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New results from a vast Mayo Clinic meta-analysis suggest that combining ezetimibe with statins to lower LDL-C could have significant mortality and MACE benefits over statin monotherapy. Statins are one of the most prescribed drugs in the U.S., with over 25% of all adults 40 and up taking them. However, not everyone with high cholesterol benefits from statins, leading many drug developers to focus on novel ways to lower LDL-C levels.
Background Heart failure with preserved ejection fraction is a recognised outcome in patients with myocardial infarction, although heart failure with reduced ejection fraction is more common. Identifying early indicators specific to heart failure with preserved ejection fraction in patients with myocardial infarction could support targeted preventive strategies.
tim.hodson Wed, 03/26/2025 - 14:25 March 17, 2025 Bayer recently announcedthat the U.S. Food and Drug Administration (FDA) accepted its supplemental new drug application (sNDA) and granted Priority Review designation for KERENDIA(finerenone) for the treatment of adult patients with heart failure (HF) with a left ventricular ejection fraction (LVEF) of 40%, i.e., mildly reduced LVEF (HFmrEF) or preserved LVEF (HFpEF).
Background Pericardial complications following cardiac surgery are common and debilitating, significantly impacting patients’ survival. We performed this network meta-analysis to identify the most effective and safest preventions and treatments for pericardial complications following cardiac surgery. Methods We systematically searched PubMed/MEDLINE, EMBASE and Cochrane CENTRAL from inception to 22 January 2024.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
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(MedPage Today) -- Obesity was tied with 16 common health concerns in a longitudinal cohort study, with the magnitude of risk correlating with the level of obesity. Based on the electronic health records of 270,657 participants from the All of.
Heart failure (HF) is a complex syndrome which leads to significant morbidity and mortality, poor quality of life and extremely high costs to healthcare systems worldwide. Although progress in the management of HF in high-income countries is leading to an overall reduction in the incidence and mortality of HF, there is a starkly different scenario in low- and middle-income countries (LMICs).
Advances in molecular genetics during the past decades led to seminal discoveries in the genetic basis of cardiovascular diseases, resulting in a new understanding of their pathogenesis, determinants of natural history and more recently paved the way for innovative therapies. A significant gap, however, exists between the rapidly increasing knowledge, especially of cardiovascular Mendelian disorders, and the medical applications in daily practice.
Stroke survivors who have attended some level of higher education may face even steeper mental declines, according to a study. The findings suggest that attending higher education may enable people to retain greater cognitive ability until a critical threshold of brain injury is reached after a stroke.
Pericardial complications are very common following cardiac surgery. It is estimated that up to 30–40% of patients may develop a postpericardiotomy syndrome (PPS) and >50–60% of patients show pericardial effusions after cardiac surgery. 1 2 Pericardial complications may range from asymptomatic pericardial and/or pleural effusion to cardiac tamponade, and may include PPS, and postoperative atrial fibrillation (POAF), triggered by pericarditis in predisposed individuals. 3 All thes
This analysis highlights the increased risk among those with psoriasis for developing such ocular conditions as conjunctivitis, dry eye, and conjunctival hyperemia.
Heart failure (HF) is one of the significant complications in patients with myocardial infarction (MI), leading to increased risk for cardiovascular morbidity and mortality. 1 Left ventricular ejection fraction (LVEF) is a crucial parameter in HF assessment and management, although the differences in mortality are little different between HF with LVEF≥50% or HF with preserved ejection fraction (HFpEF) in patients with post-MI compared with HF with LVEF≤40% or HF with reduced ejection
In this trial, patients with type 2 diabetes had a lower incidence of major cardiovascular outcomes with a systolic blood-pressure target of less than 120 mm Hg than with a target of less than 140 mm Hg.
Background Atrial fibrillation (AF) is a major and increasing burden on health services. This study aimed to evaluate the cost-effectiveness of digoxin versus beta-blockers for heart rate control in patients with permanent AF and symptoms of heart failure. Methods RAte control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) was a randomised, open-label, blinded, endpoint trial embedded in the UK National Health Service (NHS) to directly compare low-dose digoxin with beta-blockers (
Stroke, Ahead of Print. BACKGROUND:Recently, various polygenic risk score (PRS)based methods were developed to improve stroke prediction. However, current PRSs (including cross-ancestry PRS) poorly predict recurrent stroke. Here, we aimed to determine whether the best PRS for Japanese individuals can also predict stroke recurrence in this population by extensively comparing the methods and maximizing the predictive performance for stroke onset.METHODS:We used data from the disease-oriented BBJ1
Many teenagers enter adulthood with significant risk factors for cardiovascular disease, and the transition from adolescence to adulthood is a key time to address these risk factors and reduce the risk of developing future cardiovascular disease, according to a new American Heart Association scientific statement published in the Journal of the American Heart Association.
A reversible interaction between bempedoic acid and fenofibrate leading to a major, reversible decrease in HDL cholesterol levels was found in patients treated for nongenetic elevated LDL cholesterol levels.
People who have early signs of heart problems may also have changes in brain health that can be early signs of dementia, such as loss of brain volume, according to a meta-analysis published online in Neurology. The meta-analysis does not prove that early heart problems cause loss of brain cells; it only shows an association.
A scientific technique that rapidly increases the body's production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study. Once adapted to treat humans, the technique could potentially be used to repair heart muscle damage after a heart attack and be applied to a variety of inflammatory disorders.
Statement Highlights: By age 18, many adolescents have already developed heart disease risk factors, such as high blood pressure, obesity, high cholesterol or Type 2 diabetes, and a growing number of younger adults are experiencing adverse.
Many youth have heart disease risk factors by their late teens, and preventing or addressing these risks early may reduce the risk of developing cardiovascular disease in the future, according to a new scientific statement.
A scientific technique that rapidly increases the body's production of anti-inflammatory cells promotes healing from heart attacks in mice, according to a new study by investigators from the Smidt Heart Institute at Cedars-Sinai. Once adapted to treat humans, the technique could potentially be used to repair heart muscle damage after a heart attack and be applied to a variety of inflammatory disorders.
A study found many anaphylaxis patients didnt receive adrenaline, the first-line treatment. Adrenaline use correlated with better outcomes in adults and children.
Compared with those who spent most of their time in a single room, people with heart failure with preserved ejection fraction (HFpEF) who were able to travel outside of their home without assistance were significantly less likely to be hospitalized or die within a year, according to a new study. The findings underscore the value of supporting holistic care and encouraging people with heart failure to maintain an active lifestyle and engage with others in their community to the extent possible, r
This feature about a man who had had a myocardial infarction with preserved left ventricular ejection fraction offers a case vignette accompanied by two essays, one supporting the use of beta-blockers after discharge and the other recommending no use of beta-blockers.
Elevated blood pressure mediates much of the organ toxicity affecting persons with type 2 diabetes. The management of hypertension occupies as much clinical attention as that of dysglycemia, yet the recommended blood-pressure target in type 2 diabetes remains controversial. The Systolic Blood Pressure Intervention Trial (SPRINT; 9361 participants), which excluded.
A phase 1 study found neffy nasal spray provides effective epinephrine absorption in children, supporting its role as a needle-free anaphylaxis treatment.
Imagine you're at a dinner party and the person sitting across the table from you suddenly stops making sense, and not because of the glass of wine in their hand. Then maybe one side of their face starts to droop. The person you're looking at with growing concern might be feeling dizzy or may have trouble using their fork. They might suddenly be unable to move or feel half their body or see anything to their left.
One of the lasting memories from my teenage years is what I now recognize as an obsession with weight control. Thin was in, and magazines promoted a variety of diets, each claiming effectiveness, often accompanied by images of beautiful, slim models. Not much has changed.
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. BACKGROUND:Remote health management programs utilizing evidence-based algorithm-driven virtual care solutions for chronic disease management offer a novel approach to addressing implementation gaps for conditions such as hypertension. However, little is known about how to optimize patient enrollment.METHODS:Through structured interviews, we conducted a qualitative analysis of patient and primary care physician attitudes toward enr
Cardiac implantable electronic devices (CIED) can be implanted epicardial or transvenous in children. Both techniques involve procedure-specific complications, and the evidence is scares for which technique to choose for different ages.
Journal of the American Heart Association, Ahead of Print. Cardiovascular disease remains a leading cause of death in the United States, with an alarming rise in the proportion of young adults experiencing cardiovascular events. Many adolescents enter adulthood with significant cardiovascular disease risk factors. This scientific statement addresses the critical need for cardiovascular health promotion during emerging adulthood, a transitional stage between the ages of 18 and 25 or 29 years of a
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