Tue.Jun 18, 2024

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FDA Approves Risankizumab (Skyrizi) for Ulcerative Colitis

HCPLive

The approval is based on data from a pair of phase 3 studies and makes risankizumab-rzaa the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn’s disease.

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Over-the-counter supplement found to improve walking for peripheral artery disease patients

Medical Xpress - Cardiology

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

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ECG Cases 50 – STEMI: A Failed Paradigm, Enter Occlusion MI

ECG Cases

Dr. Jesse McLaren illustrates the paradigm shift from STEMI to Occlusion MI (OMI) through 9 cases, and drives home the points that if there is STEMI criteria, consider false positives (eg. secondary and proportional to LVH or BER); if there is no STEMI criteria, consider false negatives and look for other signs of occlusion (eg. acute Q waves or loss of R waves, hyperacute T waves, or reciprocal STD/TWI) and if the ECG is nondiagnostic, consider other OMI signs including clinical (refractory isc

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Diabetic foot disease carries an intrinsic high risk of mortality and other severe outcomes in type 2 diabetes: a propensity score-matched retrospective population-based study

Cardiovascular Diabetology

To evaluate the association between diabetic foot disease (DFD) and the incidence of fatal and non-fatal events in individuals with type 2 diabetes (T2DM) from primary-care settings.

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Perinatal Depression Tied to Increased Risk of Midlife Cardiovascular Disease

Med Page Today

(MedPage Today) -- Women with perinatal depression (PND) had a higher risk of cardiovascular disease (CVD) in middle adulthood than matched parous women without PND, a Swedish nationwide study found. Over a mean of 10.4 years, women with PND had.

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JACC Report Card Highlights Inequities in CV Care, Death Rates

DAIC

Getty Images milla1cf Tue, 06/18/2024 - 19:56 June 18, 2024 — As we commemorate Juneteenth 2024, JACC , the flagship journal of the American College of Cardiology , has published “Excess Cardiovascular Mortality Among Black Americans 2000-2022: A Report Card,” to highlight the persistent and tragic inequities in cardiovascular care and put in human terms the years of life lost to the Black community because of their higher cardiovascular disease death rates.

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Over-the-counter supplement improves walking for peripheral artery disease patients

Science Daily - Stroke

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

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Machine Learning Could Offer Noninvasive, Reliable Diagnostic Tool in IgA Nephropathy

HCPLive

Findings suggest machine learning models may have promising utility in IgAN, highlighting the superior diagnostic performance of certain models versus standard logistic regression.

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Elixir Medical Granted FDA Breakthrough Device Designation for DynamX Bioadaptor

DAIC

Elixir Medical has announced the company’s novel bioadaptive implant, DynamX Sirolimus-Eluting Coronary Bioadaptor System, has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration (FDA). The designation recognizes the novelty of the technology and the potential to provide a more effective treatment option for patients with coronary artery disease.

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Large-Scale Intensive BP Intervention ProvesSustainable for CVD Prevention

Med Page Today

(MedPage Today) -- A community-based intensive blood pressure (BP) intervention was safe and effective for both older and younger adults with hypertension, a randomized trial conducted in rural China showed. Among participants ages 60 and older.

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Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories

DAIC

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 trillion by 2050, according to two presidential advisories published in the AHA journal Circulation. christine.book Tue, 06/18/2024 - 11:22 June 18, 2024 — At least 6 in 10 adults in an older, more diverse U.S. population could be affected by cardiovascular disease within the next 30 years, according to two new science reports.

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Cardiology's Private Equity Hot Spots; Statin Overuse; Type B Blood & Heart Injury

Med Page Today

(MedPage Today) -- Over one in 10 cardiology practices in several states -- Rhode Island, Nevada, Louisiana, Arizona, Oklahoma, Texas, and Florida -- have been acquired by private equity. (JAMA Health Forum) Workplace sexual harassment was.

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Sotagliflozin Demonstrates Cost-Effectiveness in T2D and Heart Failure

HCPLive

New research from the SOLOST-WHF trial suggests sotagliflozin is a cost-effective treatment for diabetes patients with recent heart failure, with high cost-effectiveness probability.

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EM Quick Hits 57 – HIV Diagnosis, Failed Paradigm of STEMI Criteria, Poisoned Patient Airway Management, Spontaneous Bacterial Peritonitis, DIY Investments

ECG Cases

In this month's EM Quick Hits podcast: Megan Landes on the importance of diagnosing HIV in the ED, Jesse McLaren on the failed paradigm of STEMI criteria and ECG tips to identify acute coronary occlusion, Anand Swaminathan on evidence for non-invasive airway management in the poisoned patient, Brit Long and Hans Rosenberg on the identification, workup and management of spontaneous bacterial peritonitis, Matt Pointer on the most lucrative side-gig, DIY investing.

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JACC Report Card Documents Excess CV Mortality Among Black Americans

American College of Cardiology

Black Americans suffered nearly 800,000 excess age-adjusted deaths and 24 million excess years of potential life lost due to cardiovascular disease from 2000 to 2022, compared with their White counterparts.

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Proximity-based labelling for proteomic mapping

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 June 2024; doi:10.1038/s41569-024-01054-6 In this Tools of the Trade article, Jablonska describes the use of proximity-based labelling for the proteomic profiling of novel protein–protein interactions.

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Lumateperone Significantly Enhances Antidepressant Effects in Phase 3 Trial

HCPLive

A phase 3 trial shows lumateperone as adjunctive therapy with antidepressants significantly reduces depression symptoms in patients with major depressive disorder.

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Chronic hypertension doubled in 2 decades for pregnant patients

Becker's Hospital Review - Cardiology

New study reveals alarming increase in chronic hypertension among pregnant patients in the last two decades, with no significant impact from updated treatment

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Biologics for Psoriasis Less Effective Among Individuals with Specific Clinical Characteristics

HCPLive

These data resulted from a new meta-analysis in which biologic therapies were shown to be less effective among psoriasis patients with clinical characteristics such as age and BMI.

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Have We All Gone MAD?

American College of Cardiology

Tremendous enthusiasm about mitral annulus disjunction (MAD) emerged in 2018 when Dejgaard et al. showed that, in their cohort of patients with mitral valve prolapse (MVP), MAD was associated with an increased risk of malignant ventricular arrhythmias (VAs).

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Improving Strategies for Management of Primary Biliary Cholangitis

HCPLive

In this video segment, Palak and Trivedi discuss strategies for improving the management of patients in real-world settings given recent advances in therapies and pathophysiology.

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Seattle hospital's heart failure program cuts readmissions by 36%

Becker's Hospital Review - Cardiology

A Seattle-based UW Medicine heart failure program is keeping patients out of the hospital and providing indefinite care for vulnerable heart failure patients.

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Frederic Lavie, MD, PhD: Guselkumab Demonstrates Rapid, Sustained Improvements in Severe PsA

HCPLive

Treatment with guselkumab led to rapid, clinically meaningful improvements in disease activity among patients with severe psoriatic arthritis, which were maintained through 2 years.

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Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort

Cardiovascular Diabetology

Triglyceride glucose (TyG) index and its related parameters have been introduced as cost-effective surrogate indicators of insulin resistance, while prospective evidence of their effects on atherosclerotic car.

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Frederic Lavie, MD, PhD: Guselkumab Provides Robust Improvements in Pain Among Patients with PsA

HCPLive

Data showed a significant reduction in pain for patients with psoriatic arthritis and inadequate response to TNF treated with guselkumab compared with placebo.

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Suture-to-scan: ultrasonography-guided induction of heart injury

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 June 2024; doi:10.1038/s41569-024-01055-5 In this Tools of the Trade article, Berkeley and Thomson describe the use of a minimally invasive strategy to standardize the induction of myocardial infarction in mice.

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Cost, Healthcare Resource Utilization Greater in Patients with AATD with Liver, Lung Disease

HCPLive

Findings suggest patients with AATD with liver and/or lung disease face greater all-cause costs and healthcare resource utilization than those with AATD alone.

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Therapeutic options for neurocardiogenic syncope: a meta-analysis of randomised trials with and without blinding

Open Heart

Background Neurocardiogenic syncope is a common condition with significant associated psychological and physical morbidity. The effectiveness of therapeutic options for neurocardiogenic syncope beyond placebo remains uncertain. Methods The primary endpoint was the risk ratio (RR) of spontaneously recurring syncope following any therapeutic intervention.

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Clinical and Patient Perspectives on Unmet Needs in PBC Management

HCPLive

In this video segment, Palak and Trivedi break down their perspectives on the current state of unmet need in primary biliary cholangitis from a clinical and patient perspective.

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Electroacupuncture for slow flow/no-reflow phenomenon in patients with acute myocardial infarction undergoing percutaneous coronary intervention: protocol for a pilot randomized controlled trial

Frontiers in Cardiovascular Medicine

BackgroundSlow flow/no-reflow (SF-NR) during percutaneous coronary intervention (PCI) is associated with poor prognosis of patients with acute myocardial infarction (AMI). Currently, effective treatment is not available for SF-NR. Electroacupuncture (EA) has shown significant efficacy as an adjuvant therapy for many cardiovascular diseases by improving microcirculation and reducing ischemia-reperfusion injury.

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HE Experts on Symptoms, Risk Factors, Diagnosis Challenges, and Severity Grading

HCPLive

The expert panelists explore the symptoms and risk factors associated with HE, the challenges in diagnosing the condition due to its resemblance to neuropsychiatric l disorders, and the methods used to assess and grade the severity of the disease.

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Severe Aortic Stenosis, Titration and Acute Heart Failure, Pacemakers After TAVR

American College of Cardiology

In this week's View, Dr. Eagle looks at secular trends of incidence and outcomes in severe aortic stenosis. He then examines titration of medications after acute heart failure.

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Collaborating with Specialists: Primary Care Clinician’s Evolving Role in HE Management

HCPLive

The panel examines the evolving role of primary care clinicians in managing patients with hepatic encephalopathy (HE) and emphasizes the importance of consulting specialists when necessary, providing insights from the perspective of a primary care clinician.

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Office Measurement vs. Ambulatory BP Monitoring

American College of Cardiology

What is the relationship between office and ambulatory blood pressure (BP) measurements as well as different hypertension phenotypes with mortality in a large cohort of patients in primary care?

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Updates in Therapeutic Approaches to PBC Following Elafibranor Approval

HCPLive

In this video segment, Palak and Trivedi discuss the approval of elafibranor and other therapies that could receive approval for management of primary biliary cholangitis in the near future.

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Transcatheter mitral valve-in-valve for pregnancy with anti-phospholipid syndrome: a case report

Journal of Cardiothoracic Surgery

Perioperative management and cardiac surgery in pregnant women with anti-phospholipid syndrome combined with heart valve disease have been rarely reported.

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Rapid Treatment Initiation in HIV

HCPLive

Focusing on the importance of rapid treatment initiation in HIV, Shauna Applin, ARNP, reviews available therapies and provides clinical insights on treatment considerations.

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