Wed.May 01, 2024

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Brief anger may impair blood vessel function

American Heart News - Heart News

Research Highlights: When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow. Previous research has found that this may increase the risk of.

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ChatGPT Extracts Data for Ischaemic Stroke Almost Perfectly

DAIC

Dr Nils Lehnen, Senior Physician at the Clinic for Diagnostic and Interventional Neuroradiology and Paediatric Neuroradiology at the UKB. Image courtesy of University Hospital Bonn (UKB) / R. Müller milla1cf Wed, 05/01/2024 - 12:07 May 1, 2024 — In an ischemic stroke, an artery in the brain is blocked by blood clots and the brain cells can no longer be supplied with blood as a result.

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Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae

Journal of Clinical Investigation - Cardiology

Bacterial translocation from the gut microbiota is a source of sepsis in susceptible patients. Previous work suggests that overgrowth of gut pathobionts, including Klebsiella pneumoniae, increases the risk of disseminated infection. Our data from a human dietary intervention study found that, in the absence of fiber, K. pneumoniae bloomed during microbiota recovery from antibiotic treatment.

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Groundbreaking Data in Interventional Cardiology to be Featured at Society for Cardiovascular Angiology and Interventions SCAI 2024 Scientific Sessions

DAIC

The Society for Cardiovascular Angiography & Interventions (SCAI) kicks off its SCAI Scientific Sessions 2024 this week, May 2-4 in Long Beach, CA, bringing together more than 1,800 clinicians, scientists, researchers, and innovators in the field of interventional cardiology and endovascular medicine. Image courtesy: Long Beach Convention Center christine.book Wed, 05/01/2024 - 14:51 May 1, 2024 — The annual Society for Cardiovascular Angiography & Interventions ( SCAI ) kicks off its SCAI Scien

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Stress and cardiovascular disease: an update

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 May 2024; doi:10.1038/s41569-024-01024-y Physiological responses to stress are thought to increase the risk of cardiovascular disease via haemodynamic, vascular and immune perturbations. In this Review, Vaccarino and Bremner focus on issues with the measurement of psychological stress and the underlying pathobiology connecting stress to the risk of cardiovascular disease.

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STINGing away the pain: the role of interferon-stimulated genes

Journal of Clinical Investigation - Cardiology

Pain and inflammation are biologically intertwined responses that warn the body of potential danger. In this issue of the JCI, Defaye, Bradaia, and colleagues identified a functional link between inflammation and pain, demonstrating that inflammation-induced activation of stimulator of IFN genes (STING) in dorsal root ganglia nociceptors reduced pain-like behaviors in a rodent model of inflammatory pain.

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A blood test for stroke risk? Biomarker for risk of future cerebrovascular disease

Science Daily - Heart Disease

A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new study.

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A step closer to understanding how a diet high in simple carbohydrates may cause dysbiosis

Journal of Clinical Investigation - Cardiology

The gut microbiota is an integral part of the human metaorganism that is required to shape physiologic host immune responses including host defense against pathogens. Disease-associated gut dysbiosis has been characterized by blooms of pathobionts, which are bacterial species that can drive disease under certain conditions. Pathobionts like Enterobacteriaceae often bloom during flares of inflammatory bowel disease (IBD) and are causally linked with IBD in murine models.

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Urinary Inflammatory Biomarkers Show Prognostic Value for IgA Nephropathy

HCPLive

Urinary cytokines GDF-15, IL-6, and EGF significantly strengthened the predictability of IgAN prognosis and may be viable biomarker candidates for disease progression.

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Study finds ChatGPT fails at heart risk assessment

Medical Xpress - Cardiology

Despite ChatGPT's reported ability to pass medical exams, new research indicates it would be unwise to rely on it for some health assessments, such as whether a patient with chest pain needs to be hospitalized.

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Nationwide, 6 stroke advocates selected to receive 2024 Stroke Hero Awards

American Heart News - Stroke News

DALLAS, May 1, 2024 – Each year, approximately 800,000 people in the U.S. have a stroke.[1] Six local stroke heroes from across the country are being recognized by the American Stroke Association, a division of the American Heart Association, for.

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An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis

Journal of Clinical Investigation - Cardiology

The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues, termed senolytics. However, a major caveat with current senolytic screens is the use of cell lines as targets where senescence is induced in vitro, which does not necessarily reflect the identity and function of pathogenic senescent cells in vivo.

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Study finds network of inflammatory molecules may act as biomarker for risk of future cerebrovascular disease

Medical Xpress - Cardiology

A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.

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BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system

Journal of Clinical Investigation - Cardiology

Epigenetic regulatory mechanisms are underappreciated, yet are critical for enteric nervous system (ENS) development and maintenance. We discovered that fetal loss of the epigenetic regulator Bap1 in the ENS lineage caused severe postnatal bowel dysfunction and early death in Tyrosinase-Cre Bap1fl/fl mice. Bap1-depleted ENS appeared normal in neonates; however, by P15, Bap1-deficient enteric neurons were largely absent from the small and large intestine of Tyrosinase-Cre Bap1fl/fl mice.

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Brief anger may impair blood vessel function

Science Daily - Heart Disease

When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow, according to a new study. Previous research has found that this may increase the risk of heart disease and stroke. In this study, episodes of anxiety and sadness did not trigger the same change in functioning of the blood vessel lining.

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Cardiologists train large AI model to assess heart structure, function

Medical Xpress - Cardiology

Artificial intelligence experts at Cedars-Sinai and the Smidt Heart Institute created a dataset with more than 1 million echocardiograms, or cardiac ultrasound videos, and their corresponding clinical interpretations. Using this database, they created EchoCLIP, a powerful machine learning algorithm that can "interpret" echocardiogram images and assess key findings.

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TXA2 attenuates allergic lung inflammation through regulation of Th2, Th9, and Treg differentiation

Journal of Clinical Investigation - Cardiology

In lung, thromboxane A2 (TXA2) activates the TP receptor to induce proinflammatory and bronchoconstrictor effects. Thus, TP receptor antagonists and TXA2 synthase inhibitors have been tested as potential asthma therapeutics in humans. Th9 cells play key roles in asthma and regulate the lung immune response to allergens. Herein, we found that TXA2 reduces Th9 cell differentiation during allergic lung inflammation.

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Clogged arteries worsened by cells that behave like cancer cells

Science Daily - Heart Disease

Researchers have found that cells inside clogged arteries have cancer-like properties that aggravate atherosclerosis, and anticancer drugs could be a new treatment.

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Trial Update of Pitavastatin to Prevent Cardiovascular Events in HIV Infection

The New England Journal of Medicine

In the final results of a randomized trial involving patients with HIV infection, pitavastatin reduced the incidence of adverse cardiovascular events at 5.6 years of follow-up as compared with placebo.

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3 ways to protect your heart and brain this American Stroke Month

American Heart News - Stroke News

DALLAS, May 1, 2024 – Every 40 seconds someone in the U.S. has a stroke[1], and 1 in 4 stroke survivors will have another one[2]. During May - American Stroke Month -, the American Stroke Association, a division of the American Heart Association, is.

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Aspirin’s Lp(a) Primary Prevention Potential

CardiacWire

An observational study out of Emory suggests that aspirin could be the preventative Lp(a) treatment we’ve been looking for, finding that people with high Lp(a) levels who regularly take aspirin might significantly reduce their ASCVD mortality risks. The researchers analyzed 26-year outcomes from 2,990 people without clinical ASCVD (representative of 73M US adults), including 7% who regularly took aspirin, finding that… Among participants with high Lp(a) levels, daily aspirin-takers had far lower

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Cedars-Sinai trains most comprehensive echocardiography AI to date

Becker's Hospital Review - Cardiology

Smidt Heart Institute and Cedars-Sinai, both based in Los Angeles, used the largest dataset to date to trained a machine-learning algorithm that can interpret echocardiogram images.

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Review Characterizes CVD, Impact of SDOH in Hispanic Women

American College of Cardiology

Among Hispanic women living in the U.S., 37% are affected by cardiovascular disease and it is the primary cause of death, according to a JACC Review Topic of the Week published April 22.

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AI-Enabled Electrocardiogram Alert Intervention Reduces All-Cause Mortality

HCPLive

Implementation of an artificial intelligence-enabled ECG reduced the risk of all-cause mortality within 90 days among hospitalized patients.

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Guideline Comparison of Normal-Flow Low-Gradient AS: Key Points

American College of Cardiology

The following are key points to remember from a review comparing the US and European guidelines for normal-flow low-gradient (NFLG) aortic stenosis (AS).

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Pulmonology Month in Review: April 2024

HCPLive

In this review of April 2024, the editorial team highlighted some of the biggest stories in the pulmonary health space, touching on topics such as air quality issues, asthma, and pneumonia.

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6 defensores de ataques o derrames cerebrales seleccionados a nivel nacional para recibir los premios Stroke Hero Awards 2024

American Heart News - Stroke News

DALLAS, 1 de mayo, 2024 — Cada año, aproximadamente 800,000 personas en los Estados Unidos sufren un derrame cerebral.[1] La American Stroke Association, una división de la American Heart Association (la Asociación Americana del Corazón), reconoce a.

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FDA Approves High-Concentrate, Citrate-Free Formulation of Biosimilar Adalimumab-adbm

HCPLive

The current approval is based on the VOLTAIRE-HCLF clinical trial, which examined the bioavailability of high-concentration (100 mg/mL) and low-concentration (50 mg/mL) formulations of adalimumab-adbm.

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Complement regulation in the eye: implications for age-related macular degeneration

Journal of Clinical Investigation - Cardiology

Careful regulation of the complement system is critical for enabling complement proteins to titrate immune defense while also preventing collateral tissue damage from poorly controlled inflammation. In the eye, this balance between complement activity and inhibition is crucial, as a low level of basal complement activity is necessary to support ocular immune privilege, a prerequisite for maintaining vision.

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Tres formas de proteger el corazón y el cerebro en el Mes del Derrame Cerebral en Estados Unidos

American Heart News - Stroke News

DALLAS, 1 de mayo de 2024 — Cada 40 segundos alguien en los EE. UU. sufre un ataque o derrame cerebral[[1], y 1 de cada 4 supervivientes tendrá otro a lo largo de su vida[2].Durante mayo, el Mes del Derrame Cerebral en Estados Unidos, la American.

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Hepatology Month in Review: April 2024

HCPLive

The April 2024 month in review features HCPLive’s top coverage of resmetirom, other key hepatic pipeline updates, and recent research about hepatitis C virus.

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Enhancing anticancer activity of macrophages through rational drug combinations

Journal of Clinical Investigation - Cardiology

Targeting tumor-associated macrophages (TAMs) is an emerging approach being tested in multiple clinical trials. TAMs, depending on their differentiation state, can exhibit pro- or antitumorigenic functions. For example, the M2-like phenotype represents a protumoral state that can stimulate tumor growth, angiogenesis, metastasis, therapy resistance, and immune evasion by expressing immune checkpoint proteins.

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Cryoablation to Delay Progression of Persistent Atrial Fibrillation (EARLY-AF Study)

American College of Cardiology

Atrial fibrillation (AF) is a progressive disease that often starts with predominately sinus rhythm interrupted by paroxysms of AF. As the left atrium becomes more diseased, it progresses into persistent AF and achieving rhythm and rate control becomes more difficult.

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Rheumatology Month in Review: April 2024

HCPLive

This month's review showcases the ongoing efforts to enhance patient care through innovative treatments and comprehensive management strategies.

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Device-specific quality of life: Results from the ATLAS trial—Avoid Transvenous Leads in Appropriate Subjects

European Journal of Cardiovascular Nursing

Abstract Aim Patient reported outcomes (PROs) provide important insights into patients’ acceptance of their medical devices. ATLAS, a randomized, multi-center, open-label clinical trial, recently reported fewer perioperative complications in S-ICD compared to TV-ICD patients. This study reports PROs, including device-specific and generic quality of life (QOL) from the ATLAS trial.

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Dermatology Month in Review: April 2024

HCPLive

In this review of dermatology news in April, we highlighted several major stories on such topics as cutaneous reactions to COVID-19, topical versus oral minoxidil, and FDA news.

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Mechanisms and benefits of cardiac rehabilitation in individuals with stroke: emerging role of its impact on improving cardiovascular and neurovascular health

Frontiers in Cardiovascular Medicine

Human and animal studies have demonstrated the mechanisms and benefits of aerobic exercise for both cardiovascular and neurovascular health. Aerobic exercise induces neuroplasticity and neurophysiologic reorganization of brain networks, improves cerebral blood flow, and increases whole-body VO2peak (peak oxygen consumption). The effectiveness of a structured cardiac rehabilitation (CR) program is well established and a vital part of the continuum of care for people with cardiovascular disease.