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Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01109-8 In this Review, Lavine and colleagues describe the known subsets of cardiac macrophages, highlighting newly identified macrophage states and associated cellular neighbourhoods, and discuss the roles of cardiac macrophages in homeostasis and disease, including in inflammation, fibrosis, age-associated pathologies, mechanosensing, efferocytosis, angiogenesis, arrhythmias and transplant allograft survival.
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Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01103-0 Vascular cells are finely regulated by complex microenvironments, including biomechanical signals from the extracellular matrix. In this Review, Kong and colleagues describe the role of the extracellular matrix in vascular development, ageing and disease, and highlight the potential of novel therapies targeting this fine-tuned network.
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This prognostic study evaluates the ability of an electrocardiography-based artificial intelligence risk estimator to predict incident hypertension and stratify risk for hypertension-associated adverse events.
Abstract The participatory co-design method has received significant attention recently. Experience-based co-design is an approach that enables patients (service users) and healthcare providers (service delivers) to co-design services and care pathways in partnership to improve health outcomes based on their experience. Traditionally, it was used as a quality improvement technique.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01104-z Endovascular renal denervation has been approved for the treatment of hypertension. In this Review, Fisher and Kirtane discuss the clinical trial data on its efficacy and safety and provide practical guidance on patient selection and clinical implementation of the procedure.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01104-z Endovascular renal denervation has been approved for the treatment of hypertension. In this Review, Fisher and Kirtane discuss the clinical trial data on its efficacy and safety and provide practical guidance on patient selection and clinical implementation of the procedure.
A randomized trial of the factor XIa inhibitor asundexian was stopped early owing to a higher incidence of stroke or systemic embolism than with apixaban therapy among patients with atrial fibrillation.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01110-1 In this Review, Dey and colleagues explore the pathobiology of coronary atherosclerotic plaques and perivascular adipose tissue, describe their phenotyping with computed tomography coronary angiography, and discuss potential future applications in clinical risk prediction and patient management.
Among patients with transthyretin amyloidosis with cardiomyopathy, the risk of death from any cause and recurrent cardiovascular events was lower with vutrisiran treatment than with placebo.
Adipose tissue distribution plays a crucial role in the development of cardiovascular complications. In particular, visceral adipose tissue (VAT) has been linked to insulin resistance (IR) and cardiovascular d.
The survival of patients with the two most prevalent forms of systemic amyloidosis light chain amyloidosis, which is caused by aggregates of monoclonal immunoglobulin light chains, and transthyretin amyloidosis (ATTR amyloidosis), which is caused by aggregates of wild-type or variant transthyretin is determined largely by cardiac involvement. Therapy.
The analyses of longitudinal changes in remnant cholesterol (RC) and cardiovascular disease (CVD) remains are limited. The objective of the study was to investigate the associations of longitudinal changes in.
Prior studies have demonstrated an association between retinal vascular features and cardiovascular disease (CVD), however most studies have only evaluated a few simple parameters at a time. Our aim was to det.
Panelists discuss how proper blood pressure measurement techniques require careful attention to patient positioning, cuff size selection, and standardized procedures to ensure accurate readings.
Dual antiplatelet therapy and oral anticoagulation in combination with aspirin represent recommended treatment regimens after left atrial appendage closure (LAAC). As most patients receiving LAAC have high bleeding risk, less aggressive antithrombotic treatments are needed, such as single antiplatelet therapy.
Panelists discuss how evaluating uncontrolled hypertension in patients with early kidney dysfunction requires a careful investigation of underlying causes, including medication adherence, lifestyle factors, and potential secondary hypertension.
To the Editor We have read with great interest the study by Benziger et al, who reported exploratory analysis of the ADAPTABLE trial that evaluated potential sex differences in efficacy and safety outcomes in patients with established atherosclerotic cardiovascular disease receiving 2 aspirin doses, 81 mg and 325 mg, respectively. Although no significant differences between sexes were present regarding primary effectiveness and safety outcomes, there were notable differences regarding particular
Publication date: Available online 31 December 2024 Source: The American Journal of Cardiology Author(s): Aryan Mehta, Mridul Bansal, Abhishek Singh, Ritika Kompella, Anindita Chanda, Chirag Mehta, Christopher J Mullin, J Dawn Abbott, Saraschandra Vallabhajosyula
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01114-x In this Review, Heusch and Kleinbongard describe the deleterious and protective roles of the spleen in the inflammatory processes of atherosclerosis, myocardial infarction and heart failure, and highlight the translational potential of the cardioprotective functions of the spleen for the treatment of patients with ischaemic heart disease.
Welcome to 2025 and best wishes for a great academic journey to all readers. Collected from ACC website (Arranged in three heading) These are the creamy academic extract of whatever happened over the last one year. Thanks to ACC for compiling it. While the first one,(Trials) will be under scrutiny, the other two , ie the cardiology news stories and magazine reviews are absolute gem of learning resource.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01111-0 In this Review, Born and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque initiation and growth. They describe the causative role of LDL at the early stages of atherogenesis and discuss the relative atherogenicity of lipoprotein(a) and triglyceride-rich lipoproteins.
BackgroundAtrial fibrillation (AF) is a prevalent cardiac arrhythmia, with ventricular rate control being a critical therapeutic target. However, the optimal range for ventricular rate control remains unclear. Additionally, the relationship between different levels of ventricular rate control and cardiac remodeling in patients with atrial fibrillation remains unclear.ObjectiveThis study aims to explore the relationship between different levels of heart rate control and cardiac remodeling in pati
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01108-9 In this Review, Yvan-Charvet and colleagues discuss how cardiovascular risk factors and metabolic modifiers of atherosclerosis influence metabolism-dependent haematopoietic stem cell skewing (haematometabolism) and efferocyte reprogramming (efferotabolism) and highlight potential therapeutic strategies to reduce the risk of atherosclerosis by rebalancing haematopoiesis and efferocytosis.
Abstract Aims Improved dietary habits are important for successful secondary prevention after myocardial infarction (MI), with counselling and support on healthy dietary habits constituting a cornerstone of cardiac rehabilitation (CR). However, there is limited knowledge on how to optimize CR organization to motivate patients to adopt healthy dietary habits.
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