Science Daily - Stroke
SEPTEMBER 17, 2024
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
Science Daily - Heart Disease
SEPTEMBER 17, 2024
Lower socioeconomic status is associated with higher rates of death from coronary artery disease compared to higher socioeconomic status, and more than half of the disparities can be explained by four unhealthy behaviors, according to a new study.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
NKT cells are innate-like T cells, recruited to the skin during viral infection, yet their contributions to long-term immune memory to viruses are unclear. We identified granzyme K, a product made by cytotoxic cells including NKT cells, as linked to induction of Th1-associated antibodies during primary dengue virus (DENV) infection in humans. We examined the role of NKT cells in vivo using DENV-infected mice lacking CD1d-dependent (CD1ddep) NKT cells.
HCPLive
SEPTEMBER 17, 2024
A new study revealed those who consume a moderate amount of coffee or caffeine had a 48.1% and 40.7% reduced risk for developing cardiometabolic multimorbidity.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily - Stroke
SEPTEMBER 17, 2024
Doctors and pharmacists treating people with blood thinners can reduce the rate of inappropriate dosing -- as well as blood clots and strokes that can result from it -- using an electronic patient management system, a study suggests. Direct oral anticoagulants can be incorrectly prescribed up to 20% of the time.
HCPLive
SEPTEMBER 17, 2024
This interview with Chovatiya highlights promising therapies in the dermatology space for the treatment of patients with the skin condition HS.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
HCPLive
SEPTEMBER 17, 2024
Better known as brittle bone disease, osteogenesis imperfecta can cause severe respiratory distress at birth and longterm effect to respiratory function. Morello shares his team's research into the cause of this effect.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
Epithelial barriers are programmed for defense and repair but are also the site of long-term structural remodeling and disease. In general, this paradigm features epithelial stem cells (ESCs) that are called on to regenerate damaged tissues but can also be reprogrammed for detrimental remodeling. Here we identified a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population that functioned as an early sentinel niche for basal ESC reprogramming in mouse models of epithelial injury after
Med Page Today
SEPTEMBER 17, 2024
(MedPage Today) -- More than half of U.S. adults with uncontrolled hypertension are unaware they have hypertension in the first place, according to a recent study in JAMA Network Open. Furthermore, more than two-thirds of those on treatment had.
HCPLive
SEPTEMBER 17, 2024
Mathew emphasizes the importance of routine liver cancer screening in patients with advanced liver disease and the need to overcome insurance barriers for HCC panel testing.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
Obesity is linked to an increased risk of atrial fibrillation (AF) via increased oxidative stress. While NADPH oxidase 2 (NOX2), a major source of oxidative stress and reactive oxygen species (ROS) in the heart, predisposes to AF, the underlying mechanisms remain unclear. Here, we studied NOX2-mediated ROS production in obesity-mediated AF using Nox2-knockout mice and mature human induced pluripotent stem cell–derived atrial cardiomyocytes (hiPSC-aCMs).
DAIC
SEPTEMBER 17, 2024
tim.hodson Tue, 09/17/2024 - 12:34 Sept. 16, 2024 — Numerous social and structural factors, including immigration status, socioeconomic position and access to health care, contribute to differences in cardiovascular health and heart disease risk for Asian Americans, and these factors affect Asian ethnic subgroups in different ways, according to a new scientific statement published today in the American Heart Association’s journal, Circulation.
Medical Xpress - Cardiology
SEPTEMBER 17, 2024
University of Queensland researchers have developed a fast cognitive screening tool that can detect often-missed rehabilitation needs for people who have experienced a stroke.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
BACKGROUND Frailty significantly affects morbidity and mortality rates in the older population (age >65 years). Age-related degenerative diseases are influenced by the intestinal microbiota. However, limited research exists on alterations in the intestinal microbiota in frail older individuals, and the effectiveness of prebiotic intervention for treating frailty remains uncertain.OBJECTIVE We sought to examine the biological characteristics of the intestinal microbiome in frail older individuals
NEJM Journal Watch - Cardiology
SEPTEMBER 17, 2024
Patients with post–COVID-19 mRNA vaccination myocarditis had better clinical outcomes at 18 months than those with myocarditis of other etiologies.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
Intestinal fibrosis is a severe complication of Crohn’s disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process.
American College of Cardiology
SEPTEMBER 17, 2024
Palpitations during pregnancy are not an uncommon finding. However, arrhythmias requiring monitoring or treatment throughout the antepartum and peripartum periods are less frequent.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
BACKGROUND Metastatic hormone-sensitive prostate cancer (mHSPC) is androgen dependent, and its treatment includes androgen deprivation therapy (ADT) with gonadal testosterone suppression. Since 2014, overall survival (OS) has been prolonged with addition of other systemic therapies, such as adrenal androgen synthesis blockers, potent androgen receptor blockers, or docetaxel, to ADT.
Becker's Hospital Review - Cardiology
SEPTEMBER 17, 2024
Approximately 44.2 million people in the U.S. live more than 60 miles away from the nearest cardiac positron emission tomography center, according to a study published Aug. 28 in JACC: Cardiovascular Imaging.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
Fibrosis is a common manifestation of most progressive and degenerative diseases, with myofibroblast activation and matrix accumulation playing a key role. In this issue of the JCI, Hoeft et al. identify the important role of ADAMTS12 in fibroblast activation. ADAMTS12, a secreted protein, is involved in extracellular matrix (ECM) remodeling, cell signaling, and inflammation.
American College of Cardiology
SEPTEMBER 17, 2024
The following are key points to remember from the 2024 European Society of Cardiology (ESC) guidelines for the management of atrial fibrillation (AF).
Medical Xpress - Cardiology
SEPTEMBER 17, 2024
Doctors and pharmacists treating people with blood thinners can reduce the rate of inappropriate dosing—as well as blood clots and strokes that can result from it—using an electronic patient management system, a study suggests.
HCPLive
SEPTEMBER 17, 2024
At Maui Derm NP+PA Fall 2024, bimekizumab data demonstrates a consistent safety profile in moderate to severe plaque psoriasis over 4 years, with decreasing event rates over time.
JAMA Cardiology
SEPTEMBER 17, 2024
This mendelian randomization study investigates the association between genetic risk for cardiovascular disease and immune-mediated diseases.
HCPLive
SEPTEMBER 17, 2024
This interview featured a literature review discussion about non-FDA approved advancements in dermatology, including oral roflumilast for psoriasis, metformin for acne, and minoxidil for nails.
Journal of Clinical Investigation - Cardiology
SEPTEMBER 17, 2024
Microbial mimicry, the process in which a microbial antigen elicits an immune response and breaks tolerance to a structurally related self-antigen, has long been proposed as a mechanism in autoimmunity. In this issue of the JCI, Dolton et al. extend this paradigm by demonstrating that a naturally processed peptide from Klebsiella oxytoca acts as a superagonist for autoreactive T cells in type 1 diabetes (T1D).
HCPLive
SEPTEMBER 17, 2024
Leo Pharma announced the availability of a single-dose autoinjector of tralokinumab for moderate-to-severe atopic dermatitis, approved by the FDA in June 2024.
Medical Xpress - Cardiology
SEPTEMBER 17, 2024
A cross-sectional study of cardiovascular devices subject to Class I recalls from 2013 through 2022, found that most recalled devices did not undergo clinical testing before authorization and were not required to undergo postmarket surveillance studies. Even when premarket clinical testing was conducted, there was often a lack of evidence to support their original authorization.
HCPLive
SEPTEMBER 17, 2024
Gildeuretinol showed a clinically meaningful reduction in GA lesion growth and a favorable safety profile at 24 months in the Phase 3 SAGA trial.
Medical Xpress - Cardiology
SEPTEMBER 17, 2024
Babies born with a narrowed blood vessel now have a device specifically designed for them, thanks to research conducted at the Smidt Heart Institute and Guerin Children's at Cedars-Sinai.
HCPLive
SEPTEMBER 17, 2024
In this Maui Derm fall conference session, Callender highlights approaches to pigmentation issues such as vitiligo, melasma, and other disorders.
Medical Xpress - Cardiology
SEPTEMBER 17, 2024
Positive airway pressure (PAP) utilization is associated with lower all-cause mortality and major adverse cardiovascular event (MACE) incidence in older adults with obstructive sleep apnea (OSA), according to a study published online Sept. 11 in JAMA Network Open.
HCPLive
SEPTEMBER 17, 2024
Here's what to expect from the new pulmonology research quarterly newsletter powered by the American Lung Association Research Institute.
Journal of Cardiothoracic Surgery
SEPTEMBER 17, 2024
Connective tissue disorders such as Marfan- and Loeys-Dietz syndrome (LDS) can lead to aortic aneurysms and aortic dissections in children. Patients with LDS often necessitating multiple aortic surgeries throu.
HCPLive
SEPTEMBER 17, 2024
Iordache emphasizes the importance of a multidisciplinary approach to liver disease care in pregnant patients and the need for patient education.
Journal of Cardiothoracic Surgery
SEPTEMBER 17, 2024
Snail family zinc finger 1 (SNAI1) has been implicated in cancer progression and prognosis across various malignancies. This study aims to elucidate the prognostic significance of SNAI1 expression in Lung Squa.
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