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After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart. This is according to a new study from Karolinska Institutet published in the journal Circulation.
BackgroundIt's recognized that stress hyperglycemia ratio (SHR) is considered a significant indicator of poor prognosis in many diseases. However, its role in critically ill patients with acute heart failure (acute HF) remains underexplored.MethodsWe conducted a retrospective cohort study on patients with acute HF included in the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.2 database.
While the holidays themselves can’t cause a heart attack , certain things people do during the hectic, festive season may stress their heart health more than they realize. Heart attacks and other cardiac events, such as heart failure flare-ups and “holiday heart syndrome” – a term used to describe palpitations induced by alcohol consumption – often surge during the winter holidays.
Fabry disease (FD) is a rare X-linked inherited lysosomal storage disorder. The abnormal accumulation of metabolic substrates induces inflammation and fibrosis in cells, resulting in organ dysfunction. The clinical manifestations of FD are diverse and non-specific. In the present study, we report a case initially treated as obstructive hypertrophic cardiomyopathy for several years, which was finally identified as FD through whole-exome sequencing (WES).
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
BackgroundFollowing the identification of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, research in this area has experienced significant growth. However, a thorough bibliometric analysis of this burgeoning field remains conspicuously absent. The current study aims to delineate research hotspots and anticipate future trends on PCSK9 inhibitors employing bibliometric analysis.MethodsA systematic search was conducted in the Web of Science Core Collection (WoSCC) to identify sch
(MedPage Today) -- FDA advisors pushed for nuance in discussing whether andexanet alfa (Andexxa) should gain full approval, citing uncertainties about which dose and in which patients it could be best used to stop bleeding. Members of the Cellular.
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(MedPage Today) -- FDA advisors pushed for nuance in discussing whether andexanet alfa (Andexxa) should gain full approval, citing uncertainties about which dose and in which patients it could be best used to stop bleeding. Members of the Cellular.
After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart.
A potentially life-changing heart condition, dilated cardiomyopathy, can be caused by the cumulative influence of hundreds or thousands of genes and not just by a single "aberrant" genetic variant, as was previously thought, finds a new study led by researchers at UCL (University College London), Imperial College London and the MRC Laboratory of Medical Sciences.
Scientists have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood. The finding could open the door to better ways to manage high blood pressure and other vascular diseases.
Coronary artery fistulas (CAFs) are rare congenital heart defects that are typically managed through interventional closure, traditional surgery, or minimally invasive hybrid closure surgery. However, treating CAFs with complex anatomy, such as tortuous vessels, presents a significant challenge, particularly in young children. We report the case of a 3.8-year-old child (15 kg/100 cm) with a complex CAF, treated using a minimally invasive hybrid closure surgery approach with a 4 × 4 mm Amplatz
Drug discovery researchers have found that a natural fat molecule called 'lipoxin A4' (LXA4) could significantly reduce inflammation and improve function for diabetic hearts.
A potentially life-changing heart condition, dilated cardiomyopathy, can be caused by the cumulative influence of hundreds or thousands of genes and not just by a single 'aberrant' genetic variant, as was previously thought, finds a new study.
As the current guidelines on myocardial revascularization recommend, transit-time flow measurement (TTFM) is increasingly used for intraoperative graft flow analysis during coronary artery bypass grafting (CAB.
Arizona, Louisiana, Michigan, Ohio, Pennsylvania and Texas have the most top-ranked hospitals for heart valve replacement in the U.S., according to the WebMD Choice Awards.
"CV Sports Chat" is an interview series including expert discussions relative to sports and exercise cardiology and the health care management of athletes.
Milind Desai, MD describes favorable real-world safety outcomes from mavacamten use over 22 months of the Risk Evaluation and Mitigation Strategy (REMS) program.
Background Ventricular arrhythmias (VAs) frequently occur in the acute phase of myocarditis. Possible arrhythmic recurrences and the risk of sudden cardiac death (SCD) in this setting are reasons for concern, and limited data have been published to guide clinical management of these patients. The aim of the present paper is to report the incidence of major arrhythmic events, defined as sustained VA, SCD and appropriate implantable cardiac-defibrillator (ICD) treatment, in patients with acute myo
In this episode, hosts break down a pair of studies from AHA 2024, BPROAD and SUMMIT, as well as a study in JAMA projecting semaglutide eligibility in US adults.
Introduction Percutaneous coronary intervention (PCI) is performed by interventional cardiologists who, over their career, are exposed to substantial X-ray radiation and also face potential musculoskeletal injuries from the prolonged wearing of heavy protective equipment. Patients are also at risk from radiation exposure. Robotic-assisted PCI (R-PCI) allows millimetre control of the coronary guide-catheter, guidewires and intracoronary devices via three joysticks and touchscreens located within
Baylor College of Medicine and the Texas Heart Institute, both based in Houston, will partner to establish a cardiovascular health and research center at Baylor St. Luke's Medical Center.
Cardiovascular magnetic (CMR) resonance is a versatile tool for diagnosing cardiovascular diseases. While gadolinium-based contrast agents are the gold standard for identifying myocardial infarction (MI), their use is limited in patients with allergies or impaired kidney function, affecting a significant portion of the MI population. This has led to a growing interest in developing artificial intelligence (AI)-powered CMR techniques for MI detection without contrast agents.
Lawitz explains issues with traditional FXR agonists for MASH treatment and how FXR314 differs, potentially offering a more safe and efficacious option.
BackgroundPeripheral artery disease (PAD) affects millions globally, causing significant morbidity. Traditional treatments like plain old balloon angioplasty (POBA) have limited success due to high restenosis rates. Drug-coated balloon angioplasty (DCBA) has emerged as a promising alternative, locally delivering antiproliferative drugs like paclitaxel to reduce restenosis.
Ahmad Masri, MD, MS, discusses data from the FOREST-HCM trial examining effects of aficamten in patients with oHCM eligible for septal reduction therapy at baseline.
ObjectiveThis study aims to summarize the clinical experience of using Hem-o-lok clips for the closure of the left subclavian artery (LSA) stump in patients with acute Stanford type A aortic dissection.MethodsClinical data were collected from 96 patients with acute type A aortic dissection admitted to our hospital from January 2020 to December 2022.
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