Sun.Jan 19, 2025

article thumbnail

Fatty muscles raise the risk of serious heart disease regardless of overall body weight

Science Daily - Heart Disease

People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to new research. This 'intermuscular' fat is highly prized in beef steaks for cooking. However, little is known about this type of body fat in humans, and its impact on health.

article thumbnail

Interventions for adult congenital heart disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 20 January 2025; doi:10.1038/s41569-025-01118-1 The past 20 years have witnessed remarkable progress in the evolution of transcatheter procedures for the treatment of adult patients with congenital heart disease. In this Review, Rods-Cabau and colleagues provide a comprehensive overview of the available transcatheter interventions for these patients, focusing on their current indications and associated outcomes.

article thumbnail

Negative vs. positive experiences: what you remember may depend on emotions

Heart Sisters

If asked about a negative experience like the exact moment you were diagnosed with heart disease, would you be able to accurately recall that moment?

article thumbnail

Emergency interventions for cardiogenic shock due to decompensated aortic stenosis: a systematic review and meta-analysis

Open Heart

Background Cardiogenic shock (CS) induced by severe aortic stenosis (AS) is a life-threatening condition with high mortality. Despite advancements in emergency interventions, the optimal treatment approach remains uncertain. Aim This study aimed to systematically review and analyse the existing evidence on outcomes of emergency transcatheter aortic valve implantation (eTAVI) and emergency balloon aortic valvuloplasty (eBAV) in CS patients.

article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

Association between red cell distribution width—albumin ratio and all-cause mortality in intensive care unit patients with heart failure

Frontiers in Cardiovascular Medicine

AimThe association between red cell distribution widthalbumin ratio (RAR) and the risk of all-cause mortality in intensive care unit (ICU) patients with heart failure remains uncertain. This study aimed to investigate this association.MethodsClinical data from MIMIC- (version 2.2) database was utilized for the analysis of ICU patients with heart failure.

article thumbnail

Pregnancy and cardiovascular outcomes among patients post Fontan surgery: a 25-year single-centre retrospective cohort study

Open Heart

Introduction Data on the characteristics and outcomes of pregnancy and among patients with Fontan physiology are limited. We aimed to evaluate the immediate and long-term outcomes among these patients who were followed at our centre. Methods We included adult patients who had undergone Fontan surgery for congenital heart disease and were pregnant between 1994 and 2021.

More Trending

article thumbnail

Direct-acting oral anticoagulant removal by intraoperative hemoadsorption in CABG and/or single valve surgery: interim analysis of the International Safe and Timely Antithrombotic Removal (STAR) registry

Journal of Cardiothoracic Surgery

Patients on direct-acting oral anticoagulants (DOACs) are at high risk of perioperative bleeding complications. Intraoperative hemoadsorption is a novel strategy to reduce perioperative bleeding in patients on.

Research 105
article thumbnail

Case Report: Endovascular embolization under DSA for multivessel supply mixed pulmonary sequestration in young patients

Frontiers in Cardiovascular Medicine

Pulmonary sequestration (PS) is a rare congenital lung developmental anomaly characterized by abnormal lung tissue that receives its blood supply from the aorta. Among the various types, mixed PSrepresents a distinct subtype. Currently, there is a lack of definitive reports regarding the specific management of this condition in infants and young children.

article thumbnail

Electrocoagulation-free strategy in minimally invasive direct coronary artery bypass with hybrid revascularisation – a case report

Journal of Cardiothoracic Surgery

Hybrid coronary revascularisation benefits patients with multivessel disease, as it amalgamates the minimally invasive direct coronary artery bypass (MIDCAB) procedure and percutaneous coronary intervention (P.

105
105
article thumbnail

Case Report: Rare cardiovascular characteristics of tuberous sclerosis complex with novel TSC2 variant

Frontiers in Cardiovascular Medicine

BackgroundTuberous sclerosis complex (TSC) is a multisystem genetic disorder primarily characterized by the development of benign tumors in multiple organs. While cardiovascular involvement is less common than neurological or renal manifestations, it typically presents with cardiac rhabdomyomas (CRs). The co-occurrence of a bicuspid aortic valve (BAV) with TSC is exceedingly rare.Case summaryWe report the case of a 26-year-old woman with genetically confirmed TSC, harboring a novel pathogenic va

article thumbnail

ONS-5010 for Wet AMD Secures Noninferiority in NORSE EIGHT Trial

HCPLive

With a completed 12-week analysis, Outlook Therapeutics plans to resubmit the Biologics License Application for ONS-5010 in the first quarter of 2025.

98
article thumbnail

Case Report: A crushing sensation—a rare case of mediastinal germ cell tumor causing cardiac tamponade

Frontiers in Cardiovascular Medicine

Cardiac tamponade often presents as external compression of the heart by pericardial fluid, leading to hemodynamic instability, but it can rarely be caused by compression by a solid mass. In this report, we present a case of tamponade-like physiology resulting from a large mediastinal tumor. This is an unusual phenomenon that is rarely described in the literature, and its optimal management remains controversial.

article thumbnail

Fatty muscles raise the risk of serious heart disease regardless of overall body weight, study shows

Medical Xpress - Cardiology

People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to research published in the European Heart Journal.

article thumbnail

Accuracy of Freestyle Libre continuous glucose monitoring system in critically ill patients after cardiac surgery

Journal of Cardiothoracic Surgery

Hyperglycemia is an independent risk factor for perioperative complications and mortality after cardiac surgery. Freestyle Libre Continuous glucose monitor (CGM) is an interstitial glucose monitoring system, w.

article thumbnail

Keeping blood pressure under control is critical. There's a new option for tough cases

Medical Xpress - Cardiology

Nothing doctors prescribed controlled Michael Garrity's dangerously high blood pressureuntil they zapped away some nerves on his kidneys.

article thumbnail

The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer

Journal of Cardiothoracic Surgery

There are still gaps in the study of the miRNA and its SNPs in some diseases such as non-small cell lung cancer (NSCLC). The study aimed to provide useful information on the treatment of NSCLC by investigating.

Cancer 52
article thumbnail

Interrelation between hypoxic liver injury and Killip classification in ST-segment elevation myocardial infarction patients

Frontiers in Cardiovascular Medicine

IntroductionHypoxic liver injury (HLI) and Killip classification are poor prognostic factors in patients with ST-segment elevation myocardial infarction (STEMI). This study investigates the interrelationship between hypoxic liver injury (HLI) and Killip classification.Method and resultsA total of 1,537 STEMI patients who underwent percutaneous coronary intervention (PCI) from 2007 to 2014 at four tertiary hospitals in the Incheon-Bucheon province were enrolled in this study.

article thumbnail

Rivaroxaban versus low molecular weight heparin for managing lower extremity deep vein thrombosis following thoracoscopic lung cancer surgery: a randomized controlled trial

Journal of Cardiothoracic Surgery

To assess the effectiveness and safety profiles of rivaroxaban compared to low molecular weight heparin (LMWH) in managing lower extremity deep vein thrombosis (DVT) subsequent to thoracoscopic lung cancer sur.

article thumbnail

Role of physical activity in cardiovascular disease prevention: impact of epigenetic modifications

Frontiers in Cardiovascular Medicine

Cardiovascular disease (CVD) remains the leading cause of death worldwide, imposing a major burden on morbidity, quality of life, and societal costs, making prevention of CVD a top public health priority. Extensive research has pointed out that lack of adequate physical activity in life is one of the key risk factors for heart disease. Indeed, moderate exercise is not only beneficial to the heart in healthy populations, but also exerts a protective effect in pathological states.

article thumbnail

Role and prognostic value of growth differentiation factor 15 in patient of heart failure with preserved ejection fraction: insights from the PURSUIT-HFpEF registry

Open Heart

Background Growth differentiation factor 15 (GDF15) is a cytokine responding to oxidative stress and inflammation, and it regulates appetite and energy balance. The association between GDF15 and clinical factors and its prognostic value in elderly multimorbid patients with heart failure with preserved ejection fraction (HFpEF) have not been well unknown.

article thumbnail

Case Report: A case of Tatton-Brown–Rahman syndrome featuring mitral annular disjunction and mitral valve prolapse due to a novel mutation site in the DNMT3A gene

Frontiers in Cardiovascular Medicine

A 13-year-old child presented with specific facial features, overgrowth, and intellectual disability. Echocardiography revealed the presence of a large pericardial effusion, left ventricular enlargement, mitral annular separation, and mitral valve prolapse with moderate regurgitation. These symptoms suggested a possible genetic disorder. High-throughput sequencing revealed a specific mutation in the DNMT3A gene (NM_175629.2:c.2408+1G>A) associated with Tatton-BrownRahman syndrome.

article thumbnail

Emulation of ARISTOTLE and ROCKET AF trials in real-world atrial fibrillation patients results in similar efficacy and safety as original landmark trials: insights from the GARFIELD-AF registry

Open Heart

Aims This study aimed to determine the robustness, reproducibility and representativeness of the landmark Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (AF) (ARISTOTLE) and Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in AF (ROCKET AF) randomised trials through replication in an observational AF patient registry.

article thumbnail

Association of systemic immune-inflammatory index with in-stent restenosis in patients with and without diabetes mellitus

Frontiers in Cardiovascular Medicine

BackgroundSystemic inflammation plays a vital role in the pathogenesis and prognosis of cardiovascular disease (CAD). The systemic immune-inflammation index (SII) has been developed as a cost-effective and practical predictor for CAD outcomes. This study aimed to determine the association between the SII and the risk of ISR among ACS patients with and without diabetes mellitus (DM).MethodsIn this retrospective cohort study, a total of 1,652 patients who underwent percutaneous coronary interventi