EMS 12-Lead
MAY 15, 2024
TCP in the ROSC Patient: False Electrical Capture at 75mA Josh Kimbrell, NRP @joshkimbre Judah Kreinbrook, EMT-P @JMedic2JDoc This is the second installment of a blog series showing how transcutaneous pacing (TCP) can be difficult and how you can improve your skills. We will be using redacted information from different cases where paramedics attempted TCP in the field.
HCPLive
MAY 15, 2024
Deepak Bhatt, MD, MPH, MBA, reviews the efficacy and safety data of inclisiran, highlighting its long-term effects and noting that injection site reactions are among the most prominent adverse reactions associated with this medication.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Lymphedema is a debilitating disease with no effective cure and affects an estimated 250 million individuals worldwide. Prior studies have identified mutations in piezo-type mechanosensitive ion channel component 1 (PIEZO1), angiopoietin 2 (ANGPT2), and tyrosine kinase with Ig-like and EGF-like domains 1 (TIE1) in patients with primary lymphedema. Here, we identified crosstalk between these molecules and showed that activation of the mechanosensory channel PIEZO1 in lymphatic endothelial cells (
Science Daily - Heart Disease
MAY 15, 2024
Vegetarian and vegan diets are generally associated with better status on various medical factors linked to cardiovascular health and cancer risk, as well as lower risk of cardiovascular diseases, cancer, and death, according to a new review of 49 previously published papers.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
The mammalian SUMO-targeted E3 ubiquitin ligase Rnf4 has been reported to act as a regulator of DNA repair, but the importance of RNF4 as a tumor suppressor has not been tested. Using a conditional-knockout mouse model, we deleted Rnf4 in the B cell lineage to test the importance of RNF4 for growth of somatic cells. Although Rnf4–conditional-knockout B cells exhibited substantial genomic instability, Rnf4 deletion caused no increase in tumor susceptibility.
DAIC
MAY 15, 2024
In the dynamic realm of healthcare technology, cardiovascular information systems (CVIS) stand at the forefront, facilitating streamlined operations, enhanced patient care and efficient data management within cardiovascular departments. According to a recent market report from Credence Research, the CVIS market is projected to surge from $1,197 M in 2023 to $2,387 by 2023 — a compound annual growth rate of 7.7%.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Lactylation has been recently identified as a new type of posttranslational modification occurring widely on lysine residues of both histone and nonhistone proteins. The acetyltransferase p300 is thought to mediate protein lactylation, yet the cellular concentration of the proposed lactyl-donor, lactyl-coenzyme A, is about 1,000 times lower than that of acetyl-CoA, raising the question of whether p300 is a genuine lactyltransferase.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Elevated bone resorption and diminished bone formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, the direct effects of excess glucocorticoids on bone turnover remain unclear. Here, we explored the outcomes of exogenous glucocorticoid treatment on bone loss and delayed fracture healing in mice and found that reduced bone turnover was a dominant feature, resulting in a net loss of bone mass.
DAIC
MAY 15, 2024
milla1cf Wed, 05/15/2024 - 08:50 May 15, 2024 — The U.S. Food and Drug Administration ( FDA ) announced that Abbott is recalling the HeartMate 3 LVAS by updating the instructions for use after complaint reviews identified blood leakage or air entering the seal interface between the left ventricular assist device (LVAD) inflow cannula and the titanium apical cuff.
Science Daily - Heart Disease
MAY 15, 2024
An important new study has advanced how heart failure is detected in women -- meaning more female patients can be diagnosed and at an earlier stage.
Science Daily - Stroke
MAY 15, 2024
A recent study has found that an ion transporter protein that regulates the pH of specific brain cells can repair the blood-brain barrier and restore normal brain function after ischemic stroke. The study has revealed novel and specific therapeutic targets for ischemic stroke and related brain conditions for which no targeted treatments exist currently.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Gender-affirming hormone therapy (GAHT) is often prescribed to transgender (TG) adolescents to alleviate gender dysphoria, but the effect of GAHT on the growing skeleton is unclear. We found GAHT to improve trabecular bone structure via increased bone formation in young male mice and not to affect trabecular structure in female mice. GAHT modified gut microbiome composition in both male and female mice.
Medical Xpress - Cardiology
MAY 15, 2024
Living with a chronic medical condition after surviving a heart attack or stroke may come with additional health and personal care needs. Often survivors must rely on a family member or close friend to help. However, there's a growing body of scientific research that shows people who serve as unpaid caregivers may not be getting the care they need to live longer, healthier lives, according to the American Heart Association, celebrating 100 years of lifesaving service as the world's leading nonpr
HCPLive
MAY 15, 2024
Announced on May 15, 2024, the IND application supports a phase 1/2 study of CID among adults with chronic ITP.
Medical Xpress - Cardiology
MAY 15, 2024
A study by Rutgers Health experts of more than 31 million hospital records shows that infertility treatment patients were twice as likely as those who conceived naturally to be hospitalized with heart disease in the year after delivery.
American Heart News - Heart News
MAY 15, 2024
Despite strides in cardiopulmonary resuscitation (CPR) training, consumer research from the American Heart Association reveals only 1 in 4 Asian American individuals are confident they could correctly perform Hands-Only CPR, compared with a comparable.
Medical Xpress - Cardiology
MAY 15, 2024
In the international CONVINCE trial, presented today (15 May 2024) at the European Stroke Organization Conference (ESOC 2024), anti-inflammatory treatment with long-term colchicine did not reduce rates of recurrent stroke and cardiovascular events in patients with non-cardioembolic stroke in the primary intention-to-treat analysis.
The New England Journal of Medicine
MAY 15, 2024
A 96-year-old woman presented with a 1-day history of pleuritic chest pain 4 days after a pacemaker was implanted for complete heart block. Electrocardiography showed complete heart block.
Medical Xpress - Cardiology
MAY 15, 2024
Records from nearly 30,000 nursing home residents indicate that blood pressure medications more than double the risk of life-threatening bone fractures, according to Rutgers Health research.
The New England Journal of Medicine
MAY 15, 2024
This podcast episode considers a new treatment for hypertrophic cardiomyopathy, the world’s most common inherited heart condition, which most affected people don’t even realize they have.
HCPLive
MAY 15, 2024
These data highlighted patient-reported and clinical outcomes among those with psoriasis, with data drawn retrospectively from Germany, Poland, Czech Republic, Japan, and Canada.
Science Daily - Heart Disease
MAY 15, 2024
Researchers tie infertility treatment to a particular risk for hypertensive diseases.
HCPLive
MAY 15, 2024
Areef Ishani, MD, MS, discusses the results of the Diuretic Comparison Project (DCP), which compared chlorthalidone and hydrochlorothiazide for the treatment of cardiovascular diseases.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Neurofibromatosis type 1 (NF1) is caused by mutations in the NF1 gene that encodes neurofibromin, a RAS GTPase–activating protein. Inactivating NF1 mutations cause hyperactivation of RAS-mediated signaling, resulting in the development of multiple neoplasms, including malignant peripheral nerve sheath tumors (MPNSTs). MPNSTs are an aggressive tumor and the main cause of mortality in patients with NF1.
HCPLive
MAY 15, 2024
Sylvia Rosas, MD, MSCE, discusses highlights from the National Kidney Foundation's Spring Clinical Meeting, including innovations in xenotransplantation, artificial intelligence, and the interplay between kidney, heart, and metabolic diseases.
The New England Journal of Medicine
MAY 15, 2024
In The Prince, Niccolò Machiavelli wrote, “[W]ith those hectic fevers, as the doctors say, … at their beginning [they] are easy to cure but difficult to recognize, but in the course of time… [they] become easy to recognize but difficult to cure.
HCPLive
MAY 15, 2024
Check out this quiz on the NKF's KDOQI recommendations on nutrition in chronic kidney disease, with a focus on their guidance for nutritional assessments!
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related small vessel pathologies that affect multiple regions. Disease manifestations range from lesions incidentally detected on neuroimaging (white matter hyperintensities, small deep infarcts, microbleeds, or enlarged perivascular spaces) to severe disability and cognitive impairment. cSVD accounts for approximately 25% of ischemic strokes and the vast majority of spontaneous intracerebral hemorrhage and is also the
Cardiovascular Diabetology
MAY 15, 2024
Insulin resistance (IR) is linked to both the complexity of coronary artery lesions and the prognosis of acute coronary syndrome (ACS). However, the precise extent of this correlation and its impact on adverse.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Pediatric acute respiratory distress syndrome (ARDS) is severe, noncardiac hypoxemic respiratory failure that carries a substantial risk of death. Given the complexity of this clinically defined syndrome and the repeated failure of therapeutic trials, there has been an effort to identify subphenotypes of ARDS that may share targetable mechanisms of disease.
Med Page Today
MAY 15, 2024
(MedPage Today) -- Treatment with the bleeding reversal agent andexanet (Andexxa) in people with acute intracerebral hemorrhage on factor Xa inhibitors led to less expansion of hematoma volume but was associated with thrombotic events, the ANNEXA.
NEJM Journal Watch - Cardiology
MAY 15, 2024
A meta-analysis suggests that patients who take high-dose statins have about 1% higher risk annually for newly diagnosed diabetes.
HCPLive
MAY 15, 2024
Results showed metabolic dysfunction was an independent predictor of liver-related events and hepatocellular carcinoma in patients with chronic HCV who achieved SVR.
Medical Xpress - Cardiology
MAY 15, 2024
A new study has advanced how heart failure is detected in women—meaning more female patients can be diagnosed and at an earlier stage.
HCPLive
MAY 15, 2024
Swanpil Hiremath, MD, MPH, explains the importance of 24-hour ambulatory blood pressure monitoring (ABPM) to rule out the possibility of white coat hypertension.
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
Idiopathic systemic capillary leak syndrome (ISCLS) is a rare, recurrent condition with dramatically increased blood vessel permeability and, therefore, induction of systemic edema, which may lead to organ damage and death. In this issue of the JCI, Ablooglu et al. showed that ISCLS vessels were hypersensitive to agents known to increase vascular permeability, using human biopsies, cell culture, and mouse models.
HCPLive
MAY 15, 2024
Study results showed systemic corticosteroids induced greater remission rates alone than in combination with other immunosuppressive treatments but were linked to adverse events.
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