Dr. Malcolm Kendrick

DECEMBER 28, 2023

29th December 2023 The underlying forces In the last few blogs, I have been writing about the proliferation of guidelines, targets, and regulatory work in the NHS. Hopefully I have managed to give you a sense of how much time and effort these pile on to everyday work. Time and effort which eats away at clinical time, erodes morale and drives down productivity.

Hospital 116

Hospital Blog Blood Pressure Inpatient 116

NOVARAD

DECEMBER 28, 2023

Healthcare organizations are always looking for ways to save time and money while providing quality patient care. As innovative technology emerges, new secure image-sharing technology that maximizes time and reduces costs has taken the forefront of data mobility.

Technology 105

Technology Innovation Patient Care 105

Med Page Today

DECEMBER 28, 2023

(MedPage Today) -- Factor XIa inhibitor milvexian did not provide meaningful secondary prevention over dual antiplatelet therapy for stroke survivors, the phase II trial AXIOMATIC-SSP found. In patients with recent ischemic stroke or transient.

Stroke 83

Stroke Strokes 83

Circulation: Cardiovascular Interventions

DECEMBER 28, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:A high permanent pacemaker implantation (PPI) risk remains a concern of self-expandable transcatheter aortic valve implantation, despite the continued improvements in implantation methodology. We aimed to assess the impact of real-time direct visualization of the membranous septum using transjugular intracardiac echocardiography (ICE) during transcatheter aortic valve implantation on reducing the rates of conduction disturbanc

Aortic valve 76

Aortic valve Aortic Cardiovascular Interventions Pacemaker 76

Becker's Hospital Review - Cardiology

DECEMBER 28, 2023

Deb Kiser, RN, BSN, was named executive lead of the new cardiovascular partnership between Dayton, Ohio-based Premier Health and The Christ Hospital Health Network.

RN 64

RN Hospital 64

Circulation: Cardiovascular Interventions

DECEMBER 28, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Lower-limb amputation rates in patients with chronic limb-threatening ischemia vary across the United States, with marked disparities in amputation rates by gender, race, and income status. We evaluated the association of patient, hospital, and geographic characteristics with the intensity of vascular care received the year before a major lower-limb amputation and how intensity of care associates with outcomes after amputation

Vascular Care 61

Vascular Care Ischemia Medicare Hospital 61

Journal of Cardiovascular Pharmacology

DECEMBER 28, 2023

Amphetamine derivatives are used worldwide legally or illegally and intoxications may be accompanied by cardiac arrhythmias. Here, we tested contractile effects of cumulative applied (±)-amphetamine, pseudoephedrine, nor-pseudoephedrine (cathine) and cathinone in electrically stimulated (1 Hz) human right atrial preparations (HAP) and mouse left atrial preparations (LA) as well as in spontaneously beating mouse right atrial preparations (RA).

Arrhythmia 52

Arrhythmia Article 52

Circulation

DECEMBER 28, 2023

Circulation, Ahead of Print. BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heart failure. However, the major determinants of transcriptional network switching from normal to failed hearts remain to be determined.METHODS:In this study, we integrated human samples, genetic mouse models, and genomic approaches, including bulk RNA sequencing, single-cell RNA sequencing, chromatin immunoprecipitation followed by high-throughp

Heart Failure 53

Heart Failure Cardiac Function Circulation 53

Hypertension Journal

DECEMBER 28, 2023

Hypertension, Ahead of Print. BACKGROUND:Small arteries exhibit resting tone, a partially contracted state that maintains arterial blood pressure. In arterial smooth muscle cells, potassium channels control contraction and relaxation. Perivascular adipose tissue (PVAT) has been shown to exert anticontractile effects on the blood vessels. However, the mechanisms by which PVAT signals small arteries, and their relevance remain largely unknown.

Blood Pressure 51

Blood Pressure Physiology Hypertension 51

HCPLive

DECEMBER 28, 2023

These results provided valuable insights into occupational anaphylaxis through the use of anaphylaxis registry data.

59

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Circulation

DECEMBER 28, 2023

Circulation, Ahead of Print. BACKGROUND:Genetic and experimental studies support a causal involvement of IL-6 (interleukin-6) signaling in atheroprogression. Although trials targeting IL-6 signaling are underway, any benefits must be balanced against an impaired host immune response. Dissecting the mechanisms that mediate the effects of IL-6 signaling on atherosclerosis could offer insights about novel drug targets with more specific effects.METHODS:Leveraging data from 522 681 individuals, we c

Atherosclerosis 49

Atherosclerosis Peripheral Arterial Disease Coronary Artery Disease Pharmacology 49

HCPLive

DECEMBER 28, 2023

This study looked at results of DOC, allergy risk level risk distinctions, and rationale for families and physicians to move forward with DOC.

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HeartRhythm

DECEMBER 28, 2023

Neural remodeling in the left stellate ganglion (LSG), as mediated by neuroimmune reactions, promotes cardiac sympathetic nerve activity (SNA) and thus increases incidence of VAs. Interleukin-6 is an important factor of the neuroimmune interaction.

Ischemia 45

Ischemia Arrhythmia 45

Circulation

DECEMBER 28, 2023

Circulation, Ahead of Print. BACKGROUND:SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect the kidneys and heart, but the underlying mechanism remains poorly understood.METHODS:To gain insights on primary effects of SGLT2i that are not confounded by pathophysiologic processes or are secondary to improvement by SGLT2i, we performed an in-depth proteomics, phosphoproteomics, and metabolomics analysis by integrating signatures from multiple metabolic organs and body fluids after

Diabetes 45

Diabetes Heart Failure Circulation 45

Hypertension Journal

DECEMBER 28, 2023

Hypertension, Ahead of Print. High blood pressure causes over 10 million preventable deaths annually globally. Populations in low- and middle-income countries suffer the most, experiencing increased uncontrolled blood pressure and cardiovascular disease (CVD) deaths. Despite improvements in high-income countries, disparities persist, notably in the United States, where Black individuals face up to 4× higher CVD mortality than White individuals.Social determinants of health encompass complex, mul

Cardiovascular Disease 45

Cardiovascular Disease Hypertension Blood Pressure Outcomes 45

European Journal of Heart Failure

DECEMBER 28, 2023

Abstract Background and aim Heart Failure with preserved Ejection Fraction (HFpEF) remains under-diagnosed in clinical practice despite accounting for nearly half of all Heart Hailure (HF) cases. Accurate and timely diagnosis of HFpEF is crucial for proper patient management and treatment. In this study, we explored the potential of natural language processing (NLP) to improve the detection and diagnosis of HFpEF according to the European Society of Cardiology (ESC) diagnostic criteria.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Echocardiogram Article 40

Stroke Journal

DECEMBER 28, 2023

Stroke, Ahead of Print. BACKGROUND:Reteplase is a more affordable new-generation thrombolytic with a prolonged half-life. We aimed to determine the safety dose range of reteplase for patients with acute ischemic stroke within 4.5 hours of onset.METHODS:This is a multicenter, prospective, randomized controlled, open-label, blinded-end point phase 2 clinical trial.

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

European Journal of Heart Failure

DECEMBER 28, 2023

Abstract Background The normal (i.e., expected) hemodynamics in adults post-Fontan remain poorly delineated. Moreover, the definitions of elevated exercise pulmonary artery (PA) and PA wedge pressure (PAWP) for this population have not been described. Methods and Results Seventy-two adults post-Fontan undergoing exercise catheterization were categorized into abnormal (Group I, n = 59; defined as resting mean PA ≥14 mmHg and/or PAWP ≥12 mmHg, ΔPAWP/Δsystemic flow >2 mmHg/L/min, and/or ΔPA/Δpul

Exercise 40

Exercise Physiology Article Pulmonary 40

Circulation: Cardiovascular Interventions

DECEMBER 28, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Maldistribution of pulmonary blood flow in patients with congenital heart disease impacts exertional performance and pulmonary artery growth. Currently, measurement of relative pulmonary perfusion can only be performed outside the catheterization laboratory. We sought to develop a tool for measuring relative lung perfusion using readily available fluoroscopy sequences.METHODS:A retrospective cohort study was conducted on patie

Catheterization Laboratory 40

Catheterization Laboratory Congenital Heart Disease Laboratory Pulmonary 40

Circulation: Arrhythmia and Electrophysiology

DECEMBER 28, 2023

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Background:Effects of contact force (CF) on lesion formation during pulsed field ablation (PFA) have not been well validated. The purpose of this study was to determine the relationship between average CF and lesion size during PFA using a swine-beating heart model.Methods:A 7F catheter with a 3.5-mm ablation electrode and CF sensor (TactiCath SE, Abbott) was connected to a PFA system (CENTAURI, Galvanize Therapeutics).

Ablation 40

Ablation Electrophysiology Hemorrhage Arrhythmia 40

European Journal of Heart Failure

DECEMBER 28, 2023

Abstract Aims Preventive strategies for heart failure (HF) with preserved ejection fraction (HFpEF) include pharmacotherapies and lifestyle modifications. However, the association between cardiorespiratory fitness (CRF) assessed objectively by a standardized exercise treadmill test (ETT) and the risk of HFpEF has not been evaluated. Thus, we evaluated the association between CRF and HFpEF incidence.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Myocardial Infarction Article 40

Circulation: Cardiovascular Interventions

DECEMBER 28, 2023

Circulation: Cardiovascular Interventions, Ahead of Print.

Ischemia 40

Ischemia Cardiovascular Interventions Circulation 40

Coronary Artery Disease Journal

DECEMBER 28, 2023

No abstract available

Pacemaker 40

Pacemaker 40

Stroke Journal

DECEMBER 28, 2023

Stroke, Ahead of Print.

Stents 40

Stents Stent Stroke Strokes 40

Coronary Artery Disease Journal

DECEMBER 28, 2023

No abstract available

Pulmonary 40

Pulmonary 40

Stroke Journal

DECEMBER 28, 2023

Stroke, Ahead of Print.

Stroke 40

Stroke Strokes 40

Clinical Trial Results

DECEMBER 28, 2023

Disclosures: TBD

Interventional Cardiology 40

Interventional Cardiology 40

Stroke Journal

DECEMBER 28, 2023

Stroke, Ahead of Print.

Atherosclerosis 40

Atherosclerosis Stroke Strokes 40

Hypertension Journal

DECEMBER 28, 2023

Hypertension, Ahead of Print. BACKGROUND:Adrenaline-producing tumors are mostly characterized by a sudden release of catecholamines with episodic symptoms. Noradrenergic ones are usually less symptomatic and characterized by a continuous overproduction of catecholamines that are released into the bloodstream. Their effects on the cardiovascular system can thus be different.

Peripheral Arterial Disease 81

Peripheral Arterial Disease Myocardial Infarction Cardiomyopathy Risk Factors 81

Stroke Journal

DECEMBER 28, 2023

Stroke, Ahead of Print.

Stroke 40

Stroke Strokes Research 40

Circulation

DECEMBER 28, 2023

Circulation, Ahead of Print. BACKGROUND:Oral anticoagulation is suggested in patients with atrial fibrillation and a CHA2DS2-VASc score ≥1 (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke, vascular disease, age 65–74 years, and sex score). To assess granular differences within CHA2DS2-VASc 1, the incidence of arterial thromboembolism according to CHA2DS2-VASc 1 subgroups was examined.METHODS:The Danish National Patient Registry and the Danish Prescription Registry linked

Atrial Fibrillation 58

Atrial Fibrillation Risk Factors Heart Failure Hypertension 58

Stroke Journal

DECEMBER 28, 2023

Stroke, Ahead of Print. BACKGROUND:Many ischemic strokes are diagnosed as embolic strokes of undetermined source (ESUS). Recent evidence suggests that nonstenotic carotid plaque (nsCP) may be a substantial contributor to the risk for ESUS. We aimed to investigate the risk factor profile associated with nsCP in ESUS and defined stroke etiologies.METHODS:In this retrospective case-control study, we investigated consecutive patients with acute ischemic stroke due to ESUS, small-vessel disease, or c

Risk Factors 75

Risk Factors Plaque Embolism Stroke 75

Hypertension Journal

DECEMBER 28, 2023

Hypertension, Ahead of Print. BACKGROUND:In singleton pregnancies, fetal sexual dimorphism has been observed in hypertensive disorders of pregnancy, particularly preeclampsia, a morbid syndrome that increases the risk of adult-onset cardiovascular disease for mothers and their offspring. However, few studies have explored the effect of fetal sex on hypertensive disorders of pregnancy among twin pregnancies.METHODS:We conducted a retrospective cohort study of 1032 twin pregnancies between 2011 an

Hypertension 45

Hypertension Cardiovascular Disease Hospital Research 45

Coronary Artery Disease Journal

DECEMBER 28, 2023

Purpose To evaluate the association between osteoporosis and coronary calcification and coronary plaque burden in patients with atherosclerosis and coronary artery disease (CAD). Methods This study included 290 men and 177 postmenopausal women with angiography-confirmed atherosclerosis or CAD who underwent chest multidetector row computed tomography covering L1-L2 between September 2020 and October 2021.

Coronary Artery Disease 40

Coronary Artery Disease Plaque Atherosclerosis Research 40