Right Ventricle in Valvar Pulmonary Stenosis: Early Observations from Electrophysiology Studies Prior to Pulmonary Valve Replacement

HeartRhythm

Infants with severe valvar pulmonary stenosis (PS) are palliated by transcatheter balloon pulmonary valvuloplasty or surgical pulmonary valvotomy. Either strategy effectively relieves the obstruction, but one long-term sequela is pulmonary regurgitation (PR) necessitating pulmonary valve replacement. The recent introduction of transcatheter self-expanding platforms, such as the Harmony Transcatheter Pulmonary Valve (Medtronic Inc.) and the Alterra Adaptive Prestent (Edwards Lifesciences), has si

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Dermatology Month in Review | October 2024

HCPLive

In this Month in Review summary, some of the most notable advancements and developments in the field of dermatology were highlighted.

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Pain management following cardiac implantable electronic device procedures in a single center out of the U.S.: Emphasis on opioid prescription.

HeartRhythm

In the era of globalization, medical practices remain influenced by local norms, affecting cultural, financial, and medical dimensions. Pain management is vital in post-procedural care, with techniques employed potentially having lasting consequences, as highlighted by the ongoing opioid crisis in the United States.

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Apremilast Improves Outcomes in Scalp Psoriasis

HCPLive

The oral therapy may address limitations including difficulty in application and adverse events with topical therapies.

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Intramyocardial fibrofatty deposits in ischemic sudden cardiac death

HeartRhythm

Recent studies suggest that intramyocardial adipose tissue facilitates ventricular tachycardia (VT) in subjects with coronary artery disease (CAD) and prior myocardial infarction (MI) scar.1-2 We aimed to determine the prevalence of intramyocardial adipose deposits in sudden cardiac death (SCD) victims with CAD, and to analyze any associated characteristics.

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Roflumilast Reduces Disease Impact of Atopic Dermatitis

HCPLive

New PRO data from the INTEGUMENT-1 and –2 studies were presented at the ACAAI 2024 Meeting.

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Twin Atrioventricular Nodes and Accessory Pathways in Congenital Heart Diseases with Abnormal Atrioventricular Connections: Association with the Developmental Hierarchy of Cardiac Morphology

HeartRhythm

Twin atrioventricular nodes (TWAVNs) are common in heterotaxy syndrome.

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Clinical Images Enhance Pathologists' Accuracy in Diagnosing Skin Lesions

HCPLive

Clinical images help pathologists improve diagnostic confidence and agreement, leading to more accurate diagnoses of melanocytic skin lesions.

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Housing Insecurity and Cardiovascular Care: A Call to Action for Veteran Health

Circulation: Cardiovascular Quality & Outcomes

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print.