Thu.Mar 27, 2025

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Comparison of multiple arterial grafts vs. single arterial graft in coronary artery bypass surgery: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Observational studies and randomised controlled trials (RCTs) have yielded conflicting results regarding the outcomes of multiple arterial grafts (MAG) vs. single arterial grafts (SAG) in coronary artery bypass graft (CABG) surgery. We conducted a comprehensive search across multiple databases for RCTs that directly compared MAG and SAG. The clinical outcomes assessed included all-cause mortality, cardiac-specific mortality, myocardial infarction (MI), repeat revascularization, stroke, sternal w

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Navigating Biologic Treatment Selection in Psoriasis and Psoriatic Arthritis

HCPLive

Panelists discuss how selecting among the numerous approved biologic therapies for psoriasis requires a personalized approach that weighs factors such as efficacy data, safety profiles, comorbidities, insurance coverage, and administration preferences, with patient preferences playing a crucial role in the decision-making process, as involving patients in treatment selection enhances medication adherence and satisfaction and ultimately improves long-term outcomes.

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Scientific journey from PSCK9 discovery in familial hypercholesterolaemia

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 March 2025; doi:10.1038/s41569-025-01147-w Countries globally face major challenges in the early diagnosis and treatment of hypercholesterolaemia and cardiovascular disease, with numerous health inequities by geography and income. Perseverance, hard work, integrity and commitment can transform aspiration into reality.

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Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

HCPLive

Panelists discuss how Bruton tyrosine kinase (BTK) inhibitors represent a promising new therapeutic class for chronic spontaneous urticaria (CSU) by offering rapid symptom control through targeted inhibition of both mast cell and B cell pathways, with newer agents like remibrutinib showing high selectivity, favorable safety, and robust efficacy in clinical trials that could position them as an important oral therapy option between antihistamines and biologics.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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GE Healthcare Launches New Cardiac PET tracer

DAIC

tim.hodson Thu, 03/27/2025 - 15:40 March 27, 2025 GE HealthCare is announcing theU.S.launch of Flyrcado(flurpiridaz F 18) injection at the 2025American College of Cardiology(ACC) AnnualScientific Session & Expo inChicago. Flyrcado is aunit dose positron emission tomography myocardial perfusion imaging (PET MPI) agent. In 2024, the FDA approved Flyrcado for patients with known or suspected coronary artery disease (CAD), delivering higher diagnostic efficacy compared to single-photon emission com

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Incorporating Clinical Guidelines in Psoriasis Management

HCPLive

Panelists discuss how biologic therapies for psoriasis are increasingly considered earlier in treatment algorithms based on the American Academy of Dermatology-National Psoriasis Foundation (AAD-NPF) Guidelines and updated International Psoriasis Council (IPC) severity classifications, with decisions influenced by disease extent, impact on quality of life, presence of psoriatic arthritis, treatment history, patient preferences, and the recognition that prompt intervention with biologics can prev

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Anticipating Fitusiran’s Approval for Factor-Agnostic Hemophilia A, B, with Robert F. Sidonio Jr., MD, MSc

HCPLive

Sidonio discussed how fitusiran may improve the treatment landscape and reduce treatment burden for people with hemophilia A or B with or without inhibitors.

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Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design

Frontiers in Cardiovascular Medicine

BackgroundCardiovascular (CV) disease is the leading cause of death in women. Although 80% of CV disease events can be prevented, mortality is projected to increase, particularly in young women.ObjectivesTo promote CV health in women and encourage appropriate lifestyle changes by increasing awareness through vascular ultrasound imaging.MethodsWAKE UP is a prospective case-control study in a target population of 720 asymptomatic women, aged 4070 years with 1 major CV risk factor (RF).

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What balance could mean for heart and brain health

Medical Xpress - Cardiology

It's an ability and skill often taken for granted. It affects quality of life and has been linked to heart disease and stroke. As we age and our muscles weaken, balance becomes crucial to staying active and supporting a healthy heart and brain.

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An Athlete’s Triumph Overcoming Thoracic Outlet Syndrome

CTVS

For Michael Miskovich, an active 25-year-old, fitness is more than a hobby, it is his way of life. From mixed martial arts (MMA) and kickboxing to rigorous weightlifting, he pushes his body to the limit. But in December 2024, a slight shoulder tightness quickly took a serious turn, revealing a blood clot and a Thoracic Outlet Syndrome diagnosis.

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What is vascular dementia? A neurologist explains

Medical Xpress - Cardiology

An estimated 55 million people are believed to be living with dementia, according to health officials. Vascular diseases contribute to approximately 25% of all diagnoses.

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Elevating global heart failure care with new certification

American Heart News - Heart News

DALLAS, March 27, 2025 More than 56 million people globally live with heart failure (HF), which prevents the body from getting enough of the oxygen-rich blood it needs to work properly.[1] While there is no cure for HF, many people with this.

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Organophosphate Pesticide Exposure Linked to Atopic Dermatitis Risk

HCPLive

These data point to the role of environmental factors in the development of atopic dermatitis and indicate targeted prevention strategies for those known to be impacted.

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Unveiling the hidden risk: a case of severe jaundice triggered by intra-aortic balloon pump after cardiac surgery

Journal of Cardiothoracic Surgery

The Intra-Aortic Balloon Pump (IABP) is a widely utilized technique to provide circulatory support for critically ill patients with cardiac dysfunction. While IABP therapy offers clinical benefits, the placeme.

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Omalizumab Enhances Oral Immunotherapy for Pediatric Food Allergies

HCPLive

A study found omalizumab enables faster, safer desensitization in children with food allergies, improving oral immunotherapy outcomes and reducing reactions.

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The role of left atrio-ventricular coupling index and left atrial ejection fraction in predicting onset of atrial fibrillation and adverse cardiac events in hypertrophic cardiomyopathy

Cardiovascular Ultrasound

Several predictors of atrial fibrillation (AF) onset in patients with hypertrophic cardiomyopathy (HCM) have been proposed, however, all of them showed limited accuracy. This study aims to assess the role of n.

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Allegheny General Hospital First in Western PA to Participate in Clinical Trial Using Artificial Intelligence to Detect Deep Vein Thrombosis in Cardiac Patients

HCPLive

The AI-powered trial was officially initiated in January 2025.

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Pericoronary adipose tissue attenuation predicts compositional plaque changes: a 12-month longitudinal study in individuals with type 2 diabetes without symptoms or known coronary artery disease

Cardiovascular Diabetology

Pericoronary adipose tissue attenuation (PCATa), derived from coronary computed tomography angiography (CCTA), is a novel marker of inflammation in the coronary arteries. Patients with type 2 diabetes mellitus.

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Severity of Transient Shedding with Minoxidil for Alopecia Linked to Treatment Efficacy

HCPLive

In this analysis, the investigators evaluated the temporal increase in hair shedding amounts following topical minoxidil utilization.

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Heart rate variability tests for diagnosing cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus in advanced stages of kidney disease

Cardiovascular Diabetology

Cardiovascular Autonomic Neuropathy (CAN) is one of the most devastating complications of Diabetes Mellitus (DM) and presents high morbidity and mortality. Its association with diabetic kidney disease (DKD) wo.

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Meta-Analysis Confirms the Unlikelihood of GLP-1 RA Raising Suicidal Risk

HCPLive

A meta-analysis of 27 trials found no increased risk of suicide or self-harm with GLP-1 RAs, supporting their safety for diabetes and obesity management.

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New Frontiers at ACC Meeting: Semaglutide, INOCA, & More

Med Page Today

(MedPage Today) -- CHICAGO -- Coming this weekend, the American College of Cardiology (ACC) annual conference will feature research exploring new frontiers for GLP-1 drugs in cardiovascular medicine, and foundational answers are expected for.

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Pretransplant Immunotherapy for Hepatocellular Carcinoma, with Parissa Tabrizian, MD

HCPLive

Tabrizian discusses neoadjuvant immunotherapy for HCC, describing its success in the adjuvant setting but uncertainties about its use before transplant.

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Hypertension causes kidney changes at an early stage, finds study

Medical Xpress - Cardiology

A research team from the Medical University of Vienna has investigated structural changes in kidneys of patients with hypertension and type 2 diabetes. The results show that high blood pressure can lead to abnormalities in the podocytes, specialized cells in the renal filter, even without other pre-existing conditions such as diabetes.

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ACC 2025: 7 Trials to Watch

HCPLive

A look at 7 phase 2 and phase 3 trials with significant implications from ACC 2025's late-breaking and featured clinical research sessions.

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A caffeine kick can come with health risks

Medical Xpress - Cardiology

Caffeine is almost ubiquitous in everyday life. It is found in the typical morning cup of coffee, in black tea, in cola, in energy drinks and even in chocolate.

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Prior Oral Anticoagulant Use May Influence Stroke, Bleeding Risk in AF

HCPLive

OAC-naive patients experienced a significantly smaller increase in stroke or systemic embolism with asundexian than apixaban.

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Combination of hypertension and atrial fibrillation is a ticking time bomb—experts call for simultaneous screening

Medical Xpress - Cardiology

A group of 29 international experts says that simultaneous screening for hypertension and heart arrhythmia could prevent thousands of strokes.

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The Need for Hepatitis Vaccination in Chronic Liver Disease, with Paul Kwo, MD

HCPLive

Kwo explains why hepatitis A and B vaccination is important for people with liver disease and reviews different vaccine options.

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Mediastinal A5: a novel artery variant of the pulmonary artery system: a case report

Journal of Cardiothoracic Surgery

Variations in the pulmonary artery require increased attention from thoracic surgeons prior to or during lobectomy to avoid severe intraoperative bleeding. Patients with pleural and/or hilar adhesions typicall.

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KDIGO Announces Publication of 2025 ADPKD Guideline

HCPLive

The new guideline provides healthcare providers, people living with ADPKD, and stakeholders with practical tools to improve diagnosis, care, and treatment.

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Diagnostic characteristics of multimodality imaging for left ventricular lipoma: new insights on surgical intervention

Cardiovascular Ultrasound

The echocardiography is the first-line imaging modality in detecting the cardiac lipoma. Contrast-enhanced echocardiography improves its structural definition and characteristics of blood supply to exclude thr.

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Vascular Surgeons at Allegheny Health Network First in Western Pennsylvania to Offer New Minimally Invasive Surgical Procedure for Patients Diagnosed with Peripheral Artery Disease

HCPLive

First Procedure Performed at AHN Wexford Hospital, Demonstrating Networks Ongoing Commitment to Bringing Complex Cardiovascular Care into the Community

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Direct Oral Anticoagulants versus Warfarin for Atrial Fibrillation in Patients with Transthyretin Cardiac Amyloidosis: A Retrospective Cohort Analysis

HeartRhythm

Transthyretin cardiac amyloidosis (ATTR-CA) is frequently associated with atrial fibrillation (AF), which increases the risk of intra-cardiac thrombus formation [1, 2]. Unlike the general population with AF, patients with ATTR-CA experience extensive amyloid infiltration in the atria, leading to structural remodeling, atrial stiffness, endothelial dysfunction, and impaired atrial contractility, which may alter the thrombotic risks associated with anticoagulation [1, 2].

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Higher Astigmatism Rates Found in Children after COVID-19 Pandemic

HCPLive

Hong Kong schoolchildren exhibit increased rates of refractory and corneal astigmatism due to screen exposure during lockdown.

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Comparison of Clinical Outcomes Between Left Bundle Branch Area Pacing With a Stylet‐Driven Lead and Conventional Right Ventricular Pacing

Journal of Cardiovascular Electrophysiology

In this cohort study including 738 patients (243 left bundle branch area pacing using stylet-driven lead vs. 495 right ventricular pacing), left bundle branch area pacing was associated with a lower risk of the primary outcome by 73% compared to right ventricular pacing with comparable safety profiles. ABSTRACT Backgrounds and Aims Left bundle branch area pacing (LBBAP) has been shown to reduce the risk of pacing-facilitated heart failure (HF) compared to right ventricular pacing (RVP), but limi