Mon.Mar 04, 2024

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FDA Says Eating Yogurt May Reduce Diabetes Risk

Med Page Today

(MedPage Today) -- The FDA said that it will not object to the use of a qualified health claim that eating yogurt is associated with a reduced risk of type 2 diabetes, the agency announced Friday. After a review of the evidence -- albeit limited.

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Psychological Interventions Effectively Decrease Depression, Anxiety in Patients with Fibromyalgia

HCPLive

The overall effect of psychological interventions on patients with fibromyalgia was -0.31 for depressive symptoms and -0.15 for anxiety symptoms, which were deemed statistically significant.

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POST-PCI Surveillance Strategies for Multivessel or Left Main Coronary Artery Disease

Cardiology Update

The optimal surveillance strategy after percutaneous coronary intervention (PCI) for high-risk patients with multivessel or left main coronary artery disease (CAD) remains uncertain. In the the POST-PCI (Pragmatic Trial Comparing Symptom-Oriented Versus Routine Stress Testing in High-Risk Patients Undergoing Percutaneous Coronary Intervention; NCT03217877 ) trial, recently published in JACC, investigators aimed to determine prognostic role of routine functional testing in patients with multivess

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When the conventional algorithm diagnoses the ECG as COMPLETELY NORMAL, but there is in fact OMI, what does the Queen of Hearts PM Cardio AI app say? (with 10 case examples)

Dr. Smith's ECG Blog

I have often written about how an ECG interpreted as "normal" by a conventional algorithm may well be manifesting OMI, or even long QT or hyperkalemia. I have collected 51 OMI cases that were diagnosed as completely normal by the conventional automated computer algorithm. Shifa Karim and Gabe Keller helped with a project to assess all these ECGs with the Queen of Hearts.

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World's longest-living heart transplant recipient named

Becker's Hospital Review - Cardiology

"Discover the incredible story of Bert Janssen, the Dutch man who has lived with a donor heart for 39 years and 252 days, officially confirmed as the world's lo

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Trader Joe's 60,000-Pound Recall; Will Shortz's Stroke; Oregon Recriminalizing Drugs

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Trader Joe's is recalling more than 61,000 pounds of chicken soup dumplings for possibly containing hard plastic. (AP) CVS and Walgreens plan to start dispensing.

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Case Study Suggests Tezepelumab Efficacy for Non-Type 2 Asthma Treatment

HCPLive

This is the first instance in which a patient without a response to sequential bronchial thermoplasty, dupilumab, benralizumab, and mepolizumab ended up with a strong clinical response to tezepelumab.

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Mesangial IgM Deposition Linked to ESKD in Patients with IgA Nephropathy

HCPLive

Results identified mesangial IgM deposition as an independent risk factor for ESKD in patients with IgAN, particularly in advanced disease stages.

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Robotic hip exoskeleton shows promise for helping stroke patients regain their stride

Science Daily - Stroke

More than 80% of stroke survivors experience walking difficulty, significantly impacting their daily lives, independence, and overall quality of life. Now, new research pushes forward the bounds of stroke recovery with a unique robotic hip exoskeleton, designed as a training tool to improve walking function. This invites the possibility of new therapies that are more accessible and easier to translate from practice to daily life compared to current rehabilitation methods.

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Diabetes Dialogue: Tirzepatide and the Future of Incretin Therapies, with Timothy Garvey, MD

HCPLive

In this episode, hosts are joined by SURMOPUNT-2 principal investigator Timothy Garvey, MD, to discuss the approval of the tirzepatide for chronic weight management, data from the SURMOUNT-2, -3, and 4 programs, the future of incretin therapies, and more.

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How 1 leader went from the research lab to pediatric cardiology chief

Becker's Hospital Review - Cardiology

Research labs are not necessarily known for the leadership opportunities they create. But for Bernard Kühn, MD, the lab helped lay the groundwork of leadership and administrative work that helped him land his current position.

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Robotic mitral valve surgery

Frontiers in Cardiovascular Medicine

Totally endoscopic robotic mitral valve repair is the least invasive surgical therapy for mitral valve disease. Robotic mitral valve surgery demonstrates faster recovery with shorter hospital stays, less morbidity, and equivalent mortality and mid-term durability compared to sternotomy. In this review, we will explore the advantages and disadvantages of robotic mitral valve surgery and consider important technical details of both operative set-up and mitral valve repair techniques.

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Elevated Lp(a) Levels Linked to Cardiovascular Event Risk, Regardless of ASCVD History

HCPLive

The latest analysis of the Mass General Brigham Lp(a) Registry highlights Lp(a)'s independent association with cardiovascular events, with these associations apparent in patients regardless of baseline cardiovascular history.

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Comparison of Transcatheter Edge-to-Edge Mitral Valve Repair for Primary Mitral Regurgitation Outcomes to Hospital Volumes of Surgical Mitral Valve Repair

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Transcatheter edge-to-edge mitral valve (MV) repair (TEER) is an effective treatment for patients with primary mitral regurgitation at prohibitive risk for surgical MV repair (MVr). High-volume MVr centers and high-volume TEER centers have better outcomes than low-volume centers, respectively.

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Climate Change and Stroke: A Topical Narrative Review

Stroke Journal

Stroke, Ahead of Print. The impacts of accumulating atmospheric greenhouse gases on the earth’s climate are now well established. As a result, there have been increases in ambient temperatures and resultant higher frequency and duration of temperature extremes and other extreme weather events, which have been linked to a wide range of adverse health outcomes.

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Objective sleep characteristics and hypertension: a community-based cohort study

Frontiers in Cardiovascular Medicine

Objective The link between sleep quality and hypertension risk is well-established. However, research on the specific dose-relationship between objective sleep characteristics and hypertension incidence remains limited. This study aims to explore the dose-relationship association between objective sleep characteristics and hypertension incidence. Methods A community-based prospective cohort study design was employed using data from the Sleep Heart Health Study (SHHS).

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Transfusion Threshold in Myocardial Infarction: MINT Trial

American College of Cardiology

Hemoglobin (Hb) threshold for red cell transfusion in myocardial infarction (MI) with anemia has been a matter of debate. Previous randomized trials have not consistently shown a benefit of liberal transfusion strategy.

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Case Report: A case of Kounis syndrome induced by iodine contrast agent during coronary angiography

Frontiers in Cardiovascular Medicine

Kounis Syndrome (KS), a seldom-seen adverse reaction to iodine contrast agents, has an incidence that remains unclear. At present, there are no unified guidelines for managing KS either nationally or internationally. Ioversol, a new triiodinated hypotonic nonionic contrast agent, is commonly used in cardiovascular Computed Tomography (CT) and vascular imaging for diagnostic purposes.

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Dermatologists, Patients Divided on Augmented Intelligence for Melanoma Screening

HCPLive

This analysis explored views on safety, general levels of trust, and preferences on examination methods, with the goal being a greater awareness of opinion on AI incorporation.

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Severe COVID-19 and its cardiopulmonary effects 6 and 18 months after hospital discharge

Frontiers in Cardiovascular Medicine

Introduction SARS-CoV-2 infection affects the cardiopulmonary system in the acute as well as long-term phase. The aim of the present study was to comprehensively assess symptoms and possible long-term impairments 6 and 18 months after hospitalization for severe COVID-19 infection. Methods This prospective registry included patients with PCR-confirmed COVID-19 infection requiring hospitalization.

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ACC CardiaCast’s PulseCheck: Introduction to Structural Heart Disease

American College of Cardiology

In these panel discussions, host Andrea Price MS, AACC brings together Kim Guibone, DNP, ACNP-BC, FACC, Susan Schnell, ACNP and Bailey Estes MSN, AGNP-C, to explore best practices related to structural heart disease.

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Effects of different rehabilitation modality on cardiopulmonary function in patients with acute coronary syndrome after revascularization

Frontiers in Cardiovascular Medicine

Objective To investigate the effects of different rehabilitation modalities on cardiopulmonary function in patients with acute coronary syndrome after revascularization. Methods Two randomized controlled trials were conducted. All patients were stable for more than 48 h and less than 1 week after revascularization for acute coronary syndrome and were randomly assigned to Group A (home-based rehabilitation group) or Group B (center guided home-based rehabilitation group).

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The Benefits of Hands-On Medical Training: Why Online Certification Isn’t Enough

ADN Center of Excellence

Staying up to date on the newest breakthroughs in medicine is not only advantageous, but also necessary. While online certification courses are convenient, they can lack the depth of knowledge and practical experience that hands-on training offers. In this post, we'll look at why hands-on medical training is so important and should be a part of every doctor's career growth.

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Computed tomographic angiography measures of coronary plaque in clinical trials: opportunities and considerations to accelerate drug translation

Frontiers in Cardiovascular Medicine

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. There are numerous effective medications for modifying CAD but new pharmacologic therapies require increasingly large and expensive cardiovascular outcome trials to assess their potential impact on MACE and to ob

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Ticagrelor vs Clopidogrel in Stabilized Patients With Acute Myocardial Infarction

American College of Cardiology

The goal of the TALOS-AMI trial was to assess whether de-escalating dual antiplatelet therapy (DAPT) with clopidogrel rather than ticagrelor 1 month after percutaneous coronary intervention (PCI) for an acute myocardial infarction (AMI) would be a noninferior strategy.

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Columbia launches $50M pediatric heart center

Becker's Hospital Review - Cardiology

New York City-based Columbia University Vagelos College of Physicians and Surgeons launched its $50 million pediatric cardiovascular innovation center.

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FDA Approves Clobetasol Propionate Eye Drop for Post-Ocular Surgery Pain

HCPLive

Clobetasol propionate ophthalmic suspension 0.05% for post-ocular surgery pain marks the first new steroid in the ophthalmic market in over 15 years.

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Study on the rationality of small diameter metallic airway stent in treatment of tracheal stenosis in injured rabbits

Journal of Cardiothoracic Surgery

To observe the occurrence of related complications after self-expandable metallic (SEM) airway stents implantation with different diameters at different time points, and to provide theoretical basis for the op.

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A Conversation on Supplements and Lifestyle Strategies for Healthspan and Lifespan with Dr. Brad Stanfield

Physiologically Speaking

Greetings! Today, I’m (re)releasing a conversation I had with Dr. Brad Stanfield. This was initially an episode of my podcast, but now this is the only place you’ll find it. We talk about what “longevity” means, research on diet, supplements, and exercise for longevity, and controversies in the longevity field. See below for Dr.

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Hepatology Month in Review: February 2024

HCPLive

Our February 2024 month in review highlights some of our top hepatology content from the past few weeks, including pipeline updates, phase 2/3 trial data, and new research in liver diseases.

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Below-the-Knee Endovascular Revascularization: Key Points

American College of Cardiology

The following are key points to remember from a position statement on below-the-knee (BTK) endovascular revascularization.

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Cardiology Month in Review: February 2024

HCPLive

Our February 2024 cardiology month in review, recaps FDA news, top data from International Stroke Conference and major journals, and perspectives form a bevy of key opinion leaders in the field on hot topics and news from across the spectrum of cardiovascular medicine.

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Safety, Tolerability, and Efficacy of Rapid Optimization, Helped by NT-proBNP Testing of Heart Failure Therapies

American College of Cardiology

The goal of the STRONG-HF trial was to compare a high-intensity intervention involving up-titration of heart failure (HF) treatments versus usual care among participants with admission for acute HF.

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Serum Albumin Exhibits Nonlinear Relationship with Diabetic Retinopathy

HCPLive

A secondary analysis of cross-sectional data found that serum albumin levels negatively correlated with the prevalence of diabetic retinopathy.

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A Practical Guide to Understanding and Treating Peripheral Artery Disease

Journal of Cardiovascular Pharmacology

Peripheral arterial disease (PAD) is the third leading cause of atherosclerotic morbidity after coronary heart disease and stroke yet is widely underdiagnosed and undertreated. Treatment of risk factors such as diabetes and cigarette smoking can benefit patients with PAD. Patients should have adequate blood pressure and lipid control to decrease clinical manifestations and symptoms of PAD.

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Denosumab Biosimilar CT-P41 Demonstrates Pharmacokinetic Equivalence

HCPLive

The primary endpoint was achieved, with biosimilar CT-P41 demonstrating comparable pharmacokinetics.

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First-in-man trial of ?3-adrenoceptor agonist treatment in chronic heart failure – impact on diastolic function.

Journal of Cardiovascular Pharmacology

Diastolic dysfunction (DD) in heart failure (HF) is associated with increased myocardial cytosolic calcium, and calcium-efflux via the sodium-calcium-exchanger depends on the sodium gradient. Beta-3-adrenoceptor (β3-AR) agonists lower cytosolic sodium and have reversed organ congestion. Accordingly, β3-AR agonists might improve diastolic function, which we aimed to assess.