Mon.Feb 26, 2024

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Even Modest Lp(a) Elevations Bode Poorly for Cardiovascular Health

Med Page Today

(MedPage Today) -- Lipoprotein(a), or Lp(a), at levels well below currently accepted risk thresholds correlated with increased cardiovascular risk in a large registry study, suggesting a wider patient pool that could benefit from future preventive.

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Valvular and perivalvular thrombus after TAVR: Risks and Outcomes

Cardiology Update

Transcatheter aortic valve replacement (TAVR) is the standard treatment for severe aortic stenosis, but post-TAVR leaflet thrombus, identified by hypoattenuated leaflet thickening (HALT), poses potential risks like cerebral thromboembolic events. Perivalvular thrombus has also been reported. The ADAPT-TAVR study compared edoxaban with dual antiplatelet therapy (DAPT) to prevent leaflet thrombus and associated risks post-TAVR.

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Ohio State First in Central Ohio to Use Novel Heart Failure Therapy

DAIC

milla1cf Mon, 02/26/2024 - 12:40 February 26, 2024 — More than 6 million Americans live with heart failure , and about half have an enlarged left ventricle, which causes stress on the heart and less blood pumped with each heartbeat. The Ohio State University Wexner Medical Center is the first in central Ohio to take part in a global clinical trial to use a novel therapy to reduce the size of the left ventricle without open-heart surgery.

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Survodutide, a Glucagon/GLP-1 RA, Reduces MASH in Phase 2 Trial

HCPLive

Survivodutide, a dual agonist from Boehringer Ingelheim and Zealand Pharma, was associated with MASH resolution without worsening fibrosis among 83% of participants in a phase 2 trial.

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Arterial Connections Improve Treatment Outcomes Following Stroke

DAIC

Visualization of the blood vessels in the brain of a patient without early venous filling, meaning without excessive reperfusion of the brain area after removal of the blood clot in the blocked artery. Image courtesy of P. Thurner und Z. Kulcsar, University Hospital Zurich milla1cf Mon, 02/26/2024 - 12:13 February 26, 2024 — Ischemic strokes are a major health burden.

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Hackensack Meridian hospital to pour $45M into cardiovascular suite expansion

Becker's Hospital Review - Cardiology

Neptune City, N.J.-based Hackensack Meridian Health Jersey Shore University Medical Center is investing $45 million to expand its cardiovascular suite, BNN Breaking reported Feb. 26.

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Providers May Be Overlooking Average-Risk Patients for HCV Screening

HCPLive

Cross-sectional survey results suggest most providers are recommending HCV screening based on patient risk factors rather than universally for all patients 18-79 years of age.

More Trending

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Simultaneous management of aortic and mitral regurgitation through one-stage transcatheter aortic valve replacement and transcatheter edge-to-edge repair: case report

Frontiers in Cardiovascular Medicine

This case report presents a 72-year-old male patient who presented with exertional dyspnea for over 10 years, which had progressively worsened over the past 4 months. Transthoracic echocardiography revealed severe aortic and mitral regurgitation, with a left ventricular ejection fraction of 37% and a left ventricular end-diastolic diameter of 64 mm.

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Booster Vaccination With SARS-CoV-2 mRNA Vaccines and Myocarditis

American College of Cardiology

What is the rate of myocarditis after booster vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines?

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Dose Response to Upper Extremity Stroke Rehabilitation Varies by Individual: Early Indicators of Treatment Response

Stroke Journal

Stroke, Volume 55, Issue 3 , Page 696-704, March 1, 2024. BACKGROUND:Dose response has remained a priority area in motor rehabilitation research for decades, prompting several large randomized trials and meta-analyses. These between-subjects comparisons have revealed equivocal relationships between the duration of motor practice and rehabilitation response.

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Ischemic Stroke Severity After LAAC vs. NOAC

American College of Cardiology

Is there a difference in the severity of ischemic stroke in patients with atrial fibrillation (AF) who have undergone left atrial appendage closure (LAAC) versus patients on direct oral anticoagulation (NOAC)?

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Case Report: Enhancing lead extraction techniques: a novel approach using a loop formed by an ablation catheter and a gooseneck snare

Frontiers in Cardiovascular Medicine

The difficulty and complexity of lead extraction procedures increase with the age of the lead to be extracted. The extraction of old (>20 years) leads is more time-consuming and requires advanced tools and a complex technique. In this case, we retrieved a very old (>30 years) lead using a loop formed by a catheter and a gooseneck snare. The catheter was rotated to remove the lead-bound sites.

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Thomas B. Casale, MD: Discussing New Findings on Neffy for Urticaria Flares

HCPLive

In an interview during the 2024 AAAAI conference, Casale addressed his team’s findings regarding epinephrine nasal spray and its effectiveness with regard to exacerbations of urticaria.

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Prediction of acute kidney injury after cardiac surgery with fibrinogen-to-albumin ratio: a prospective observational study

Frontiers in Cardiovascular Medicine

Background The occurrence of acute kidney injury (AKI) following cardiac surgery is common and linked to unfavorable consequences while identifying it in its early stages remains a challenge. The aim of this research was to examine whether the fibrinogen-to-albumin ratio (FAR), an innovative inflammation-related risk indicator, has the ability to predict the development of AKI in individuals after cardiac surgery.

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Updates Announced for Clinical Practice Guidelines on Inhalant Allergy Treatment

HCPLive

Twelve evidence-based Key Action Statements were provided for clinicians to guide them in the treatment of patients reporting inhalant allergy symptoms.

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Correlation of the serum cell division cycle 42 with CD4+ T cell subsets and in-hospital mortality in Stanford type B aortic dissection patients

Frontiers in Cardiovascular Medicine

Objective Cell division cycle 42 (CDC42) regulates CD4 + T -cell differentiation and participates in vascular stiffness and atherosclerosis and is involved in the progression of Stanford type B aortic dissection (TBAD). This study aimed to explore the correlation between serum CDC42 level and CD4 + T cell subsets and in-hospital mortality in TBAD patients.

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Female Teens Took More Antidepressants During COVID-19, Male Teens Took Less

HCPLive

A new study found female teens and young adults were more likely to have an increased antidepressant dispensing rate during the pandemic than male peers.

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Consensus statement—graft treatment in cardiovascular bypass graft surgery

Frontiers in Cardiovascular Medicine

Coronary artery bypass grafting (CABG) is and continues to be the preferred revascularization strategy in patients with multivessel disease. Graft selection has been shown to influence the outcomes following CABG. During the last almost 60 years saphenous vein grafts (SVG) together with the internal mammary artery have become the standard of care for patients undergoing CABG surgery.

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Randomized Trial to Prevent Vascular Events in HIV

American College of Cardiology

The goal of the REPRIEVE trial was to evaluate pitavastatin compared with placebo among individuals with human immunodeficiency virus (HIV) infection and low-to-moderate risk of cardiovascular disease.

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Development and validation of mortality prediction models for heart transplantation using nutrition-related indicators: a single-center study from China

Frontiers in Cardiovascular Medicine

Objective We sought to develop and validate a mortality prediction model for heart transplantation (HT) using nutrition-related indicators, which clinicians could use to identify patients at high risk of death after HT. Method The model was developed for and validated in adult participants in China who received HT between 1 January 2015 and 31 December 2020. 428 subjects were enrolled in the study and randomly divided into derivation and validation cohorts at a ratio of 7:3.

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Guselkumab Significantly Improves Disease Activity in PsA Over 100 Weeks

HCPLive

Continuous improvement across all MDA domains was demonstrated over the 100-week timeframe, with approximately 70% of patients achieving near remission in swollen joint count, enthesitis, and the Psoriasis Area and Severity Index (PASI).

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Introducing CineECG Demonstrator

CineECG

By Introducing CineECG Demonstrator ECG Excellence provides a free downloadable interactive view on how 12 lead ECG interpretation can be so much easier and delivering better results. Much needed since over the past 110 years 12 lead ECG waveform interpretation has remained a major challenge for both Healthcare practitioners and even ECG experts. Recent meta studies have indicated the struggle to correctly interpret an ECG output is there between all kind of expertise levels.

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FDA Approves Humira Biosimilar Adalimumab-ryvk

HCPLive

The approval was based on clinical data from 3 multicenter, randomized trials which demonstrated the safety, efficacy, and biosimilarity of adalimumab-ryvk compared with the reference product.

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Understanding Our Brain: Why We Get Hooked and What to Do about It

Physiologically Speaking

What can slot machines teach us about human behavior? Slot machines make more money than movies, books, and music combined. In Las Vegas, you can find them everywhere — gas stations, grocery stores, bars, and even the airport. Everyone knows that the house always wins. So why do we keep playing? What gets us so hooked? A wealth of human behavior research provides the answers to this question and also explains why humans get hooked on all sorts of behaviors that don’t make sense.

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Voxelotor Benefits Red Blood Cell Functionality in Pediatric Sickle Cell Disease

HCPLive

An ancillary study of the phase 2 HOPE-KIDS 1 trial revealed voxelotor is associated with reduced sickling and hemolysis in children with SCD.

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ACC CardiaCast: Conversations with Critical Care Cardiologists: Closing the Gap: Research Priorities in Critical Care Cardiology

American College of Cardiology

Drs. Morrow and Miller explore the challenges and opportunities in generating high-quality evidence for treating complex, critically ill cardiac patients. With limited clinical trials and guidelines specific to CCC, they examine the variation in cardiovascular intensive care unit practices and identify key areas for CCC research, challenges in the field, and important strategies to enhance future progress.

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Quality Initiative Enhances Iron Deficiency Screening, Treatment in Heart Failure

HCPLive

Introduction of curated materials to assist clinicians was linked to better rates of screening and treatment of iron deficiency anemia among patients with heart failure.

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Case Report: Totally endoscopic minimally invasive mitral valve surgery during pregnancy: a case series

Frontiers in Cardiovascular Medicine

A totally endoscopic minimally invasive approach is widely used for cardiac valve surgery in normal adults. However, minimally invasive cardiac surgery during pregnancy is rarely reported. In addition to traditional median thoracotomy, totally endoscopic minimally invasive approaches can now be used for pregnant patients. We describe our experience with totally endoscopic cardiac valve surgery (TECVS) during pregnancy, which is safe for both mothers and fetuses.

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Nasal Powder Epinephrine Formulation Comparable to EpiPens for Anaphylaxis

HCPLive

These findings may allow for patients with severe allergic reactions to have an alternative to epinephrine auto-injector devices.

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TRI-SCORE and Benefit of Intervention in Severe Tricuspid Regurgitation

American College of Cardiology

What are survival rates after surgical or transcatheter intervention compared to conservative management based on tricuspid regurgitation (TR) clinical stage assessed using TRI-SCORE?

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Clinician Quiz: Recommendations on Treatment Approaches for Eating Disorders

HCPLive

Check your knowledge on the American Psychiatric Association 2023 practice guideline for the treatment of patients with eating disorders.

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Prehospital Stroke Detection in Women Is More Than Identifying LVOs

Stroke Journal

Stroke, Volume 55, Issue 3 , Page 555-557, March 1, 2024.

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NAFLD, Viral Hepatitis Among Liver Diseases Associated With Risk of Incident Cataract

HCPLive

NAFLD, ALD, liver fibrosis and cirrhosis, and recently diagnosed viral hepatitis were all associated with a greater risk of cataract.

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Association of IL-17 Inhibitors with Hypertension in Patients with Autoimmune Diseases: A Systematic Review and Meta-analysis on Randomized Controlled Trials

Journal of Cardiovascular Pharmacology

The influence of IL-17 inhibition on blood pressure in autoimmune disease patients remains inconclusive. Our objective is to examine the risk of hypertension in patients with autoimmune diseases undergoing IL-17 inhibition therapies via meta-analysis of randomized, placebo-controlled trials (RCTs). We obtained integrated data from PubMed, Embase, and ClinicalTrials.gov.

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Both HFpEF and HFmrEF Should be Included in Calculating CHA2DS2–VASc score: a Taiwanese Longitudinal Cohort

HeartRhythm

Congestive heart failure (CHF) as a risk of stroke in AF patients mainly referred to patients with left ventricular systolic dysfunction (HFrEF). Whether this should include patients with preserved ejection fraction (HFpEF) is debatable.

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Dl-3-n-Butylphthalide Alleviates Secondary Brain Damage and Improves Working Memory After Stroke in Cynomolgus Monkeys

Stroke Journal

Stroke, Volume 55, Issue 3 , Page 725-734, March 1, 2024. BACKGROUND:Remote secondary neurodegeneration is associated with poststroke cognitive impairment (PSCI). Dl-3-n-butylphthalide (NBP) improves PSCI clinically. However, whether it ameliorates PSCI by alleviating secondary neurodegeneration remains uncertain. Nonhuman primates provide more relevant models than rodents for human stroke and PSCI.

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Role of arrhythmic phenotype in prognostic stratification and management of dilated cardiomyopathy

European Journal of Heart Failure

Dilated cardiomyopathy with arrhythmic phenotype. AR, arrhythmogenic; CI, confidence interval; CIF, cumulative incidence function; ECG, electrocardiogram; FLNC, filamin C; LMNA, lamin; MVA, major ventricular arrhythmia; NSVT, non-sustained ventricular tachycardia; RBM20, RNA binding motif 20; RMTL, restricted mean time lost; SCD, sudden cardiac death.