Wed.Mar 13, 2024

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Children with Sickle Cell Disease Experience Severe COVID-19 Infection

HCPLive

In a registry-based analysis, more hospitalized children with SCD and COVID-19 had severe infection requiring supplemental oxygen, compared with the general population.

COVID-19 115
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Don't Drive on These Meds; Darryl Strawberry's Heart Attack; CDC Airport Screening

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. These types of medications don't mix well with driving, the FDA warned. About 11% of high school seniors reported using delta-8-tetrahydrocannabinol (delta-8-THC.

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BioCardia Announces CMS Approval of Coverage for CardiAMP Cell Therapy Confirmatory Phase III Heart Failure Study

DAIC

Getty Images milla1cf Wed, 03/13/2024 - 16:49 March 13, 2024 — BioCardia, Inc. , a developer of cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, today announced Centers for Medicare & Medicaid Services (CMS) approval for reimbursement coverage of the confirmatory Phase III clinical trial of CardiAMP autologous cell therapy for the treatment of patients with ischemic heart failure.

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Slowing of Peripheral Artery Disease: Another Liraglutide Benefit?

Med Page Today

(MedPage Today) -- Liraglutide (Victoza), a type 2 diabetes drug, may help prevent peripheral artery disease (PAD) progression, the small, open-label STARDUST trial suggested. Over 6 months, adults with type 2 diabetes on subcutaneous liraglutide.

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Association between triglyceride-glucose index and intracranial/extracranial atherosclerotic stenosis: findings from a retrospective study

Cardiovascular Diabetology

The association of the triglyceride-glucose (TyG) index with intracranial atherosclerotic stenosis (ICAS) and extracranial atherosclerotic stenosis (ECAS) is unclear. This study aimed to investigate the relati.

Stenosis 105
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Positive Topline 36-Week Data from Ongoing Phase 2 Study of Zerlasiran in Patients with High Lp(a) Announced by Silence Therapeutics

DAIC

Silence Therapeutics has announces positive topline 36-week data from its ongoing Phase 2 Study of Zerlasiran in patients with high Lipoprotein(a), reporting that the study met the primary endpoint and demonstrated highly significant reductions in Lp(a) to week 36. Image courtesy: Silence Therapeutics christine.book Wed, 03/13/2024 - 13:00 March 13, 2024 — Silence Therapeutics has announced positive topline 36-week data from the ongoing ALPACAR-360 phase 2 study of zerlasiran ( SLN360 ) in 178 s

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Oral Systemics for the Treatment of Plaque Psoriasis

HCPLive

April W. Armstrong, MD, MPH, discusses emerging therapies in oral systemics for the treatment of plaque psoriasis and shares developments in TYK2 inhibition.

Plaque 98

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Artificial intelligence detects heart defects in newborns

Science Daily - Heart Disease

Researchers from ETH Zurich and KUNO Klinik St. Hedwig in Regensburg have developed an algorithm that provides an automatic and reliable method of detecting a certain heart defect in newborns. Researchers from ETH Zurich and KUNO Klinik St. Hedwig in Regensburg have developed an algorithm that provides an automatic and reliable method of detecting a certain heart defect in newborns.

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Case 8-2024: A 55-Year-Old Man with Cardiac Arrest, Cardiogenic Shock, and Hypoxemia

The New England Journal of Medicine

A 55-year-old man had an out-of-hospital cardiac arrest. An evaluation showed 2-mm ST-segment elevations in the inferior leads on electrocardiography, cardiogenic shock, and a new systolic murmur. A diagnosis was made.

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Novel cardiovascular therapeutics and the risk of financial toxicity

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 14 March 2024; doi:10.1038/s41569-024-01010-4 Novel cardiovascular therapeutics have the potential to improve health outcomes, but financial toxicity from high out-of-pocket costs can limit the reach of these medications and worsen existing health disparities. Understanding the phenomenon of financial toxicity in treating cardiovascular disease is crucial to achieving health equity.

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Not Otherwise Specified — Season 2: The Quiet Revolution in Medical Training: Debt Et Cetera — NOS Episode 2.6

The New England Journal of Medicine

In this podcast episode, host Lisa Rosenbaum talks with two trainees whose lives and careers have been changed by educational debt, and to an economist who has a rather different take on the problem.

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Atlantic Health, NYU Langone partner on heart care

Becker's Hospital Review - Cardiology

Morristown, N.J.-based Atlantic Health System's Morristown Medical Center and New York City-based NYU Langone Health expanded their partnership to include adult congenital heart disease services.

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Gilbert H. L. Tang Named Next Editor-in-Chief of JACC: Case Reports

American College of Cardiology

Gilbert H. L. Tang, MD, MSc, MBA, FACC, has been selected as the next editor-in-chief of JACC: Case Reports. He will officially assume the role of editor-in-chief on Aug. 1, with his first issue slated for Aug. 7.

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Wegovy Gains Expanded Approval for CVD Risk Reduction

CardiacWire

The hottest drug class in the world just got even hotter after the FDA approved Novo Nordisk’s weight-loss drug Wegovy for cardiovascular event risk reduction, opening new cardiology-focused routes for GLP-1 care and coverage. Wegovy’s expanded FDA approval now supports its use for the reduction of major adverse cardiovascular events in obese or overweight adults with established CVD.

Obesity 64
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Andrew F. Alexis, MD, MPH: ADORING Trials, Tapinarof Cream, and Improving Skin of Color Research Representation

HCPLive

Alexis discusses clinical and demographic hurdles in treating skin of color for conditions like atopic dermatitis, and the potential of research like that being done in tapinarof cream 1%.

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The Revolution of Continuous Medical Education: Transforming Healthcare Worldwide

ADN Center of Excellence

In the ever-changing environment of healthcare, one thing remains constant: the need for continuous learning and adaptation. The field of medicine is rapidly evolving, with new discoveries, technologies, and therapies arriving on a daily basis. In this blog, we'll focus at how continuing medical education is more than simply a professional requirement; it's also a catalyst for good change, altering healthcare throughout the world.

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COVID-19 Never Truly Goes Away: Long COVID’s Debilitating Symptoms Uproots Lives

HCPLive

Now, 4 years since the start of the pandemic, how has sleep been impacted? Sleep experts provide their perspective.

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The “arrhythmic” presentation of peripartum cardiomyopathy: case series and critical review of the literature

Frontiers in Cardiovascular Medicine

Peripartum Cardiomyopathy (PPCM) is a polymorphic myocardial disease occurring late during pregnancy or early after delivery. While reduced systolic function and heart failure (HF) symptoms have been widely described, there is still a lack of reports about the arrhythmic manifestations of the disease. Most importantly, a broad range of unidentified pre-existing conditions, which may be missed by general practitioners and gynecologists, must be considered in differential diagnosis.

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Next-Gen Cologuard Test Shows Promise for Early Detection of Colorectal Cancer

HCPLive

A new study suggests a next-generation stool DNA test from Exact Sciences has improved sensitivity for colorectal cancer and precancerous lesions but lower specificity than FIT.

Cancer 59
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DAPT Maintains Early Neurologic Function in Mild-Moderate Stroke

Med Page Today

(MedPage Today) -- In certain patients with mild-to-moderate acute ischemic stroke, dual antiplatelet therapy (DAPT) with aspirin and clopidogrel (Plavix) reduced early neurologic deterioration better than aspirin alone, the Chinese randomized.

Stroke 59
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Maralixibat Approval for Cholestatic Pruritus in PFIC Signals New Frontier for IBAT Inhibitor

HCPLive

Saeed Mohammed, MD, MS, discusses maralixibat for pruritus in PFIC, describing how IBAT inhibitors have changed the way clinicians are able to treat cholestatic liver disease.

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New findings on the prevention of heart attacks and strokes

Science Daily - Heart Disease

Blockage of arterial blood vessels caused by atherosclerosis is largely responsible for heart attacks and strokes, which are the most common causes of death worldwide. The complex mechanisms that lead to pathological changes in the arteries are not yet fully understood. An international research team has now made important progress in understanding this disease and identified potential new approaches for early detection and therapy.

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Daniel Karlin, MD: FDA Grants Breakthrough Designation to MM120 for Anxiety

HCPLive

In an interview with HCPLive, Daniel Karlin, MD, discussed how their phase 2B trial demonstrated MM120’s durability through week 12 for the treatment of generalized anxiety disorder.

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“False-Positive” Stress Tests in Patients with Coronary Microvascular Dysfunction

NEJM Journal Watch - Cardiology

In patients with angina and no obstructive coronary disease, positive stress tests were highly predictive of CMD.

Angina 75
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Early Treatment of Perinatally Acquired HCV More Cost-Effective Than DAA Deferral

HCPLive

Treatment with DAA therapy at 3 years of age was associated with better health outcomes and cost savings versus deferring initiation to 6 years of age or older.

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Heart Valve Disease Forum 2024

Society of Thoracic Surgeons - Congenital

Event Heart Valve Disease Forum 2024 kchalko Wed, 03/13/2024 - 08:19 Event dates Aug 30–31, 2024 Mayfield Hotel, Seoul, Korea Location Seoul, Korea STS is pleased to co-present the Heart Valve Disease Forum (HVDF) with the Korean Society for Thoracic and Cardiovascular Surgery, offering the latest knowledge regarding the basics, diagnosis, treatment, and future of valvular heart disease.

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An innovative reconstruction of an enbloc resected composite giant chest and abdominal wall chondrosarcoma with 3D-composite mesh

Journal of Cardiothoracic Surgery

Chest wall chondrosarcomas, although common, pose unique challenges due to their aggressive nature, rarity of abdominal wall involvement, and propensity for recurrence. We highlight the critical role of meticu.

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Incidence, presentation and outcome of acute aortic dissection: results from a population-based study

Open Heart

Objectives To describe the incidence of acute aortic dissection in a clearly defined population, to assess onset symptoms and admission biochemical marker levels and to analyse variables potentially associated to mortality. Methods Medical records and CT angiograms of all patients hospitalised for acute aortic dissection in the Stockholm County during the 5-year period 2012–2016 were reviewed.

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Iptacopan Promotes Anemia Resolution in Paroxysmal Nocturnal Hemoglobinuria

HCPLive

Iptacopan monotherapy improved hematologic outcomes in both anti-C5–treated patients with persistent anemia and those not treated with complement inhibitors across two phase 3 trials.

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Time to childbirth and assisted reproductive treatment in women with congenital heart disease

Open Heart

Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified.

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Atlantic Health System’s Morristown Medical Center and NYU Langone Health Expand Partnership to Include Adult Congenital Heart Disease

DAIC

New Jersey-based Atlantic Health System’s Morristown Medical Center and New York-based NYU Langone Health, both nationally recognized cardiovascular programs, have announced that they are expanding their partnership to provide patients improved access to adult congenital heart disease services and the specialist directed care. Shown here, Trish O’Keefe, Senior Vice President, and President of Morristown Medical Center.

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Prevalence of abnormal left ventricular global longitudinal strain by speckle tracking echocardiography and its prognostic value in patients with COVID-19

Open Heart

Importance Although cardiac injury is a known complication of COVID-19 infection, there is no established tool to predict cardiac involvement and in-hospital mortality in this patient population. Objective To assess if left ventricular global longitudinal strain (LV-GLS) can detect cardiac involvement and be used as a risk-stratifying parameter for hospitalised patients with COVID-19.

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POETYK PSO-1 and POETYK PSO-2 Trials for Plaque Psoriasis

HCPLive

Dr April W. Armstrong reviews key findings from the phase 3 POETYK PSO-1 and POETYK PSO-2 clinical trials evaluating the use of deucravacitinib for the treatment of plaque psoriasis.

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Is VO2 Max the Best Measure of Fitness and Performance?

Physiologically Speaking

Within exercise and sports science, no one measure has gotten more attention than VO2 max. VO2 max refers to your maximum rate of oxygen consumption, and it’s typically measured during a maximal exercise test to exhaustion (they’re not fun, trust me). It is used as an indicator of an individual's cardiorespiratory fitness and is often used to demonstrate the effects of training.

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A Study of Cardiovascular Events in Diabetes

American College of Cardiology

The goal of the ASCEND Aspirin trial was to evaluate aspirin compared with placebo among diabetics with no known cardiovascular disease (CVD).

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Despite Progress, Access to PCSK9 Inhibitors Remains Subpar Among US Patients

HCPLive

New data from the Family Heart Foundation highlights low access to PCSK9 inhibitors due to insurance rejections, despite guidelines recommending their use for high-risk patients.

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Eagle’s Eye View: Blood Pressure and PAD, Leadless Pacemakers, Palliative Care and Heart Failure

American College of Cardiology

In this week’s View, Dr. Eagle covers various blood pressure parameters and their predictability for peripheral arterial disease (PAD) and complications, then explores the five-year outcomes of leadless pacemakers.