Wed.Jun 12, 2024

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Amino Acid Infusion Before Cardiac Surgery Reduced Acute Kidney Injury

Med Page Today

(MedPage Today) -- An amino acid infusion reduced the occurrence of acute kidney injury (AKI) in adults undergoing elective cardiac surgery with cardiopulmonary bypass, the randomized PROTECTION trial showed. Among over 3,500 patients, in-hospital.

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New heart disease risk tool finds 40% fewer people need statins: Study

Becker's Hospital Review - Cardiology

New study suggests that 40% fewer people may need statins for heart disease prevention, according to a risk assessment published in JAMA Internal Medicine.

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Postpartum Readmissions Up With High Blood Pressures Lingering From Pregnancy

Med Page Today

(MedPage Today) -- The myriad rehospitalizations required by women with ongoing hypertension in the postpartum period signaled a need to better manage these patients, researchers said. Among people with new-onset hypertensive disorder of pregnancy.

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Results Involving Philips FDA-cleared AI-enabled Cardiovascular Ultrasound Platform to be Presented at American Society of Echocardiography Scientific Sessions, ASE 2024

DAIC

Royal Philips has announced its AI-enabled cardiovascular ultrasound platform to help speed up cardiac ultrasound analysis with proven AI technology, reporting that results of a new scientific abstract being presented at the American Society of Echocardiography (ASE 2024) annual meeting, June 14-16 in Portland, OR, will demonstrate how first-of-kind AI algorithms co-developed with Philips provide highly accurate detection of regional wall motion abnormalities (RWMA) on echocardiography.

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Heart regeneration: Researchers discover key role of growth factor

Medical Xpress - Cardiology

An international research team, coordinated by academics from the University of Bologna and the IRCCS—Policlinico Sant'Orsola Hospital, has identified a key growth factor capable of exerting a proliferative and regenerative effect on cardiac muscle cells. The research, published in the journal Cell Reports, paves the way for potential new therapies to regenerate damaged hearts.

Research 101
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Philips launches Duo Venous Stent System for Treatment of Symptomatic Venous Outflow Obstruction

DAIC

milla1cf Wed, 06/12/2024 - 21:54 June 12, 2024 — Royal Philips , a global leader in health technology, announced the first implant of the Duo Venous Stent System , an implantable medical device indicated to treat symptomatic venous outflow obstruction in patients with chronic venous insufficiency (CVI), following premarket approval (PMA) from the U.S.

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Ghada Bourjeily, MD: Research Gaps on Sleep Issues During Pregnancy

HCPLive

Bourjeily told HCPLive at SLEEP 2024 that sleep issues, such as insomnia and restless legs syndrome, are the most common during the first and third trimester of pregnancy.

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Case 18-2024: A 64-Year-Old Woman with the Worst Headache of Her Life

The New England Journal of Medicine

A 64-year-old woman was evaluated because of a sudden onset of the worst headache of her life. Computed tomography of the head revealed a convexal subarachnoid hemorrhage. A diagnosis was made.

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Comparative Effectiveness and Safety of Apixaban and Rivaroxaban in Older Patients with Atrial Fibrillation: A Population-Based Cohort Study

HeartRhythm

There are no clinical trials with head-to-head comparison between the two most commonly used oral anticoagulants (apixaban and rivaroxaban) in patients with atrial fibrillation (AF). The comparative efficacy and safety between these drugs remain unclear, especially among older patients who are at the highest risk for stroke and bleeding.

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Study suggests hypoxia overexpression causes pericytes to contribute to pulmonary hypertension

Medical Xpress - Cardiology

Pericytes, the multifunctional cells that work within the walls of capillaries, have been a subject of focus in the study of vascular development, cerebral blood flow, cancer, and neurodevelopment diseases.

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John Winkelman, MD, PhD: When to Use Low-Dose Opioids for Restless Legs Syndrome

HCPLive

The first line treatment for restless legs syndrome—dopamine agonists—may be making a patient’s condition worse in the long-term, Winkelman told HCPLive at SLEEP 2024.

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Uncovering links between mental stress and physical health, including cardiovascular disease

Medical Xpress - Cardiology

In June 2016, the German national football team was gearing up to face Slovakia in the European championship. With pulses set to race among thousands of fans in the crunch match in host country France, a group of scientists in Germany was watching with interest.

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Halobetasol Propionate, Tazarotene Lotion Demonstrates Clinically Significant Skin Clearance in Hyperkeratotic Psoriasis

HCPLive

Significantly greater improvements were reported at week 2, which were sustained through week 12, in patients receiving the halobetasol propionate/tazarotene lotion compared with the vehicle cohort.

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Impact of age-related gut microbiota dysbiosis and reduced short-chain fatty acids on the autonomic nervous system and atrial fibrillation in rats

Frontiers in Cardiovascular Medicine

ObjectiveAging is the most significant contributor to the increasing prevalence of atrial fibrillation (AF). Dysbiosis of gut microbiota has been implicated in age-related diseases, but its role in AF development remains unclear. This study aimed to investigate the correlations between changes in the autonomic nervous system, short-chain fatty acids (SCFAs), and alterations in gut microbiota in aged rats with AF.MethodsElectrophysiological experiments were conducted to assess AF induction rates

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Discussing Changes to Atopic Dermatitis Guidelines, with Robert Sidbury, MD, MPH

HCPLive

Sidbury covered the similarities and differences between the new guideline updates by the AAD on atopic dermatitis as well as differences with other organizations’ guidelines.

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Artificial Intelligence Advances in Cardiology—Part 1: Key Points

American College of Cardiology

The following are key points to remember from a JACC review topic of the week on advances in artificial intelligence (AI) for cardiovascular care—part 1.

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Report Details Racial/Ethnic Differences in Treatment Satisfaction, Provider Trust in Atopic Dermatitis

HCPLive

An analysis of survey data from more than 200 patients with atopic dermatitis details treatment satisfaction and provider trust based on racial/ethnic backgrounds of patients.

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Artificial Intelligence Applications in Cardiology—Part 2: Key Points

American College of Cardiology

The following are key points to remember from a JACC review topic of the week on applications in artificial intelligence (AI) for cardiovascular care—part 2.

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Guselkumab Achieves Durable Control of Key Psoriatic Arthritis Endpoints

HCPLive

Adults with active PsA treated with guselkumab exhibited durable achievement of study endpoints associated with disease control, irrespective of baseline characteristics.

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CHA2DS2-VASc Score Guides Oral Anticoagulation in Patients With SCAF

American College of Cardiology

The baseline CHA2DS2-VASc score helped to identify patient with subclinical atrial fibrillation (SCAF) in whom the benefit for reducing the risk of stroke and systemic embolism (SE) with an oral anticoagulant (OAC) was greater than the risk of increased major bleeding, according to a subgroup analysis from the ARTESiA study presented at Heart Rhythm 2024 and simultaneously published in JACC.

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Menopause and the heart connection

Medical Xpress - Cardiology

Women experience menopause at different ages—and different ways—which can, among other things, affect their heart health.

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Imdusiran Reduces HBsAg, Maintains Response After End of Treatment in Phase 2a Trials

HCPLive

Findings from a pair of phase 2a trials showed combination imdusiran and IFN or VTP-300 with standard-of-care NA therapy led to meaningful and sustained reductions in HBsAg levels.

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2024 STS Coronary Conference Showcases Latest Research and Techniques

Society of Thoracic Surgeons - Congenital

On June 7-8, 2024, in Miami, more than 120 cardiothoracic surgeons and heart team members from around the world gathered for the third annual STS Coronary Conference. With a focus on the technical aspects of coronary surgery, attendees experienced case-based panel discussions, abstract sessions, practical tips and tricks, and interactive “How I Do It” video presentations featuring surgical techniques.

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Case Report: Primary malignant mesothelioma of the left atrium easily misdiagnosed as myxoma

Frontiers in Cardiovascular Medicine

BackgroundMalignant mesothelioma (MM) is a rare and aggressive tumor that is found in the pleura and peritoneum. A few cases of MM in the pericardium and tunica vaginalis testis have been reported. Moreover, primary occurrence in the atrium is extremely rare. The visual appearance of this tumor is similar to that of a common atrial myxoma, which makes it challenging for clinicians and radiologists to diagnose and treat this disease.Case demonstrationAn 18-year-old woman presented with symptoms o

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Cardiometabolic Medicine: Seeing the Patient as a Whole

HCPLive

The panelists stress the significance of a comprehensive approach to patient care, acknowledging the interconnected nature of cardiovascular, kidney, endocrine, and obesity-related benefits, and highlighting that addressing secondary diseases can minimize overall disease risk in patients.

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One- Versus Three-Month Dual Antiplatelet Therapy in High Bleeding Risk Patients With Chronic Kidney Disease

The American Journal of Cardiology

Publication date: Available online 12 June 2024 Source: The American Journal of Cardiology Author(s): Nader Mankerious, Ralph Toelg, Birgit Vogel, Samantha Sartori, Dominick J. Angiolillo, Pascal Vranckx, Yihan Feng, Jose M. De la Torre Hernandez, Mitchell W. Krucoff, Deepak L. Bhatt, Alessandro Spirito, Davide Cao, Bassem M.

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GINA Guidelines and Biologics for Treatment of Asthma

HCPLive

Sande Okelo, MD, leads a discussion on the updates in the GINA 2021 report regarding difficult-to-treat and severe asthma, as well as considerations for GINA Step 4 and 5 treatment approaches.

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Inflammation in Fabry disease: stages, molecular pathways, and therapeutic implications

Frontiers in Cardiovascular Medicine

Fabry disease, a multisystem X-linked disorder caused by mutations in the alpha-galactosidase gene. This leads to the accumulation of globotriaosylceramide (Gb3) and globotriaosylsphingosine (Lyso-Gb3), culminating in various clinical signs and symptoms that significantly impact quality of life. Although treatments such as enzyme replacement, oral chaperone, and emerging therapies like gene therapy exist; delayed diagnosis often curtails their effectiveness.

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Use of Biologics for Asthma in Patients with Allergies

HCPLive

Medical experts discuss eligibility criteria for biologic therapies, noting that biologics can be used for other allergies and in patients with comorbidities, highlighting the potential for these targeted treatments to benefit a broad age range of patients.

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The interaction between oral microbiota and gut microbiota in atherosclerosis

Frontiers in Cardiovascular Medicine

Atherosclerosis (AS) is a complex disease caused by multiple pathological factors threatening human health-the pathogenesis is yet to be fully elucidated. In recent years, studies have exhibited that the onset of AS is closely involved with oral and gut microbiota, which may initiate or worsen atherosclerotic processes through several mechanisms. As for how the two microbiomes affect AS, existing mechanisms include invading plaque, producing active metabolites, releasing lipopolysaccharide (LPS)

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Excess Apolipoprotein-B and Cardiovascular Risk, Treating Pulmonary Arterial Hypertension, SGLT2i and CV Outcomes

American College of Cardiology

In this week’s View, Dr. Eagle looks at excess apolipoprotein-B and cardiovascular risk, then examines a recent meta-analysis on treating pulmonary arterial hypertension. Finally, Dr. Eagle shares some thoughts on a SMART-C collaborative meta-analysis of sodium-glucose cotransporter-2 inhibitors and major adverse cardiovascular outcomes.

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Case Report: unexpected cause of cyanosis in an infant after acute exposure to high altitude—severe tricuspid regurgitation secondary to tricuspid valve prolapse

Frontiers in Cardiovascular Medicine

BackgroundSevere tricuspid regurgitation (TR) causing cyanosis with patent foramen ovale (PFO) and right-to-left atrial shunting requires a precise diagnosis for optimal therapy. Tricuspid valve prolapse (TVP) can lead to TR and is sometimes overlooked, especially in complex cases with factors like pulmonary hypertension (PH). We present an infant with cyanosis and profound TR after high-altitude exposure, initially misattributed to PH but found to be primarily due to spontaneous chordae tendine

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Brodalumab Demonstrates Efficacy, Safety in Moderate to Severe Psoriasis

HCPLive

Overall, 189 (74.1%) patients treated with brodalumab achieved PASI 75, 133 (52.2%) achieved PASI 90, and 98 (38.4%) achieved PASI 100.

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Unraveling the mystery of atherosclerosis in patients with Werner syndrome

Medical Xpress - Cardiology

Approximately one in every 20,000 to 40,000 children born in Japan and about one in every 100,000 throughout the world bear a mutation in the WRN gene. This gene is responsible for producing the Werner protein, which belongs to the family of human helicases and is responsible for the maintenance of genomic stability, DNA replication, repair of DNA damage, and telomere maintenance.

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Adherence to Urate-Lowering Therapy Supports Target Benchmarks in Gout

HCPLive

Urate-lowering therapy was strongly associated with successful treat-to-target benchmarks in gout, including serum uric acid levels, but adherence remained low.

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Vascular neurologist explains how poor sleep can be linked to stroke

Medical Xpress - Cardiology

Sleep problems can increase someone's risk of stroke. Sleep problems can include too little sleep (less than five hours), too much sleep (more than nine hours), poor quality, difficulty getting to sleep or staying asleep, prolonged napping, and snoring and breathing cessation.

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Discrete Choice Experiment: Treatment Preferences of Atopic Dermatitis Patients

HCPLive

These data presented at RAD 2024 highlight the differences among eczema patient preferences in terms of administration modes, risk levels, and more.

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