Wed.Nov 22, 2023

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Infection and DKA, then sudden dyspnea while in the ED

Dr. Smith's ECG Blog

To learn more about Occlusion MI, join us in this Free Webinar on November 27 12 noon US Central Time: Sign up at this link: [link] Infection and DKA, then sudden dyspnea while in the ED A 63 year old male with a PMH of CAD and peripheral vascular disease from type 1 DM presented to clinic and was found to have a very high blood sugar and so was sent to the emergency department.

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How Alcohol Affects Your Sleep

Physiologically Speaking

Greetings and Happy Holidays! Before getting to today’s post, I have TWO “Black Friday Week” promos to announce. First: now and through the end of November, all monthly and yearly Substack subscriptions are 20% off. If you want full access to all of my content (or want to give it as an early holiday gift), now’s the time. Get 20% off for 1 year Second: you can get the ePub or PDF version of my eBook “VO2 Max Essentials” for just $5 (formerly $15) on Gumroad.

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Why Hospitals Are Moving beyond the Limits of Physical Media Storage

NOVARAD

The traditional mode of storing data in hospitals has primarily been through physical media storage, encompassing film, paper records, and on-premises digital storage systems.

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The Importance of Cardiovascular Health: An Overview

GEMMS

What is cardiovascular health? Cardiovascular health refers to the overall well-being of the heart and blood vessels, and it plays a vital role in maintaining optimal physical function. It encompasses several factors, including the strength and efficiency of the heart, the flexibility and health of the blood vessels, and the ability of the cardiovascular system to deliver oxygen and nutrients to the body’s tissues.

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How Alcohol Affects Your Sleep

Physiologically Speaking

Greetings and Happy Holidays! Before getting to today’s post, I have TWO “Black Friday Week” promos to announce. First: now and through the end of November, all monthly and yearly Substack subscriptions are 20% off. If you want full access to all of my content (or want to give it as an early holiday gift), now’s the time. Get 20% off for 1 year Second: you can get the ePub or PDF version of my eBook “VO2 Max Essentials” for just $5 (formerly $15) on Gumroad.

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Pde5 Inhibition Reduced Blood Pressure and Alleviated Target Organ Damage in Chronic Intermittent Hypoxia

Journal of Cardiovascular Pharmacology

Abstract: The role of phosphodiesterase 5 (Pde5) in obstructive sleep apnea (OSA) induced damage remains unclear. Our study aimed to investigate the role of Pde5 in chronic intermittent hypoxia (CIH) model. C57BL/6J wild-type (WT) mice (n=48) and Pde5 knockout (Pde5-/-) mice (n=24) were randomly assigned to CIH group and room air (RA) group. After 6 weeks, some WT mice (n=24) in CIH group were given sildenafil or saline gavage for another 4 weeks.

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The Changing Landscape of Aortic-Valve Stenosis Management

The New England Journal of Medicine

Aortic-valve stenosis is an increasingly important cause of cardiovascular disease, particularly among older adults, with an overall prevalence of 2.8% among adults older than 75 years of age.1 Aortic stenosis is a progressive disease in which the rate of change of the aortic-valve area is estimated to be.

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Thrombus in Transit across a Patent Foramen Ovale

The New England Journal of Medicine

Hypoxemia and shock developed in a woman with atrial fibrillation who had been admitted for management of an ischemic stroke. Imaging (shown in videos) showed a thrombus in transit across a patent foramen ovale.

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Nocturnal Hypertension and Left Ventricular Diastolic Dysfunction in Patients With Diabetes With the Absence of Heart Failure: Prospective Cohort HSCAA Study

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Diabetes is an important risk factor for heart failure (HF) and is associated with left ventricular (LV) diastolic dysfunction. However, diabetic comorbid conditions, such as nocturnal hypertension, as predictors of diastolic dysfunction are not known in the absence of an HF period. The present study was conducted as the longitudinal examination of the predictive value of nocturnal hypertension profiles on the progression of LV diastolic dysfunction in pa

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Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years

The New England Journal of Medicine

Among patients at low surgical risk who underwent TAVR or surgery, there was no apparent difference between groups in the incidence of the composite end point of death, stroke, or rehospitalization at 5 years.

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Growth differentiation factor?15 and the effect of empagliflozin in heart failure: Findings from the EMPEROR program

European Journal of Heart Failure

Aims Growth differentiation factor-15 (GDF-15) is upregulated in part in response to cardiomyocyte stretch and stress, and it exerts a protective role that is mediated by its action to suppress signalling through insulin-like growth factor (IGF) and enhance signalling through adenosine monophosphate-activated protein kinase (AMPK). Sodium–glucose cotransporter 2 (SGLT2) inhibitors improve outcomes in heart failure, which has been experimentally linked to AMPK.

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ICMR study on sudden unexplained deaths in Covid times : An atypical observation

Dr. S. Venkatesan MD

News: A rare large scale study from ICMR is making news even in the mainstream media. ([link] ) A casual read of the original paper threw up some thoughts. India’s apex medical body, ICMR, initiated a study primarily on sudden deaths among young people in covid times. The primary intention of this study was to find what causes sudden unexplained deaths. and also test the hypothesis that the deaths were not probably related to covid vaccination.

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Guideline?directed medical therapy in severe heart failure with reduced ejection fraction: an analysis from the HELP?HF registry

European Journal of Heart Failure

Rates of guideline-directed medical therapy (GDMT) prescription in real-world patients with severe heart failure (HF) with reduced ejection fraction (HFrEF), reasons for underdosing and association with outcome. Upper left panel: rates of GDMT prescription and dosing, including beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/angiotensin receptor neprilysin inhibitors (ACEi/ARB/ARNI) and mineralocorticoid receptor antagonists (MRA).

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Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats

Hypertension Journal

Hypertension, Ahead of Print.

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Rethinking Culture to Unlock the Potential of Medical Research

Hypertension Journal

Hypertension, Ahead of Print.