Dr. Smith's ECG Blog
DECEMBER 7, 2023
Written by Willy Frick The OMI paradigm has taught me that any diagnosis of NSTEMI is cause for immediate evaluation. "A patient just arrived as a transfer for NSTEMI." I quickly reviewed the patient’s records and saw that she was a 53 year old woman with a history of BMI 40, but no other identifiable risk factors for coronary artery disease. Her first hsTnI at the referring facility was undetectable.
Open Heart
DECEMBER 7, 2023
Objective This study aimed to investigate the association between heart failure (HF) severity measured based on brain natriuretic peptide (BNP) levels and future bleeding events after percutaneous coronary intervention (PCI). Background The Academic Research Consortium for High Bleeding Risk presents a bleeding risk assessment for antithrombotic therapy in patients after PCI.
Med Page Today
DECEMBER 7, 2023
(MedPage Today) -- Taking glucagon-like peptide 1 (GLP-1) receptor agonists for type 2 diabetes was associated with greater reductions in colorectal cancer (CRC) risk compared with several other diabetes medication classes, a nationwide cohort.
Open Heart
DECEMBER 7, 2023
Objectives Prognostic impact of lung ultrasound-derived B-lines (LUS-BL) in heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) patients remains elusive. We evaluated the correlation between LUS-BL and prognosis in HFmrEF patients. Methods This is a subgroup analysis based on our previously published retrospective study with 1691 HFmrEF patients.
Circulation
DECEMBER 7, 2023
Circulation, Ahead of Print. Resistance training not only can improve or maintain muscle mass and strength, but also has favorable physiological and clinical effects on cardiovascular disease and risk factors. This scientific statement is an update of the previous (2007) American Heart Association scientific statement regarding resistance training and cardiovascular disease.
Becker's Hospital Review - Cardiology
DECEMBER 7, 2023
A Weill Cornell Medicine and NewYork-Presbyterian study found removing race information from cardiovascular risk calculators did not affect patients' risk scores.
Circulation
DECEMBER 7, 2023
Circulation, Ahead of Print. BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heart failure (HF) and cardiovascular death in patients with HF irrespective of left ventricular ejection fraction. It is important to determine whether therapies for HF improve symptoms and functional capacity.METHODS:The DETERMINE (Dapagliflozin Effect on Exercise Capacity Using a 6-Minute Walk Test in Patients With Heart Failure) double-blind, placebo-controlled, multicenter trials a
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ADN Center of Excellence
DECEMBER 7, 2023
The relentless dedication of physicians often comes at the expense of their own well-being. Physician burnout, a pressing concern, stems from the demanding schedules, immense responsibility, and emotional strain inherent in the medical profession. This guide aims to shed light on tailored mental health interventions designed explicitly for physicians, offering strategies to combat burnout, alleviate stress, and nurture overall well-being.
Open Heart
DECEMBER 7, 2023
Background Sepsis is associated with an increased risk of adverse cardiovascular events in a magnitude comparable to other major cardiovascular risk factors. Sepsis is one of the most common reasons for intensive care admission and survivors often have significant functional limitations following discharge. However, it is not clear to what extent chronic cardiovascular dysfunction might mediate these functional impairments, or how we might screen and manage these patients at risk of chronic card
ADN Center of Excellence
DECEMBER 7, 2023
The relentless dedication of physicians often comes at the expense of their own well-being. Physician burnout, a pressing concern, stems from the demanding schedules, immense responsibility, and emotional strain inherent in the medical profession. This guide aims to shed light on tailored mental health interventions designed explicitly for physicians, offering strategies to combat burnout, alleviate stress, and nurture overall well-being.
Open Heart
DECEMBER 7, 2023
Background Cryoballoon ablation, especially Arctic Front Advance Pro (AFA-Pro) (Medtronic, Minneapolis, Minnesota, USA), has been widely recognised as a standard approach to atrial fibrillation (AF). Recently, Boston Scientific has released a novel cryoballoon system (POLARx). Despite comparable acute clinical outcomes of these two cryoballoons, the recent study reported a higher complication rate, especially for phrenic nerve palsy, with POLARx.
Nature Reviews - Cardiology
DECEMBER 7, 2023
Nature Reviews Cardiology, Published online: 08 December 2023; doi:10.1038/s41569-023-00980-1 The use of intravenous levothyroxine does not increase the likelihood of hearts being transplanted from haemodynamically unstable, brain-dead potential donors, suggesting that current practice recommendations should be revised.
Open Heart
DECEMBER 7, 2023
Smoking cessation is the most effective intervention to reduce mortality in patients with established atherosclerotic cardiovascular disease (ASCVD), with ‘e-cigarettes’ becoming an increasingly used intervention to achieve smoking cessation. The current review aims to summarise the current evidence base for their efficacy and safety in the ASCVD cohort.
Hypertension Journal
DECEMBER 7, 2023
Hypertension, Ahead of Print. ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions. ETs exert their effects through ETAand ETBreceptors, which can be blocked by selective receptor antagonists.
Open Heart
DECEMBER 7, 2023
Introduction Cardiogenic shock (CS) complicates 5%–15% of cases of acute myocardial infarction (AMI) with inpatient mortality greater than 40%. The implementation of standardised protocols may improve clinical outcomes in patients with AMI-CS. Methods and analysis The Durango model is a prospective single-centre registry designed to enable early identification of patients with STEMI-CS to facilitate primary reperfusion therapy with a shock team management algorithm in a rural level II hear
Cardiovascular Diabetology
DECEMBER 7, 2023
The assessment of obesity-related health risks has traditionally relied on the Body Mass Index and waist circumference, but their limitations have propelled the need for a more comprehensive approach. The diff.
Journal of Cardiovascular Pharmacology
DECEMBER 7, 2023
An abstract is unavailable. This article is available as a PDF only.
Open Heart
DECEMBER 7, 2023
Background/objectives Heart failure (HF) is a growing clinical and economic burden for patients and health systems. The COVID-19 pandemic has led to avoidance and delay in care, resulting in increased morbidity and mortality among many patients with HF. The increasing burden of HF during the COVID-19 pandemic led us to evaluate the quality and safety of the Hospital at Home (HAH) for patients presenting to their community providers or emergency department (ED) with symptoms of acute on chronic H
Science Daily - Heart Disease
DECEMBER 7, 2023
Researchers have laid the foundation for the development of a gene therapy for the genetic heart disease arrhythmogenic cardiomyopathy (ACM). Their approach, based on replacement of the PKP2 gene, led to significant structural and functional improvements in laboratory models of the disease.
Nature Reviews - Cardiology
DECEMBER 7, 2023
Nature Reviews Cardiology, Published online: 08 December 2023; doi:10.1038/s41569-023-00981-0 In aged mice, but not young mice, with atherosclerosis, depletion of CD8+ T cells significantly reduces atherosclerotic lesion size and necrotic core area.
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
Abstract Introduction Left bundle branch pacing has gained significant momentum in the last few years. The procedure involves deploying the lead deep inside the interventricular septum through left subclavian vein. We aimed at analyzing the feasibility, efficacy and long-term outcome of left bundle branch pacing (LBBP) using lumen-less lead through the right subclavian vein.
Journal of Cardiothoracic Surgery
DECEMBER 7, 2023
Descending necrotizing mediastinitis (DNM) is a type of acute mediastinitis that is rarely reported but is regarded as a fatal disease despite improvements in technological methods and antibiotic therapies. We.
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
Abstract Whether a pacemaker can sense concealed ventricular extrasystoles still remains debatable since its occurrence was first proposed in 1972. It must remain a diagnosis of exclusion if it really exists. Isoelectric complexes and all the causes of oversensing especially discrete false signals generated by a defective pacemaker lead must be excluded before concealed ventricular extrasystoles can be postulated.
Journal of Cardiothoracic Surgery
DECEMBER 7, 2023
Lung transplantation is the only life-saving treatment for lung diseases that do not respond to medical treatment. Heart-lung harvesting requires a careful procedure to protect an adequate donor left atrial cu.
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
Abstract Introduction Catheter ablation of atrial fibrillation (AF) has emerged as the most effective therapy. However, rare anatomical abnormalities such as situs inversus totalis, dextrocardia, or interrupted inferior vena cava can make ablation challenging. Methods and Results We report a case of a 55-year-old woman with situs inversus totalis, dextrocardia, surgical atrial septal defect repair, left-sided dual chamber pacemaker in place, and symptomatic recurrent persistent AF who underwent
Journal of Cardiothoracic Surgery
DECEMBER 7, 2023
Frailty develops as a result of age-related decline in many physiological systems and is associated with increased vulnerability to adverse outcomes following thoracic surgery. We prospectively tested our hypo.
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
Abstract Introduction Acquired Wolff–Parkinson–White (WPW) syndrome can occur after congenital heart disease (CHD) surgery. Methods and Results A 27-year-old male with Ebstein's anomaly and manifest WPW syndrome received catheter ablation twice. The first electrophysiology study (EPS) induced orthodromic atrioventricular reentrant tachycardia and successfully eliminated the posteroseptal accessory pathway (AP).
European Journal of Heart Failure
DECEMBER 7, 2023
Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Patients with increasing obesity have higher right- and left-sided ventricular filling pressures, increased cardiac output (CO), lower 6-min walk distance (6MWD) and worse Kansas City Cardiomyopathy Questionnaire (KCCQ) scores.
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
This retrospective data reports comparison of a minimal postprocedure anti-thrombotic strategy versus standard care anti-thrombotic strategy in a high bleeding risk population undergoing left atrial appendage occlusion (LAAO). It reports that there was significant increase in the combined endpoint of bleeding, device-related thrombus, and stroke after 90 days in the standard anti-thrombotic group.
European Journal of Heart Failure
DECEMBER 7, 2023
ABSTRACT Background Left atrial (LA) myopathy is increasingly recognized as an important phenotypic trait in heart failure (HF) with preserved ejection fraction (HFpEF). Right atrial (RA) remodeling and dysfunction also develop in HFpEF, but little data is available regarding the clinical characteristics and pathophysiology among patients with isolated LA, RA, or biatrial myopathy.
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
This economic model demonstrates that the treatment of selected patients with leadless cardiac resynchronization therapy is likely to be cost-effective. The factor most likely to impact overall cost-effectiveness is system battery longevity. Advancements in battery technology will be beneficial in improving the treatment's economic profile. Abstract Background The Wireless Stimulation Endocardially for CRT (WiSE-CRT) system is a novel technology used to treat patients with dyssynchronous heart f
European Journal of Heart Failure
DECEMBER 7, 2023
Abstract Background and Aims Patients who experience hospitalizations due to heart failure (HF) face a significant risk of readmission and mortality. Our objective was to evaluate whether the risk of hospitalization and mortality following discharge from HF hospitalization differed based on adherence to the outpatient follow-up (FU) protocol comprising an appointment with a general practitioner (GP) within 15 days, a cardiologist within 2 months or both (termed combined FU).
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
The study investigated the outcomes of 400 patients with PAF who underwent an index ablation procedure, while also identifying the predictors associated with recurrence and progression to PersAF. CI, confidence interval; OR, odd ratio; PAF, paroxysmal atrial fibrillation; PersAF, persistent atrial fibrillation; SR, sinus rhythm. Abstract Introduction Despite undergoing an index ablation, some patients progress from paroxysmal atrial fibrillation (PAF) to persistent AF (PersAF), and the mechanism
Circulation: Genomic and Precision Medicine
DECEMBER 7, 2023
Circulation: Genomic and Precision Medicine, Ahead of Print. BACKGROUND:Few clinical data are available onNEXNmutation carriers, and the gene’s involvement in cardiomyopathies or sudden death has not been fully established. Our objectives were to assess the prevalence of putative pathogenic variants inNEXNand to describe the phenotype and prognosis of patients carrying the variants.METHODS:DNA samples from consecutive patients with cardiomyopathy or sudden cardiac death/sudden infant death syndr
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
Abstract Introduction Atrial tachyarrhythmia recurrence during the blanking period (early ATA) after pulmonary vein isolation (PVI) is associated with an increased risk of later recurrence, but its relationship with pulmonary vein reconduction (PVR) is poorly understood. The objective of the present study was to evaluate the relationship between early ATA and PVR.
Cardiovascular Diabetology
DECEMBER 7, 2023
The effects of diabetes on the cardiac and aortic structure and function remain unclear. Detecting and intervening these variations early is crucial for the prevention and management of complications. Cardiova.
Journal of Cardiovascular Electrophysiology
DECEMBER 7, 2023
Abstract Introduction The prospective, nonrandomized, multicenter Q-FFICIENCY study demonstrated the safety and 12-month efficacy of paroxysmal atrial fibrillation (AF) ablation with the novel QDOT MICRO temperature-controlled, contact force-sensing, radiofrequency (RF) catheter. Participants underwent pulmonary vein isolation with very high-power short-duration (vHPSD) mode (90 W, ≤4 s) alone or combined with conventional-power temperature-controlled (CPTC) mode (25–50 W).
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