Tue.Jun 25, 2024

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Global epidemiology of heart failure

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 26 June 2024; doi:10.1038/s41569-024-01046-6 In this Review, Khan and colleagues explore the evolving global epidemiology of heart failure (HF), focusing on changes in incidence and prevalence across the spectrum of left ventricular ejection fraction. The authors highlight the disparities in our understanding of HF epidemiology in low-income and middle-income countries, affirming the need for improved surveillance and resource allocation in vulnerable

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Challenges and opportunities in the management of type 2 diabetes in patients with lower extremity peripheral artery disease: a tailored diagnosis and treatment review

Cardiovascular Diabetology

Lower extremity peripheral artery disease (PAD) often results from atherosclerosis, and is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Individuals with T2DM exhibit a more severe manifes.

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Cardiovascular Risks Established in Childhood Don't Just Go Away

Med Page Today

(MedPage Today) -- People showed lingering long-term effects of childhood cardiovascular risk factors no matter the changes in adulthood, a population-level cohort study found. Various childhood risk factors were associated with adult cardiovascular.

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AliveCor Announces Dual FDA Clearance of AI Technology That Delivers 35 Cardiac Determinations and First-of-its-Kind Kardia 12L ECG System

DAIC

Pocket-Sized Kardia 12L ECG System milla1cf Tue, 06/25/2024 - 18:55 June 25, 2024 — AliveCor , the global leader in AI -powered cardiology, today announced the U.S. Food and Drug Administration ( FDA ) clearance and commercial launch of KAI 12L AI technology and the Kardia 12L ECG System. This is the world’s first AI that can detect life-threatening cardiac conditions, including heart attacks, using a reduced leadset.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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A Call to Action on Gestational Diabetes

Med Page Today

(MedPage Today) -- ORLANDO -- Earlier screening and treatment for gestational diabetes, as well as a "shift to a holistic life-course approach," are needed to reduce the toll it takes on women. That was the conclusion of a series of papers published.

Diabetes 118
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'A hearty debate' concludes plant-based meat alternatives are healthier for your heart than meat

Science Daily - Heart Disease

Even though there is substantial variability in the contents and nutritional profiles of plant-based meat alternatives (PBMAs), the nutritional profiles tend to reflect a heart-healthy dietary pattern. A review article of the available studies directly comparing the impact of plant-based and animal-based meats consistently suggests that the plant-based alternatives improve cardiovascular risk factors.

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We have a judgment (Part 1)

Dr. Malcolm Kendrick

25 June 2024 In the case against the Mail on Sunday (Associated Newspapers) and Barney Calman, Health Editor of the Mail on Sunday. I have written nothing on this blog for a while, because of my on-going legal case. Now we have a judgment, part one. Step backwards for a moment. Zoë Harcombe and I are suing the Mail on Sunday and Barney Calman for libel.

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Routine Stress Testing After PCI in Patients With and Without Acute Coronary Syndrome

JAMA Cardiology

This prespecified analysis of the POST-PCI randomized clinical trial analyzes clinical outcomes in patients with vs without acute coronary syndrome (ACS) who have undergone high-risk percutaneous coronary intervention (PCI) according to a follow-up strategy of routine surveillance stress testing vs standard care.

Outcomes 108
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Surprisingly High Hypercortisolism Prevalence With Uncontrolled Type 2 Diabetes

Med Page Today

(MedPage Today) -- ORLANDO -- A surprisingly high prevalence of hypercortisolism was found in people with uncontrolled diabetes, according to the two-part, phase IV CATALYST study. Of 1,055 patients with difficult-to-treat type 2 diabetes, 24.

Diabetes 106
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Data Supporting Nanox.AI Cardiac Solution to Be Presented at 19th Annual Meeting of the Society of Cardiovascular Computed Tomography

DAIC

milla1cf Tue, 06/25/2024 - 18:58 June 25, 2024 — Nano-X Imaging (Nanox), an innovative medical imaging technology company, today announced that data from five studies supporting the AI Cardiac Solution (HealthCCSng) of its subsidiary, Nanox AI, will be presented at the 19th Annual Meeting of the Society of Cardiovascular Computed Tomography ( SCCT ), being held July 18-21 in Washington, D.C.

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Duke Health launches cardiology AI testing lab

Becker's Hospital Review - Cardiology

The healthcare field is facing a deluge of potential artificial intelligence products, and Durham, N.C.-based Duke Health has opened an AI testing lab to determine which products are the most effective for heart care.

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Heart Hospital of New Mexico at Lovelace Medical Center and GE HealthCare Collaborate to Install the First Allia IGS Pulse Electrophysiology Lab in the United States for Minimally Invasive Cardiovascular Procedures

DAIC

milla1cf Tue, 06/25/2024 - 18:52 June 25, 2024 — Heart Hospital of New Mexico at Lovelace Medical Center (HHNM) and GE HealthCare (announced HHNM as the first location in the United States to install GE HealthCare ’s latest Allia Image Guided System (IGS) Pulse, which was designed to provide exceptional image quality and improve workflow for the diagnosis and treatment of cardiovascular diseases ( CVD ).

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Low-Dose SGLT2 Inhibitor May Protect Kidneys in Youth With T1D

Med Page Today

(MedPage Today) -- ORLANDO -- Adding a low dose of an SGLT2 inhibitor to insulin improved renal function and glycemic control in adolescents with type 1 diabetes (T1D), the late-breaking ATTEMPT trial found. In the 98-patient study, treatment.

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Plaque Psoriasis: Comorbidities, Classification, and Testing Practices

HCPLive

Linda Stein Gold, MD, and Bruce Strober, MD PhD, discuss classification and monitoring practices for patients with plaque psoriasis.

Plaque 97
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Preeclampsia Can Be Fatal. New Blood Tests Aim to Determine Who Is at Risk.

Med Page Today

(MedPage Today) -- When patients are expecting a baby, they hope nothing goes wrong. But at least one in 20 people who are pregnant develop preeclampsia, a high blood pressure disorder that kills 70,000 women and 500,000 babies worldwide every.

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New drug cuts cardiovascular events, death by 36%

Becker's Hospital Review - Cardiology

Vutrisiran, a new drug made by Alnylam Pharmaceuticals to treat ATTR amyloidosis with cardiomyopathy, reduced the risk of death by 36% in patients, the drugmaker announced June 24.

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Autoimmune Diseases and Coronary Atherosclerosis

American College of Cardiology

Do autoimmune diseases independently correlate with coronary atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) risk, and do traditional cardiovascular risk factors modulate the risk?

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Older adults still taking aspirin for heart health despite push to stop

Becker's Hospital Review - Cardiology

Despite 2019 recommendations from the American College of Cardiology and the American Heart Association warning adults against routinely taking aspirin for heart health, many are still doing so , according to a new study from Cleveland Clinic researchers.

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Ixekizumab Leads to Consistent Efficacy for Psoriatic Arthritis, Despite Psoriasis Severity

HCPLive

These data, resulting from a post-hoc analysis, highlighted the musculoskeletal, skin, and nail outcomes among patients with psoriasis and PsA.

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Palpitations in athletes: diagnosis, workup and treatment

Heart BMJ

Palpitations are a common reason for athletes to seek medical care. Although often benign, palpitations may serve as a harbinger for underling cardiac pathology. Given the unique challenges in this population, this review will serve to discuss the basic underlying pathophysiology, which may predispose athletes to palpitations. In addition, we will review the aetiologies, diagnostic evaluation, management and counselling strategies for some of the most common diagnoses seen in athletes.

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FDA Grants Priority Review for Olezarsen in Familial Chylomicronemia Syndrome

HCPLive

The FDA accepted the NDA for olezarsen, an RNA-targeted medicine, in familial chylomicronemia syndrome for priority review, with a PDUFA date set for December 19, 2024.

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Thoracic versus coronary calcification for atherosclerotic cardiovascular disease events prediction

Heart BMJ

This study compared the prognostic value of quantified thoracic artery calcium (TAC) including aortic arch on chest CT and coronary artery calcium (CAC) score on ECG-gated cardiac CT. Methods A total of 2412 participants who underwent both chest CT and ECG-gated cardiac CT at the same period were included in the Multi-Ethnic Study of Atherosclerosis Exam 5.

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FDA Accepts sNDA for Brexpiprazole in Combination with Sertraline for Adult PTSD

HCPLive

FDA accepts a supplemental New Drug Application for brexpiprazole in combination with sertraline for the treatment of adults with PTSD, with a PDUFA date of February 8, 2025.

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Effectiveness of polypill for primary and secondary prevention of cardiovascular disease: a pragmatic cluster-randomised controlled trial (PolyPars)

Heart BMJ

Background We aimed to investigate the effectiveness of fixed-dose combination therapy (polypill) for primary and secondary prevention of major cardiovascular diseases in a typical rural setting. Methods The PolyPars Study is a two-arm pragmatic cluster-randomised trial nested within the PARS cohort study, including all residents aged over 50 years in the entire district in southern Iran.

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Higher Fertility Rates Observed in Male Patients with Rheumatic Disease

HCPLive

Among all groups, fewer men with rheumatic disease were childless compared with controls.

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Unexpected finding on imaging: an aortic valve mass

Heart BMJ

Clinical introduction Vignette A woman in her 50s, with a history of atrial fibrillation, was admitted for a coronary angiography (CA) due to dyspnoea on exertion with a reduced ejection fraction of 40%. CA was performed after 24 hours interruption of apixaban and demonstrated normal coronary arteries. The patient was discharged and apixaban was restarted 10 hours later.

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Mezagitamab Achieves Platelet Response, Favorable Safety in ITP Treatment

HCPLive

Mezagitamab demonstrated no new safety signals and rapid increases in platelet counts across Phase 2b data in treating persistent or chronic ITP.

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Cardiogeriatrics: the current state of the art

Heart BMJ

It is estimated that by 2050, 17% of the world’s population will be greater than 85 years old, which, combined with cardiovascular disease (CVD) being the leading cause of death and disability, sets an unprecedented burden on our health and care systems. This perfect storm will be accompanied by a rise in the prevalence of CVD due to increased survival of patients with pre-existing CVD and the incidence of CVD that is associated with the process of ageing.

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Clinical Quiz: Pharmacotherapy Recommendations from ESC/EAS 2019 Dyslipidemia Guidelines

HCPLive

The latest in our series of quizzes on the ESC/EAS 2019 Dyslipidemia guidelines tests your knowledge on pharmacotherapy recommendations from the document!

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Future applications of incidental detection of thoracic and coronary calcium for atherosclerotic cardiovascular disease events prediction

Heart BMJ

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death around the world. Consequently, the identification of asymptomatic patients at high risk of ASCVD events is vital to ensure the timely initiation of primary prevention therapies. Traditional clinical risk factor-based models are currently recommended for initial risk stratification in patients at low risk or without ASCVD. 1 These remain imperfect, with low sensitivity for detection of premature artery disease in you

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Socioeconomic Status Linked to Disparities in RA Care, Management

HCPLive

Findings underscore the impact of socioeconomic factors on disease management and therapeutic outcomes in patients with rheumatoid arthritis from different socioeconomic classes.

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Polypill: a harmonious blend of stoicism and pragmatism in primary cardiovascular prevention

Heart BMJ

Despite the existence of well-established risk factors and effective pharmacological treatments for major cardiovascular disease (CVD), these conditions remain among the leading causes of premature death and disability, exerting a substantial burden on health systems worldwide. Previous randomised studies have provided compelling evidence for the efficacy of blood pressure and lipid-lowering treatments in reducing the risk of CVD, suggesting unique opportunities for the prevention of this chroni

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Gout Patients on Ruzinurad Were More Likely to Achieve Target Serum Uric Acid Level

HCPLive

Phase 2 data presented at EULAR 2024 showed gout patients on febuxostat and ruzinurad were more likely to achieve the target serum uric acid level than those on febuxostat alone.

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Early Extracorporeal Life Support Fails to Improve Survival in Cardiogenic Shock Associated With Acute Myocardial Infarction

American College of Cardiology

Cardiogenic shock is a common complication in patients who present with acute myocardial infarction (AMI) and is the leading cause of death in this population. Even with immediate revascularization, death rates remain high.

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Intraocular Pressure Events Rare After Lampalizumab for Geographic Atrophy

HCPLive

These data pointed to a low risk of persistent IOP increases of intravitreous 0.1-mL injection volumes administered for 1 year in eyes with GA.

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Inpatient Initiation of HF GDMT: What Are You Waiting For?

American College of Cardiology

In this interview, Stephen Greene, MD, FACC and Sidney C. Smith Jr., MD, MACC discuss inpatient initiation of HF GDMT.