Wed.Mar 27, 2024

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ECG Blog #422 — Was Clubbing an ECG Hint?

Ken Grauer, MD

I was sent the ECG in Figure-1 — with the following history: The patient is a young man in his early 20s — who presents to the ED ( E mergency D epartment ) because of SOB ( S hortness O f B reath ) that had been ongoing for several hours. No chest pain. He reports a number of similar previous episodes over the past few years ( although apparently has not been formerly evaluated for this ).

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Sotatercept's FDA Approval a New Chapter for Pulmonary Arterial Hypertension

Med Page Today

(MedPage Today) -- The FDA approved sotatercept (Winrevair) for treating pulmonary arterial hypertension (PAH) in adults, Merck announced on Tuesday. A novel activin signaling inhibitor, sotatercept is indicated to increase exercise capacity.

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Google Street View reveals how built environment correlates with risk of cardiovascular disease

Medical Xpress - Cardiology

Researchers have used Google Street View to study hundreds of elements of the built environment, including buildings, green spaces, pavements and roads, and how these elements relate to each other and influence coronary artery disease in people living in these neighborhoods.

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Social, environmental factors may raise risk of developing heart disease and stroke

American Heart News - Heart News

Research Highlights: People living in neighborhoods with more environmental adversities, including pollution, toxic sites, high traffic and few parks, had higher rates of cardiovascular disease and cardiovascular disease risk factors. This association.

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Study suggests earlier puberty onset may affect adult cardiometabolic health

Medical Xpress - Cardiology

Experiencing puberty earlier, compared to same-age peers, may be one of the mechanisms through which childhood risk factors influence adult cardiometabolic health issues, according to a study published March 27, 2024 in the open-access journal PLOS ONE by Maria Bleil from the University of Washington and colleagues.

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Need 10,000 Daily Steps to Prevent Obesity? It May Depend on Genetics

Med Page Today

(MedPage Today) -- The daily step count needed to reduce the risk of obesity may be largely dependent on genetics, a retrospective cohort study indicated. Among U.S. adults without obesity in the All of Us Research Program, incidence of obesity.

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Elixir Medical Receives FDA Breakthrough Device Designation for DynamX BTK System for Below-The-Knee Arterial Disease

DAIC

Elixir Medical has announced it has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration (FDA) for its DynamX BTK System, a novel, adaptive implant for use in the treatment of narrowed or blocked vessels below-the-knee (BTK) in patients with chronic limb-threatening ischemia (CLTI). The company reports this broadens the use of the novel bioadaptor platform technology beyond the treatment of coronary artery disease.

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HeartFlow Initiates DECIDE Registry to Evaluate Utility of HeartFlow AI-Enabled Plaque Analysis for Patients with Suspected Coronary Artery Disease

DAIC

mtaschetta-millane Wed, 03/27/2024 - 08:08 March 27 2024 — HeartFlow, Inc. , a leader in AI-driven healthcare technology, announced the launch of the DECIDE Registry, the largest prospective registry of its kind, with the first site initiated, Cone Health Care. The registry will collect multi-site, real-world information on how the Plaque Analysis product provides enhanced patient insights, empowering physicians and helping to inform their medical management decisions for patients with suspecte

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ADHD stimulants may increase risk of heart damage in young adults

Medical Xpress - Cardiology

Young adults who were prescribed stimulant medications for attention-deficit/hyperactivity disorder (ADHD) were significantly more likely to develop cardiomyopathy (weakened heart muscle) compared with those who were not prescribed stimulants, according to a study presented at the American College of Cardiology's Annual Scientific Session.

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Novel CAR-T Cell Therapy Trial for Lupus Launched by Atlantic Health System

HCPLive

Mohamed Cherry, MD, and Neil Kramer, MD, shed light on a phase 1 trial using CAR-T cell therapy for SLE and its potential implications for lupus treatment.

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Study finds link between getting too little sleep and high blood pressure

Medical Xpress - Cardiology

Sleeping fewer than seven hours is associated with a higher risk of developing high blood pressure over time, according to a study presented at the American College of Cardiology's Annual Scientific Session.

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Getting too little sleep linked to high blood pressure

Science Daily - Heart Disease

Sleeping fewer than seven hours is associated with a higher risk of developing high blood pressure over time, according to a new study.

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Could AI play a role in locating damage to the brain after stroke?

Science Daily - Stroke

Artificial intelligence (AI) may serve as a future tool for neurologists to help locate where in the brain a stroke occurred. In a new study, AI processed text from health histories and neurologic examinations to locate lesions in the brain. The study looked specifically at the large language model called generative pre-trained transformer 4 (GPT-4).

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ADHD stimulants may increase risk of heart damage in young adults, study finds

Science Daily - Heart Disease

Young adults who were prescribed stimulant medications for attention-deficit/hyperactivity disorder (ADHD) were significantly more likely to develop cardiomyopathy (weakened heart muscle) compared with those who were not prescribed stimulants, in a new study.

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Allogenic HSCT May Improve Sickle Cell Disease-Related Organ Dysfunction

HCPLive

A new analysis summarized evidence on the effects of allogeneic HSCT on SCD-related organ dysfunction in pediatric and adult patients with SCD.

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Secrets of the naked mole-rat: new study reveals how their unique metabolism protects them from heart attacks

Science Daily - Heart Disease

This unusual, subterranean mammal with extreme longevity shows genetic adaptations to low oxygen environments which could offer opportunities for advancing other areas of physiological and medical research in humans, including the development of novel therapeutic approaches.

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Monitoring your own blood pressure can save money—and possibly your life

Medical Xpress - Cardiology

A new study from the Texas A&M University School of Public Health shows that when patients regularly monitor their blood pressure outside of the clinic, they tend to have better quality of life and lower health care expenses.

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Social, environmental factors may raise risk of developing heart disease and stroke

Science Daily - Heart Disease

Neighborhoods with more adversity have up to twice the increased risk of heart disease and stroke, according to a new study.

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Study finds your genes may raise your heart attack risk during high-stress times

Medical Xpress - Cardiology

People with specific genetic traits and those who have anxiety or depression have a significantly higher heart attack risk during periods of social or political stress than at other times, according to a new study being presented at the American College of Cardiology's Annual Scientific Session. Researchers said the findings suggest opportunities to identify those at elevated risk and perhaps even prevent cardiac events.

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Malignant atrophic papulosis treated with eculizumab and hirudin: a fatal case report and literature review

Frontiers in Cardiovascular Medicine

Background Malignant atrophic papulosis (MAP) is a rare obliterative vasculopathy whose etiology and pathophysiological mechanisms remain unknown, and the treatment is still empirical. It can involve multiple systems, especially the gastrointestinal tract and central nervous system, and has a poor prognosis. Case presentation A 20-year-old Chinese male appeared to have Widespread atrophic papules and plaques, intermittent abdominal pain, recurrent bowel perforation, and psoas abscess.

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Social and environmental factors may raise risk of developing heart disease and stroke

Medical Xpress - Cardiology

People who live in areas with social and environmental adversities may have up to twice the increased risk for developing heart disease and stroke, according to new research published in the Journal of the American Heart Association.

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Case Report: Can preoperative implantation of veno-arterial extracorporeal membrane oxygenation lead to embolic events in infective endocarditis?

Frontiers in Cardiovascular Medicine

Early-stage infective endocarditis (IE) can lead to severe complications, including infarctions and metastatic infections caused by inflammatory embolus shedding. Common embolism sites include the brain, spleen, kidneys, lungs, and intestines. Additionally, acute heart failure (AHF) can occur in up to 40% of cases, and its presence can impact the clinical outcomes of patients with IE.

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High blood pressure hurts the kidneys

Medical Xpress - Cardiology

Hypertension, also known as high blood pressure, is a common problem that affects the body's arteries. If you have high blood pressure, the heart has to work harder to pump blood.

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Case Report: Thrombus aspiration and in situ thrombolysis via a Guidezilla guide extension catheter in a patient with high-risk pulmonary embolism

Frontiers in Cardiovascular Medicine

Standard catheter-directed thrombolysis (CDT) and thrombus aspiration are considered potentially promising approaches for reopening the embolism-related pulmonary artery in patients with pulmonary embolism (PE) with high thrombotic burden and deteriorating hemodynamics, especially in those for whom systemic thrombolysis is contraindicated or has failed.

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Standardized Consent, De-Identification Preferred for AI Image Use in Dermatology

HCPLive

Following this analysis, the conclusions provide more information on the views of potential dermatology patients on the future of their own medical images by artificial intelligence systems.

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New trial highlights promising intervention to reduce sitting and improve blood pressure in older adults

Medical Xpress - Cardiology

A new Kaiser Permanente study found that a health coaching intervention successfully reduced sitting time for a group of older adults by just over 30 minutes a day. Study participants also showed meaningful improvements in blood pressure, comparable to the effect of other interventions focused on physical activity.

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Less sitting tied to lower blood pressure in older adults: Kaiser study 

Becker's Hospital Review - Cardiology

Reducing the amount of time older adults spend sitting could help improve their blood pressure, according to a study published March 27 in JAMA Network Open.

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Tenapanor Significantly Reduces Key Abdominal Symptoms in Patients with IBS-C

HCPLive

The post-hoc analysis found tenapanor significantly improved weekly scores for abdominal pain, discomfort, and bloating, as measured by the Abdominal Score.

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Case Report: Multiple types of arrhythmias in a late-confirmed Danon disease

Frontiers in Cardiovascular Medicine

Introduction Danon disease is an X-linked disorder caused by pathogenic variants in lysosome-associated membrane protein 2 ( LAMP2 ) gene, typically characterized by the triad of hypertrophic cardiomyopathy, myopathy, and intellectual disability. However, many patients may not present the typical presentation, especially in the early stage. Electrocardiogram (ECG) abnormalities can be found in almost all patients, with Wolff–Parkinson–White (WPW) syndrome being the most common.

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REDUCE-IT Lp(a) Analysis Details Icosapent Ethyl Effect on MACE Across Lp(a) Range

HCPLive

A REDUCE-IT analysis highlights consistent cardiovascular benefits with icosapent ethyl across varying levels of Lp(a).

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Merck’s Sotatercept Lands PAH Approval

CardiacWire

Patients with pulmonary arterial hypertension (PAH) suddenly have a new and potentially powerful treatment option available to them, following the FDA approval of Merck’s sotatercept-csrk, which will be marketed as Winrevair in the US. PAH is a rare (40k patients in the US) and usually fatal disease caused by the overproduction of activin proteins. Although evolving treatments have helped improve PAH symptoms, available medications haven’t made much of an impact on mortality rates.

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Social Isolation Linked to Being Older Than Biological Age, Greater Mortality

HCPLive

In a new study, investigators evaluated if social contact influenced the age gap between biological age, estimated with artificial intelligence (AI), and chronological age.

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Risk of Dementia During Antihypertensive Drug Therapy

American College of Cardiology

What is the effect of antihypertensive drug treatment on the risk of dementia or Alzheimer’s disease among new users of antihypertensive medications?

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Impact of delayed removal of pectus bar on outcomes following Nuss repair: a retrospective analysis

Journal of Cardiothoracic Surgery

Usually, pectus bars are removed 3 years after the Nuss procedure in patients with pectus excavatum. However, the optimal timing for postoperative pectus bar removal remains undefined. Our study investigated t.

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Trends in transcatheter aortic valve implantation practice and clinical outcomes at an Irish tertiary referral centre

Open Heart

Objective A paucity of data exists on how transcatheter aortic valve implantation (TAVI) practice has evolved in Ireland. This study sought to analyse temporal trends in patient demographics, procedural characteristics, and clinical outcomes at an Irish tertiary referral centre. Methods The prospective Mater TAVI database was divided into time tertiles based on when TAVI was performed: Group A, November 2008–April 2013; Group B, April 2013–September 2017; and Group C, September 2017&

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Unusual presentation and delayed diagnosis of cardiac angiosarcoma

Journal of Cardiothoracic Surgery

Primary cardiac angiosarcomas are very rare and present aggressively with high rates of metastasis. Given the poor prognosis, particularly once disease has spread, early diagnosis and multidisciplinary treatme.

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Prevalence of transthyretin cardiac amyloidosis in patients with high-degree AV block

Open Heart

Objective Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative cardiac disorder caused by deposition of wild type or mutated transthyretin. As ATTR-CM is associated with conduction disease, we sought to determine its prevalence in patients with idiopathic high-degree atrioventricular (AV) block requiring permanent pacemaker (PPM) implantation.