Mon.Apr 29, 2024

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Age-Related Somatic Mutations Implicated in Cardiovascular Death

Med Page Today

(MedPage Today) -- Cardiovascular death had a strong tie to the somatic mutations that often accrue with aging in people with subclinical atherosclerosis, an observational study found. For asymptomatic people who had atherosclerosis detected by.

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CV Societies Propel Plans Forward for a New Board of Cardiovascular Medicine

DAIC

Getty Images milla1cf Mon, 04/29/2024 - 13:11 April 29, 2024 — Efforts by the American College of Cardiology , the American Heart Association , the Heart Failure Society of America , the Heart Rhythm Society and The Society for Cardiovascular Angiography & Interventions to create a new, independent Board of Cardiovascular Medicine under the American Board of Medical Specialties ( ABMS ) are closer to becoming a reality with the creation of a formal Board of Directors and the announcement by th

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Dissolving Stent Approved for Peripheral Artery Disease Below the Knee

Med Page Today

(MedPage Today) -- The FDA approved the Esprit BTK everolimus-eluting scaffold system for chronic limb-threatening ischemia (CLTI) below the knee, Abbott announced on Monday. This system represents the first drug-eluting resorbable scaffold with.

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Fujifilm Introduces First-of-its-Kind Transducer for On-Pump Intracardiac Echocardiography Imaging (OPIE) for Septal Myectomy

DAIC

milla1cf Mon, 04/29/2024 - 13:17 April 29, 2024 — FUJIFILM Healthcare Americas Corporation, a leading provider of diagnostic and enterprise imaging solutions, announced the launch of its first-of-kind OPIE Transducer for on-pump intracardiac echocardiography (OPIE) for septal myectomy. Early clinical users of the OPIE transducer will discuss how the technology helps to evaluate the ventricular septal thickness during septal myectomy surgery by providing real-time imaging visualization during t

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Cardio-fitness cuts death and disease by nearly 20%

Science Daily - Heart Disease

Groundbreaking new research finds that an increased cardio fitness level will reduce your risk of death from any cause by nearly 20%.

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Jonathan Barratt, MD: Atacicept Could ‘Transform How We Think About Treating IgA Nephropathy’

HCPLive

Barratt explained findings from the phase 2b ORIGIN trial of atacicept and how it compares to current standard therapies in IgAN and other agents in the pipeline.

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Building a Practice in the Community

Society of Thoracic Surgeons - Early Career

Blog Building a Practice in the Community KCummings Mon, 04/29/2024 - 12:35 Medical Student Resident / Fellow “Jack of all trades, master of none, though oftentimes better than a master of one.” Image Heather Palomino, MD In training, you are surrounded by highly specialized cardiac and thoracic surgeons who are often subspecialized and have created a niche within their practice.

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And That's a Wrap! ACC.24: An ACPC Perspective

American College of Cardiology

The American College of Cardiology Scientific Sessions 2024 (ACC.24), building on the successes and lessons of past gatherings, marked a significant return to in-person collaboration and learning for the Adult Congenital and Pediatric Cardiology (ACPC) community.

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Clinic Days with Telemedicine, In-Person Visits Increases EHR Work for PCPs

HCPLive

A combination of telemedicine and in-person visits led to a nearly 6% increase in electronic health record work for primary care physicians.

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Review and Treatment Options for the Tricuspid Valve: Key Points

American College of Cardiology

The following are key points to remember from an American Heart Association scientific statement, which reviews the pathology, imaging, and current treatment options for the tricuspid valve (TV).

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Brief Mindfulness Intervention for Psoriasis Boosts Awareness, Not Skin Health

HCPLive

A new study found a 2-week mindfulness-based intervention for patients with psoriasis does not improve skin status—it only helps the mind.

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The role of transcription factors in the pathogenesis and therapeutic targeting of vascular diseases

Frontiers in Cardiovascular Medicine

Transcription factors (TFs) constitute an essential component of epigenetic regulation. They contribute to the progression of vascular diseases by regulating epigenetic gene expression in several vascular diseases. Recently, numerous regulatory mechanisms related to vascular pathology, ranging from general TFs that are continuously activated to histiocyte-specific TFs that are activated under specific circumstances, have been studied.

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FDA Issues a CRL for Ketamine’s Abbreviated New Drug Application

HCPLive

FDA issued a CRL the abbreviated new drug application of ketamine, which had sought to enhance accessibility to the limited drug supply.

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Genetically predicted lipids mediate the association between intrahepatic cholestasis of pregnancy and cardiovascular disease

Frontiers in Cardiovascular Medicine

IntroductionIntrahepatic cholestasis of pregnancy (ICP), the most prevalent liver disorder specific to pregnancy, affects approximately 1.5%-4% of pregnancies. However, the influence of ICP on cardiovascular disease (CVD), including hypertension (HTN) and coronary artery disease (CAD), has not been thoroughly investigated.MethodsThis study explores the causal relationship between ICP and CVD (HTN, CAD) using Mendelian Randomization (MR).

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Colchicine Treatment Significantly Improves COVID-19 Outcomes

HCPLive

Findings indicated treatment with colchicine resulted in a significant reduction in mortality rate compared with placebo or standard care.

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Exhibitor Prospectus - 2024 STS Mastering Valve Surgery Workshop

Society of Thoracic Surgeons - Congenital

Exhibitor Prospectus - 2024 STS Mastering Valve Surgery Workshop smccarthy Mon, 04/29/2024 - 10:59 Exhibitor Application Stand Out Among Your Competitors & Partners Increase your company’s opportunity for personalized interactivity with attendees by exhibiting at the Workshop. Several breaks will take place in the exhibit area and have been scheduled so that attendees have plenty of time to visit your booth.

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Leveraging Mammograms to Improve Cardiovascular Risk Assessment, with Matthew Nudy, MD

HCPLive

A recent study found breast arterial calcification on mammograms could help predict higher risk of stroke, cardiovascular death, and heart disease in women.

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Should you take medications for high blood pressure lifelong?

All About Cardiovascular System and Disorders

The answer depends on what caused your high blood pressure. If it is a reversible cause which can be removed, then of course medications can be stopped. But if a reversible cause has not been found, you should be cautious about stopping medications. What are the reversible causes of high blood pressure? A transient drop in kidney function due to some illness (acute kidney injury) can raise the blood pressure.

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FDA Approves Mavorixafor (XOLREMDI) as First Drug Indicated for WHIM Syndrome

HCPLive

FDA approves mavorixafor (XOLREMDI) for WHIM syndrome, the first approved treatment for the rate disease.

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ACC CardiaCast: Bempedoic Acid at ACC.24

American College of Cardiology

In this episode, Drs. Erin Michos and Leslie Cho discuss the research presented at ACC.24 related to statin intolerance and bempedoic acid. Dr. Cho’s research publication “Characteristics and Outcomes for Statin Intolerant Women Receiving Bempedoic Acid in The Clear Outcomes Trial” is discussed, as well as lipid management for women, Hispanic, Latinx, and obese patients in the CLEAR Outcomes Trial.

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FDA Accepts Tapinarof Cream sNDA for Atopic Dermatitis Patients Aged 2 Years and Older

HCPLive

The announcement by Dermavant followed positive findings from the ADORING trials on tapinarof and an open label extension for children aged 2 - 17.

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Durability of Pulmonary Vein Isolation Using Pulsed-Field Ablation

American College of Cardiology

What is the real-world lesion durability of pulmonary vein isolation (PVI) with pulsed-field ablation (PFA) among patients with clinically indicated redo procedures?

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Barriers to Accessing New Anti-Diabetes Medications

HCPLive

Medical experts underscore disparities in diabetes treatment access, stressing the impact of insurance plans on treatment decisions, which can hinder patients and providers, especially when considering newer medications like GLP-1 agonists.

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David E. Haines, MD, September 1, 1954, to February 10, 2024

HeartRhythm

It is with great sadness but also with honor we write in memory of our dear friend and colleague David E. Haines, MD. David passed away suddenly on February 10, 2024. He was a dear friend and colleague of the Heart Rhythm Society and electrophysiologists around the world. David’s many scholarly contributions focused on ablation energy sources, starting in 1986 when he was at the University of Virginia (UVA) and radiofrequency ablation was being introduced.

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Suspecting Hypercortisolism in Patients With Resistant Diabetes

HCPLive

Key Opinion Leaders address the psychiatric issues associated with hypercortisolism and highlight crucial clinical symptoms to look for when diagnosing the condition, such as hypertension in patients under 30 without a family history, diabetes in those under 40 with no family history, and bone issues among other signs.

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Six-month Electrical Performance of the First Dual-Chamber Leadless Pacemaker

HeartRhythm

The first dual-chamber leadless pacemaker (DC-LP) system consists of two separate atrial and ventricular devices that communicate to maintain synchronous atrioventricular pacing and sensing. The initial safety and efficacy were previously reported.

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Clinical Experience With Initiating Adalimumab Biosimilars

HCPLive

Specialists in rheumatology, dermatology and gastrointestinal disease share their clinical experience on initiating or switching their patients on adalimumab biosimilars.

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Peak Frequency Analysis for Epicardial Contact Mapping: How (In)Frequent is Epicardial Adipose Tissue?

HeartRhythm

Combined endo-epicardial catheter ablation is an established treatment for ventricular arrhythmias. Abnormal omnipolar voltage (OV) <1.5mV is a surrogate of underlying myocardial fibrosis/scar. Yet, epicardial adipose tissue (EAT) is a common confounder when interpretating epicardial OV maps and can result in “false” low voltage annotation even in the absence of scar.

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Switching From Adalimumab to a Biosimilar

HCPLive

Specialists in rheumatology, dermatology and gastrointestinal disease discuss the evidence on efficacy and safety on switching patient to an adalimumab biosimilar.

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Mind the gap! Interdisciplinary approach to anterior chest wall reconstruction after total sternectomy

Journal of Cardiothoracic Surgery

There are various reconstructive methods after total sternectomy. Reproducibility is scarce due to overall small patient numbers. Therefore we present a standardized, interdisciplinary approach for thoracic an.

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Demodex Mite Density Increases in Psoriasis Patients Treated with Biologic Therapy

HCPLive

These data allow for a basis for additional research and possible interventions to address psoriasis patients’ demodicosis risk.

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Association Between Coronary Assessment in Heart Failure and Clinical Outcomes Within a Safety-Net Setting Using a Target Trial Emulation Observational Design

Circulation: Cardiovascular Quality & Outcomes

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. BACKGROUND:Ischemic cardiomyopathy is the leading cause of heart failure (HF). Most patients do not undergo coronary assessment after HF diagnosis. There are no randomized clinical trials of coronary assessment after HF diagnosis.METHODS:Using an electronic health record cohort of all individuals with HF within the San Francisco Health Network from 2001 to 2019, we identified factors associated with coronary assessment.

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Daniel Gaudet, MD, PhD: Contextualizing Plozasiran Data from SHASTA-2, Upcoming MUIR Data

HCPLive

Daniel Gaudet, MD, PhD, discusses SHASTA-2 data and what cardiologists could learn from the forthcoming 48-week MUIR trial data from EAS 2024.

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TRANSCATHETER AORTIC VALVE REPLACEMENT WITH THE NAVITOR SYSTEM: REAL-WORLD UNITED KINGDOM EXPERIENCE

The American Journal of Cardiology

Publication date: Available online 29 April 2024 Source: The American Journal of Cardiology Author(s): Apurva H Bharucha, Ritesh Kanyal, Michael Mullen, Kush Patel, David Smith, Joy Shome, Daniel J Blackman, Suleman Aktaa, Paul D Williams, Saib Khogali, Rafal Dworakowski, Mehdi Eskandari, Jonathan Byrne, Philip MacCarthy

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Intestinal Dysbiosis is Present in Many Patients with RA

HCPLive

Internal dysbiosis was present in 66% of patients at baseline and was more common among those with a disease duration of > 2 years.

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Top stories on pulsed field ablation (2024)

HeartRhythm

Pulsed field ablation (PFA) has emerged as a safe and effective alternative to thermal ablation modalities. Its tissue selectiveness stands out as a most important advantage over radiofrequency (RF) ablation or cryoablation, along with a shorter ablation time. Because of the multiple factors that drive the lesion formation, each report on PFA should be regarded as platform specific.

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Cardiovascular Monosodium Urate Deposits Intensify MACE Risk in Gout

HCPLive

Monosodium urate deposits significantly increased the risk of major cardiovascular events in patients with gout and hyperuricemia.

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