Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, in reactions to transfusions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. Harmful antibodies often activate the complement cascade. A model for how IgG antibodies trigger complement activation involves interactions between IgG Fc domains driving the assembly of IgG hexamer structures that activate C1 complexes.

Transplant 124

Transplant 124

Med Page Today

JUNE 3, 2024

(MedPage Today) -- Around the world, cardiovascular deaths associated with cold temperatures vastly outnumbered those from the heat, though high temperature-related deaths gained steam in recent years. From 2000 to 2019, based on daily cardiovascular.

Heart Disease 113

Heart Disease 113

Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited. Here, we generated retinal organoids carrying retinal disease–causing variants in NR2E3, as well as isogenic and unrelated controls.

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DAIC

JUNE 3, 2024

Morristown Medical Center’s Gagnon Cardiovascular Institute’s structural heart program recently reported it has reached a significant milestone of performing over 5,000 transcatheter aortic valve replacement (TAVR) procedures, the first in New Jersey and among the first to accomplish this in the United States. Image courtesy: Atlantic Health System. christine.book Mon, 06/03/2024 - 13:16 June 3, 2024 — Morristown Medical Center ’s Gagnon Cardiovascular Institute ’s structural heart program recen

TAVR 105

TAVR Aortic valve Aortic Hospital 105

Science Daily - Heart Disease

JUNE 3, 2024

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a new study. Importantly, the researchers also found that inhibiting CDK7 could help enhance the medication's cancer-killing capability. Based on an animal model, the study findings could provide a foundation for future treatment strategies to reduce chemotherapy-related heart toxicity and increase treatment effectiveness.

Cancer 108

Cancer Research 108

DAIC

JUNE 3, 2024

Heuron ICH Worklist (Graphic: Business Wire) milla1cf Mon, 06/03/2024 - 12:59 June 3, 2024 — Heuron , a specialized medical AI startup focused on brain and neurological disorders based in South Korea, announced that its non-contrast CT imaging analysis solution, Heuron ICH, has received FDA 510(k) clearance. This marks the first FDA approval of an AI-based brain disorder analysis solution from Korea for computer-aided triage and notification devices (CADt).

Certification 105

Certification Hemorrhage Stroke Strokes 105

Science Daily - Stroke

JUNE 3, 2024

For survivors of strokes, regaining fine motor skills is critical for recovering independence and quality of life. But getting intensive, frequent rehabilitation therapy can be challenging and expensive. Now, researchers are developing a new technology that could allow stroke patients to undergo rehabilitation exercises at home by tracking their wrist movements through a simple setup: a smartphone strapped to the forearm and a low-cost gaming controller called the Novint Falcon.

Technology 101

Technology Research Quality of Life Stroke 101

Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of the immune system that propagates inflammation in the central nervous system remains incompletely unde

Pharmacology 98

Pharmacology Transplant 98

HCPLive

JUNE 3, 2024

Sands reviews key findings from the phase 3 VIVID-1 study of mirikizumab in Crohn’s disease presented at DDW.

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114

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

The prevalence of congenital heart disease (CHD) in adult patients has risen with advances in diagnostic and surgical techniques. Surgical modifications and hemodynamic changes increase the susceptibility to arrhythmias, impacting morbidity and mortality rates, with arrhythmias being the leading cause of hospitalizations and sudden deaths. Patients with CHD commonly experience both supraventricular and ventricular arrhythmias, with each CHD type associated with different arrhythmia patterns.

Congenital Heart Disease 81

Congenital Heart Disease Congenital Heart Disease Arrhythmia 81

Becker's Hospital Review - Cardiology

JUNE 3, 2024

Scottsdale, Ariz.-based HonorHealth Research and Innovation Institute is among the first facilities in the nation — and one of 30 worldwide — to use new stroke prevention stents, according to a May 29 news release.

Stent 69

Stent Stents Stroke Strokes 69

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Abdominal aortic aneurysm (AAA) is a significant source of mortality worldwide and carries a mortality of greater than 80% after rupture. Despite extensive efforts to develop pharmacological treatments, there is currently no effective agent to prevent aneurysm growth and rupture. Current treatment paradigms only rely on the identification and surveillance of small aneurysms, prior to ultimate open surgical or endovascular repair.

Aneurysm 69

Aneurysm Aortic Pharmacology Innovation 69

HCPLive

JUNE 3, 2024

At SLEEP 2024, Revana told HCPLive her thoughts on the potential of pitolisant to address excessive daytime sleepiness in Prader-Willi syndrome compared to treating narcolepsy.

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59

Cardiovascular Diabetology

JUNE 3, 2024

The purpose of this study was to explore the prognostic significance of the lesion-specific pericoronary fat attenuation index (FAI) in forecasting major adverse cardiovascular events (MACE) among patients wit.

Diabetes 59

Diabetes Research 59

HCPLive

JUNE 3, 2024

Emerson previews the highly anticipated FDA advisory committee this week, and Lykos' plans for rolling out MDMA-assisted therapy in the event it is approved to treat PTSD.

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Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

The occurrence of clonal hematopoiesis of indeterminate potential (CHIP), in which advantageous somatic mutations result in the clonal expansion of blood cells, increases with age, as do an increased risk of mortality and detrimental outcomes associated with CHIP. However, the role of CHIP in susceptibility to pulmonary infections, which also increase with age, is unclear.

Pulmonary 78

Pulmonary Outcomes 78

HCPLive

JUNE 3, 2024

Topline data from the pivotal Phase 3 trial show plozasiran met the primary endpoint of triglyceride-lowering in patients with the ultrarare genetic disease.

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American College of Cardiology

JUNE 3, 2024

The following are key points to remember from a state-of-the-art review on arrhythmia-induced cardiomyopathy (AiCM).

Arrhythmia 75

Arrhythmia Cardiomyopathy Article 75

American Heart News - Heart News

JUNE 3, 2024

DALLAS, 3 de junio de 2024 — Actualmente, más estadounidenses que nunca afirman estar dispuestos a realizar una reanimación cardiopulmonar (RCP) en caso de emergencia[1], según los datos de una encuesta recientemente publicada por la American Heart.

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52

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Abdominal Aortic Aneurysm (AAA) is a disease characterized by localized dilation of the abdominal aorta, involving multiple factors in its occurrence and development, ultimately leading to vessel rupture and severe bleeding. AAA has a high mortality rate, and there is a lack of targeted therapeutic drugs. Epigenetic regulation plays a crucial role in AAA, and the treatment of AAA in the epigenetic field may involve a series of related genes and pathways.

Aneurysm 52

Aneurysm Aortic 52

HCPLive

JUNE 3, 2024

A panel of ophthalmologists discuss how retinal disease management has evolved in the past decade and continues to change with advancements in diagnostics and therapies.

Innovation 52

Innovation 52

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

BackgroundLacosamide is frequently used as a mono- or adjunctive therapy for the treatment of adults with epilepsy. Although lacosamide is known to act on both neuronal and cardiac sodium channels, potentially leading to cardiac arrhythmias, including Brugada syndrome (BrS), its adverse effects in individuals with genetic susceptibility are less understood.CaseWe report a 33-year-old female with underlying epilepsy who presented to the emergency department with a four-day history of seizure clus

Sudden Cardiac Death 52

Sudden Cardiac Death Coronary Angiogram Cardiac Arrest Laboratory 52

HCPLive

JUNE 3, 2024

A significantly greater improvement in total FIQ scores was observed among patients with fibromyalgia receiving rTMS compared with placebo.

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59

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Spontaneous coronary artery dissection (SCAD), an uncommon cause of acute coronary syndrome, continues to be a poorly understood disease predominantly affecting females. It is characterized by an abrupt separation in the coronary arterial wall due to intramural bleeding. Fibromuscular dysplasia (FMD) is a non-atherosclerotic arteriopathy manifesting in medium and small-sized arteries.

SCAD 52

SCAD Risk Factors Exercise Research 52

American College of Cardiology

JUNE 3, 2024

What is the benefit of a routine invasive strategy among patients with prior coronary artery bypass grafting (CABG) presenting with non–ST-elevation acute coronary syndrome (NSTE-ACS)?

Coronary Artery Bypass Graft 56

Coronary Artery Bypass Graft Article 56

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

The kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most mammalian organisms, with its downstream metabolites actively involved in various physiological and pathological processes. Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) serve as the initial and pivotal enzymes of the KP, with IDO playing important and intricate roles in cardiovascular diseases.

Cardiovascular Disease 52

Cardiovascular Disease Atherosclerosis Myocardial Infarction Biomarkers 52

Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

Lifetime and temporal co-occurrence of substance use disorders (SUDs) is common and compared with individual SUDs is characterized by greater severity, additional psychiatric comorbidities, and worse outcomes. Here, we review evidence for the role of generalized genetic liability to various SUDs. Coaggregation of SUDs has familial contributions, with twin studies suggesting a strong contribution of additive genetic influences undergirding use disorders for a variety of substances (including alco

Document 72

Document Outcomes 72

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

BackgroundCardiovascular disease (CVD) is a prevalent non-communicable disease globally and holds the position of being the primary cause of mortality worldwide. Consequently, considerable focus has been directed towards the prevention and management of CVD. PCSK9, a frequently targeted element in the treatment and prevention of CVD, can reduce cardiovascular risk by effectively lowering lipid levels even in the context of statin therapy.

Cardiovascular Disease 52

Cardiovascular Disease Research Article Atherosclerosis 52

HCPLive

JUNE 3, 2024

Ahead of the FDA decision on MDMA-assisted therapy to treat PTSD this summer, van der Kolk shares his thoughts on the logistics of care.

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Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Preeclampsia (PE) is a pregnancy-related disorder associated with serious complications. Its molecular mechanisms remain undefined; hence, we aimed to identify molecular subgroups of patients with PE using bioinformatics to aid treatment strategies. R software was used to analyze gene expression data of 130 patients with PE and 138 healthy individuals from the Gene Expression Omnibus database.

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HCPLive

JUNE 3, 2024

Experts discuss strategies for making dry eye care an appealing practice option for optometry students and supporting their success in this specialized field.

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52

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Hypertrophic cardiomyopathy (HCM) is a very prevalent inherited disease with a wide global distribution and a prevalence rate of approximately 0.2% in the general population. Left ventricular hypertrophy (LVH) caused by sarcomere mutation is the primary reason of HCM. The histopathology feature is that cardiomyocyte hypertrophy, myocyte disorder and myocardial fibrosis lead to diminished diastolic function, left ventricular outflow tract obstruction (LVOTO) and arrhythmia, all of which result in

Cardiomyopathy 52

Cardiomyopathy Article Arrhythmia 52

Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

Alcohol-related harm, a major cause of disease burden globally, affects people along a spectrum of use. When a harmful pattern of drinking is present in the absence of significant behavioral pathology, low-intensity brief interventions that provide information about health consequences of continued use provide large health benefits. At the other end of the spectrum, profound behavioral pathology, including continued use despite knowledge of potentially fatal consequences, warrants a medical diag

Pharmacology 69

Pharmacology Outcomes 69

American College of Cardiology

JUNE 3, 2024

Increasingly, hospitals and health systems around the world are leveraging ACC Accreditation Services to help streamline cardiovascular team efficiency and optimize care delivery based on the latest evidence-based clinical guidance.

Hospital 49

Hospital Article 49

Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

Increasing evidence suggests a role of neuroinflammation in substance use disorders (SUDs). This Review presents findings from neuroimaging studies assessing brain markers of inflammation in vivo in individuals with SUDs. Most studies investigated the translocator protein 18 kDa (TSPO) using PET; neuroimmune markers myo-inositol, choline-containing compounds, and N-acetyl aspartate using magnetic resonance spectroscopy; and fractional anisotropy using MRI.

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64

HCPLive

JUNE 3, 2024

A quality improvement initiative exhibited a sustained increase in transcranial Doppler screening rates over an 8-year intervention period.

Stroke 52

Stroke Strokes 52

Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

The macula densa (MD) is a distinct cluster of approximately 20 specialized kidney epithelial cells that constitute a key component of the juxtaglomerular apparatus. Unlike other renal tubular epithelial cell populations with functions relating to reclamation or secretion of electrolytes and solutes, the MD acts as a cell sensor, exerting homeostatic actions in response to sodium and chloride changes within the tubular fluid.

Blood Pressure 64

Blood Pressure Diet 64