Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

NKT cells are innate-like T cells, recruited to the skin during viral infection, yet their contributions to long-term immune memory to viruses are unclear. We identified granzyme K, a product made by cytotoxic cells including NKT cells, as linked to induction of Th1-associated antibodies during primary dengue virus (DENV) infection in humans. We examined the role of NKT cells in vivo using DENV-infected mice lacking CD1d-dependent (CD1ddep) NKT cells.

Outcomes 119

Outcomes 119

HCPLive

SEPTEMBER 17, 2024

Better known as brittle bone disease, osteogenesis imperfecta can cause severe respiratory distress at birth and longterm effect to respiratory function. Morello shares his team's research into the cause of this effect.

Research 105

Research 105

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

Epithelial barriers are programmed for defense and repair but are also the site of long-term structural remodeling and disease. In general, this paradigm features epithelial stem cells (ESCs) that are called on to regenerate damaged tissues but can also be reprogrammed for detrimental remodeling. Here we identified a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population that functioned as an early sentinel niche for basal ESC reprogramming in mouse models of epithelial injury after

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HCPLive

SEPTEMBER 17, 2024

A new study revealed those who consume a moderate amount of coffee or caffeine had a 48.1% and 40.7% reduced risk for developing cardiometabolic multimorbidity.

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111

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

Maintaining protein homeostasis (proteostasis) requires precise control of protein folding and degradation. Failure to properly respond to stresses disrupts proteostasis, which is a hallmark of many diseases, including cataracts. Hibernators are natural cold-stress adaptors; however, little is known about how they keep a balanced proteome under conditions of drastic temperature shift.

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Science Daily - Stroke

SEPTEMBER 17, 2024

Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.

Dementia 110

Dementia Risk Factors Research 110

Med Page Today

SEPTEMBER 17, 2024

(MedPage Today) -- More than half of U.S. adults with uncontrolled hypertension are unaware they have hypertension in the first place, according to a recent study in JAMA Network Open. Furthermore, more than two-thirds of those on treatment had.

Hypertension 99

Hypertension 99

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

Obesity is linked to an increased risk of atrial fibrillation (AF) via increased oxidative stress. While NADPH oxidase 2 (NOX2), a major source of oxidative stress and reactive oxygen species (ROS) in the heart, predisposes to AF, the underlying mechanisms remain unclear. Here, we studied NOX2-mediated ROS production in obesity-mediated AF using Nox2-knockout mice and mature human induced pluripotent stem cell–derived atrial cardiomyocytes (hiPSC-aCMs).

Atrial Fibrillation 97

Atrial Fibrillation Obesity Diet 97

DAIC

SEPTEMBER 17, 2024

tim.hodson Tue, 09/17/2024 - 12:34 Sept. 16, 2024 — Numerous social and structural factors, including immigration status, socioeconomic position and access to health care, contribute to differences in cardiovascular health and heart disease risk for Asian Americans, and these factors affect Asian ethnic subgroups in different ways, according to a new scientific statement published today in the American Heart Association’s journal, Circulation.

Health Disparities 97

Health Disparities Research Nursing Heart Disease 97

HCPLive

SEPTEMBER 17, 2024

Mathew emphasizes the importance of routine liver cancer screening in patients with advanced liver disease and the need to overcome insurance barriers for HCC panel testing.

Cancer 94

Cancer 94

Science Daily - Heart Disease

SEPTEMBER 17, 2024

Lower socioeconomic status is associated with higher rates of death from coronary artery disease compared to higher socioeconomic status, and more than half of the disparities can be explained by four unhealthy behaviors, according to a new study.

Coronary Artery Disease 99

Coronary Artery Disease 99

Science Daily - Stroke

SEPTEMBER 17, 2024

Doctors and pharmacists treating people with blood thinners can reduce the rate of inappropriate dosing -- as well as blood clots and strokes that can result from it -- using an electronic patient management system, a study suggests. Direct oral anticoagulants can be incorrectly prescribed up to 20% of the time.

Blood Clot 86

Blood Clot Stroke Strokes 86

Medical Xpress - Cardiology

SEPTEMBER 17, 2024

University of Queensland researchers have developed a fast cognitive screening tool that can detect often-missed rehabilitation needs for people who have experienced a stroke.

Research 76

Research Stroke Strokes 76

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

BACKGROUND Frailty significantly affects morbidity and mortality rates in the older population (age >65 years). Age-related degenerative diseases are influenced by the intestinal microbiota. However, limited research exists on alterations in the intestinal microbiota in frail older individuals, and the effectiveness of prebiotic intervention for treating frailty remains uncertain.OBJECTIVE We sought to examine the biological characteristics of the intestinal microbiome in frail older individuals

Research 113

Research 113

Becker's Hospital Review - Cardiology

SEPTEMBER 17, 2024

Approximately 44.2 million people in the U.S. live more than 60 miles away from the nearest cardiac positron emission tomography center, according to a study published Aug. 28 in JACC: Cardiovascular Imaging.

Cardiovascular Imaging 69

Cardiovascular Imaging 69

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

Intestinal fibrosis is a severe complication of Crohn’s disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process.

Research 103

Research 103

American College of Cardiology

SEPTEMBER 17, 2024

Palpitations during pregnancy are not an uncommon finding. However, arrhythmias requiring monitoring or treatment throughout the antepartum and peripartum periods are less frequent.

Arrhythmia 74

Arrhythmia Article 74

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

BACKGROUND Metastatic hormone-sensitive prostate cancer (mHSPC) is androgen dependent, and its treatment includes androgen deprivation therapy (ADT) with gonadal testosterone suppression. Since 2014, overall survival (OS) has been prolonged with addition of other systemic therapies, such as adrenal androgen synthesis blockers, potent androgen receptor blockers, or docetaxel, to ADT.

Cancer 75

Cancer Pharmacology Physiology Outcomes 75

NEJM Journal Watch - Cardiology

SEPTEMBER 17, 2024

Patients with post–COVID-19 mRNA vaccination myocarditis had better clinical outcomes at 18 months than those with myocarditis of other etiologies.

COVID-19 75

COVID-19 Outcomes 75

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

Fibrosis is a common manifestation of most progressive and degenerative diseases, with myofibroblast activation and matrix accumulation playing a key role. In this issue of the JCI, Hoeft et al. identify the important role of ADAMTS12 in fibroblast activation. ADAMTS12, a secreted protein, is involved in extracellular matrix (ECM) remodeling, cell signaling, and inflammation.

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HCPLive

SEPTEMBER 17, 2024

At Maui Derm NP+PA Fall 2024, bimekizumab data demonstrates a consistent safety profile in moderate to severe plaque psoriasis over 4 years, with decreasing event rates over time.

Plaque 59

Plaque 59

Medical Xpress - Cardiology

SEPTEMBER 17, 2024

Doctors and pharmacists treating people with blood thinners can reduce the rate of inappropriate dosing—as well as blood clots and strokes that can result from it—using an electronic patient management system, a study suggests.

Blood Clot 59

Blood Clot Stroke Strokes 59

HCPLive

SEPTEMBER 17, 2024

This interview featured a literature review discussion about non-FDA approved advancements in dermatology, including oral roflumilast for psoriasis, metformin for acne, and minoxidil for nails.

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Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

Microbial mimicry, the process in which a microbial antigen elicits an immune response and breaks tolerance to a structurally related self-antigen, has long been proposed as a mechanism in autoimmunity. In this issue of the JCI, Dolton et al. extend this paradigm by demonstrating that a naturally processed peptide from Klebsiella oxytoca acts as a superagonist for autoreactive T cells in type 1 diabetes (T1D).

Diabetes 80

Diabetes 80

HCPLive

SEPTEMBER 17, 2024

Leo Pharma announced the availability of a single-dose autoinjector of tralokinumab for moderate-to-severe atopic dermatitis, approved by the FDA in June 2024.

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59

American College of Cardiology

SEPTEMBER 17, 2024

The following are key points to remember from the 2024 European Society of Cardiology (ESC) guidelines for the management of atrial fibrillation (AF).

Atrial Fibrillation 64

Atrial Fibrillation Article 64

Medical Xpress - Cardiology

SEPTEMBER 17, 2024

A cross-sectional study of cardiovascular devices subject to Class I recalls from 2013 through 2022, found that most recalled devices did not undergo clinical testing before authorization and were not required to undergo postmarket surveillance studies. Even when premarket clinical testing was conducted, there was often a lack of evidence to support their original authorization.

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52

Journal of Cardiothoracic Surgery

SEPTEMBER 17, 2024

Connective tissue disorders such as Marfan- and Loeys-Dietz syndrome (LDS) can lead to aortic aneurysms and aortic dissections in children. Patients with LDS often necessitating multiple aortic surgeries throu.

Aortic 52

Aortic Aneurysm 52

Medical Xpress - Cardiology

SEPTEMBER 17, 2024

Babies born with a narrowed blood vessel now have a device specifically designed for them, thanks to research conducted at the Smidt Heart Institute and Guerin Children's at Cedars-Sinai.

Stents 52

Stents Stent Research 52

Journal of Cardiothoracic Surgery

SEPTEMBER 17, 2024

Snail family zinc finger 1 (SNAI1) has been implicated in cancer progression and prognosis across various malignancies. This study aims to elucidate the prognostic significance of SNAI1 expression in Lung Squa.

Cancer 52

Cancer Research 52

Medical Xpress - Cardiology

SEPTEMBER 17, 2024

Positive airway pressure (PAP) utilization is associated with lower all-cause mortality and major adverse cardiovascular event (MACE) incidence in older adults with obstructive sleep apnea (OSA), according to a study published online Sept. 11 in JAMA Network Open.

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52

Journal of Cardiothoracic Surgery

SEPTEMBER 17, 2024

The objective of this study is to evaluate the diagnostic accuracy of noninvasive serum liver fibrosis markers and portal vein diameter (PVD) in predicting the occurrence of esophageal variceal bleeding (EVB).

Research 52

Research 52

CTVS

SEPTEMBER 17, 2024

It is estimated that more than 10 million Americans are living with PAD, or Peripheral Artery Disease. PAD is a serious condition affecting circulation and blood vessels, causing them to narrow from plaque buildup in the arteries and blocking blood flow to the extremities, typically the legs and feet.

Peripheral Arterial Disease 52

Peripheral Arterial Disease Atherosclerosis Plaque Cholesterol 52

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

BACKGROUND Teplizumab, a non-FcR-binding anti-CD3 mAb, is approved to delay progression of type 1 diabetes (T1D) in at-risk patients. Previous investigations described the immediate effects of the 14-day treatment, but longer-term effects of the drug remain unknown.METHODS With an extended analysis of study participants, we found that 36% were undiagnosed or remained free of clinical diabetes after 5 years, suggesting operational tolerance.

Diabetes 52

Diabetes Kidney Disease Research 52

Becker's Hospital Review - Cardiology

SEPTEMBER 17, 2024

The American Heart Association is teaming up with Providence Health Plan, the health insurance division of Renton, Wash.-based Providence Health & Services, to broaden cardiovascular care in underserved communities throughout Oregon and Washington.

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52

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

Strategies beyond hormone-related therapy need to be developed to improve prostate cancer mortality. Here, we show that FUBP1 and its methylation were essential for prostate cancer progression, and a competitive peptide interfering with FUBP1 methylation suppressed the development of prostate cancer. FUBP1 accelerated prostate cancer development in various preclinical models.

Cancer 52

Cancer 52

HCPLive

SEPTEMBER 17, 2024

Gildeuretinol showed a clinically meaningful reduction in GA lesion growth and a favorable safety profile at 24 months in the Phase 3 SAGA trial.

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