Mon.Mar 11, 2024

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ECG Blog #420 — A "Fast" Complete Heart Block?

Ken Grauer, MD

I was asked to interpret the 2-lead rhythm strip shown in Figure-1 — without the benefit of any history. What are YOUR thoughts? Is there AV block? If so — Is it complete AV block? Figure-1: You are asked to interpret this 2-lead rhythm strip without the benefit of any history. = NOTE: Today's rhythm is challenging — especially if you have not seen this type of rhythm before.

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Serious Issues With Slow Heartbeat Flagged for Afib Patients on Antiarrhythmics

Med Page Today

(MedPage Today) -- Old concerns about the safety of rhythm control drugs for atrial fibrillation (Afib or AF) resurfaced in a contemporary large Korean population-based study. Afib patients prescribed antiarrhythmic drugs (AADs) had several-fold.

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6 Ways AI Mammography and Mobile Access Is Improving Physician Burnout

NOVARAD

There's no denying it: burnout is a serious problem among physicians. Over 50% of radiologists say that they've experienced “long-term, unresolved, job-related stress leading to exhaustion, cynicism, detachment from job responsibilities, and lacking a sense of personal accomplishment.” The numbers are startling and point to the need for immediate action to address the high level of burnout among physicians.

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Switch to Efmoroctocog Alfa May Lower Bleeding Events in Hemophilia A

HCPLive

Patients in France with hemophilia A who switched their FVIII replacement treatment trended towards fewer bleeding events and articular non-bleeding events requiring hospitalization.

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Cardiovascular Infection on the Rise: New Multisociety Statement on Use of PET/CT and SPECT/CT for Evaluation

Society of Thoracic Surgeons - Congenital

News Cardiovascular Infection on the Rise: New Multisociety Statement on Use of PET/CT and SPECT/CT for Evaluation KCummings Mon, 03/11/2024 - 08:11 4 min read

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Baseline, Post-AKD Kidney Function Associated with Long-Term Prognosis After Dialysis for AKI

HCPLive

Baseline kidney function, AKD severity, and post-AKD kidney function were identified as important factors for predicting outcomes in patients with acute kidney injury requiring dialysis.

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Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With or Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials

Circulation

Circulation, Ahead of Print. BACKGROUND:Diabetes may be associated with differential outcomes in patients undergoing left main coronary revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The aim of this study was to investigate outcomes in patients with left main disease with and without diabetes undergoing PCI versus CABG.METHODS:Individual patient data were pooled from 4 trials (SYNTAX [TAXUS Drug-Eluting Stent Versus Coronary Artery Bypa

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Sodium–glucose cotransporter 2 inhibitors influence skeletal muscle pathology in patients with heart failure and reduced ejection fraction

European Journal of Heart Failure

This study found that treatment with sodium–glucose cotransporter 2 (SGLT2) inhibitors in patients with heart failure and reduced ejection fractions (HFrEF) was associated with lower skeletal muscle pathology. Muscle biopsies were collected from patients treated with SGLT2 inhibitors (>12 months) and compared to untreated controls. State-of-the-art techniques were employed (from structural imaging to metabolomics), which revealed SGLT2 inhibitor treatment was associated with various improveme

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Cardiology deserves its own board, Northwell leader says

Becker's Hospital Review - Cardiology

Big changes could be coming to cardiology thanks in part to the work of Jeffrey Kuvin, MD, co-executive director of the New York City-based Northwell Cardiovascular Institute and professor and chair of the department of cardiology New Hyde Park, N.Y.-based Northwell Health.

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Alirocumab Approved for Heterozygous Familial Hypercholesterolemia in Patients 8 Years and Older

HCPLive

Nearly a decade after becoming the first PCSK9 inhibitor to receive approval from the FDA, alirocumab (Praluent) has now received approval for pediatric patients with HeFH based on data from a phase 3 trial.

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Navigating Cardiovascular Risk Assessment in Older Patients: Insights From Coronary Artery Calcium Scoring

American College of Cardiology

Many research studies have focused on evaluating the predictive ability of coronary artery calcium (CAC) scoring in cohorts primarily consisting of middle-aged individuals.

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Rizankizumab and the KNOCKOUT Study, with Andrew Blauvelt, MD, MBA

HCPLive

Blauvelt discusses the impetus for his phase 2 trial looking at the ability to mitigate pivotal psoriasis memory T cells with risankizumab.

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In our cellular 'glue,' scientists find answers about heart attacks, strokes, more

Science Daily - Heart Disease

Doctors may be able to leverage the new insights to identify patients at greatest risk of having atherosclerotic plaques break free and cause heart attacks or strokes.

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Pediatric Hidradenitis Suppurativa Severity not Linked to Obesity

HCPLive

New data from the Mayo Clinic show high BMI does not correlate with severe hidradenitis suppurativa in affected children and adolescents.

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The liver immune system eats up 'bad cholesterol'

Science Daily - Heart Disease

A new study reveals that immune cells in the liver react to high cholesterol levels and eat up excess cholesterol that can otherwise cause damage to arteries. The findings suggest that the response to the onset of atherosclerosis begins in the liver.

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Jonathan Silverberg, MD, PhD: Safety Data, Implications of Nemolizumab Findings for Atopic Dermatitis

HCPLive

Another segment of Silverberg’s interview at AAD 2024 featured a discussion on safety data and the larger implications of these phase 3 findings for eczema management.

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The world's top hospitals for cardiac surgery

Becker's Hospital Review - Cardiology

Discover the top 10 cardiac surgery hospitals in the world according to Newsweek's 2024 "World's Best Hospitals" list, with 7 based in the U.S.

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Jonathan Silverberg, MD, PhD: New Phase 3 Findings on Nemolizumab for Atopic Dermatitis

HCPLive

This interview at AAD featured a discussion with Silverberg on nemolizumab’s efficacy and safety at Week 48 among patients with moderate-to-severe atopic dermatitis.

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Summer Camp: Where Connection Makes a Splash

Conquering CHD

Summer camp. The very words conjure up images of bonfires, canoeing, and making lifelong friends. But for children with Congenital Heart Disease (CHD), the traditional camp experience might not be an option. Yet, the desire for connection, for belonging, remains just as strong. Thankfully, there are incredible summer camps designed specifically for kids with CHD.

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New 3-Year Data Released on PASI Outcomes for Psoriasis Patients on Deucravacitinib

HCPLive

These study findings, presented at AAD 2024, were the results of a recent analysis conducted to assess long-term outcomes among patients with psoriasis.

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Hydration Facts & Myths with Dr. Tamara-Hew-Butler

Physiologically Speaking

You can also find this podcast episode on Apple Podcasts. Dr. Tamara Hew-Butler ( @hyponaqueen ) is a podiatric physician and associate professor of Exercise and Sports Science at Wayne State University. She earned her PhD at the University of Cape Town, South Africa, where she studied and trained under the legendary sports scientist and physician Dr.

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Johnson & Johnson Submits Guselkumab Application to FDA for Ulcerative Colitits

HCPLive

The submission could grant guselkumab its third indication, after being approved by the FDA for psoriasis and psoriatic arthritis.

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A Conversation about Hydration Facts & Myths and Exercise-associated Hyponatremia with Dr. Tamara Hew-Butler

Physiologically Speaking

You can find the audio-only version of this post here. Dr. Tamara Hew-Butler ( @hyponaqueen ) is a podiatric physician and associate professor of Exercise and Sports Science at Wayne State University. She earned her PhD at the University of Cape Town, South Africa, where she studied and trained under the legendary sports scientist and physician Dr.

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Reinsurance Programs May Make Insurance Less Affordable for Middle Class

HCPLive

A new study found how premiums for lower-cost plans in Georgia did not reduce enough to make up for the decrease in subsidies, causing people in middle class to have to pay more.

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ACC CardiaCast’s PulseCheck: Aortic Valve Stenosis

American College of Cardiology

In these panel discussions, host Andrea Price, MS, AACC brings together Marian Hawkey, RN and Misty Theriot, BSN to explore best practices related to structural heart disease.

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Iron Deficiency Prevalent, Linked to Adverse Outcomes in Patients with HFrEF

HCPLive

Iron deficiency marks more than a comorbidity in heart failure, with adverse manifestations, including anemia and a higher risk of mortality, influencing the clinical trajectory of patients with HFrEF.

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Neurodevelopmental Outcomes in Congenital Heart Disease: Key Points

American College of Cardiology

The following are key points to remember from an American Heart Association Scientific Statement on neurodevelopmental outcomes for individuals with congenital heart disease, which includes updates in neuroprotection, risk-stratification, evaluation, and management.

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RASi Use Linked to Improved Survival, Lower Risk of ESKD in Patients with IgA Nephropathy

HCPLive

Findings reveal a 20% mortality rate in an Eastern European cohort, primarily due to cardiovascular diseases and linked to an absence of RASi use, among other factors.

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Pragmatic Trial Comparing Symptom-Oriented Versus Routine Stress Testing in High-Risk Patients Undergoing Percutaneous Coronary Intervention

American College of Cardiology

The goal of the POST-PCI trial was to evaluate functional testing compared with standard of care among patients who underwent percutaneous coronary intervention (PCI) and had high-risk characteristics.

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Iltefat Hamzavi, MD: Long-Term Implications of New Data on Upadacitinib for Nonsegmental Vitiligo

HCPLive

In this segment of his AAD interview, Hamzavi discussed more about his team’s findings on upadacitinib as well as their implications and future in terms of research.

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Tackling inflammation in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 12 March 2024; doi:10.1038/s41569-024-01007-z Shoaran and Maffia recount how our understanding of the role of inflammation in atherosclerosis has evolved and highlight the study by Göran Hansson and colleagues that provided the first hint of the involvement of the adaptive immune response in atherosclerosis.

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Addressing Access Barriers for Patients with IgG4-RD, with John H Stone, MD, MPH

HCPLive

John H Stone, MD, MPH, discusses the recent clinician-authored white paper from the Alliance for Patient Access: "Addressing Access Barriers for IgG4-RD Patients.

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Advanced Medicare Payments Now Available to Clinicians in Response to Cyberattack

American College of Cardiology

The Centers for Medicare and Medicaid Services (CMS) announced on March 9 a new opportunity to request advanced Medicare payments for clinicians impacted by the cyberattack and resulting claims disruptions with Change Healthcare. CMS will consider applications for accelerated payments for Medicare Part A providers and advanced payments for Part B suppliers.

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Clinical Quiz: ACR Guideline for the Management of Gout

HCPLive

Test your knowledge of the ACR's guideline for the management of gout with this quiz!

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Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking. This American Heart Association scientific statement summarizes the data on transplantation-related complications and provides guidance for the cardiovascular management throughout transplantation.

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Secondary Analysis of the Salt Substitute and Stroke Study (SSaSS): Effects of Potassium-Enriched Salt on Cardiac Outcomes

Hypertension Journal

Hypertension, Ahead of Print. Background:The SSaSS (Salt Substitute and Stroke Study) has shown that use of a potassium-enriched salt lowers the risk of stroke, total cardiovascular events, and premature death. The effects on cause-specific cardiac outcomes are reported here.Methods:SSaSS was an unblinded, cluster-randomised trial assessing the effects of potassium-enriched salt compared with regular salt among 20 995 Chinese adults with established stroke and older age and uncontrolled hyperten

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Case Report: Neurological adverse events in subject with myasthenia gravis after PCSK9 inhibitor administration

Frontiers in Cardiovascular Medicine

Background Myasthenia gravis is a rare chronic autoimmune neuromuscular disorder mainly caused by autoantibodies to the nicotinic acetylcholine receptor. Cholesterol is an essential molecule that affects the distribution and proper functioning of this receptor. Several reports have described the potential worsening of myasthenia gravis in patients treated with statins.