Mon.Sep 16, 2024

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The gut microbiota in thrombosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 17 September 2024; doi:10.1038/s41569-024-01070-6 The gut microbiota has emerged as a risk factor that affects thrombotic phenotypes in several cardiovascular diseases. In this Review, Reinhardt and colleagues discuss the link between the gut microbiota, its metabolites and thromboembolic diseases, and summarize potential therapeutic interventions to modulate the gut microbiota.

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Brain Health Risks: Digital Quality Measures and the Future of Neurological Care

Med Page Today

(MedPage Today) -- As the American Academy of Neurology's (AAN) Brain Health Summit convenes in September, it's an opportune moment to explore the future of neurology and the role that digital quality measures (dQMs) will play in the evolution.

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Long-term risk of heart failure in adult cancer survivors: a systematic review and meta-analysis

Heart BMJ

Background Cancer survivors are at increased risk of heart failure (HF). While cardiotoxicity is commonly sought at the time of cancer chemotherapy, HF develops as a result of multiple ‘hits’ over time, and there is limited evidence regarding the frequency and causes of HF during survivorship. Objectives This systematic review sought to investigate the relationship between cardiotoxic cancer therapies and HF during survivorship.

Cancer 98
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Biotronik Catheter Gets FDA Approval

DAIC

tim.hodson Mon, 09/16/2024 - 15:15 Sept. 16, 2024 — Biotronik has received U.S. Food and Drug Administration (FDA) labeling approval of its Selectra 3D catheter in conjunction with its Solia S lead for use in left bundle branch area pacing (LBBAP). The two products represent the first and only FDA-approved stylet-driven lead and dedicated delivery catheter system approved for LBBAP.

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Inadequate Eczema Control Observed in 30% of Patients on Topicals, Systemic Therapies

HCPLive

These poster data highlight that atopic dermatitis treatment may be suboptimal in certain patients, demonstrating the necessity of additional effective therapy options.

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Researchers discover new blood group system

Medical Xpress - Cardiology

The discovery of a new blood group, MAL, has solved a 50-year-old mystery. Researchers from NHS Blood and Transplant (Bristol), NHSBT's International Blood Group Reference Laboratory (IBGRL) and the University of Bristol identified the genetic background of the previously known but mysterious AnWj blood group antigen. The findings allow identification and treatment of rare patients lacking this blood group.

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Helping Schools Calculate Respiratory Infection Risk

HCPLive

Wilson details how her team plans to develop risk assessment models to estimate respiratory viral infection risk reductions for interventions in elementary schools.

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FDA Warns of Liver Injury Risk from Fezolinetant for Hot Flashes

HCPLive

The FDA advises stopping the fezolinetant treatment at the first signs of liver injury to prevent further damage and help restore normal liver function.

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Study shows estrogen blocker treatment does not increase risk of coronary heart disease in breast cancer patients

Medical Xpress - Cardiology

New evidence shows that extended estrogen suppression treatment using aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe; it does not increase the risk of coronary artery calcification, a sign of active coronary atherosclerosis, as some prior studies had indicated.

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Low Purine Diet Lower Uric Acid in People With Gout

HCPLive

Patients also experienced a substantial decrease in systolic blood pressure and diastolic blood pressure.

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How a pause can cause cardiac arrest

Dr. Smith's ECG Blog

Written by Magnus Nossen — with edits by Grauer The tracings in today’s case is from a patient in his 80s being admitted due to dyspnea. Below is the presentation ECG. What do you think? The above ECG shows sinus rhythm. There is one premature atrial contraction which is blocked and this causes a short pause. The following sinus P wave conducts with a slightly shorter PR interval.

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Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL

HCPLive

Notably, people with fewer vaccine doses were more likely to experience post-acute sequelae of COVID-19.

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Spontaneous termination of ventricular tachycardia in the human heart

Journal of Cardiovascular Electrophysiology

Abstract Introduction Understanding the spatiotemporal location of the spontaneous termination of ventricular tachycardia (VT) may provide new insights for ablation. To test the hypothesis that spontaneous VT termination most frequently occurs at the VT exit due to source-sink mismatch and to characterize electrophysiological properties of the sites termination during VT and with extra-stimulus technique.

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The APAC Recap: ASPC 2024 Congress on CVD Prevention, with Viet Le, DMSc, PA-C

HCPLive

In this edition of the APAC Recap, Erin Pardee, PA-C, discusses the American Society of Preventive Cardiology 2024 Congress on CVD Prevention with Viet Le, DMSc, PA-C.

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Five ways to rethink what a 'balanced diet' means

Medical Xpress - Cardiology

Most of us probably think we have a pretty good idea of what a "balanced diet" looks like. And a lot of us may be wrong.

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Hospitals with the highest excess readmission rates for heart failure patients

Becker's Hospital Review - Cardiology

Discover the top 10 hospitals with the highest excess readmission rates for heart failure patients, according to CMS' hospital readmissions reduction program

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GLP-1 RA Linked to Lower Risk of Cirrhosis Development in Patients with MASLD

HCPLive

A new study found glucagon-like peptide 1 receptor agonist use was associated with a lower risk of cirrhosis complications for patients with MASLD who did not have cirrhosis.

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Can mammograms help identify heart disease?

Becker's Hospital Review - Cardiology

Mammography can be used to identify a key indicator for heart disease in women, according to a study presented at the Menopause Society's annual meeting.

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Heart healthy indicators and behaviors in adolescents linked to better cognitive function

Medical Xpress - Cardiology

Cardiovascular health behaviors and overall cardiovascular health were directly associated with adolescent brain development and cognitive function, according to UTHealth Houston research published recently in the journal Mental Health and Physical Activity.

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Reproductive options and genetic testing for patients with an inherited cardiac disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 17 September 2024; doi:10.1038/s41569-024-01073-3 Genetic testing for inherited cardiac disease has become part of routine clinical care. In this Review, Verdonschot et al. provide an overview of the reproductive options in the context of monogenic cardiac diseases, with a focus on preimplantation genetic testing, to prepare health-care professionals for discussions with their patients.

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HCPLive Five at ESC 2024

HCPLive

Counting down the most impactful news at major medical meetings, it’s the HCPLive Five! This episode focuses on 5 key updates from the European Society of Cardiology (ESC) Congress 2024.

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Interferon response at the border zone of the infarcted heart

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 17 September 2024; doi:10.1038/s41569-024-01078-y Cardiomyocytes can activate the type I interferon response in the infarct border zone after myocardial infarction, indicating that the type I interferon pathway, in addition to its well-established role in antiviral responses, is also involved in cardiac injury.

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HIMSS Cybersecurity Forum Set to Take Place Next Month

DAIC

tim.hodson Mon, 09/16/2024 - 16:01 HIMSS will present a two-day Healthcare Cybersecurity event next month in Washington, D.C. The Healthcare Cybersecurity Forum will take place Oct. 3 to Nov. 1, 2024, at the Renaissance Arlington Capital View hotel. The Forum is designed for decision-makers, cybersecurity experts, technology leaders, and other healthcare professionals tasked with safeguarding health systems against cyber threats.

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Are Regulators the Root of the Problem of Serious Device Recalls?

Med Page Today

(MedPage Today) -- Among cardiovascular devices that were deemed unsafe enough to warrant urgent regulatory action, many had been allowed to skip rigorous premarket clinical testing in the first place, a report showed. Researchers identified 137.

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Monitoring Schedule for JAK Inhibitors in Atopic Dermatitis

HCPLive

Lindsay S. Ackerman, MD, FAAD, and Jonathan Silverberg, MD, PhD, MPH, provide clinical insights on best practices for monitoring patients with atopic dermatitis who are receiving JAK inhibitors.

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Emerging Role of Circulating Tumor DNA in the Management of Thoracic Malignancies

Society of Thoracic Surgeons - Surgeon

Webinar Emerging Role of Circulating Tumor DNA in the Management of Thoracic Malignancies gmckinney Mon, 09/16/2024 - 13:27 September 26, 2024 Sponsored by AstraZeneca Circulating tumor DNA (ctDNA) is a blood test that can be used to detect and monitor thoracic malignancies. It is being used to detect mutations, monitor for recurrence after surgery and other treatments, and can even be used in conjunction with screening to help identify malignancy.

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Shockwave Medical Expands U.S. Peripheral IVL Portfolio with Enhanced Catheter

DAIC

tim.hodson Mon, 09/16/2024 - 10:49 Sept. 16, 2024 – Shockwave Medical, Inc., part of Johnson & Johnson MedTech* has announced the full U.S. launch of the Shockwave E 8 Peripheral IVL Catheter, following clearance by the U.S. Food and Drug Administration (FDA). The Shockwave E 8 catheter is designed to optimize the treatment of patients with calcified femoro-popliteal and below-the-knee peripheral artery disease (PAD), including patients with complex chronic limb-threatening ischemia (CLTI).

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Persistence of residual shunt at 6 and 12 months after transoesophageal echocardiography-guided percutaneous closure of a patent foramen ovale for cryptogenic stroke

Heart BMJ

Background Young patients suffering from cryptogenic stroke alongside a patent foramen ovale (PFO) are often considered for percutaneous device closure to reduce the risk of stroke recurrence. Residual right-to-left shunt after device closure may persist in approximately a quarter of the patients at 6 months, and some may close at a later time point.

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Long-term Safety Data for JAK Inhibitors in Atopic Dermatitis

HCPLive

Medical experts review phase 3 and long-term efficacy and safety data for abrocitinib and upadacitinib in atopic dermatitis and discuss how these data influence treatment decisions and any ongoing safety concerns.

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Tirzepatide and blood pressure reduction: stratified analyses of the SURMOUNT-1 randomised controlled trial

Heart BMJ

Background Treating obesity may be a pathway to prevent and control hypertension. In the SURMOUNT-1 trial in people with obesity or overweight with weight-related complications, 72-week tirzepatide treatment led to clinically meaningful body weight and blood pressure reduction. Post hoc analyses were conducted to further explore the effects of tirzepatide on the pattern of blood pressure reduction and whether the effects were consistent across various subgroups.

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Melodie Young, ASN, RN: Updates on Therapies for Pediatric Patients with Psoriasis, PsA

HCPLive

This interview at the Fall 2024 Maui Derm conference features Melodie Young, with a discussion about updates in psoriasis and psoriatic arthritis therapy for children.

RN 52
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Too fast, too furious

Heart BMJ

Clinical introduction A woman in her 30s, a case of rheumatic mitral stenosis status post balloon mitral valvuloplasty 15 years prior, presented to urgent care with palpitations and dyspnoea for 1 week. She was noted to be in heart failure, with hypotension and tachycardia. Initial assessment with electrocardiography revealed a regular narrow complex tachycardia with 2:1 atrioventricular (AV) relationship, no clear isoelectric baseline and positive P waves in lead V1 consistent with an atrial fl

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Melissa Franco, PA: Pregnancy Planning in Patients with Liver Disease

HCPLive

Franco describes the importance of discussing pregnancy intentions with patients with liver disease and the need for multidisciplinary comanagement of these patients.

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Circulating biomarkers of myocardial remodelling: current developments and clinical applications

Heart BMJ

Myocardial remodelling, entailing cellular and molecular changes in the different components of the cardiac tissue in response to damage, underlies the morphological and structural changes leading to cardiac remodelling, which in turn contributes to cardiac dysfunction and disease progression. Since cardiac tissue is not available for histomolecular diagnosis, surrogate markers are needed for evaluating myocardial remodelling as part of the clinical management of patients with cardiac disease.

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Lucy Mathew, NP: Preventing PBC Progression with Timely Diagnosis, Treatment

HCPLive

Mathew reviews common reasons for diagnostic delays in PBC, emphasizing the importance of timely identification and prompt treatment for improving patient outcomes.

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From urinary proteomic signature to individualised pharmacotherapy

Heart BMJ

As the number of patients suffering from heart failure is constantly rising worldwide, optimised medical treatment is indispensable to reduce mortality and prevent patients from hospitalisation. 1 Despite new drug development in recent years, heart failure is still associated with a poor prognosis: more than every second patient dies within 5 years after diagnosis. 2 Mineralocorticoid receptor antagonists (MRA), such as spironolactone, play a key role in the treatment of heart failure as this dr

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Study Highlights Laboratory Parameters in 4 Years of Psoriasis Treatment with Deucravacitinib

HCPLive

These poster data presented at the Maui Derm Fall 2024 conference highlight changes in laboratory parameters for patients using the TYK2 inhibitor deucravacitinib.