Tue.Jan 09, 2024

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More Evidence Linking ADT for Prostate Cancer to Adverse Neurocognitive Effects

Med Page Today

(MedPage Today) -- Men treated with androgen deprivation therapy (ADT) for prostate cancer had a significantly higher risk of dementia and other neurocognitive disorders, according to a meta-analysis of more than 2.5 million patients. The magnitude.

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Cleerly Launches Cleerly ISCHEMIA Solution for Heart Disease Analysis

DAIC

milla1cf Tue, 01/09/2024 - 11:32 January 9, 2024 — Cleerly , the company working to create a new standard of care for the diagnosis of heart disease, announced the launch of Cleerly ISCHEMIA , which recently received U.S. Food and Drug Administration (FDA) 510(k) medical device clearance. Cleerly ISCHEMIA analysis software is an automated machine learning-based decision support tool, intended as a diagnostic aid for patients undergoing coronary computed tomography angiography (CCTA) analysis u

Ischemia 119
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Key Takeaways From The Newly Updated Guidelines On AD Management

HCPLive

Advanced practice providers in dermatology discuss the key updates on the newly released guidelines on the management of AD and what this means for clinical practice.

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Three researchers awarded $1 million each to study new heart disease treatments, causes

American Heart News - Heart News

DALLAS, Jan. 9, 2024 — A physician-scientist from Massachusetts researching whether chemicals naturally occurring in foods could help treat heart disease, a genetics expert from Pennsylvania exploring the molecular mechanisms of lipid metabolism and.

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Clinical Research Shows AI-enabled Digital Stethoscope can Detect Pregnancy-related Heart Disease

DAIC

Dr. Demilade Adedinsewo milla1cf Tue, 01/09/2024 - 11:41 January 9, 2024 — New research from Mayo Clinic suggests that artificial intelligence (AI) could improve the diagnosis of peripartum cardiomyopathy , a potentially life-threatening and treatable condition that weakens the heart muscle of women during pregnancy or in the months after giving birth.

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Early Menopause Significantly Increases Risk of Developing RA

HCPLive

Entering menopause prior to age 45 was associated with a 46% increased risk of developing RA compared with those who began menopause at ≥50 years.

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Injectable hydrogel electrodes open door to a novel painless treatment regimen for arrhythmia

Science Daily - Heart Disease

Biomedical engineers set the foundation for a ground-breaking treatment regimen for treating ventricular arrhythmia. The study demonstrates the design and feasibility of a new hydrogel-based pacing modality. The scientific advance is significant considering pain management is highly relevant to overall wellness for patients with heart, lung, and blood diseases.

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Diabetes Dialogue: Updates in Management of Hypercortisolism in Type 2 Diabetes

HCPLive

In this episode, hosts sit down with Ralph DeFronzo, MD, for a discussion on how advances in management have transformed the diagnosis and management of hypercortisolism among people with type 2 diabetes.

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First-in-the-field application of non-contrast optical coherence tomography for coronary artery disease

Medical Xpress - Cardiology

A research team has demonstrated the clinical feasibility and safety of non-contrast optical coherence tomography (OCT) for patients with coronary artery disease.

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Atrial Fibrillation Ablation in Congenital Heart Disease: Therapeutic Challenges and Future Perspectives

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. The increasing prevalence of atrial fibrillation (AF) in adults with congenital heart disease raises significant questions regarding its management. The unique underlying anatomic and physiological background further adds to the difficulty in eliminating the AF burden in these patients. Herein, we provide an overview of the current knowledge on the pathophysiology and risk factors for AF in adult congenital heart disease, with a special

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Researchers prevent myocardial ischemia/reperfusion injury with oral fullerenes

Medical Xpress - Cardiology

Myocardial infarction (MI) is a deadly disease. It can cause serious myocardial ischemic necrosis due to coronary occlusion. The most effective treatment for MI in clinic is reperfusion, e.g., interventional or thrombolytic therapy. However, reperfusion itself could induce more severe injury, called myocardial ischemia/reperfusion injury (MI/RI).

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Temporal Trends in Substance Use and Cardiovascular Disease–Related Mortality in the United States

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundThere are limited data on substance use (SU) and cardiovascular disease (CVD)–related mortality trends in the United States. We aimed to evaluate SU+CVD–related deaths in the United States using the Centers for Disease Control and Prevention Wide‐Ranging, Online Data for Epidemiologic Research database.Methods and ResultsThe Multiple Cause‐of‐Death Public Use record death certificates were used to identify deaths related to bot

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Low fitness in youth associated with higher risk of cardiometabolic diseases in middle age: Study

Medical Xpress - Cardiology

An extended follow-up study conducted at the University of Jyväskylä and now published in Scandinavian Journal of Medicine & Science in Sports shows that low cardiorespiratory fitness in adolescence is associated with higher risk for cardiovascular and metabolic diseases in middle age. The study provides real-life evidence for the far-reaching consequences of deteriorating fitness in youth.

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Rethinking False Positive Exercise ECG Tests in ANOCA

American College of Cardiology

What is the specificity of exercise electrocardiogram stress testing (EST) in detecting ischemic substrate in patients with angina and nonobstructive coronary arteries (ANOCA)?

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Rheumatoid Arthritis Quiz: RA and Employment

HCPLive

Investigators evaluated employment rates at various disease stages of rheumatoid arthritis (RA) to uncover the key predictors influencing work among this patient population. Test your knowledge of employment and RA with this quiz.

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Direct Thrombin Inhibitor Shows Benefit for Progressing Stroke

Med Page Today

(MedPage Today) -- Argatroban could revive the practice of acute anticoagulation for reducing disability after stroke, based on the EASE trial from China. In patients with acute ischemic stroke and early neurological deterioration, urgent application.

Stroke 64
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Increases in HCV-Related Liver Cancer Incidence, Mortality Suggest Rising Global Health Burden

HCPLive

Investigators examined data from the Global Burden of Disease, Injuries, and Risk Factors study 2019 to describe the global, regional, and national burden of liver cancer due to hepatitis C since 1990.

Cancer 64
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Non-alcoholic fatty liver disease increases the risk of cardiovascular disease in young adults and children: a systematic review and meta-analysis of cohort studies

Frontiers in Cardiovascular Medicine

Background and aims It is uncertain if there is a link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) in young adults and children. To evaluate the potential link between these two conditions, we conducted a systematic review and meta-analysis of cohort studies. Methods A comprehensive search was conducted in PubMed, Web of Science and Embase in order to locate all relevant cohort studies published until August 2023.

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Active Vitiligo Considered a Risk Factor for Vitiligo Progression Following COVID-19 Vaccination

HCPLive

These data indicate the necessity of further research to clarify any associations between COVID-19 infection, the virus’s associated vaccines, and progression of vitiligo.

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Constructing a competitive endogenous RNA network of EndMT-related atherosclerosis through weighted gene co-expression network analysis

Frontiers in Cardiovascular Medicine

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development. However, the specific regulatory mechanisms by which EndMT contributes to atherosclerosis remain unclear and require further investigation.

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Strong-HF Analysis Supports Quick HF Medication Optimization

CardiacWire

Secondary analysis of STRONG-HF trial data highlighted the benefits of quickly bringing heart failure patients up to full guideline-directed medical therapy (GDMT), showing that rapid uptitration to optimal doses of at least three classes of guideline-directed meds reduces readmissions and mortality, while improving quality of life. The analysis included 515 acute HF patients who weren’t taking optimal GDMT doses before discharge, and were randomly assigned to be uptitrated within 2 weeks. 39 pa

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Comparison between transthoracic echocardiography and transoesophageal echocardiography in the diagnosis of acute aortic dissection from an emergency perspective. A systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Background Acute aortic dissection (AAD) is a life-threatening medical condition with high early fatality. Therefore, a prompt and precise diagnosis, which can be achieved through invasive and non-invasive techniques is vital. Echocardiography, unlike MRI and CT, is accessible in emergency units and bedside-compatible. The recommended echocardiographic techniques for AAD are transthoracic and transoesophageal echocardiography (TTE and TOE).

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Expert Panel Supports Intravascular Ultrasound Use in Peripheral Interventions

HCPLive

A multidisciplinary panel assembled by the Society for Cardiovascular Angiography & Interventions examined and supported the role of intravascular ultrasounds in lower extremity revascularization procedures.

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Anticoagulation Management of Distal Deep Vein Thrombosis in Cancer Patients

American College of Cardiology

Active cancer is a strong risk factor for venous thromboembolism (VTE) events and recurrent events following discontinuation of anticoagulation therapy, and cancer patients are also at a heightened risk for bleeding complications related to anticoagulation treatment.

Cancer 65
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New Phase 3 Data Reinforces Safety, Efficacy of Linaclotide for Pediatric Functional Constipation

HCPLive

The new data was published in The Lancet Gastroenterology & Hepatology and highlighted additional efficacy endpoints from the study used to support linaclotide’s FDA approval in 2023.

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Study: A novel cell-penetrating peptide exerts therapeutic effects against ischemic stroke

Medical Xpress - Cardiology

Stroke is a major public health concern worldwide. The lack of effective therapies heightens the need for new therapeutic agents.

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Disrupted Sleep in 30s and 40s Linked to Cognitive Problems a Decade Later

HCPLive

Participants with poor sleep quality were 85% more likely to have poor cognitive performance on the Stroop test than participants with good sleep quality, a new study found.

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Evaluation of atherosclerosis as a risk factor in COPD patients by measuring the carotid intima-media thickness

Cardiovascular Ultrasound

This study aimed to evaluate atherosclerosis as comorbidity by measuring the carotid (bulb and common carotid artery) Carotid intima-media thickness in COPD-diagnosed patients and to evaluate the relationship.

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Heart: An Owners Guide

Dr. Paddy Barrett

So many of you have asked when I was going to write a book. Well. Here it is. Heart: An Owners Guide. This book is a tactical guide for anyone looking to: Better understand what heart disease is. How to assess their risk of heart disease. How to reduce their risk of heart disease. This book was born out of my frustration with not being able to spend more time with patients explaining the above concepts.

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BP Tracking Undergarment; COPD Exacerbations & HF Events; Hemolysis After PFA

Med Page Today

(MedPage Today) -- The FDA cleared the algorithm for continuous blood pressure monitoring for the SimpleSense wearable garment, Nanowear announced. (FierceBiotech) Occlutech announced FDA approval of its ASD Occluder for transcatheter closure.

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Home-Use tDCS is Not an Effective Treatment for Major Depressive Disorder

HCPLive

A new study does not support the home-use tDCS since the findings show the home-use tDCS combined with either a digital psychological intervention or digital placebo was not superior to the sham.

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Study reveals cardiac arrest figures in England: Just 1 in 12 people survive and leave hospital

Medical Xpress - Cardiology

A national research database has revealed stark figures for cardiac arrests in England for 2022. Survival rates remain low, with around 8% patients surviving to 30 days after a cardiac arrest.

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Grass Allergen Levels Better Measured Through Monitoring Patients’ Hay Fever Symptoms

HCPLive

This research had been conducted to look into prior studies linking daily pollen counts to respiratory allergic health outcomes.

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ACCEL Lite: Top Takeaways from 2023: General Cardiology with Andrew Kates, MD, FACC

American College of Cardiology

In this interview, Andrew Kates, MD, FACC, and Alison L. Bailey, MD, FACC, discuss the top takeaways in general cardiology from 2023 including ARAMIS, ORBITA-2, and STOP-CA trials.

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Intravenous Iron Reduces CV Death, Hospitalizations in Iron-Deficient Heart Failure

HCPLive

A meta-analysis of 14 randomized trials suggests a beneficial effect of intravenous iron on cardiovascular mortality and heart failure readmissions.

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Strategies to maximize lead tensile strength during extraction in three families of pacing leads.

HeartRhythm

Traction force that can be applied to an extraction rail is based on lead tensile strength, a product of its construction. A strong rail allows safe advancement of the extraction sheath. This study expands previous work providing strategies to optimize INGEVITY rail strength.

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Mechanism of Action and Safety Data on Systemic Therapies for AD

HCPLive

Andrea Nguyen, PA reviews the mechanism of action of the biologics available for AD as well as the safety data on these systemic therapies.

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