Sat.Nov 16, 2024

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Tirzepatide Officially Puts GLP-1 Meds on the Map for Obesity-Related Heart Failure

Med Page Today

(MedPage Today) -- CHICAGO -- A long-acting GIP/GLP-1 receptor agonist conferred significant clinical benefit for people with obesity and accompanying heart failure with preserved ejection fraction (HFpEF), according to the SUMMIT trial. Incident.

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Tirzepatide lowered risk of worsening heart failure and CVD death for obese adults

American Heart News - Heart News

Research Highlights: In an international trial of 713 adults in nine countries including the U.S. called SUMMIT, participants with heart failure with preserved ejection fraction (HFpEF) and obesity taking tirzepatide for an average of 2 years had.

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Ablation Bests Drugs for Ventricular Tachycardia After Heart Attack

Med Page Today

(MedPage Today) -- CHICAGO -- For patients with ventricular tachycardia (VT) and ischemic cardiomyopathy, going right to catheter ablation improved outcomes compared with trying antiarrhythmic drugs first, the VANISH2 trial showed. Death or.

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Ablation may be better than medication for those with dangerous heartbeat after heart attack

American Heart News - Heart News

Research Highlights: A new, multicenter study demonstrated that ablation treatment may be a better first option than medication for many heart attack survivors who develop abnormal electrical short circuits in their heart, which are episodes of.

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Intensive Blood Pressure Regimen Lowers CVD Risk in People with T2D

HCPLive

Reducing systolic blood pressure to less than 120 mmHg lowered the risk of major cardiovascular events for most people with diabetes in the BPROAD trial.

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Intensive Blood Pressure Control Benefits People With Type 2 Diabetes Too

Med Page Today

(MedPage Today) -- CHICAGO -- The cardiovascular outcome benefit of a tighter systolic blood pressure target was affirmed in patients with type 2 diabetes in the randomized BPROAD trial from China. A target of less than 120 mm Hg reduced a composite.

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Jonathan Stine, MD: Exercise’s Benefit in MASH is Independent of Weight Loss

HCPLive

Stine reviews findings from a posthoc analysis of the NASHFit trial suggesting the impact of exercise on MASH resolution, even without weight loss.

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Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure

JAMA Cardiology

This multicenter secondary analysis of the FINEARTS-HF randomized clinical trial examines the treatment effect of finerenone, relative to placebo, on clinical outcomes based on postrandomization potassium levels.

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SUMMIT: Tirzepatide Improves Outcomes and Quality of Life For Patients With HFpEF and Obesity

American College of Cardiology

In patients with obesity and heart failure with preserved ejection fraction (HFpEF), weekly treatment with tirzepatide over approximately two years reduced the risk of worsening heart failure events, based on findings from the SUMMIT trial.

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Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction

JAMA Cardiology

This prespecified secondary analysis of a randomized clinical trial examines the efficacy and safety of finerenone in women and men with heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction.

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Giving pharmacists feedback improved care for veterans with heart failure

American Heart News - Heart News

Research Highlights: Pharmacists in the Veterans Health Administration System who received feedback on their patients' heart failure medication rates, along with educational tools and targeted information, had a significant increase in the frequency.

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BPROAD: Findings Supporting Intensive BP Control in Patients With Type 2 Diabetes Put Pressure on Standard Treatment

American College of Cardiology

Intensive treatment to control systolic blood pressure (BP) to less than 120 mmHg significantly reduced the incidence of major cardiovascular events in patients over the age of 50 with type 2 diabetes, based on results from the BPROAD trial.

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AI image-recognition program could read heart images faster, speed care

American Heart News - Heart News

Research Highlights: A new software program that uses artificial intelligence to read echocardiograms may reduce the wait times for results and lead to more timely medical care. PanEcho is the first AI system to automatically assess all key areas of.

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BRAIN-AF: Rivaroxaban Did Not Reduce Cognitive Decline, Stroke and TIA in Younger, Low-Risk Patients With AFib

American College of Cardiology

Rivaroxaban did not reduce the incidence of cognitive decline, stroke or transient ischemic attack (TIA) in patients younger than 65 with nonvalvular atrial fibrillation (AFib) and low risk for stroke, according to results from the BRAIN-AF trial.

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Rapid Initiation of SGLT2 Inhibitors Improves Cost-Effectiveness of Therapy, with Ankeet Bhatt, MD, MBA

HCPLive

Ankeet Bhatt, MD, MBA, discusses a study he led from AHA 2024 examining the cost-effectiveness of dapagliflozin based on how soon therapy was initiated following diagnosis or hospitalization.

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VANISH2: Catheter Ablation vs. AAD as First-Line Strategy

American College of Cardiology

Among patients with ischemic cardiomyopathy and ventricular tachycardia (VT), catheter ablation as a first-line strategy over antiarrhythmic drugs (AAD) was associated with a lower risk of the primary outcome, according to results of the VANISH2 trial.

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SUMMIT Trial Proves Tirzepatide's Benefit in HFpEF with Obesity

HCPLive

Tirzepatide reduced the risk of heart failure hospitalization or cardiovascular death by 38% and improved body weight by up to 21% in the SUMMIT trial.

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Instructor Collection ECG: Anterior M.I. and Left Ventricular Hypertrophy

ECG Guru

The Patient: Sixty-year-old man with a complaint of severe substernal chest pain. Denies hx of M.I., but reports feeling short of breath on exertion for about a year. Hx of hypertension, but admits he is non-compliant with his medication. Appears pale and diaphoretic, BP 110/68. The ECG: The rhythm is sinus at 62 bpm. The QRS is slightly wide at 110 ms (.11 seconds), but still within normal limits.

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Blood thinners didn’t reduce cognitive decline in adults 65 and younger with AFib

American Heart News - Heart News

Research Highlights: In the first large trial of its kind, the anti-clotting medication rivaroxaban did not lower the risk of cognitive decline, stroke or transient ischemic attack (TIA) in people younger than age 65 who had atrial fibrillation (AFib).

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Multiple Chronic Conditions and Death; Diabetes Treatment for Gout

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Systolic BP of less than 120 mm Hg reduced CVD risk in adults with Type 2 diabetes

American Heart News - Heart News

Research Highlights: A study of almost 13,000 adults with Type 2 diabetes and high systolic blood pressure assessed if a more intensive treatment approach with a lower blood pressure goal would decrease the risk of major cardiovascular events,

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Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After CABG

JAMA Cardiology

This randomized clinical trial examines whether a partial cardiac denervation procedure reduces the incidence of postoperative atrial fibrillation among patients undergoing isolated coronary artery bypass grafting (CABG) in China.

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Single-Dose Novel Nex-Z May Reduce Serum TTR Levels

American College of Cardiology

A single dose of nexiguran ziclumeran (nex-z) in patients with transthyretin amyloidosis cardiomyopathy (ATTR-CM) was associated with a substantial reduction in serum transthyretin (TTR) levels, according to a phase 1, single-group, open-label ongoing study.

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Chari Cohen, DrPH, MPH: Healthcare Providers’ Role in HBV Clinical Trial Diversity

HCPLive

Cohen explains patient perspectives about how healthcare providers can help address the lack of diversity in chronic HBV clinical trials.

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Study Shows CV Mortality Hitting Harder in Rural America

American College of Cardiology

People who live in rural areas are dying from cardiovascular disease at a much greater rate than those living in urban areas, according to a report presented at AHA 2024 and simultaneously published in JACC. The report shows that disparities in mortality are greater among younger adults and was more pronounced during the COVID-19 pandemic.

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Hide Okuno, MS: Tube Weaning Reduces Parental Stress, Findings Guide Future Studies

HCPLive

At NASPGHAN 2024, Okuno shared findings on reduced parental stress after children’s tube weaning, emphasizing the potential for new outpatient weaning protocols.

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OPTION: LAAC vs. Oral Anticoagulation in High-Risk Patients Undergoing AFib Ablation

American College of Cardiology

Left atrial appendage closure (LAAC) in patients at moderate to high risk for stroke who were undergoing catheter atrial fibrillation (AFib) ablation resulted in significantly less bleeding compared with oral anticoagulation, based on findings from the OPTION trial presented at AHA 2024 and simultaneously published in NEJM.

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VANISH2: Catheter Ablation Viable First-Line Option for Ventricular Tachycardia

HCPLive

Initial catheter ablation achieved a lower risk of a composite primary endpoint event than anti-arrhythmic drug therapy in patients who survived a heart attack.

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Late-Breaking Science Explores AI and Other Innovations Designed to Improve Heart Health

American College of Cardiology

A late-breaking session at AHA 2024 highlighted new research focusing on “Smart Cardiology” innovations, including artificial intelligence (AI), aimed at improving heart health.

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Interim Phase 1 Update Shows Favorable Effect of Nex-z for ATTR-CM

HCPLive

A single dose of nex-z achieved consistent and rapid reductions in serum TTR levels over 12 months of follow-up in patients with ATTR-CM.

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Blinded Randomized trial of Anticoagulation to prevent Ischemic stroke and Neurocognitive impairment in Atrial Fibrillation

American College of Cardiology

The goal of the BRAIN-AF trial was to evaluate the impact of rivaroxaban compared with placebo on preventing cognitive decline, stroke, or TIA among patients with atrial fibrillation (AF).

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Elafibranor Improves Predicted Transplant-Free Survival Based on GLOBE, UK-PBC Scores

HCPLive

Treatment with elafibranor (Iqirvo) improved prognostic GLOBE and UK-PBC scores as early as week 4 in the phase 3 ELATIVE trial.

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P2Y12 Inhibitor Pretreatment in NSTE-ACS: NCDR Chest Pain-MI Registry

American College of Cardiology

What are temporal U.S. trends, variability, and clinical outcomes of P2Y12 inhibitor pretreatment in non–ST-segment elevation acute coronary syndrome (NSTE-ACS)?

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Vitamin D Deficiency Linked to Worse Autoimmune Hepatitis Outcomes

HCPLive

Patients with autoimmune hepatitis who are deficient in vitamin D had worse outcomes than patients with normal vitamin D levels.

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Slowly conducting anatomic isthmuses of tetralogy of Fallot: An opportunity for “prophylactic” ventricular tachycardia ablation

HeartRhythm

Patients with repaired tetralogy of Fallot are at risk of ventricular tachycardia (VT) and sudden cardiac death. Most VTs arise from 5 slowly conducting anatomic isthmuses (SCAIs; conduction velocity ≤0.5 m/s) bound by the right ventriculotomy, ventricular septal defect patch, and tricuspid and pulmonic valves. Historically, risk stratification electrophysiologic studies involved programmed ventricular stimulation with VT induction guiding implantable cardioverter-defibrillator (ICD) implantatio

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TCE Therapy Demonstrates Quick Responses for Systemic Lupus Erthematosus in Early Data

HCPLive

A-319 has been well-tolerated so far and dose-escalation is ongoing in the phase 1 trial.

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NEJM at AHA — Routine Spironolactone in Acute Myocardial Infarction

The New England Journal of Medicine

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.