Wed.Oct 09, 2024

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COVID-19 infection appeared to increase risk of heart attack & stroke up to 3 years later

American Heart News - Heart News

Research Highlights: An analysis of UK Biobank health data that included adults who had mild to severe COVID-19 before vaccines were available found an increased risk of heart attack, stroke and death among those adults during the nearly three-year.

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History of COVID-19 found to double long-term risk of heart attack, stroke and death

Medical Xpress - Cardiology

A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.

COVID-19 145
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One Way to Spot Early Cognitive Decline? Medicare Wellness Visits

Med Page Today

(MedPage Today) -- A Medicare annual wellness visit (AWV) was associated with greater recognition of mild cognitive impairment in older adults, a population-based cohort study in Texas showed. Compared with those who didn't have an annual visit.

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AstraZeneca Adds Lp(a) Candidate with CSPC Licensing Move

CardiacWire

AstraZeneca expanded its cardiovascular pipeline this week, signing an exclusive license agreement for CSPC Pharmaceutical Group’s Lp(a) disruptor candidate, YS2302018. The deal comes with a $100M upfront investment that could reach $1.92B depending on further milestones. YS2302018 is a small molecule Lipoprotein (a) disruptor intended to treat dyslipidemia patients by preventing the formation of excess blood lipids.

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Researchers succeed in creating two interconnected vascular networks

Medical Xpress - Cardiology

Researchers from the Faculty of Medicine and Health Technology (MET) at Tampere University have successfully created a cell culture platform that allows two cultivated vascular networks to interconnect. The blood vessels in these networks are equivalent to human capillaries in size and structure, facilitating the study of human capillary networks in a laboratory setting.

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Comorbid Migraine, Insomnia Linked to Aberrant Locus Coeruleus Functional Connectivity

HCPLive

Comorbid migraine and insomnia are linked to altered locus coeruleus connectivity, suggesting it is a biomarker for sleep disturbances and a potential therapeutic target.

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COVID-19 infection appeared to increase risk of heart attack and stroke up to 3 years later

Science Daily - Heart Disease

An analysis of data in the UK Biobank has found that COVID-19 infection may increase the risk of heart attack, stroke and death from any cause for up to three years for people with and without cardiovascular disease, according to new research.

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Having a sweet tooth is linked to higher risk of depression, diabetes, and stroke, study finds

Science Daily - Heart Disease

People with a preference for sweets are at a higher risk of developing depression, diabetes, and suffering a stroke, according to new research.

Diabetes 101
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FDA Reviewers Cast Doubt on Drug Candidate for Barth Syndrome

Med Page Today

(MedPage Today) -- Ahead of an FDA advisory committee meeting on Thursday, agency reviewers cast doubt on the efficacy of elamipretide for Barth syndrome, an ultra-rare disease that has no approved treatments. In its new drug application, Stealth.

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Exaggerated Claims about Newly Discovered "Exercise in a Pill"

Physiologically Speaking

Researchers claim to have discovered “exercise in a pill” every few years, like clockwork. They then proceed to oversell its benefits and potential applications to human health and disease. Inevitably the media becomes fascinated with this new molecule or pill and runs wild with headlines about how we have found a way to mimic exercise without all of the hard work (finally).

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Researchers succeed in creating two interconnected vascular networks

Science Daily - Heart Disease

Researchers have developed a groundbreaking cell culture platform that enables the formation of two distinct but interconnected vascular networks. Their breakthrough holds tremendous promise for advancing biomedical research. Organ-on-chips are microfluidic cell cultures that replicate human physiology, significantly reducing the costs of drug development, minimizing the need for animal testing and enabling personalized treatment.

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Study Finds Adrenaline Auto-Injectors Mostly Ineffective Against Fatal Anaphylaxis

HCPLive

During situations in which those with severe allergies suffer from fatal anaphylaxis, adrenaline autoinjectors were shown in this study to have little effect on such reactions.

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Arrhythmic hearts after excessive alcohol consumption

Science Daily - Heart Disease

Researchers find cardiac arrhythmias in partygoers who had drunk a lot of alcohol.

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Optimizing GDMT in Heart Failure Could Slash Global Mortality Rates

HCPLive

Optimal use of GDMT therapy in heart failure could save an estimated 1.19 million lives globally over the course of 1 year.

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“Weekend Warrior� Physical Activity and Cardiometabolic Health

American College of Cardiology

Does the “weekend warrior” pattern of physical activity yield similar reduction in risk for disease as spreading the physical activity across a week?

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Electrocardiogram monitoring study finds arrhythmic hearts after excessive alcohol consumption

Medical Xpress - Cardiology

Medicine is subjecting the negative effects of alcohol on body and health to ever greater scrutiny. This should not surprise us, as alcohol is one of the strongest cell toxins that exist. In a recent study, doctors at LMU University Hospital took mobile ECG monitors along to parties of young people who had one principal aim: to drink and be merry.

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Safety and Efficacy of Renal Denervation in Patients With Hypertension: RADIANCE II Trial

American College of Cardiology

Renal denervation (RDN) is an adjunct treatment for hypertension (HTN) that involves catheter ablation of the sympathetic plexus in the adventitia of the renal arteries using radiofrequency (RF) or ultrasound waves.

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New Providence heart center gets $1M assist from Michael Jordan

Becker's Hospital Review - Cardiology

Renton, Wash.-based Providence Heart Institute's new Howard "H" White Center for Cardiac Amyloidosis has received a $1 million donation from former NBA star Michael Jordan.

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Simplified Gout Remission Definition Feasible, Valid

HCPLive

Remission according to the simplified definition correlated with the 2016 preliminary gout remission definition and GIS score improvements.

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Myocardial strain analysis by feature tracking cardiac magnetic resonance to identify subclinical cardiac dysfunction in patients with MINOCA

Journal of Cardiothoracic Surgery

To investigate whether feature tracking cardiac magnetic resonance (FT-CMR) can identify subclinical myocardial dysfunction in patients with myocardial infarction with non-obstructed coronary arteries (MINOCA).

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Zobair Younossi, MD, MPH: Resmetirom’s Impact on Health-Related Quality of Life in MASH

HCPLive

Younossi explains how MASH negatively impacts patients’ quality of life and describes resmetirom’s benefit across multiple HRQoL domains.

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Fine tuning for totally endoscopic mitral valve surgery: ERAS applications

Frontiers in Cardiovascular Medicine

AimOne of the philosophies of minimally invasive mitral surgery is to enhance recovery after surgery (ERAS). Beyond surgical applications, ERAS applications provide a complementary approach to optimize postoperative course and discharge. In this report, we aim to present institutional protocol for ERAS and its results in patients who underwent totally endoscopic mitral valve surgery (TEMVS).Patients and methodsBetween 2021 and 2023, totally 113 patients who underwent TEMVS were included in this

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Updates in Primary Biliary Cholangitis Care, with Allysa Saggese, NP

HCPLive

Saggese explains the importance of second-line therapies in PBC, newly approved treatment options, and their impact on treatment goals and timelines.

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Mapping the landscape of PSC-CM research through bibliometric analysis

Frontiers in Cardiovascular Medicine

ObjectivesThe discovery of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) has not only deepened our understanding of the pathogenesis and progression of heart disease, but also advanced the development of engineered cardiac tissues, cardiac regenerative therapy, drug discovery and the cardiotoxicity assessment of drugs. This study aims to visualize the developmental trajectory of PSC-CM research over the past 18 years to identify the emerging research frontiers and challenges.MethodsThe

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Nearly 50 years after research began, more questions than answers about Hispanic heart health

Medical Xpress - Cardiology

There are more than 65 million Hispanic and Latino people living in the U.S.—the second-largest racial or ethnic minority population in the country. Yet when it comes to heart and brain health, less may be understood about this population than any other.

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Prevalence and predictors of false positive QTc prolongation by the automated measurement

Frontiers in Cardiovascular Medicine

BackgroundCorrected QT (QTc) is an important electrocardiographic (ECG) interval. Physicians rely on automated QTc provided by ECG machines while the manual method is the recommended method. We sought to assess the prevalence and predictors of false positive QTc prolongation by the automated measurement.Methods and resultsConsecutive ECGs were retrieved from the ECG database at King Khaled University Hospital.

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Study Identifies Lack of Diversity in Food Allergy Immunotherapy Research

HCPLive

These findings highlight the underrepresentation of Black and Hispanic food allergy clinical trial participants and raise concerns about the generalizability of clinical research findings.

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Machine-learning based risk prediction of in-hospital outcomes following STEMI: the STEMI-ML score

Frontiers in Cardiovascular Medicine

BackgroundTraditional prognostic models for ST-segment elevation myocardial infarction (STEMI) have limitations in statistical methods and usability.ObjectiveWe aimed to develop a machine-learning (ML) based risk score to predict in-hospital mortality, intensive care unit (ICU) admission, and left ventricular ejection fraction less than 40% (LVEF < 40%) in STEMI patients.MethodsWe reviewed 1,863 consecutive STEMI patients undergoing primary percutaneous coronary intervention (pPCI) or rescue PCI

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Report Details Presentation, Treatment of Poppers Dermatitis

HCPLive

New research reveals amyl nitrite (poppers) use is linked to dermatitis, with perianal and perioral regions most affected.

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P-wave terminal force in lead V1 is associated with recurrence after catheter ablation in patients with paroxysmal atrial fibrillation and normal left atrial size

Frontiers in Cardiovascular Medicine

BackgroundA previous investigation reported that an abnormal P-wave terminal force in lead V1 (PTFV1) is a marker for electrical remodeling of the left atrium (LA). We aimed to assess the relationship of PTFV1 with LA tachyarrhythmia (LATA) recurrence after radiofrequency catheter ablation (RFCA) in patients with paroxysmal atrial fibrillation (PAF) and normal LA size.MethodsPatients with PAF and normal LA size (LA volume index   4,000 μV*ms were 1.22 (1.13–1.32, p < 0.001) and 2.32 (1.54–3.48,

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Is Intracranial Atherosclerotic Disease Associated with Dementia Risk?

NEJM Journal Watch - Cardiology

After adjustment for known risk factors, ICAD was associated with elevated dementia risk at 5 years.

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Association of body roundness index with abdominal aortic calcification among middle aged and elderly population: findings from NHANES

Frontiers in Cardiovascular Medicine

AimWe aim to investigate the association between body roundness index (BRI) and abdominal aortic calcification (AAC) among middle aged and elderly US residents.MethodsThis cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014 cycle, including 3,079 middle-aged and elderly participants aged 40 and above.

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ODYSSEY: CLS-AX Maintains Stable Visual Acuity in Wet AMD Treatment

HCPLive

Topline results from the Phase 2b ODYSSEY trial show suprachoroidal CLS-AX achieved all primary and secondary outcomes for wet AMD.

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Case Report: Ethanol ablation of the Marshall vein as the first step for left atrial tachycardia ablation

Frontiers in Cardiovascular Medicine

Electroanatomic mapping guides complex atrial tachycardia ablations; however, challenges may emerge after pulmonary vein isolation. 3D mapping systems can reveal the mechanism of tachycardia and critical areas that need to be ablated. Sometimes, however, these areas may be located deep inside, to the extent that they cannot be successfully reached by endocardial ablation.

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Cupping Therapy Eases Migraine Pain but Fails to Enhance Quality of Life

HCPLive

A meta-analysis shows that wet cupping reduces migraine intensity but doesn't improve quality of life. Adjunctive therapies offer limited additional benefits.

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Prognostic value of the left ventricular ejection fraction reserve acquired by gated myocardial perfusion SPECT in patients with CAD and reduced stress LVEF

Frontiers in Cardiovascular Medicine

PurposeLeft ventricular ejection fraction (LVEF) strongly predicts cardiac events. However, conflicting findings exist regarding the prognostic value of the LVEF reserve (ΔLVEF) when measured by gated single-photon emission computed tomography myocardial perfusion imaging (SPECT G-MPI). In particular, data related to the prognostic value of ΔLVEF when measured by SPECT in patients with reduced LVEF are scarce.

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Bivalirudin vs. Heparin Anticoagulation in STEMI

American College of Cardiology

What are the outcomes of bivalirudin vs. heparin anticoagulation during percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI)?

STEMI 53