Wed.Nov 20, 2024

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Weight-loss drug found to shrink heart muscle in mice and human cells

Medical Xpress - Cardiology

Trendy weight-loss drugs making headlines for shrinking waistlines may also be shrinking the human heart and other muscles, according to a new University of Alberta study in JACC: Basic to Translational Science. The authors say the research should serve as a "cautionary tale" about possible long-term health effects of these drugs.

Research 143
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GLP-1 Use Prior to Surgery: Analyzing the Updated Guidance

Med Page Today

(MedPage Today) -- Since the modern practice of anesthesia has evolved, providers have been concerned about pulmonary aspiration -- when gastric contents enter the lung, resulting in severe complications including pneumonitis, and aspiration.

Pulmonary 122
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Weight-loss drug reduces risk of early death for patients with heart failure, trial finds

Science Daily - Heart Disease

Weight-loss and diabetes drug tirzepatide can reduce the risk of death or worsening heart failure for patients with obesity and heart failure with preserved pump function, new research reveals.

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Sacubitril/Valsartan Curbs Cardiotoxicity From Chemotherapy

Med Page Today

(MedPage Today) -- CHICAGO -- Sacubitril/valsartan (Entresto) was effective at keeping cardiotoxicity at bay in high-risk people receiving anthracycline chemotherapy in the SARAH trial. Cancer patients were less likely to have a greater than.

Cancer 116
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Mapping of atherosclerotic plaque cells may predict future risk of stroke or heart attack

Medical Xpress - Cardiology

In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions for causing a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future.

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Metformin, Lifestyle Changes Fail to Reduce Afib Burden

Med Page Today

(MedPage Today) -- CHICAGO -- Metformin with or without lifestyle modification did not reduce daily atrial fibrillation (Afib) burden over standard of care for patients with implanted heart devices, the randomized TRIM-AF trial showed. In fact.

AFIB 94
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Data brief: Prevalence of high total cholesterol 11.3% in US adults from Aug. 2021–Aug. 2023

Medical Xpress - Cardiology

The prevalence of high total cholesterol was 11.3% among U.S. adults from August 2021 to August 2023, according to a November data brief published by the National Center for Health Statistics.

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Clinically validated, wearable ultrasound patch enables continuous blood pressure monitoring

Medical Xpress - Cardiology

A team of researchers at the University of California San Diego has developed a new and improved wearable ultrasound patch for continuous and noninvasive blood pressure monitoring. Their work marks a major milestone, as the device is the first wearable ultrasound blood pressure sensor to undergo rigorous and comprehensive clinical validation on over 100 patients.

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New Medical Guidance Provides Insurance Recommendations for Allergen Immunotherapy

HCPLive

In these guidelines compiled by the ACAAI, the AAAAI, and the AAOA, recommendations are provided to insurance companies for documentation needed for allergen immunotherapy.

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Diagnostic Complexity in Monoclonal Gammopathy of Thrombotic Significance

The New England Journal of Medicine

A man with monoclonal gammopathy of undetermined significance and thrombosis was found to have a previously undetected pathogenic monoclonal antibody that activated platelets in a PF4-dependent manner.

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New cardiac MRI technique better spots serious heart ailment

Medical Xpress - Cardiology

A new technology that allows doctors to quantify blood flow in the heart can improve their ability to diagnose potentially deadly coronary artery disease (CAD), an international study led by School of Medicine investigators has found.

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Quantitative Coronary Plaque Analysis by Coronary Computed Tomography Angiography: Is it Ready For Primetime?

American College of Cardiology

A unique strength of coronary computed tomography angiography (CCTA) is the ability to noninvasively detect nonobstructive and obstructive coronary plaque.

Plaque 71
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Viral myocarditis study uncovers three key heart responses to infection

Medical Xpress - Cardiology

Researchers at the University of Virginia have made a significant discovery that could change how doctors treat viral infections of the heart. The study, published in Science Advances, reveals that the heart responds to viral infections in one of three distinct ways, offering new insights that may lead to better treatments for people at risk of heart failure.

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FDA Approves Bimekizumab for Adults with Hidradenitis Suppurativa

HCPLive

UCB has announced the FDA’s approval of bimekizumab, also known as Bimzelx, for patients with moderate-to-severe HS.

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Recycled pacemakers function as well as new devices, international study suggests

Science Daily - Heart Disease

Recycled pacemakers can function as well as new devices, according to a new study. These used and reconditioned devices have the potential to increase access to pacemaker therapy in low- and middle-income countries, where many patients cannot afford the treatment.

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JACC State-of-the-Art Review Explores Relationship Between Obesity and SCD

American College of Cardiology

Sudden cardiac death (SCD) in obesity is the focus of a JACC: State-of-the-Art review of the mechanisms as well as current evidence for its management, gaps in knowledge and future research, published in JACC.

Obesity 65
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Marianna Fontana, MD, PhD: Nex-Z Shows Promise in ATTR-CM Phase 1 Trial

HCPLive

Marianna Fontana, MD, PhD discusses Phase 1 interim results on the CRISPR-based gene-editing therapy, nex-z, for ATTR-CM.

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State-of-the Art Review Discusses Risk and Potential of AI in Clinical Trials

American College of Cardiology

A State-of-the-Art review published in JACC outlines the range of potential opportunities for the incorporation of artificial intelligence (AI) in the design and implementation of cardiovascular clinical trials, as well as the limitations and potential pitfalls.

Article 63
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Anticoagulation in Patients with Cancer-Associated Pulmonary Embolism: How Long is Long Enough?

NEJM Journal Watch - Cardiology

Among patients with low-risk pulmonary embolism, 18 months of anticoagulation significantly reduced its recurrence, compared with 6 months of treatment.

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Peanut-Sensitized Infants with Eczema Already Co-Sensitized to Tree Nuts

HCPLive

This analysis evaluated the frequency of peanut-sensitized infants and toddlers being sensitized to other types of nuts.

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Exercise Training in HCM; Management of Kawasaki Disease; Race, SDoH, Polygenic Risk for CHD

American College of Cardiology

In this week’s View, Dr. Eagle looks at exercise training in patients with hypertrophic cardiomyopathy (HCM).

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Differential Diagnosis of PBC

HCPLive

The panel of experts focus on strategies for distinguishing primary biliary cholangitis (PBC) from other liver diseases with similar clinical presentations, emphasizing key diagnostic markers and assessment techniques.

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The factors behind the shifting trends of ischemic heart disease and stroke

Science Daily - Heart Disease

Incidence of stroke and ischemic heart disease are declining around the world, except for in a handful of regions, according to a new study. Researchers find that in East and West Sub-Saharan Africa, East and Central Asia and Oceania, ischemic heart disease is increasing, which may be attributed to eight factors that include diet, high BMI, household air pollution and more.

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Distinct Genetic Risk Profile Found in Aortic Stenosis

American College of Cardiology

Which genetic and cardiovascular risk factors are aortic stenosis (AS)-specific, and which could be shared between AS and with coronary artery disease (CAD)?

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Pathways from insulin resistance to incident cardiovascular disease: a Bayesian network analysis

Cardiovascular Diabetology

Insulin resistance coexist with many metabolic disorders, whether these disorders were promotors or pathway-factors for the association of insulin resistance and cardiovascular disease (CVD) remained unclear.

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Researchers explore new therapy for diabetes-related heart disease

Medical Xpress - Cardiology

Monash University drug discovery researchers have found that a natural fat molecule called "lipoxin A4" (LXA4) could significantly reduce inflammation and improve function for diabetic hearts.

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Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults

Cardiovascular Diabetology

Objectives This study aimed to investigate the impact of hepatic steatosis on cardiometabolic outcomes in young adults with prediabetes. Methods A nationwide cohort study was conducted with 896,585 young adults under 40 years old without diabetes or previous history of cardiovascular disease. Hepatic steatosis was identified using a fatty liver index of ≥ 60.

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Study highlights feasibility of cranial accelerometry device for prehospital detection of large-vessel occlusion stroke

Medical Xpress - Cardiology

A new study exploring the use of cranial accelerometry (CA) headsets for the prehospital detection of large-vessel occlusion (LVO) strokes has been published in Academic Emergency Medicine.

Strokes 52
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Respiratory endoscopy intervention in 12 patients with refractory persistent air leakage after pulmonary surgery: a preliminary study of case series

Journal of Cardiothoracic Surgery

To explore the value of our protocol of respiratory endoscopy intervention in the treatment of refractory persistent air leakage(PAL) after pulmonary surgery.

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Research highlights disparities in heart disease, stroke trends worldwide

Medical Xpress - Cardiology

Incidence of stroke and ischemic heart disease are declining around the world, except for in a handful of regions, according to research in PLOS Global Public Health. Wanghong Xu of Fudan University and colleagues find that in East and West Sub-Saharan Africa, East and Central Asia and Oceania, ischemic heart disease is increasing, which may be attributed to eight factors that include diet, high BMI, household air pollution and more.

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AI Assessments, Robotics Perform to Rheumatologist Levels in Joint Assessment

HCPLive

Data from 2 studies presented at ACR 2024 demonstrate the potential of AI to improve access to quality rheumatological assessments.

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Potassium Binder Cuts Hyperkalemia Risk in HF Patients on Spironolactone

Med Page Today

(MedPage Today) -- CHICAGO -- Treatment with the potassium binder sodium zirconium cyclosilicate (SZC; Lokelma) stabilized potassium levels among patients with heart failure with reduced ejection fraction (HFrEF) during spironolactone optimization.

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Phase 2 Data Support Muvalaplin for Lowering Lp(a), with Stephen Nicholls, MBBS, PhD

HCPLive

Stephen Nicholls, MBBS, PhD, provides additional insight into KRAKEN trial data and the potential of muvalaplin.

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A-fib plus heart failure a dangerous combo

Medical Xpress - Cardiology

For the four in 10 patients with newly diagnosed heart failure who also have the heart rhythm disorder atrial fibrillation, the prognosis can be poor.

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Zerlasiran Achieves Durable Lp(a) Reductions at 60 Weeks, with Stephen J. Nicholls, MD, PhD

HCPLive

Stephen J. Nicholls, MD, PhD discusses the robust efficacy and tolerability of zerlasiran for Lp(a) lowering, paving the way for Phase 3 development.

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Effectiveness of Photoplethysmography-based Rhythm Monitoring after Atrial Fibrillation Ablation using a Smartphone Application: DIGITOTAL-Study

HeartRhythm

Recurrence after atrial fibrillation (AF) ablation is frequent. Monitoring with (long-term) electrocardiograms (ECG) is constrained by limited monitoring time, measurement dispersion, and cost. Selected photoplethysmography (PPG) smartphone applications have demonstrated excellent accuracy for AF detection and could mitigate these limitations.

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Disease Progression and Extrahepatic Manifestations of PBC

HCPLive

The panel of experts examine major complications and comorbidities associated with primary biliary cholangitis (PBC), including vitamin deficiencies, osteoporosis, and conditions like metabolic-associated steatohepatitis (MASH), autoimmune disorders, and obesity.

Obesity 52