Wed.Sep 25, 2024

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Sexual and Gender Minorities More Likely to Have Adverse Brain Outcomes

Med Page Today

(MedPage Today) -- People who identified as a sexual or gender minority (LGBTQ+) had a higher likelihood of adverse brain health outcomes, cross-sectional data showed. Among nearly 400,000 participants in the All of Us research program, sexual.

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The Computer and Overreading Cardiologist call this completely normal. Is it?

Dr. Smith's ECG Blog

This is another case sent by the undergraduate (who is applying to med school) who works as an EKG tech. The undergraduate is now willing to identify himself: Hans Helseth. A 56 year old male with a history of diabetes, dyslipidemia, hypertension, and coronary artery disease presented to the emergency department with sudden onset weakness, fatigue, lethargy, and confusion.

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Measure of body roundness may help to predict risk of cardiovascular disease

Medical Xpress - Cardiology

Having a high body roundness index (BRI) over a 6-year period was associated with an increased risk of developing cardiovascular disease for adults older than age 45, according to new research published today in the Journal of the American Heart Association. Previous research has indicated that BRI, a measure to reflect abdominal fat and body shape, may be helpful to predict CVD risk.

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Tissue inhibitor of metalloproteinase (TIMP)-1 predicts failure of recovery of ejection fraction in acute heart failure with reduced ejection fraction

Open Heart

Background Heart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF).

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Treating iron deficiency in patients with heart failure: what, why, when, how, where and who

Heart BMJ

For patients with heart failure and reduced or mildly reduced left ventricular ejection fraction, iron deficiency is common and associated with more severe symptoms, worse quality of life and an increased risk of hospitalisations and death. Iron deficiency can be swiftly, effectively and safely treated by administering intravenous iron, either as ferric carboxymaltose or ferric derisomaltose, which improves patient well-being and reduces the risk of hospitalisations including those for heart fai

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Soil and water pollution: An invisible threat to cardiovascular health

Medical Xpress - Cardiology

Pesticides, heavy metals, micro- and nanoplastics in the soil and environmentally harmful chemicals can have a detrimental effect on the cardiovascular system, according to a review paper published today in Nature Reviews Cardiology.

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Universal definition of myocardial infarction: what must we know? What is next?

Heart BMJ

In the beginning of the 20th century, the first reports of the clinical manifestations of myocardial infarction (MI) appeared, followed around a decade later by reports regarding the electrocardiographic (ECG) changes associated with MI ( figure 1 ). From the middle of the 20th century, the application of assays for muscle enzymes for the diagnosis of MI became widespread, culminating in the WHO definition of MI based on clinical, ECG and cardiac enzyme criteria.

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Peripheral artery disease: Leg pain, leg cramps, lingering foot wounds among symptoms

Medical Xpress - Cardiology

Leg pain and leg cramps aren't always an orthopedic issue: Both can be signs of peripheral artery disease, or PAD, a serious blood-flow issue with implications for the heart. In this expert alert, Young Erben, M.D., a vascular surgeon at Mayo Clinic in Jacksonville, Florida, explains how the most common form, PAD that affects the legs and feet, is treated.

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Healthy 45-year-old with chest pain: early repolarization, pericarditis or injury?

Dr. Smith's ECG Blog

Submitted by Dr. George Mastoras (Twitter @georgemastoras), written by Jesse McLaren It’s a busy day in the ED when you’re sent another ECG to sign off from a patient at triage. A healthy 45-year-old female presented with chest pain, with normal vitals. The computer interpretation was “ST elevation, consider early repolarization, pericarditis or injury.

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Measure of body roundness may help to predict risk of cardiovascular disease

Science Daily - Heart Disease

Abdominal body fat could hint at cardiovascular disease risk even when other health factors are not considered, a new study finds.

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ACC, AHA Release New Perioperative Guideline For Patients Undergoing Noncardiac Surgery

American College of Cardiology

The newest clinical guideline released by the ACC and American Heart Association (AHA), in collaboration with seven other societies, provides updated recommendations for perioperative cardiovascular management of patients undergoing noncardiac surgery.

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Organ Donation After Euthanasia Can Safely Expand Kidney Donor Pool, Study Finds

HCPLive

Leveraging deceased donor kidney transplantation data, study results suggest DCD-V kidney transplantation has similar short- and long-term outcomes versus DCD-III and DBD.

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Obstructive sleep apnea may increase risk of abdominal aortic aneurysms

Medical Xpress - Cardiology

Obstructive sleep apnea may be a risk factor for developing abdominal aortic aneurysms, according to researchers from the University of Missouri School of Medicine and NextGen Precision Health. "Chronic Intermittent Hypoxia Facilitates the Development of Angiotensin II-Induced Abdominal Aortic Aneurysm in Male Mice" was recently published in the Journal of Applied Physiology.

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FDA Approves Levacetylleucine for Niemann-Pick Disease Type C

HCPLive

Announced on September 24, 2024, the approval marks the second treatment approved by the FDA for Niemann-Pick disease type C within one week.

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Windtree’s Istaroxime Scores in Cardiogenic Shock Trial

CardiacWire

Windtree Therapeutics’ istaroxime appears to have scored in its latest Phase 2b trial , showing that the steroidal drug significantly improves systolic blood pressure in cardiogenic shock patients. Istaroxime is a novel dual-mechanism therapy designed to improve both systolic and diastolic cardiac function by increasing myocardial contractility and facilitating myocardial relaxation.

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Genetic syndromes associated with congenital heart disease

Heart BMJ

Congenital heart defects are the most common type of birth defect, affecting 1% of live births. The underlying cause of congenital heart disease is frequently unknown. However, advances in human genetics and genome technologies have helped expand congenital heart disease pathogenesis knowledge during the last few decades. When the cardiac defects are part of a genetic syndrome, they are associated with extracardiac conditions and require multidisciplinary care and surveillance.

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Home-Based UVB Phototherapy as Effective as Office-Based Phototherapy for Psoriasis

HCPLive

These data suggest that the use of narrowband UVB phototherapy at home among patients with guttate or plaque psoriasis may function as a slightly less costly alternative to in-office use.

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Post-Stroke Fever Prevention Still Lacking in Clinical Benefit

Med Page Today

(MedPage Today) -- A dedicated temperature management machine dampened the risk of fever for stroke patients in the intensive care unit (ICU), though this did not translate into better functional outcomes months later in the INTREPID randomized.

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Ertugliflozin Lowers UA, Improves Gout Outcomes in People With Type 2 Diabetes and ASCVD

HCPLive

There were no differences in the treatment effect of ertugliflozin on gout-related outcomes in subgroups based on eric acid quintile or other baseline characteristics.

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HCA Florida, U of Central Florida launch cardiovascular disease fellowship

Becker's Hospital Review - Cardiology

Orlando-based University of Central Florida College of Medicine and Davie-based HCA Florida Healthcare have launched a cardiovascular disease fellowship, marking the 40th program to be offered through the partnership's Graduate Medical Education Consortium.

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Roflumilast Cream 0.15% Leads to Consistent Eczema Improvements for Diverse Skin Types

HCPLive

These new findings were released by Arcutis Biotherapeutics and presented at the European Academy of Dermatology & Venereology Congress.

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6 care challenges facing cardiologists

Becker's Hospital Review - Cardiology

Research and consulting firms KS&R and EMI have published a survey of 429 board-certified, practicing cardiologists, highlighting the challenges cardiologists said they are facing with patient care.

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The Value of Team-Based Care, Technology in Managing CVD Risk Factors, with Benjamin Scirica, MD

HCPLive

Benjamin Scirica, MD, discusses the importance of team-based care and leveraging technology to optimize the management of cardiovascular risk factors.

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Experienced surgeons could reduce the need for pacemakers after heart valve surgery

Medical Xpress - Cardiology

People having surgery to repair tight or leaking heart valves may receive a pacemaker more often than necessary—leading to a greater risk for life-threatening complications, studies show.

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British Cardiovascular Society/British Heart Foundation/British Atherosclerosis Society/British Society for Cardiovascular Research Young Investigator Award 2024

Heart BMJ

Introduction The British Cardiovascular Society (BCS)/British Heart Foundation (BHF)/British Atherosclerosis Society (BAS)/British Society for Cardiovascular Research (BSCR) Young Investigator Award (YIA) was established in 2001. The competition is open to both clinicians (who are not consultants) and basic scientists, who are no more than 5 years post-PhD.

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Study Reveals Biomarkers for Fibrosis Detection in Homozygous ZZ AATD Liver Disease

HCPLive

Findings from the prospective cohort study suggest the value of serum Z polymer levels as a non-invasive disease-specific biomarker in patients with homozygous ZZ AATD liver disease.

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Randomised study for the Optimal Treatment of symptomatic patients with low-gradient severe Aortic valve Stenosis and preserved left ventricular ejection fraction (ROTAS trial)

Heart BMJ

Background The best management of symptomatic patients with low-gradient (LG) severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF) has not been established. The Randomised study for the Optimal Treatment of symptomatic patients with low-gradient severe Aortic valve Stenosis (ROTAS) trial aimed to assess the superiority of aortic valve replacement (AVR) versus medical treatment (MT) in this specific group of AS patients.

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AHA/ACC Update Guidelines on Cardiovascular Risk in Noncardiac Surgery

HCPLive

The joint guidelines address evidence on the management of patients before, during, and after noncardiac surgery since the last update in 2014.

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Impact of multiple obesity metrics on hypertensive disorders of pregnancy: a meta-analysis and Mendelian randomisation study

Heart BMJ

Background The relationships between various obesity measures and hypertensive disorders of pregnancy (HDP) remain inadequately explored, and their causal links are not well understood. This study aims to clarify these associations and investigate the mediating role of triglycerides. Methods We conducted a comprehensive meta-analysis of observational studies alongside Mendelian randomisation (MR) analysis to assess the impact of 10 obesity measures on HDP risk.

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Lebrikizumab Leads to Sustained Disease Control for Atopic Dermatitis Up to 3 Years

HCPLive

These new findings were released by Arcutis Biotherapeutics and presented at the European Academy of Dermatology & Venereology Congress.

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Associations between circulating proteins and cardiometabolic diseases: a systematic review and meta-analysis of observational and Mendelian randomisation studies

Heart BMJ

Background Integration of large proteomics and genetic data in population-based studies can provide insights into discovery of novel biomarkers and potential therapeutic targets for cardiometabolic diseases (CMD). We aimed to synthesise existing evidence on the observational and genetic associations between circulating proteins and CMD. Methods PubMed, Embase and Web of Science were searched until July 2023 for potentially relevant prospective observational and Mendelian randomisation (MR) studi

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AED Access, Cardiomyopathy and Congenital Heart Defect Legislation Advances Ahead of ACC Legislative Conference

American College of Cardiology

The U.S. House of Representatives passed two significant pieces of cardiovascular legislation on Sept. 23 – the Cardiomyopathy Health, Education, Awareness, Research, and Training in Schools (HEARTS) Act (H.R. 6829) and the Congenital Heart Futures Reauthorization Act of 2024 (H.R. 7189).

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A rare case of atrial flutter and a cystic mass in the left atrium

Heart BMJ

Clinical introduction A woman is her 60s with no medical history presented to the hospital with palpitations and occasional nausea. The patient reported no chest pain or shortness of breath. Observations revealed a normal temperature of 36.5°C and a normal blood pressure of 123/83 mm Hg. A 24-hour 12-lead ECG revealed sinus rhythm, frequent atrial premature beats, paroxysmal atrial flutter with an atrial flutter burden of 9.37% and no paroxysmal ST-T abnormalities.

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Risk Stratification in Nonischemic Dilated Cardiomyopathy, 2024 Guideline for Perioperative CV Management for Noncardiac Surgery, Lipoprotein(a) and CVD

American College of Cardiology

In this week’s View, Dr. Eagle looks at risk stratification in nonischemic dilated cardiomyopathy using CMR imaging.

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Decoding proteins in cardiometabolic disease: the power and challenges of proteomics

Heart BMJ

Circulating proteins are the result of genetically inherited predispositions to diseases and the influences of environmental exposures, diet, lifestyle behaviours and the ageing process. 1 This dual capacity of proteins to reflect both genetic and environmental factors is crucial for understanding and stratifying risks for common complex diseases like cardiometabolic disorders.

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Using Technology to Advance Care in Hyperlipidemia, Cardiovascular Disease, with Nihar Desai, MD

HCPLive

A Q&A with Nihar Desai, MD, on the PROMPT-Lipid trial and the potential of advancing technology for improving patient care in pragmatic ways.

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Tenecteplase vs. Alteplase for Patients With Acute Ischemic Stroke

American College of Cardiology

The goal of the ORIGINAL trial was to test the noninferiority of tenecteplase, a bioengineered tissue plasminogen activator, to alteplase in a Chinese cohort of acute ischemic stroke qualifying for intravenous thrombolytic therapy.

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