Thu.Sep 19, 2024

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FDA Approves Digital Health Solution for Heart Failure Management

DAIC

tim.hodson Thu, 09/19/2024 - 09:42 Sept. 18, 2024 – Astellas Pharma Inc. recently announced that Digitiva, a non-invasive digital health solution for heart failure management, has been listed with the U.S. Food and Drug Administration (FDA). Digitiva is classified as a Class I Software as a Medical Device (SaMD) and is exempt from 510(k) premarket submission*.

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Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 20 September 2024; doi:10.1038/s41569-024-01072-4 In this Review, the authors describe the bidirectional crosstalk between lysosome biology and immune cell function and polarization, focusing on immunometabolic reprogramming in the context of atherosclerosis and highlighting knowledge gaps and potential therapeutic strategies targeting immune cell lysosomes.

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Migraine Patients Achieve Remission of Medication Overuse Headaches with Erenumab

HCPLive

A study revealed erenumab at 140 mg is effective and safe in achieving remission of headaches caused by non-opioid medication overuse.

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Providence Heart Institute planning $42M renovation

Becker's Hospital Review - Cardiology

Renton, Wash.-based Providence is planning a $42 million renovation of the Providence Heart Institute in Spokane, which will increase its patient capacity by 15%, according to a Sept. 17 report from the Spokane Journal of Business.

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Management of Patients With Cardiac Arrest Requiring Interfacility Transport: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. People who experience out-of-hospital cardiac arrest often require care at a regional center for continued treatment after resuscitation, but many do not initially present to the hospital where they will be admitted. For patients who require interfacility transport after cardiac arrest, the decision to transfer between centers is complex and often based on individual clinical characteristics, resources at the presenting hospital, and available transport resources.

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Matthew Zirwas, MD: Discussing Upadacitinib, Other JAK Inhibitors for Atopic Dermatitis

HCPLive

In this segment of his interview, Zirwas highlighted the use of JAK inhibitors such as upadacitinib, discussed safety, and touched on topical options for patients with eczema.

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FDA Approves First Year-Long Continuous Glucose Monitoring Sensor for Diabetes

Cardiometabolic Health Congress

The U.S. Food and Drug Administration (FDA) has approved Eversense 365, the first and only continuous glucose monitoring (CGM) system designed to function for an entire year, according to a company press release. Developed by Senseonics and Ascensia Diabetes Care, the device represents a significant advancement in long-term glucose monitoring technology.

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Genetic testing, AI and PET deserts: 5 cardiology study updates

Becker's Hospital Review - Cardiology

"Stay updated on the latest findings in cardiology, including the use of machine-learning models and genetic testing to improve patient care and outcomes.

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FDA Issues CRL to Vanda Pharmaceuticals’ Tradipitant for Gastroparesis Symptoms

HCPLive

The FDA declined to approve the NDA for tradipitant for the treatment of symptoms of gastroparesis, suggesting that Vanda conduct additional studies.

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Detection of serum SNHG22 and its correlation with prognosis of non-small cell lung cancer

Journal of Cardiothoracic Surgery

Lung cancer accounts for a significant proportion of cancer-related deaths in China, with the majority of the cases being classified as non-small cell lung cancer (NSCLC). The study aimed to investigate the ex.

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EDG-7500 Achieves Positive Phase 2 Results in Obstructive HCM

HCPLive

EDG-7500 was well-tolerated in healthy patients in Phase 1 while achieving gradient relief without LVEF reductions in the Phase 2 CIRRUS-HCM trial.

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Uncommon presentation of acute type A aortic dissection: sleeve-severed and everted proximal right coronary artery intima without myocardial ischaemia

Journal of Cardiothoracic Surgery

Background Type A aortic dissection (TAAD) with coronary involvement is rare but potentially fatal. Proper myocardial protection during surgery is essential. Case presentation Here, we describe a 52-year-old woman who presented with sudden chest pain. CT angiography revealed TAAD with right coronary artery involvement. During surgery, the proximal intima of the right coronary artery was found to be completely severed and everted.

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Empirical superior vena cava electrical isolation guided by quantitative ablation index improves outcomes of radiofrequency catheter ablation for paroxysmal atrial fibrillation

Open Heart

Background The value of empirical superior vena cava isolation (SVCI) following pulmonary vein isolation (PVI) to improve the efficacy of radiofrequency catheter ablation (RFCA) for paroxysmal atrial fibrillation (PAF) remains controversial. Objective To evaluate the efficacy and safety of quantitative ablation index (AI)-guided empirical SVCI, in addition to PVI, for patients with PAF.

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Large ventricular myxoma causing inflow and outflow obstruction of the right ventricle; A Case Report

Journal of Cardiothoracic Surgery

Myxomas are the most common primary benign heart tumors, typically found in the left atrium, with only 2–4% occurring in the right ventricle. Clinical presentations vary widely, including congestive heart fail.

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Interleukin 6 plasma levels are associated with progression of coronary plaques

Open Heart

Background Inflammation plays a pivotal role in atherogenesis and is a causal risk factor for atherosclerotic cardiovascular disease. Non-invasive coronary CT angiography (CCTA) enables evaluation of coronary plaque phenotype. This study investigates the relationship between a comprehensive panel of inflammatory markers and short-term plaque progression on serial CCTA imaging, hypothesising that inflammation is associated with increased plaque volume.

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Gene therapy shows promise in treating heart arrhythmia: Study

Becker's Hospital Review - Cardiology

A pharmaceutical gene therapy has shown promise in treating calmodulinopathy, a rare and hard-to-treat heart arrhythmia, according to a study published Aug. 19 in Circulation.

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Managing Relationships with Patients

Society of Thoracic Surgeons - Early Career

Blog Managing Relationships with Patients KCummings Thu, 09/19/2024 - 10:19 Medical Student Resident / Fellow Early career cardiothoracic surgeons have many important relationships that need to be managed and developed. The patient relationship can be excellent, a source of pride and healing, or damaging, a source of stress and contempt. In training, there are many explicit lessons about technical parts of procedures and guidelines to follow, and publications to remember, but there are few expli

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Outcomes of Class Switching vs Cycling TNF Inhibitors

HCPLive

Panelists discuss how switching to a biologic with a different mechanism of action can enhance clinical outcomes in patients with inadequate responses to tumor necrosis factor inhibitors.

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Mineralocorticoid Antagonism in HF: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on the established and emerging therapeutic role of mineralocorticoid antagonism in patients with heart failure (HF).

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Cycling Within TNF Inhibitors: Complications and Factors Influencing Treatment Choices

HCPLive

Panelists discuss how continued cycling of tumor necrosis factor inhibitors (TNFis) without achieving remission can lead to complications like irreversible joint erosion, significantly diminishing patient quality of life, and explore why providers may persist with TNFis despite failure, access barriers to switching mechanisms of action, and treatment considerations for patients whose initial positive response to TNFis declines over time.

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Coronary Artery Calcium Density and Risk of CV Events

American College of Cardiology

Is coronary artery calcium (CAC) density by computed tomography (CT) inversely associated with plaque vulnerability and atherosclerotic cardiovascular disease (ASCVD) events (coronary heart disease [CHD] and stroke)?

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Noninvasive SAFE Score Stratifies Long-Term Outcomes in Steatotic Liver Disease

HCPLive

High-risk SAFE scores were linked to increased mortality, especially in participants with alcohol-associated liver disease, as this group demonstrated the worst survival.

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Disparities in Prehospital Care of Acute Stroke Patients

American College of Cardiology

How do patient-level factors, including race/ethnicity and county-level socioeconomic status (SES) affect inequities in prehospital care of patients with stroke?

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HERALD: ALG-055009 Demonstrates Liver Fat Reduction in Phase 2a MASH Study

HCPLive

Positive topline results from the phase 2a HERALD study of ALG-055009 in MASH highlight the THR-β agonist’s impact on liver fat reduction.

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Extended Ambulatory ECG Monitoring Enhances Identification of Higher-Risk Ventricular Tachyarrhythmias in Patients with Hypertrophic Cardiomyopathy

HeartRhythm

In hypertrophic cardiomyopathy (HCM), 48-hour ambulatory monitoring has been standard practice to detect nonsustained ventricular tachycardia (NSVT), a sudden death risk marker. Extended wear ambulatory ECG devices have more recently utilized for monitoring HCM patients.

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Differentiating Between Different Types of Alopecia, with Jerry Shapiro, MD

HCPLive

Shapiro spoke in his Maui Derm NP+PA Fall conference interview about differentiating between types of alopecia areata and about the potential use of JAK inhibitors.

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Refractory inappropriate sinus tachycardia treated with pulsed field ablation of the sinus node.

HeartRhythm

Inappropriate sinus tachycardia (IST) is a clinical syndrome for which the pathogenesis is not well understood (1). It is a diagnosis of exclusion defined by otherwise unexplained persistent or paroxysmal sinus tachycardia with a resting heart rate > 100 beats/min (2). The symptoms associated with IST can be distressing and difficult to manage. The cause of IST is considered multifactorial with autonomic dysfunction being the central abnormality (1).

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Updates on the Diagnosis of Blistering Diseases, with Donna Culton, MD, PhD

HCPLive

This interview with Culton featured a discussion of key challenges faced when treating patients with blistering diseases such as pemphigus and bullous pemphigoid.

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Renal Denervation by Iberis Multi-Electrode Renal Denervation System in Patients With Primary Hypertension

American College of Cardiology

The goal of the Iberis-HTN trial was to assess the efficacy and safety of the multi-electrode, unipolar AngioCare Iberis renal denervation (RDN) system in patients with treatment-resistant primary hypertension (HTN) on a standardized three-drug regimen.

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Self-Guided Digital Behavioral Therapy Improved Fibromyalgia Management and Pain

HCPLive

Digital ACT demonstrated superiority over active control in a number of outcomes in a phase 3 trial.

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The molecular landscape of vascular cells in the human brain

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 20 September 2024; doi:10.1038/s41569-024-01079-x A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.

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Gout Prevalence to Increase by More Than 70% by 2050

HCPLive

The increase will largely be driven by population growth and aging.

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Surgical treatment of graft infection combined with aortoesophageal fistula after TEVAR: a retrospective single-center, single-arm study

Journal of Cardiothoracic Surgery

Aortoesophageal fistula (AEF) secondary to thoracic aortic endovascular repair (TEVAR) is rare and fatal. The author reports the treatment methods and outcomes of 10 patients with a TEVAR graft infection and a.

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New Model Predicts the Hepatocellular Carcinoma Risk in Chronic Hepatitis B

HCPLive

The model Revised REACH-B outperforms an earlier model by incorporating predictors of predictors of age, sex, platelet count, ALT levels, and positive hepatitis B antigen result.

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